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KCl，10mM二硫苏糖醇和[3H] -BRL49653的缓冲液中于4℃温育3小时（比活性，在存在或不存在未标记的罗格列酮的情况下，40Ci \u002F mmol）。通过1-mL Sephadex G-25脱盐柱洗脱，将结合与游离放射性分离。结合的放射性在柱空隙体积中洗脱，并通过液体闪烁计数[1]进行定量。",{"key":259,"value":260},"细胞实验","C3H10T1 \u002F 2细胞在补充有10％胎牛血清的DME培养基中的24孔板中生长。每3天更换培养基和化合物（罗格列酮）。细胞在第7天用油红O染色并拍照[1]。",{"key":262,"value":263},"动物实验","大鼠静脉注射38mg \u002F kg链脲佐菌素，48小时后，通过尿糖尿症鉴定糖尿病，然后测量随机血糖，这一天被视为第0天。血清葡萄糖水平为220-300mg \u002F dL的动物被选择用于本研究。将大鼠随机分成5组，每日给药8周：第1组：仅给予载体的对照非糖尿病大鼠（0.5mL \u002F kg口服0.5％羧甲基纤维素），第2组：给予载体的对照糖尿病大鼠，组3：接受罗格列酮（5mg \u002F kg口服）的糖尿病大鼠，第4组：接受氯沙坦（2mg \u002F kg，口服）的糖尿病大鼠，和第5组：接受罗格列酮和氯沙坦的糖尿病大鼠[2]。",{"key":265,"value":266},"参考文献","[1].\nLehmann JM, et al. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J Biol Chem. 1995 Jun 2;270(22):12953-6.\n[2].\nWillson TM, et al. The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones. J Med Chem. 1996 Feb 2;39(3):665-8.\n[3].\nThouennon E, et al. Rosiglitazone-activated PPARγ induces neurotrophic factor-α1 transcription contributing to neuroprotection. J Neurochem. 2015 Aug;134(3):463-70.\n[4].\nMajeed Y, et al. Rapid and contrasting effects of rosiglitazone on transient receptor potential TRPM3 and TRPC5 channels. Mol Pharmacol. 2011 Jun;79(6):1023-30.\n[5].\nAteyya H, et al. Beneficial effects of rosiglitazone and losartan combination in diabetic rats. 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