[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"currency-rates":3,"$fyk2oeqxpb7bd":8,"compound-J-42683-3":171,"verified-suppliers-J-42683-3":385},{"rates":4,"source":7},{"USD":5,"CNY":6},1,6.689327,"live",{"rows":9,"total":170,"current":5,"size":145},[10,33,45,60,74,85,96,113,123,135,146,158],{"slug":11,"cid":12,"imgSvg":13,"name":14,"nameZh":15,"cas":16,"formula":17,"iupac":14,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":22,"offersCount":24,"supplierCount":25,"bestOffer":26},"843627791009189888","J-1971488-8","\u002Fimages\u002Fchem_structures_svg\u002F399\u002F65845-61-6.svg","N-Methylcyclohexanamine hydrochloride","N-甲基环己胺盐酸盐","65845-61-6","C7H16ClN","acids","有机酸","Organic Acids","",[23],"In Stock",4,2,{"unitPrice":27,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},2.64,"500g","CNY","China","CN","in-stock",{"slug":34,"cid":35,"imgSvg":36,"name":37,"nameZh":38,"cas":39,"formula":40,"iupac":37,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":41,"offersCount":24,"supplierCount":5,"bestOffer":42},"785882541994283008","J-1323843-4","\u002Fimages\u002Fchem_structures_svg\u002F104\u002F67627-18-3.svg","Potassium indigotrisulfonate","靛蓝三磺酸钾","67627-18-3","C16H7K3N2O11S3",[23],{"unitPrice":43,"pack":44,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},180,"5g",{"slug":46,"cid":47,"imgSvg":48,"name":49,"nameZh":50,"cas":51,"formula":52,"iupac":49,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":56,"offersCount":57,"supplierCount":25,"bestOffer":58},"785889752443260928","J-28559-9","\u002Fimages\u002Fchem_structures_svg\u002F292\u002F15060-55-6.svg","Ammonium tetrathiomolybdate","四硫钼酸铵","15060-55-6","H8MoN2S4","inorganic","无机化合物","Inorganic Chemicals",[23],7,{"unitPrice":59,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},24,{"slug":61,"cid":62,"imgSvg":63,"name":64,"nameZh":65,"cas":66,"formula":67,"iupac":64,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":68,"offersCount":69,"supplierCount":25,"bestOffer":70},"855452191530422272","J-1994428-7","\u002Fimages\u002Fchem_structures_svg\u002F500\u002F16350-96-2.svg","N-benzylcyclohexanamine.hydrochloride","N-苄基环己胺盐酸盐","16350-96-2","C13H20ClN",[23],5,{"unitPrice":71,"pack":72,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},6,"1000g","中国",{"slug":75,"cid":76,"imgSvg":77,"name":78,"nameZh":79,"cas":80,"formula":81,"iupac":78,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":82,"offersCount":25,"supplierCount":25,"bestOffer":83},"785871840001134592","J-982001-0","\u002Fimages\u002Fchem_structures_svg\u002F001\u002F10517-44-9.svg","1,3-Diaminopropane dihydrochloride","1,3-二氨基丙烷二盐酸盐","10517-44-9","C3H12Cl2N2",[23],{"unitPrice":84,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},3.78,{"slug":86,"cid":87,"imgSvg":88,"name":89,"nameZh":90,"cas":91,"formula":92,"iupac":89,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":93,"offersCount":57,"supplierCount":94,"bestOffer":95},"785880365658017792","J-14975-6","\u002Fimages\u002Fchem_structures_svg\u002F262\u002F12003-67-7.svg","Lithium aluminate","氧化铝锂","12003-67-7","AlHLiO2",[23],3,{"unitPrice":94,"pack":28,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},{"slug":97,"cid":98,"imgSvg":99,"name":100,"nameZh":101,"cas":102,"formula":103,"iupac":100,"category":104,"categoryName":105,"categoryEnName":106,"industry":21,"tags":107,"offersCount":108,"supplierCount":108,"bestOffer":109},"785871830249377792","J-6931-9","\u002Fimages\u002Fchem_structures_svg\u002F456\u002F58068-80-7.svg","1-Octanoylbenzotriazole","N-辛酰苯并三唑","58068-80-7","C14H19N3O","aromatics","芳香烃","Aromatic Hydrocarbons",[],0,{"unitPrice":110,"pack":21,"currency":111,"origin":21,"originFlag":21,"moq":21,"stock":112},9007199254740991,"USD","made-to-order",{"slug":114,"cid":115,"imgSvg":116,"name":117,"nameZh":118,"cas":119,"formula":120,"iupac":117,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":121,"offersCount":69,"supplierCount":25,"bestOffer":122},"785871842446413824","J-1960944-3","\u002Fimages\u002Fchem_structures_svg\u002F495\u002F10534-86-8.svg","Hexaamminecobalt(III) nitrate","六氨合钴(III)硝酸盐","10534-86-8","CoH18N9O9",[23],{"unitPrice":71,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},{"slug":124,"cid":125,"imgSvg":126,"name":127,"nameZh":128,"cas":129,"formula":130,"iupac":127,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":131,"offersCount":24,"supplierCount":25,"bestOffer":132},"785871842576437248","J-814544-6","\u002Fimages\u002Fchem_structures_svg\u002F221\u002F12037-42-2.svg","vanadium oxide","氧化钒","12037-42-2","O13V6",[23],{"unitPrice":133,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},112.8,"100g",{"slug":136,"cid":137,"imgSvg":138,"name":139,"nameZh":140,"cas":141,"formula":142,"iupac":139,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":143,"offersCount":57,"supplierCount":5,"bestOffer":144},"785871842647740416","J-1333345-2","\u002Fimages\u002Fchem_structures_svg\u002F479\u002F26490-63-1.svg","COBALT TETRAFLUOROBORATE HEXAHYDRATE","四氟化硼钴水合物","26490-63-1","B2CoF8H12O6",[23],{"unitPrice":145,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},12,{"slug":147,"cid":148,"imgSvg":149,"name":150,"nameZh":151,"cas":152,"formula":153,"iupac":150,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":154,"offersCount":155,"supplierCount":94,"bestOffer":156},"785871842698072064","J-814953-0","\u002Fimages\u002Fchem_structures_svg\u002F432\u002F72259-10-0.svg","Copper(II) tetrafluoroborate hexahydrate","六水合四氟硼酸铜(II)","72259-10-0","B2CuF8H12O6",[23],10,{"unitPrice":157,"pack":28,"currency":29,"origin":21,"originFlag":21,"moq":21,"stock":32},2.6,{"slug":159,"cid":160,"imgSvg":161,"name":162,"nameZh":163,"cas":164,"formula":165,"iupac":162,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":166,"offersCount":25,"supplierCount":5,"bestOffer":168},"785871863254355968","J-1990080-7","\u002Fimages\u002Fchem_structures_svg\u002F149\u002F123333-60-8.svg","Cerium(IV) sulfate hydrate","铈(IV)硫酸盐水合物","123333-60-8","CeH2O9S2",[167],"Made to Order",{"unitPrice":169,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},5.6,3204,{"slug":172,"cid":173,"imgSvg":174,"name":175,"nameZh":175,"cas":176,"formula":177,"iupac":175,"mdl":21,"mw":178,"category":179,"categoryName":180,"categoryEnName":181,"industry":21,"tags":182,"synonyms":183,"properties":190,"ghs":246,"offers":256,"activity":257,"upstream":282,"downstream":295,"customs":298,"safetyRows":311,"toxicity":342,"msds":343,"updatedAt":344,"isProhibited":345,"related":346,"__ts":383,"__lang":384,"__slug":173},"785895735538225152","J-42683-3","\u002Fimages\u002Fchem_structures_svg\u002F153\u002F3895-92-9.svg","氯化白屈菜红碱","3895-92-9","C21H18ClNO4","383.825","bases","有机碱","Organic Bases",[],[184,185,186,187,188,189],"盐酸白屈菜红碱","氯化白屈菜赤碱","白屈菜赤(红)碱","白屈菜赤碱","白菜屈红碱氯化物","白屈菜红碱盐酸盐",[191,196,201,206,211,215,219,222,226,230,234,238,242],{"label":192,"labelZh":193,"value":194,"prop":195},"Melting Point","熔点","195-205ºC","meltingPoint",{"label":197,"labelZh":198,"value":199,"prop":200},"Boiling Point","沸点","711.4ºC at 760 mmHg","boilingPoint",{"label":202,"labelZh":203,"value":204,"prop":205},"Density","密度","1.36g\u002Fcm3","density",{"label":207,"labelZh":208,"value":209,"prop":210},"Flash Point","闪点","219.3ºC","flashPoint",{"label":212,"labelZh":213,"value":214},"Exact Mass","精确质量","383.092438",{"label":216,"labelZh":217,"value":218},"PSA","其他信息","40.80000",{"label":220,"labelZh":220,"value":221},"LogP","0.72060",{"label":223,"labelZh":224,"value":225},"Appearance","外观性状","黄色至橙色固体",{"label":227,"labelZh":228,"value":229},"Refractive Index","折射率","1.681",{"label":231,"labelZh":232,"value":233},"Storage Conditions","储存条件","常温，避光，通风干燥处，密封保存",{"label":235,"labelZh":236,"value":237},"Stability","稳定性","常温常压下稳定，黄色至橘黄色粉末  ，溶于二甲亚砜，>10mg\u002FmL",{"label":239,"labelZh":240,"value":241},"Additional Property","水溶解性","DMSO: ≥10 mg\u002FmL",{"label":243,"labelZh":244,"value":245},"Computational Chemistry","计算化学","1.疏水参数计算参考值（XlogP）:无\n2.氢键供体数量:0\n3.氢键受体数量:5\n4.可旋转化学键数量:2\n5.互变异构体数量:无\n6.拓扑分子极性表面积40.8\n7.重原子数量:27\n8.表面电荷:0\n9.复杂度:516\n10.同位素原子数量:0\n11.确定原子立构中心数量:0\n12.不确定原子立构中心数量:0\n13.确定化学键立构中心数量:0\n14.不确定化学键立构中心数量:0\n15.共价键单元数量:2",{"pictogram":247,"signal":248,"hazards":249},"Irritant","Warning",[250,251,252,253,254,255],"H302 — Harmful if swallowed \u002F 吞咽有害","H312 — Harmful in contact with skin \u002F 皮肤接触有害","H315 — Causes skin irritation \u002F 造成皮肤刺激","H319 — Causes serious eye irritation \u002F 造成严重眼刺激","H332 — Harmful if inhaled \u002F 吸入有害","H335 — May cause respiratory irritation \u002F 可能造成呼吸道刺激",[],[258,261,264,267,270,273,276,279],{"key":259,"value":260},"描述","Chelerythrine Chloride 是一种有效,可渗透细胞的蛋白酶 C (protein kinase C) 抑制剂,能够抑制 PKC 活性,IC50 值为 660 nM。",{"key":262,"value":263},"相关类别","信号通路\n>>\n自噬\n>>\n自噬\n信号通路\n>>\n表观遗传学\n>>\nPKC\n信号通路\n>>\nTGF-beta\u002FSmad 信号通路\n>>\nPKC\n研究领域\n>>\n炎症\u002F免疫\n天然产物\n>>\n生物碱",{"key":265,"value":266},"靶点","PKC:660 nM (IC50)\nPKA:0.17 mM (IC50)\nTPK:0.1 mM (IC50)",{"key":268,"value":269},"体外研究","白屈菜红碱抑制BclXL-Bak BH3肽结合,IC50为1.5μM,并取代BclXL中含有BH3的蛋白质Bax。用白屈菜红碱处理的哺乳动物细胞经历细胞凋亡,其特征在于线粒体途径的参与[1]。白屈菜红碱处理通过选择性抑制p38丝裂原活化蛋白激酶(MAPK)和细胞外信号调节蛋白激酶1和2(ERK1\u002F2)激活,抑制LPS诱导的小鼠腹腔巨噬细胞中LPS诱导的TNF-α水平和NO产生。此外,白屈菜红碱对NO和细胞因子TNF-α产生的影响可能可以通过p38 MAPK和ERK1\u002F2在调节炎症介质表达中的作用来解释[2]。白屈菜红碱对人单核细胞白血病细胞具有细胞毒作用,LD50值为3.46μM。 LPS刺激后2小时,受血根碱和白屈菜红碱影响的细胞使CCL-2表达显着下降3.5和1.9 [3]。白屈菜红碱以剂量依赖性方式显着增强ERK1\u002F2的磷酸化。此外,白屈菜红碱抑制p38的磷酸化[4]。",{"key":271,"value":272},"体内研究","白屈菜红碱通过抑制LPS诱导的肿瘤坏死因子-α(TNF-α)水平和血清中一氧化氮(NO)的产生,在体内实验诱导的小鼠内毒素休克模型中显示出显着的抗炎作用[2]。白屈菜红碱氯化物(5mg\u002Fkg \u002F天,ip)诱导RCC细胞凋亡而对小鼠没有显着毒性。白屈菜红碱治疗导致p53的剂量依赖性积累[4]。",{"key":274,"value":275},"细胞实验","通过MTT测定评估细胞活力。将100μL培养基中的细胞（2×103 HEK-293细胞\u002F孔和3×103 SW-839细胞\u002F孔）接种到96孔板中，并孵育12小时。接下来，用含有各种浓度的白屈菜红碱的培养基替换每个孔中的培养基，并将细胞在37℃下再培养24和48小时。随后，向每个孔中加入20μLMTT（5mg \u002F mL）。在37℃下另外温育4小时后，除去上清液，并向每个孔中加入100μLDMSO。使用iMark™微孔板吸光度读数器测定吸光度值（在540nm处读数）。使用Microplate Manager软件（版本6.3; 1689520）分析数据。",{"key":277,"value":278},"动物实验","将总共5×106个SW-839细胞与Matrigel®混合，并皮下注射到14只5周龄雄性BALB \u002F c裸鼠的侧腹中。将小鼠保持在18×30-cm笼中，每笼3只小鼠，温度为22℃，使用12小时光照\u002F黑暗循环。食物和水随意提供。小鼠随机分为两组（n = 7）。如前所述，通过腹膜内注射给小鼠施用剂量为5mg \u002F kg \u002F天的白屈菜红碱氯化物5周，在注射SW-839细胞后第一次注射白屈菜红碱24小时。对照小鼠施用相同体积的含有1％DMSO的PBS。每周测量一次小鼠肿瘤的体积和重量。在切除肿瘤后，在接种癌细胞后36天处死所有小鼠。",{"key":280,"value":281},"参考文献","[1].\nChan, et al. Identification of chelerythrine as an inhibitor of BclXL function. J Biol Chem. 2003 Jun 6;278(23):20453-6.\n[2].\nLi W, et al. Effect of Chelerythrine Against Endotoxic Shock in Mice and Its Modulation of Inflammatory Mediators in Peritoneal Macrophages Through the Modulation of Mitogen-Activated Protein Kinase (MAPK) Pathway. Inflammation. 2012 Jul 24.\n[3].\nPencikova K, et al. Investigation of sanguinarine and chelerythrine effects on LPS-induced inflammatory gene expression in THP-1 cell line. Phytomedicine. 2012 Jul 15;19(10):890-5. Epub 2012 May 14.\n[4].\nChen XM, et al. Chelerythrine chloride induces apoptosis in renal cancer HEK-293 and SW-839 cell lines. Oncol Lett. 2016 Jun;11(6):3917-3924\n[5].\nHerbert JM, et al. Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun. 1990 Nov 15;172(3):993-9.",[283,289],{"slug":284,"cid":285,"name":286,"nameZh":286,"cas":287,"imgSvg":288},"785894461237366800","J-1929-1","二氢白屈菜红碱","6880-91-7","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F161\u002F6880-91-7.svg",{"slug":290,"cid":291,"name":292,"nameZh":292,"cas":293,"imgSvg":294},"785896207602946000","J-1982291-2","氧基白屈菜季铵碱","28342-33-8","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F341\u002F28342-33-8.svg",[296,297],{"slug":290,"cid":291,"name":292,"nameZh":292,"cas":293,"imgSvg":294},{"slug":284,"cid":285,"name":286,"nameZh":286,"cas":287,"imgSvg":288},[299,302,305,308],{"key":300,"value":301},"海关编码","2933990090",{"key":303,"value":304},"中文概述","2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%",{"key":306,"value":307},"申报要素","品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期",{"key":309,"value":310},"Summary","2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%",[312,315,317,320,323,326,329,332,335,338,341],{"key":313,"value":314},"符号","GHS07",{"key":316,"value":248},"信号词",{"key":318,"value":319},"危害声明","H302-H312-H315-H319-H332-H335",{"key":321,"value":322},"警示性声明","P261-P280-P305 + P351 + P338",{"key":324,"value":325},"危害码 (欧洲)","Xn",{"key":327,"value":328},"风险声明 (欧洲)","R20\u002F21\u002F22",{"key":330,"value":331},"安全声明 (欧洲)","S36\u002F37",{"key":333,"value":334},"危险品运输编码","NONH for all modes of transport",{"key":336,"value":337},"WGK德国","3",{"key":339,"value":340},"RTECS号","FL9200000",{"key":300,"value":301},"\u003Ctd>\n\n\u003Cp>\u003Cstrong>氯化白屈菜红碱生态学数据:\u003C\u002Fstrong>\u003C\u002Fp>\n\u003Cp>\u003C\u002Fp>\u003Cp>通常对水是不危害的，若无政府许可，勿将材料排入周围环境  \u003C\u002Fp>\n\u003Cp>\u003C\u002Fp>\n\u003Cp>\u003Ca href=\"\u002Fen\u002Fcas\u002F3895-92-9_1028729.html#duXinDiv\">氯化白屈菜红碱毒性英文版\u003C\u002Fa>\u003C\u002Fp>\n\n\u003C\u002Ftd>","\u003Ctd>\n\n\u003Ca href=\"\u002Fen\u002Fcas\u002F3895-92-9_1028729.html#MSDSDiv\">氯化白屈菜红碱MSDS英文版\u003C\u002Fa>\n\n\u003C\u002Ftd>","2026-08-21T07:51:12.859463Z",false,[347,353,359,365,371,377],{"slug":348,"cid":349,"name":350,"nameZh":351,"cas":352},"785881272906944512","J-18533-0","Tris(ethylenediamine)cobalt(III) chloride dihydrate","三(乙二胺)合氯化钴(III)二水合物","207802-43-5",{"slug":354,"cid":355,"name":356,"nameZh":357,"cas":358},"785872803055276032","J-979062-3","N,N-bis(2-ethylhexyl)-4-methyl-1H-benzotriazole-1-methylamine","N,N-二(2-乙基己基)-4-甲基-1H-苯并三唑-1-甲胺","80584-90-3",{"slug":360,"cid":361,"name":362,"nameZh":363,"cas":364},"785876670308421632","J-13996-8","2,2-Diphenyl-1-picrylhydrazyl","2,2-联苯基-1-苦基肼基","1898-66-4",{"slug":366,"cid":367,"name":368,"nameZh":369,"cas":370},"785898832582938624","J-1839293-5","N-[4-(2-Naphthalenyl)phenyl]-[1,1'-biphenyl]-4-amine","N-[4-(2-萘基)苯基]-[1,1'-联苯]-4-胺","897921-60-7",{"slug":372,"cid":373,"name":374,"nameZh":375,"cas":376},"785884690279043072","J-23887-8","Perfluorotriethylamine","全氟三乙胺","359-70-6",{"slug":378,"cid":379,"name":380,"nameZh":381,"cas":382},"785875602539286528","J-10557-8","Tris(ethylenediamine)cobalt(III) chloride trihydrate","三(乙二胺)氯化钴(III)三水合物","14883-80-8",1792671985449,"zh-CN",[]]