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McClellan, Manidipine: a review of its use in hypertension. Drugs, 2001. 61(12): p. 1777-99.\n[2].\nMcKeage, K. and L.J. Scott, Manidipine: a review of its use in the management of hypertension. Drugs, 2004. 64(17): p. 1923-40.\n[3].\nRoca-Cusachs, A. and F. Triposkiadis, Antihypertensive effect of manidipine. Drugs, 2005. 65 Suppl 2: p. 11-9.",[249,255,261,267,273,279],{"slug":250,"cid":251,"name":252,"nameZh":252,"cas":253,"imgSvg":254},"785893310047719400","J-1426586-2","1-二苯基甲基-4-(2-羟基乙基)哌嗪","10527-64-7","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F262\u002F10527-64-7.svg",{"slug":256,"cid":257,"name":258,"nameZh":258,"cas":259,"imgSvg":260},"785895506655055900","J-1510116-5","乐卡地平母核","74936-72-4","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F116\u002F74936-72-4.svg",{"slug":262,"cid":263,"name":264,"nameZh":264,"cas":265,"imgSvg":266},"785892795620528100","J-33740-7","间硝基苯甲醛","99-61-6","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F069\u002F99-61-6.svg",{"slug":268,"cid":269,"name":270,"nameZh":270,"cas":271,"imgSvg":272},"785891296416895000","J-1397183-2","2-(4-二苯甲基哌嗪)乙基 乙酰乙酸酯","89226-49-3","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F399\u002F89226-49-3.svg",{"slug":274,"cid":275,"name":276,"nameZh":276,"cas":277,"imgSvg":278},"785892795373064200","J-992430-7","3-氨基巴豆酸甲酯","14205-39-1","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F351\u002F14205-39-1.svg",{"slug":280,"cid":281,"name":282,"nameZh":282,"cas":283,"imgSvg":284},"785873086195961900","J-1335743-6","二苯甲基哌嗪","841-77-0","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F255\u002F841-77-0.svg",[286],{"slug":287,"cid":288,"name":289,"nameZh":289,"cas":290,"imgSvg":291},"785892717140906000","J-1961590-1","盐酸马尼地平","89226-75-5","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F430\u002F89226-75-5.svg",[],[294],{"key":295,"value":296},"危害码 (欧洲)","Xi","\u003Cp>方法1：一锅煮。2.66g 3-硝基苯甲醛、6.09g化合物(Ⅰ)和2.03g 3-氨基丁烯酸甲酯溶于25ml异丙醇，搅拌回流6h。浓缩后，剩余物用硅胶层析，己烷-乙酸乙酯(1：1，体积比)洗脱。洗脱液浓缩，剩余的油状物溶于小量异丙醚，加入己烷于0℃搅拌，得到7.35g淡黄色的分析纯的马尼地平，收率75.2%。\u003Cbr \u002F> 3.90g马尼地平溶于10ml二氯甲烷，加入微过量的盐酸的二氧六烷溶液，在0℃加入小量的水一起搅拌。过滤收集析出的结晶，用乙醚洗，得4.23g二盐酸马尼地平单水合物，收率94.4%。该结晶可用下列方法来提纯：将该结晶溶于二氯甲烷-甲醇混合液中，再把溶剂蒸去，剩余物溶于乙酸乙酯，加入小量水，冰冷却后得淡黄色结晶，熔点167～170℃。\u003Cbr \u002F>方法2：大量制备，所有的中间体均无需分离。将，552g油状的4-二苯甲基-1-哌嗪乙醇加热至约70℃，在搅拌下滴入175ml二乙烯酮，滴加的速度保持反应液不超过80℃。加毕，在70～80℃搅拌2h。减压蒸去过量的二乙烯酮，得739.8g淡棕色油状的化合物(I)的粗品。该油状物、281.0g3-硝基苯甲醛、30ml哌啶和2000ml苯，一起回流5h，并不断移去生成的水。反应结束后，苯层用水洗，无水硫酸镁干燥。浓缩后，得油状的化合物(Ⅱ)的粗品。将该粗品和200g 3-氨基丁烯酸甲酯溶于2500ml异丙醇，搅拌回流7h。减压蒸去溶剂，剩余物在3500ml氯仿和1000ml水之间进行分配。分出氯仿层，用1000ml水洗，无水硫酸镁干燥。蒸去溶剂后，剩余物用502g 16.2%盐酸的甲醇溶液处理后，减压浓缩。剩余物溶于1200ml热乙酸乙酯，用700ml乙醚稀释，室温放置过夜。过滤析出的黄色沉淀，用丙酮洗，得467.9g二盐酸马尼地平，总收率36.8%。纯二盐酸马尼地平有两种晶体，可通过下列方法得到。\u003Cbr \u002F>α-晶型：461.1g粗二盐酸马尼地平溶于3300ml热的95%乙醇，依其放置过夜。过滤析出的沉淀，用约400ml乙醇洗，于60℃真空干燥，得316.4gα-晶型的二盐酸马尼地平，熔点157～163℃。\u003Cbr \u002F>β-晶型：314.2gα-晶型的二盐酸马尼地平悬浮于5000ml丙酮，搅拌3h后，在室温放置过夜。其间，黄色的α-晶型转化为淡黄色的细微的β-晶型。过滤收集，用1000ml丙酮洗，于75～80℃真空干燥，得273.4gβ-二盐酸马尼地平，熔点174～180℃。如用开口的毛细管测，其熔点204～206.5℃(分解)。\u003Cbr \u002F>马尼地平游离碱的制备：6.0gβ-二盐酸马尼地平溶于乙醚，用5%氨水处理。分出乙醚层，用水洗，无水硫酸镁干燥。浓缩后，用异丙醚-己烷重结晶，得4．78g淡黄色的马尼地平，收率89.2%，熔点125～128℃。\u003C\u002Fp>\u003Cp>\u003Cbr \u002F>方法3：3.0g化合物(Ⅰ)溶于5ml乙醇，加入过量的20%氨的乙醇溶液，在冰箱中放置过夜。减压除去溶剂，得油状的化合物(Ⅲ)粗品。该粗品和1.97g化合物(Ⅳ)溶于30ml异丙醇，搅拌回流10h。和方法1同样处理后得0.83g二盐酸马尼地平单水合物，收率15.0%，熔点164～169℃。\u003Cbr \u002F>方法4：3.21g化合物(Ⅲ)的粗品、0.88g 3-硝基苯甲醛和1.15g乙酰乙酸甲酯溶于15ml异丙醇，搅拌回流6h。和方法1同样处理后得1.06g二盐酸马尼地平单水合物，收率17.8%，熔点166～169℃。\u003Cbr \u002F>方法5：其光学活性的异构体可从化合物(V)出发，经和辛可尼丁(cinchonidine)成盐进行光学拆分为(R)-(-)型和(S)-(+)型后，再经水解，酯化，成盐得二盐酸马尼地平。\u003C\u002Fp>","2026-08-21T07:51:12.859463Z",false,[301,307,313,319,325,331],{"slug":302,"cid":303,"name":304,"nameZh":305,"cas":306},"785897513524662272","J-1986770-8","Chitotriose trihydrochloride hydrate","壳聚糖三聚物","117436-78-9",{"slug":308,"cid":309,"name":310,"nameZh":311,"cas":312},"785882336590827520","J-3149-7","Pigment Blue 15:2","颜料蓝15:2","12239-87-1",{"slug":314,"cid":315,"name":316,"nameZh":317,"cas":318},"785882292106039296","J-2937-1","Chromeazurol S","铬天青S","1667-99-8",{"slug":320,"cid":321,"name":322,"nameZh":323,"cas":324},"785883464929906688","J-1346552-6","anthiolimine","安锑锂明","305-97-5",{"slug":326,"cid":327,"name":328,"nameZh":329,"cas":330},"785891955300110336","J-1960214-3","Cobalt protoporphyrin IX","原卟啉钴","14325-03-2",{"slug":332,"cid":333,"name":334,"nameZh":335,"cas":336},"785880514379649024","J-15940-9","Calcein","钙黄绿素","1461-15-0",1792618573908,"zh-CN",[]]