[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"currency-rates":3,"$fyk2oeqxpb7bd":8,"compound-J-38484-7":171,"verified-suppliers-J-38484-7":378},{"rates":4,"source":7},{"USD":5,"CNY":6},1,6.691314,"live",{"rows":9,"total":170,"current":5,"size":145},[10,33,45,60,74,85,96,113,123,135,146,158],{"slug":11,"cid":12,"imgSvg":13,"name":14,"nameZh":15,"cas":16,"formula":17,"iupac":14,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":22,"offersCount":24,"supplierCount":25,"bestOffer":26},"843627791009189888","J-1971488-8","\u002Fimages\u002Fchem_structures_svg\u002F399\u002F65845-61-6.svg","N-Methylcyclohexanamine hydrochloride","N-甲基环己胺盐酸盐","65845-61-6","C7H16ClN","acids","有机酸","Organic Acids","",[23],"In Stock",4,2,{"unitPrice":27,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},2.64,"500g","CNY","China","CN","in-stock",{"slug":34,"cid":35,"imgSvg":36,"name":37,"nameZh":38,"cas":39,"formula":40,"iupac":37,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":41,"offersCount":24,"supplierCount":5,"bestOffer":42},"785882541994283008","J-1323843-4","\u002Fimages\u002Fchem_structures_svg\u002F104\u002F67627-18-3.svg","Potassium indigotrisulfonate","靛蓝三磺酸钾","67627-18-3","C16H7K3N2O11S3",[23],{"unitPrice":43,"pack":44,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},180,"5g",{"slug":46,"cid":47,"imgSvg":48,"name":49,"nameZh":50,"cas":51,"formula":52,"iupac":49,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":56,"offersCount":57,"supplierCount":25,"bestOffer":58},"785889752443260928","J-28559-9","\u002Fimages\u002Fchem_structures_svg\u002F292\u002F15060-55-6.svg","Ammonium tetrathiomolybdate","四硫钼酸铵","15060-55-6","H8MoN2S4","inorganic","无机化合物","Inorganic Chemicals",[23],7,{"unitPrice":59,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},24,{"slug":61,"cid":62,"imgSvg":63,"name":64,"nameZh":65,"cas":66,"formula":67,"iupac":64,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":68,"offersCount":69,"supplierCount":25,"bestOffer":70},"855452191530422272","J-1994428-7","\u002Fimages\u002Fchem_structures_svg\u002F500\u002F16350-96-2.svg","N-benzylcyclohexanamine.hydrochloride","N-苄基环己胺盐酸盐","16350-96-2","C13H20ClN",[23],5,{"unitPrice":71,"pack":72,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},6,"1000g","中国",{"slug":75,"cid":76,"imgSvg":77,"name":78,"nameZh":79,"cas":80,"formula":81,"iupac":78,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":82,"offersCount":25,"supplierCount":25,"bestOffer":83},"785871840001134592","J-982001-0","\u002Fimages\u002Fchem_structures_svg\u002F001\u002F10517-44-9.svg","1,3-Diaminopropane dihydrochloride","1,3-二氨基丙烷二盐酸盐","10517-44-9","C3H12Cl2N2",[23],{"unitPrice":84,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},3.78,{"slug":86,"cid":87,"imgSvg":88,"name":89,"nameZh":90,"cas":91,"formula":92,"iupac":89,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":93,"offersCount":57,"supplierCount":94,"bestOffer":95},"785880365658017792","J-14975-6","\u002Fimages\u002Fchem_structures_svg\u002F262\u002F12003-67-7.svg","Lithium aluminate","氧化铝锂","12003-67-7","AlHLiO2",[23],3,{"unitPrice":94,"pack":28,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},{"slug":97,"cid":98,"imgSvg":99,"name":100,"nameZh":101,"cas":102,"formula":103,"iupac":100,"category":104,"categoryName":105,"categoryEnName":106,"industry":21,"tags":107,"offersCount":108,"supplierCount":108,"bestOffer":109},"785871830249377792","J-6931-9","\u002Fimages\u002Fchem_structures_svg\u002F456\u002F58068-80-7.svg","1-Octanoylbenzotriazole","N-辛酰苯并三唑","58068-80-7","C14H19N3O","aromatics","芳香烃","Aromatic Hydrocarbons",[],0,{"unitPrice":110,"pack":21,"currency":111,"origin":21,"originFlag":21,"moq":21,"stock":112},9007199254740991,"USD","made-to-order",{"slug":114,"cid":115,"imgSvg":116,"name":117,"nameZh":118,"cas":119,"formula":120,"iupac":117,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":121,"offersCount":69,"supplierCount":25,"bestOffer":122},"785871842446413824","J-1960944-3","\u002Fimages\u002Fchem_structures_svg\u002F495\u002F10534-86-8.svg","Hexaamminecobalt(III) nitrate","六氨合钴(III)硝酸盐","10534-86-8","CoH18N9O9",[23],{"unitPrice":71,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},{"slug":124,"cid":125,"imgSvg":126,"name":127,"nameZh":128,"cas":129,"formula":130,"iupac":127,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":131,"offersCount":24,"supplierCount":25,"bestOffer":132},"785871842576437248","J-814544-6","\u002Fimages\u002Fchem_structures_svg\u002F221\u002F12037-42-2.svg","vanadium oxide","氧化钒","12037-42-2","O13V6",[23],{"unitPrice":133,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},112.8,"100g",{"slug":136,"cid":137,"imgSvg":138,"name":139,"nameZh":140,"cas":141,"formula":142,"iupac":139,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":143,"offersCount":57,"supplierCount":5,"bestOffer":144},"785871842647740416","J-1333345-2","\u002Fimages\u002Fchem_structures_svg\u002F479\u002F26490-63-1.svg","COBALT TETRAFLUOROBORATE HEXAHYDRATE","四氟化硼钴水合物","26490-63-1","B2CoF8H12O6",[23],{"unitPrice":145,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},12,{"slug":147,"cid":148,"imgSvg":149,"name":150,"nameZh":151,"cas":152,"formula":153,"iupac":150,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":154,"offersCount":155,"supplierCount":94,"bestOffer":156},"785871842698072064","J-814953-0","\u002Fimages\u002Fchem_structures_svg\u002F432\u002F72259-10-0.svg","Copper(II) tetrafluoroborate hexahydrate","六水合四氟硼酸铜(II)","72259-10-0","B2CuF8H12O6",[23],10,{"unitPrice":157,"pack":28,"currency":29,"origin":21,"originFlag":21,"moq":21,"stock":32},2.6,{"slug":159,"cid":160,"imgSvg":161,"name":162,"nameZh":163,"cas":164,"formula":165,"iupac":162,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":166,"offersCount":25,"supplierCount":5,"bestOffer":168},"785871863254355968","J-1990080-7","\u002Fimages\u002Fchem_structures_svg\u002F149\u002F123333-60-8.svg","Cerium(IV) sulfate hydrate","铈(IV)硫酸盐水合物","123333-60-8","CeH2O9S2",[167],"Made to Order",{"unitPrice":169,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},5.6,3204,{"slug":172,"cid":173,"imgSvg":174,"name":175,"nameZh":175,"cas":176,"formula":177,"iupac":175,"mdl":21,"mw":178,"category":179,"categoryName":180,"categoryEnName":181,"industry":21,"tags":182,"synonyms":183,"properties":189,"ghs":225,"offers":226,"activity":227,"upstream":249,"downstream":274,"customs":323,"safetyRows":327,"toxicity":335,"synthesis":336,"updatedAt":337,"isProhibited":338,"related":339,"__ts":376,"__lang":377,"__slug":173},"785894653927886848","J-38484-7","\u002Fimages\u002Fchem_structures_svg\u002F483\u002F59-43-8.svg","维生素B1","59-43-8","C12H17ClN4OS","300.808","organic","有机化合物","Organic Compounds",[],[184,185,186,187,188],"硫胺素","3-((4-氨基-2-甲基-5-嘧啶基)甲基)-5-(2-羟基乙基)-4-甲基噻唑氯化物","氯化硫胺","抗神经炎素","抗脚气病维生素",[190,194,198,202,205,208,211,215,218,222],{"label":191,"labelZh":191,"value":192,"prop":193},"Melting Point","125 °C","meltingPoint",{"label":195,"labelZh":195,"value":196,"prop":197},"Density","6 g\u002Fcm3","density",{"label":199,"labelZh":200,"value":201},"Exact Mass","精确质量","300.081146",{"label":203,"labelZh":203,"value":204},"PSA","104.15000",{"label":206,"labelZh":206,"value":207},"LogP","1.99090",{"label":209,"labelZh":209,"value":210},"外观性状","微白色至淡黄色晶体或结晶粉末",{"label":212,"labelZh":213,"value":214},"Storage Conditions","储存条件","室温，干燥，密封",{"label":216,"labelZh":216,"value":217},"水溶解性","soluble",{"label":219,"labelZh":220,"value":221},"Computational Chemistry","计算化学","1.疏水参数计算参考值（XlogP）:无\n2.氢键供体数量:2\n3.氢键受体数量:6\n4.可旋转化学键数量:4\n5.互变异构体数量:3\n6.拓扑分子极性表面积104\n7.重原子数量:19\n8.表面电荷:0\n9.复杂度:269\n10.同位素原子数量:0\n11.确定原子立构中心数量:0\n12.不确定原子立构中心数量:0\n13.确定化学键立构中心数量:0\n14.不确定化学键立构中心数量:0\n15.共价键单元数量:2",{"label":223,"labelZh":223,"value":224},"更多","1.性状：白色针状结晶性粉末，有微弱米糠似的特异臭，味苦。\n2.熔点（ºC）：248～250\n3.溶解性：极易溶于水(1g溶于1mL20℃的水)，微溶于乙醇，不溶于乙醚、苯、氯仿和丙酮。",null,[],[228,231,234,237,240,243,246],{"key":229,"value":230},"描述","Thiamine nitrate是必不可少的维生素,在摄入食物的细胞产生能量中起重要作用,并能增强正常的神经元活性。",{"key":232,"value":233},"相关类别","信号通路\n>>\n其他\n>>\n其他\n研究领域\n>>\n代谢疾病\n研究领域\n>>\n神经疾病",{"key":235,"value":236},"靶点","Vitamin[1]",{"key":238,"value":239},"体外研究","与WT小鼠(0.796±0.259μM)相比,在7周时,常规饮食的纯合KO和KI小鼠血液中的硫胺素水平分别降低至0.058±0.051和0.126±0.092μM。当WT和纯合KO和KI小鼠喂食硫胺素限制饮食(硫胺素：0.60 mg\u002F100 g食物)时,血清硫胺素浓度在第5天和第14天分别显着降低至0.010±0.009和0.010±0.006μM, WT小鼠(0.609±0.288μM)。喂食常规饮食的WT小鼠脑匀浆中的硫胺素浓度为3.81±2.18nmol\u002Fg湿重,KO和KI的浓度分别为1.33±0.96和2.16±1.55nmol\u002Fg湿重。值得注意的是,KO和KI小鼠的脑匀浆中硫胺素浓度稳定下降,喂食硫胺素限制饮食(硫胺素：0.60 mg\u002F100 g食品)5天(0.95±0.72 nmol\u002Fg湿重)和14天(1.11±0.24)在小鼠呈现疾病表型之前,分别与WT(3.65±1.02nmol\u002Fg湿重)相比,nmol\u002Fg湿重)[2]。",{"key":241,"value":242},"体内研究","WT,纯合和杂合KO和KI小鼠喂食常规饮食(硫胺素：1.71mg\u002F100g)存活超过6个月而没有任何疾病表型。纯合的KO和KI小鼠喂食受硫胺素限制的饮食(硫胺素：0.60mg\u002F100g食物)显示瘫痪,体重减轻和不动,并分别在12和30天内死亡。类似地,纯合的KO和KI小鼠喂食硫胺素限制饮食,其中硫胺素(硫胺素：0.27mg\u002F100g食物)的百分比分别在14天和18天内死亡。然而,WT和杂合KO和KI小鼠喂食硫胺素限制饮食(硫胺素：0.60 mg或0.27 mg\u002F100g食物)存活超过6个月,没有任何疾病表型[2]。",{"key":244,"value":245},"动物实验","Slc19a3 E314Q KI小鼠常规维持常规饮食，其具有1.71mg \u002F 100g食物的硫胺素浓度（盐酸硫胺素，MW = 337.3）。制备了两种基于“实验室啮齿动物的纯化日粮”的硫胺素限制食品，其中硫胺素浓度为0.60 mg \u002F 100 g食品（35％常规食品硫胺素）或0.27 mg \u002F 100 g食品（16％硫胺素）传统食品）。含有高硫胺素的食物也由AIN-93M制备，其中硫胺素浓度是CE-2的5倍（硫胺素：8.50mg \u002F 100g食物）。硫胺浓度由日本食品研究实验室[2]确定。",{"key":247,"value":248},"参考文献","[1].\nKenneth Osiezagha, et al.Thiamine Deficiency and Delirium. Innov Clin Neurosci. 2013 Apr; 10(4): 26-32.\n[2].\nKaoru Suzuki, et al. High-dose thiamine prevents brain lesions and prolongs survival ofSlc19a3-deficient mice. PLoS One. 2017; 12(6): e0180279.",[250,256,262,268],{"slug":251,"cid":252,"name":253,"nameZh":253,"cas":254,"imgSvg":255},"785893068434837500","J-1495066-1","盐酸硫胺","67-03-8","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F402\u002F67-03-8.svg",{"slug":257,"cid":258,"name":259,"nameZh":259,"cas":260,"imgSvg":261},"785883762662576100","J-1173630-1","4-氨基-5-氨甲基-2-甲基嘧啶","95-02-3","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F177\u002F95-02-3.svg",{"slug":263,"cid":264,"name":265,"nameZh":265,"cas":266,"imgSvg":267},"785872897674580000","J-1319324-3","硫代硫胺素","299-35-4","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F368\u002F299-35-4.svg",{"slug":269,"cid":270,"name":271,"nameZh":271,"cas":272,"imgSvg":273},"785891931673595900","J-1754715-0","甲醇","67-56-1","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F233\u002F67-56-1.svg",[275,281,287,293,299,305,311,317],{"slug":276,"cid":277,"name":278,"nameZh":278,"cas":279,"imgSvg":280},"785888242737090600","J-24384-1","糠偶酰","492-94-4","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F470\u002F492-94-4.svg",{"slug":282,"cid":283,"name":284,"nameZh":284,"cas":285,"imgSvg":286},"785872178535993300","J-1991346-3","2,2'-联糠醛","552-86-3","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F211\u002F552-86-3.svg",{"slug":288,"cid":289,"name":290,"nameZh":290,"cas":291,"imgSvg":292},"785872240582332400","J-1991485-7","4-甲基-5-噻唑乙醇","137-00-8","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F267\u002F137-00-8.svg",{"slug":294,"cid":295,"name":296,"nameZh":296,"cas":297,"imgSvg":298},"785894702304989200","J-38714-3","2-甲基四氢呋喃-3-酮","3188-00-9","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F427\u002F3188-00-9.svg",{"slug":300,"cid":301,"name":302,"nameZh":302,"cas":303,"imgSvg":304},"785894695225004000","J-1504147-2","3-巯基-2-丁酮","40789-98-8","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F431\u002F40789-98-8.svg",{"slug":306,"cid":307,"name":308,"nameZh":308,"cas":309,"imgSvg":310},"785894697762558000","J-1504153-9","3-巯基-2-戊酮","67633-97-0","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F045\u002F67633-97-0.svg",{"slug":312,"cid":313,"name":314,"nameZh":314,"cas":315,"imgSvg":316},"785894696852394000","J-38687-2","2-甲基-3-巯基呋喃","28588-74-1","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F167\u002F28588-74-1.svg",{"slug":318,"cid":319,"name":320,"nameZh":320,"cas":321,"imgSvg":322},"785884779508666400","J-24195-1","糠醛","98-01-1","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F167\u002F98-01-1.svg",[324],{"key":325,"value":326},"海关编码","3004500000",[328,331,334],{"key":329,"value":330},"危害码 (欧洲)","Xi",{"key":332,"value":333},"安全声明 (欧洲)","S26-S36\u002F37\u002F39-S22",{"key":325,"value":326},"\u003Ctd>\n\n\u003Cp>\u003Ca href=\"\u002Fen\u002Fcas\u002F59-43-8_951918.html#duXinDiv\">维生素 B1毒性英文版\u003C\u002Fa>\u003C\u002Fp>\n\n\u003C\u002Ftd>","\u003Cp> 通常由过量的盐酸乙脒与α-二甲氧基β-甲氧基丙腈经缩合、水解、中和、氧化、酸化得硫胺盐酸盐。\u003Cbr \u002F> \u003C\u002Fp>","2026-08-21T07:51:12.859463Z",false,[340,346,352,358,364,370],{"slug":341,"cid":342,"name":343,"nameZh":344,"cas":345},"785891737703813120","J-30957-4","Hispidulin","高车前素","1447-88-7",{"slug":347,"cid":348,"name":349,"nameZh":350,"cas":351},"785898449647177728","J-50465-0","Ovalbumin","卵清蛋白","9006-59-1",{"slug":353,"cid":354,"name":355,"nameZh":356,"cas":357},"785882574307201024","J-4791-1","Azure B","天青B","531-55-5",{"slug":359,"cid":360,"name":361,"nameZh":362,"cas":363},"847438775779856384","J-1134038-0","1,5-dimethyl-4-[[(Z)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]-2-phenylpyrazol-3-one","水杨醛缩4-氨基安替比林","30957-66-5",{"slug":365,"cid":366,"name":367,"nameZh":368,"cas":369},"785892791585607680","J-1099303-5","Paclobutrazol","多效唑","76738-62-0",{"slug":371,"cid":372,"name":373,"nameZh":374,"cas":375},"785884688790065152","J-1109893-1","Alizarin yellow GG","茜素黄GG","584-42-9",1792600785955,"zh-CN",[]]