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吞咽会中毒",[],[230,233,236,239,242,245,248,251],{"key":231,"value":232},"描述","Ketanserin tartrate 是一种选择性的 5-HT receptor 拮抗剂。Ketanserin tartrate 也抑制 hERG 电流 (IhERG),IC50 为 0.11 μM,这种作用具有浓度依赖性。",{"key":234,"value":235},"相关类别","信号通路\n>>\nG 蛋白偶联受体\u002FG 蛋白\n>>\n5-HT受体\n信号通路\n>>\n神经信号通路\n>>\n5-HT受体\n信号通路\n>>\n自噬\n>>\n自噬\n信号通路\n>>\n跨膜转运\n>>\n钾通道\n天然产物\n>>\n生物碱\n研究领域\n>>\n神经疾病",{"key":237,"value":238},"靶点","IC50: 0.11 μM (hERG current)[1] IC50: 152±23 μM (5-HT receptor)[2]",{"key":240,"value":241},"体外研究","0.3μM的酮色林抑制hERG通道的电压依赖性步进电流(IhERG.step)和尾电流(IhERG.tail),暴露时间为5分钟[1]。对于具有5-HT的AA观察到的协同效应也被5-HT受体阻断剂赛庚啶(IC50 = 22.0±7μM),酮色林(IC50 = 152±23μM)阻断。酮色林(50-350μM)通过以剂量依赖性方式阻断受体来抑制协同作用。 Cyproheptadine的IC50值为22±7μM,Ketanserin的IC50值为152±23μM[2]。酮色林抑制血小板聚集,IC50为240(169-339)nM [3]。",{"key":243,"value":244},"体内研究","酮色林是5-HT2A受体拮抗剂。 Ketanserin显着降低许多大脑区域(海马CA1和CA3,前额叶皮质,中央杏仁核,背内侧下丘脑核,齿状回,伏隔核和中脑导水管周围灰质)的BDNF蛋白水平。 5-HT2A拮抗剂Ketanserin可以显着降低各脑区的BDNF mRNA水平[4]。",{"key":246,"value":247},"细胞实验","将建立的稳定表达hERG通道的HEK 293细胞系在补充有10％胎牛血清，400μg\u002F mL G418的Dulbecco改良的Eagle培养基（DMEM）中培养。稳定表达重组人心脏KCNQ1 \u002F KCNE1通道电流（IKs）的HEK 293细胞系维持在含有10％胎牛血清和100μg\u002F mL潮霉素的DMEM中。将用于电生理学的细胞接种在玻璃盖玻片上。构建突变体hERG通道，并使用10μLLipofectamine2000和pCDNA3载体中的4μghERG突变体cDNA在HEK 293细胞中瞬时表达[1]。",{"key":249,"value":250},"动物实验","大鼠[4]使用总共155只无特定病原体的2月龄雄性Sprague-Dawley大鼠，体重180-220g。将大鼠随机分为以下六组：5-HT1A受体激动剂（8-OH-DPAT）PS组（DPAT-PS组，n = 30）; 5-HT1A受体拮抗剂（MDL73005）PS组（MDL-PS组，n = 30）; 5-HT2A受体激动剂（DOI）PS组（DOI-PS组，n = 30）; 5-HT2A受体拮抗剂（Ketanserin）PS组（Ketan-PS组，n = 30）;溶剂对照无应激组（0.9％生理盐水组，CON组）;和仅PS组（PS组，n = 30）。根据应力和分析之间的时间，将DPAT-PS，MDL-PS，DOI-PS，Ketan-PS和PS组进一步分为六个亚组（每组n = 5）;压力后立即，压力后0.5,1,2,6和24小时。 CON组（n = 5）接收正常饲料。对于Ketan-PS组，溶解于0.9％生理盐水中的酮色林在每次应激暴露前1小时以5mg \u002F kg腹膜内注射。",{"key":252,"value":253},"参考文献","[1].\nTang Q, et al. The 5-HT2 antagonist Ketanserin is an open channel blocker of human cardiac ether-à-go-go-related gene (hERG) potassium channels. Br J Pharmacol. 2008 Oct;155(3):365-73.\n[2].\nKhan N, et al. Investigation of cyclooxygenase and signaling pathways involved in human platelet aggregation mediated by synergistic interaction of various agonists. Drug Des Devel Ther. 2015 Jul 6;9:3497-506.\n[3].\nKekewska A, et al. Antiserotonergic properties of terguride in blood vessels, platelets, and valvular interstitial cells. J Pharmacol Exp Ther. 2012 Feb;340(2):369-76.\n[4].\nJiang DG, et al. Serotonin regulates brain-derived neurotrophic factor expression in select brain regions during acute psychological stress. Neural Regen Res. 2016 Sep;11(9):1471-1479.",[255,261,267,273,279,285,291],{"slug":256,"cid":257,"name":258,"nameZh":258,"cas":259,"imgSvg":260},"785895667066212400","J-42435-1","凯他色林","74050-98-9","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F094\u002F74050-98-9.svg",{"slug":262,"cid":263,"name":264,"nameZh":264,"cas":265,"imgSvg":266},"785872017550217200","J-1990710-9","酒石酸","87-69-4","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F272\u002F87-69-4.svg",{"slug":268,"cid":269,"name":270,"nameZh":270,"cas":271,"imgSvg":272},"785897548459020300","J-1522240-9","4-(4-氟苯甲酰基)哌啶盐酸盐","25519-78-2","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F081\u002F25519-78-2.svg",{"slug":274,"cid":275,"name":276,"nameZh":276,"cas":277,"imgSvg":278},"785894070458257400","J-37095-6","2-氨基苯甲酸乙酯","87-25-2","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F262\u002F87-25-2.svg",{"slug":280,"cid":281,"name":282,"nameZh":282,"cas":283,"imgSvg":284},"785889410628456400","J-1360695-6","3-(2-羟乙基)-1,2,3...","1207-75-6","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F428\u002F1207-75-6.svg",{"slug":286,"cid":287,"name":288,"nameZh":288,"cas":289,"imgSvg":290},"785873131922264000","J-1341169-3","4-(4-氟苯甲酰基)哌啶","56346-57-7","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F485\u002F56346-57-7.svg",{"slug":292,"cid":293,"name":294,"nameZh":294,"cas":295,"imgSvg":296},"785872931992375300","J-1344775-1","3-(2-氯乙基)-2,4(1...","5081-87-8","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F459\u002F5081-87-8.svg",[],[],[300,303,305,308,311,314,317,320,323,326,329,332],{"key":301,"value":302},"符号","GHS06",{"key":304,"value":225},"信号词",{"key":306,"value":307},"危害声明","H301",{"key":309,"value":310},"警示性声明","P301 + P310",{"key":312,"value":313},"个人防护装备","Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges",{"key":315,"value":316},"危害码 (欧洲)","T: Toxic;",{"key":318,"value":319},"风险声明 (欧洲)","R25",{"key":321,"value":322},"安全声明 (欧洲)","S22-S36\u002F37\u002F39-S45",{"key":324,"value":325},"危险品运输编码","UN 2811 6.1\u002FPG 3",{"key":327,"value":328},"WGK德国","3",{"key":330,"value":331},"RTECS号","VA1411195",{"key":333,"value":334},"危险类别","6.1","\u003Ctd>\n\n\u003Cp>\u003Ca href=\"\u002Fen\u002Fcas\u002F83846-83-7_1104959.html#duXinDiv\">酒石酸酮色林毒性英文版\u003C\u002Fa>\u003C\u002Fp>\n\n\u003C\u002Ftd>","\u003Ctd>\n\n\n\u003Cstrong>模块1. 化学品\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>1.1 产品标识符\u003C\u002Fb>\n\u003Cbr \u002F> : Ketanserin (+)-tartrate salt\n\u003Cbr \u002F> 产品名称\n\u003Cbr \u002F>\n\u003Cb>1.2 鉴别的其他方法\u003C\u002Fb>\n\u003Cbr \u002F> R 41468\n\u003Cbr \u002F> 3-(2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl)-2,4(1H,3H)-quinazolinedione\n\u003Cbr \u002F>\n\u003Cb>1.3 有关的确定了的物质或混合物的用途和建议不适合的用途\u003C\u002Fb>\n\u003Cbr \u002F> 仅用于研发。不作为药品、家庭或其它用途。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块2. 危险性概述\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>2.1 GHS-分类\u003C\u002Fb>\n\u003Cbr \u002F> 急性毒性, 经口 (类别 3)\n\u003Cbr \u002F>\n\u003Cb>2.2 GHS 标记要素，包括预防性的陈述\u003C\u002Fb>\n\u003Cbr \u002F> 象形图\n\u003Cbr \u002F> 警示词危险\n\u003Cbr \u002F> 危险申明\n\u003Cbr \u002F> H301吞咽会中毒\n\u003Cbr \u002F> 警告申明\n\u003Cbr \u002F> 预防措施\n\u003Cbr \u002F> P264操作后彻底清洁皮肤。\n\u003Cbr \u002F> P270使用本产品时不要进食、饮水或吸烟。\n\u003Cbr \u002F> 事故响应\n\u003Cbr \u002F> P301 + P310如果吞下去了: 立即呼救解毒中心或医生。\n\u003Cbr \u002F> P321具体处置（见本标签上提供的急救指导）。\n\u003Cbr \u002F> P330漱口。\n\u003Cbr \u002F> 安全储存\n\u003Cbr \u002F> P405存放处须加锁。\n\u003Cbr \u002F> 废弃处置\n\u003Cbr \u002F> P501将内容物\u002F 容器处理到得到批准的废物处理厂。\n\u003Cbr \u002F>\n\u003Cb>2.3 其它危害物 - 无\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块3. 成分\u002F组成信息\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>3.1 物 质\u003C\u002Fb>\n\u003Cbr \u002F> : R 41468\n\u003Cbr \u002F> 别名\n\u003Cbr \u002F> 3-(2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl)-2,4(1H,3H)-\n\u003Cbr \u002F> quinazolinedione\n\u003Cbr \u002F> : C22H22FN3O3 · C4H6O6\n\u003Cbr \u002F> 分子式\n\u003Cbr \u002F> : 545.51 g\u002Fmol\n\u003Cbr \u002F> 分子量\n\u003Cbr \u002F> 组分浓度或浓度范围\n\u003Cbr \u002F> 3-[2-[4-(4-Fluorobenzoyl)piperidino]ethyl]quinazoline-2,4(1H3H)-dione [R-(R*,R*)]-tartrate\n\u003Cbr \u002F> <=100%\n\u003Cbr \u002F> 化学文摘登记号(CAS 83846-83-7\n\u003Cbr \u002F> No.) 281-062-8\n\u003Cbr \u002F> EC-编号\n\u003Cbr \u002F>\n\n\u003Cstrong>模块4. 急救措施\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>4.1 必要的急救措施描述\u003C\u002Fb>\n\u003Cbr \u002F> 一般的建议\n\u003Cbr \u002F> 请教医生。 向到现场的医生出示此安全技术说明书。\n\u003Cbr \u002F> 吸入\n\u003Cbr \u002F> 如果吸入,请将患者移到新鲜空气处。 如呼吸停止,进行人工呼吸。 请教医生。\n\u003Cbr \u002F> 皮肤接触\n\u003Cbr \u002F> 用肥皂和大量的水冲洗。 立即将患者送往医院。 请教医生。\n\u003Cbr \u002F> 眼睛接触\n\u003Cbr \u002F> 用水冲洗眼睛作为预防措施。\n\u003Cbr \u002F> 食入\n\u003Cbr \u002F> 切勿给失去知觉者通过口喂任何东西。 用水漱口。 请教医生。\n\u003Cbr \u002F>\n\u003Cb>4.2 主要症状和影响，急性和迟发效应\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>4.3 及时的医疗处理和所需的特殊处理的说明和指示\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\n\u003Cstrong>模块5. 消防措施\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>5.1 灭火介质\u003C\u002Fb>\n\u003Cbr \u002F> 灭火方法及灭火剂\n\u003Cbr \u002F> 用水雾,抗乙醇泡沫,干粉或二氧化碳灭火。\n\u003Cbr \u002F>\n\u003Cb>5.2 源于此物质或混合物的特别的危害\u003C\u002Fb>\n\u003Cbr \u002F> 碳氧化物, 氮氧化物, 氟化氢\n\u003Cbr \u002F>\n\u003Cb>5.3 给消防员的建议\u003C\u002Fb>\n\u003Cbr \u002F> 如必要的话,戴自给式呼吸器去救火。\n\u003Cbr \u002F>\n\u003Cb>5.4 进一步信息\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\n\u003Cstrong>模块6. 泄露应急处理\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>6.1 作业人员防护措施、防护装备和应急处置程序\u003C\u002Fb>\n\u003Cbr \u002F> 戴呼吸罩。 避免粉尘生成。 避免吸入蒸气、烟雾或气体。 保证充分的通风。 人员疏散到安全区域。\n\u003Cbr \u002F> 避免吸入粉尘。\n\u003Cbr \u002F>\n\u003Cb>6.2 环境保护措施\u003C\u002Fb>\n\u003Cbr \u002F> 如能确保安全，可采取措施防止进一步的泄漏或溢出。 不要让产品进入下水道。\n\u003Cbr \u002F>\n\u003Cb>6.3 泄漏化学品的收容、清除方法及所使用的处置材料\u003C\u002Fb>\n\u003Cbr \u002F> 收集和处置时不要产生粉尘。 扫掉和铲掉。 放入合适的封闭的容器中待处理。\n\u003Cbr \u002F>\n\u003Cb>6.4 参考其他部分\u003C\u002Fb>\n\u003Cbr \u002F> 丢弃处理请参阅第13节。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块7. 操作处置与储存\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>7.1 安全操作的注意事项\u003C\u002Fb>\n\u003Cbr \u002F> 避免接触皮肤和眼睛。 避免形成粉尘和气溶胶。\n\u003Cbr \u002F> 在有粉尘生成的地方,提供合适的排风设备。\n\u003Cbr \u002F>\n\u003Cb>7.2 安全储存的条件,包括任何不兼容性\u003C\u002Fb>\n\u003Cbr \u002F> 贮存在阴凉处。 使容器保持密闭，储存在干燥通风处。\n\u003Cbr \u002F> 建议的贮存温度： 2 - 8 °C\n\u003Cbr \u002F>\n\u003Cb>7.3 特定用途\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\n\u003Cstrong>模块8. 接触控制和个体防护\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>8.1 容许浓度\u003C\u002Fb>\n\u003Cbr \u002F> 最高容许浓度\n\u003Cbr \u002F> 没有已知的国家规定的暴露极限。\n\u003Cbr \u002F>\n\u003Cb>8.2 暴露控制\u003C\u002Fb>\n\u003Cbr \u002F> 适当的技术控制\n\u003Cbr \u002F> 避免与皮肤、眼睛和衣服接触。 休息前和操作本品后立即洗手。\n\u003Cbr \u002F> 个体防护设备\n\u003Cbr \u002F> 眼\u002F面保护\n\u003Cbr \u002F> 面罩與安全眼鏡请使用经官方标准如NIOSH (美国) 或 EN 166(欧盟) 检测与批准的设备防护眼部。\n\u003Cbr \u002F> 皮肤保护\n\u003Cbr \u002F> 戴手套取 手套在使用前必须受检查。\n\u003Cbr \u002F> 请使用合适的方法脱除手套(不要接触手套外部表面),避免任何皮肤部位接触此产品.\n\u003Cbr \u002F> 使用后请将被污染过的手套根据相关法律法规和有效的实验室规章程序谨慎处理. 请清洗并吹干双手\n\u003Cbr \u002F> 所选择的保护手套必须符合EU的89\u002F686\u002FEEC规定和从它衍生出来的EN 376标准。\n\u003Cbr \u002F> 完全接触\n\u003Cbr \u002F> 物料: 丁腈橡胶\n\u003Cbr \u002F> 最小的层厚度 0.11 mm\n\u003Cbr \u002F> 溶剂渗透时间: 480 min\n\u003Cbr \u002F> 测试过的物质Dermatril® (KCL 740 \u002F Z677272, 规格 M)\n\u003Cbr \u002F> 飞溅保护\n\u003Cbr \u002F> 物料: 丁腈橡胶\n\u003Cbr \u002F> 最小的层厚度 0.11 mm\n\u003Cbr \u002F> 溶剂渗透时间: 480 min\n\u003Cbr \u002F> 测试过的物质Dermatril® (KCL 740 \u002F Z677272, 规格 M)\n\u003Cbr \u002F> , 测试方法 EN374\n\u003Cbr \u002F> 如果以溶剂形式应用或与其它物质混合应用，或在不同于EN\n\u003Cbr \u002F> 374规定的条件下应用，请与EC批准的手套的供应商联系。\n\u003Cbr \u002F> 这个推荐只是建议性的,并且务必让熟悉我们客户计划使用的特定情况的工业卫生学专家评估确认才可.\n\u003Cbr \u002F> 这不应该解释为在提供对任何特定使用情况方法的批准.\n\u003Cbr \u002F> 身体保护\n\u003Cbr \u002F> 全套防化学试剂工作服, 防护设备的类型必须根据特定工作场所中的危险物的浓度和数量来选择。\n\u003Cbr \u002F> 呼吸系统防护\n\u003Cbr \u002F> 如危险性评测显示需要使用空气净化的防毒面具，请使用全面罩式多功能微粒防毒面具N99型（US）\n\u003Cbr \u002F> 或P2型（EN\n\u003Cbr \u002F> 143）防毒面具筒作为工程控制的候补。如果防毒面具是保护的唯一方式，则使用全面罩式送风防毒\n\u003Cbr \u002F> 面具。 呼吸器使用经过测试并通过政府标准如NIOSH（US）或CEN（EU）的呼吸器和零件。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块9. 理化特性\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>9.1 基本的理化特性的信息\u003C\u002Fb>\n\u003Cbr \u002F> a) 外观与性状\n\u003Cbr \u002F> 形状: 固体\n\u003Cbr \u002F> 颜色: 白色\n\u003Cbr \u002F> b) 气味\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> c) 气味阈值\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> d) pH值\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> e) 熔点\u002F凝固点\n\u003Cbr \u002F> 熔点\u002F凝固点: 183 - 186 °C\n\u003Cbr \u002F> f) 沸点、初沸点和沸程\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> g) 闪点\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> h) 蒸发速率\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> i) 易燃性(固体,气体)\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> j) 高的\u002F低的燃烧性或爆炸性限度 无数据资料\n\u003Cbr \u002F> k) 蒸气压\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> l) 蒸汽密度\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> m) 密度\u002F相对密度\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> n) 水溶性\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> o) n-辛醇\u002F水分配系数\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> p) 自燃温度\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> q) 分解温度\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> r) 粘度\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\n\u003Cstrong>模块10. 稳定性和反应活性\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>10.1 反应性\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>10.2 稳定性\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>10.3 危险反应\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>10.4 应避免的条件\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>10.5 不相容的物质\u003C\u002Fb>\n\u003Cbr \u002F> 强氧化剂\n\u003Cbr \u002F>\n\u003Cb>10.6 危险的分解产物\u003C\u002Fb>\n\u003Cbr \u002F> 其它分解产物 - 无数据资料\n\u003Cbr \u002F>\n\n\u003Cstrong>模块11. 毒理学资料\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>11.1 毒理学影响的信息\u003C\u002Fb>\n\u003Cbr \u002F> 急性毒性\n\u003Cbr \u002F> 半数致死剂量 (LD50) 经口 - 大鼠 - 129 mg\u002Fkg\n\u003Cbr \u002F> 备注: 行为的：睡眠时间改变（包括正位反射的改变）。 行为的：嗜睡（全面活力抑制）。 呼吸失调\n\u003Cbr \u002F> 皮肤刺激或腐蚀\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> 眼睛刺激或腐蚀\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> 呼吸道或皮肤过敏\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> 生殖细胞致突变性\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> 致癌性\n\u003Cbr \u002F> IARC:\n\u003Cbr \u002F> 此产品中没有大于或等于 0。1%含量的组分被 IARC鉴别为可能的或肯定的人类致癌物。\n\u003Cbr \u002F> 生殖毒性\n\u003Cbr \u002F> 生殖毒性 - 大鼠 - 经口\n\u003Cbr \u002F> 父体效应：睾丸、附睾、输精管。\n\u003Cbr \u002F> 生殖毒性 - 大鼠 - 经口\n\u003Cbr \u002F> 母体效应：分娩。 对新生儿的影响：存活率（例如＃第4天存活率每＃出生成活数）。\n\u003Cbr \u002F> 对新生儿的影响：生长统计数据（例如体重增长的减少）。\n\u003Cbr \u002F> 生殖毒性 - 大鼠 - 经口\n\u003Cbr \u002F> 对生殖的影响：交配能力（例如＃交配成功雌性每＃交配的雌性；＃交配每＃发情周期）。\n\u003Cbr \u002F> 生殖毒性 - 大鼠 - 经口\n\u003Cbr \u002F> 对生殖的影响：胚胎植入前死亡率（例如每个雌性的植入胚胎数减少；每个黄体的植入总数。\n\u003Cbr \u002F> 对胚胎或胎儿的影响：胎儿毒性（死亡除外，例如矮小胎儿）。 特定发育异常：肌肉骨骼系统。\n\u003Cbr \u002F> 特异性靶器官系统毒性（一次接触）\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> 特异性靶器官系统毒性（反复接触）\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> 吸入危险\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> 潜在的健康影响\n\u003Cbr \u002F> 吸入吸入可能有害。 可能引起呼吸道刺激。\n\u003Cbr \u002F> 摄入误吞会中毒。\n\u003Cbr \u002F> 皮肤通过皮肤吸收可能有害。 可能引起皮肤刺激。\n\u003Cbr \u002F> 眼睛可能引起眼睛刺激。\n\u003Cbr \u002F> 附加说明\n\u003Cbr \u002F> 化学物质毒性作用登记: VA1411195\n\u003Cbr \u002F>\n\n\u003Cstrong>模块12. 生态学资料\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>12.1 生态毒性\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>12.2 持久性和降解性\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>12.3 潜在的生物累积性\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>12.4 土壤中的迁移性\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>12.5 PBT 和 vPvB的结果评价\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>12.6 其它不良影响\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\n\u003Cstrong>模块13. 废弃处置\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>13.1 废物处理方法\u003C\u002Fb>\n\u003Cbr \u002F> 产品\n\u003Cbr \u002F> 将剩余的和不可回收的溶液交给有许可证的公司处理。\n\u003Cbr \u002F> 与易燃溶剂相溶或者相混合，在备有燃烧后处理和洗刷作用的化学焚化炉中燃烧\n\u003Cbr \u002F> 受污染的容器和包装\n\u003Cbr \u002F> 按未用产品处置。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块14. 运输信息\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>14.1 联合国危险货物编号\u003C\u002Fb>\n\u003Cbr \u002F> 欧洲陆运危规: 2811国际海运危规: 2811国际空运危规: 2811\n\u003Cbr \u002F>\n\u003Cb>14.2 联合国运输名称\u003C\u002Fb>\n\u003Cbr \u002F> 欧洲陆运危规: TOXIC SOLID, ORGANIC, N.O.S. (3-[2-[4-(4-Fluorobenzoyl)piperidino]ethyl]quinazoline-\n\u003Cbr \u002F> 2,4(1H3H)-dione [R-(R*,R*)]-tartrate)\n\u003Cbr \u002F> 国际海运危规: TOXIC SOLID, ORGANIC, N.O.S. (3-[2-[4-(4-Fluorobenzoyl)piperidino]ethyl]quinazoline-\n\u003Cbr \u002F> 2,4(1H3H)-dione [R-(R*,R*)]-tartrate)\n\u003Cbr \u002F> 国际空运危规: Toxic solid, organic, n.o.s. (3-[2-[4-(4-Fluorobenzoyl)piperidino]ethyl]quinazoline-2,4(1H3H)-\n\u003Cbr \u002F> dione [R-(R*,R*)]-tartrate)\n\u003Cbr \u002F>\n\u003Cb>14.3 运输危险类别\u003C\u002Fb>\n\u003Cbr \u002F> 欧洲陆运危规: 6.1国际海运危规: 6.1国际空运危规: 6.1\n\u003Cbr \u002F>\n\u003Cb>14.4 包裹组\u003C\u002Fb>\n\u003Cbr \u002F> 欧洲陆运危规: III国际海运危规: III国际空运危规: III\n\u003Cbr \u002F>\n\u003Cb>14.5 环境危险\u003C\u002Fb>\n\u003Cbr \u002F> 欧洲陆运危规: 否国际海运危规国际空运危规: 否\n\u003Cbr \u002F> 海洋污染物（是\u002F否）: 否\n\u003Cbr \u002F>\n\u003Cb>14.6 对使用者的特别提醒\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cbr \u002F>\n\n\u003Cstrong> 模块 15 - 法规信息 \u003C\u002Fstrong>\n\u003Cbr \u002F>N\u002FA\n\u003Cbr \u002F>\n\u003Cbr \u002F>\n\n\u003Cstrong> 模块16 - 其他信息 \u003C\u002Fstrong>\n\u003Cbr \u002F>N\u002FA\n\u003Cbr \u002F>\u003Cbr \u002F>\u003Cbr \u002F>\u003Cbr \u002F>\u003Cbr \u002F>\n\u003Cbr \u002F>\n\u003C\u002Ftd>","2026-08-21T07:51:12.859463Z",false,[340,346,352,358,364,370,376,382,388,394,400,406],{"slug":341,"cid":342,"name":343,"nameZh":344,"cas":345},"785944316286603264","J-720174-3","Benzoic acid, methyl-, cerium(3+) salt (3:1)","苯甲酸甲基铈(3+)盐 (3:1)","68928-81-4",{"slug":347,"cid":348,"name":349,"nameZh":350,"cas":351},"785872502478868480","J-1992227-1","lead bis(4-cyclohexylbutyrate)","环己基丁酸铅(II)","62637-99-4",{"slug":353,"cid":354,"name":355,"nameZh":356,"cas":357},"785880573599027200","J-16328-0","Praseodymium oxalate","草酸镨","3269-10-1",{"slug":359,"cid":360,"name":361,"nameZh":362,"cas":363},"785889416726974464","J-1958878-4","5-Phospho-α-D-ribosyl diphosphate pentasodium salt","5-磷酰核糖-1-焦磷酸钠盐","108321-05-7",{"slug":365,"cid":366,"name":367,"nameZh":368,"cas":369},"852215453966143488","J-1135190-9","2-(4-Sulfonylphenylazo)-7-acetamido-1-hydroxynaphthalen-3.6-disulfonat","2-(4-磺酰氨基苯偶氮)-7-乙酰氨基-1-萘酚-3,6-二磺酸钠","132-38-7",{"slug":371,"cid":372,"name":373,"nameZh":374,"cas":375},"785876376379985920","J-13102-2","Cerium(III) oxalate nonahydrate","草酸铈(III)九水合物","13266-83-6",{"slug":377,"cid":378,"name":379,"nameZh":380,"cas":381},"785898095253655552","J-1987401-2","Gadopentetic acid","钆喷酸","80529-93-7",{"slug":383,"cid":384,"name":385,"nameZh":386,"cas":387},"785883467849142272","J-8064-8","Lutetium(III) carbonate hydrate","碳酸镥(III)水合物","64360-99-2",{"slug":389,"cid":390,"name":391,"nameZh":392,"cas":393},"785871902064250880","J-1312829-5","Manganese(II) citrate","柠檬酸锰","10024-66-5",{"slug":395,"cid":396,"name":397,"nameZh":398,"cas":399},"785888452406153216","J-1346356-4","Tributylammonium pyrophosphate","三丁基焦磷酸铵","5975-18-8",{"slug":401,"cid":402,"name":403,"nameZh":404,"cas":405},"785892866458128384","J-1339336-7","Lanthanum oxalate decahydrate","草酸镧","6451-21-4",{"slug":407,"cid":408,"name":409,"nameZh":410,"cas":411},"785883152315846656","J-1445540-4","Calcium 1-naphthyl phosphate trihydrate","1-萘基磷酸酯钙盐三水合物","57775-19-6",1794254573830,"zh-CN",[]]