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Pharmacogenomics of the triazole antifungal agent voriconazole. Pharmacogenomics. 2011 Jun;12(6):861-72. doi: 10.2217\u002Fpgs.11.18.\n[2].\nScholz I, Oberwittler H, Riedel KD, et al. Pharmacokinetics, metabolism and bioavailability of the triazole antifungal agent voriconazole in relation to CYP2C19 genotype. Br J Clin Pharmacol. 2009 Dec;68(6):906-15. doi: 10.1111\u002Fj.1365-2125.2009.03534.x.\n[3].\nHerbrecht R. Voriconazole: therapeutic review of a new azole antifungal. Expert Rev Anti Infect Ther. 2004 Aug;2(4):485-97.\n[4].\nLouis D. Saravolatz, Section Editor, Leonard B. Johnson, et al. Voriconazole: A New Triazole Antifungal Agent. Clin Infect Dis. 2003,36 (5): 630-637.\n[5].\nJohn R. Perfect, Kieren A. Marr, Thomas J. Walsh, et al. Voriconazole Treatment for Less-Common, Emerging, or Refractory Fungal Infections. 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VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%",[303,306,308,311,314,317,320,323,326,329],{"key":304,"value":305},"符号","GHS02, GHS06, GHS08",{"key":307,"value":239},"信号词",{"key":309,"value":310},"危害声明","H225-H301 + H311 + H331-H370",{"key":312,"value":313},"警示性声明","P210-P260-P280-P301 + P310-P311",{"key":315,"value":316},"危害码 (欧洲)","Xn: Harmful;",{"key":318,"value":319},"风险声明 (欧洲)","R22;R36\u002F38",{"key":321,"value":322},"安全声明 (欧洲)","S26-S36\u002F37\u002F39",{"key":324,"value":325},"危险品运输编码","UN 2811 6.1\u002FPG 3",{"key":327,"value":328},"RTECS号","UV9145000",{"key":291,"value":292},"\u003Cp>合成文献较多#推荐如下路线进行制备和合成.\u003C\u002Fp>\u003Cp>1. 6-乙基-5-氟嘧啶-4(3H)-酮的制备\u003C\u002Fp>\u003Cp>在反应瓶中加入甲醇钠的甲醇溶液[8.64g(160mmol)甲醇钠溶于50ml甲醇],搅拌冷至0 ºC,向该溶液中加入a-氟代丙酰乙酸乙酯12.96g(80mmol)和甲脒乙酸盐8.32g(80mmol)溶于甲醇50ml的溶液,将混合物于0 ºC拌反应1h.于室温下搅拌反应过夜.再在回流温度下搅拌30min.冷却,加入冰醋酸10g中和过量的甲醇钠,反应液在减压下浓缩,剩余物用热乙酸乙酯溶解,过滤掉不溶的乙酸钠,滤液于减压下浓缩.剩余物用“闪式”色谱分离纯化,用乙酸乙酯洗脱,合并洗脱流出液,对分取的目的流出液进行蒸发.剩余物用乙醚捣碎,过滤,抽干,得6-乙基-5-氟嘧啶-4(3H)-酮 5.5g,收率48%,mp105~106 ºC.\u003C\u002Fp>\u003Cp>2. 4-氯-6-乙基-5-氟嘧啶的制备\u003C\u002Fp>\u003Cp>在反应瓶中加入6-乙基-5-氟嘧啶-4(3H)-酮 6.4g(45mmol)和三氯氧磷30ml,搅拌加热回流反应3h.反应毕,将过量的三氯氧磷在减压下蒸除,剩余物倾入冰水.用二氯甲烷(50ml*3)提取,合并有机相,水洗,无水MgSO4干燥,过滤,滤液减压蒸除溶剂后的剩余物在减压下蒸馏,收集74ºC2.933kPa馏分,得4-氯-6-乙基-5-氟嘧啶油状物4.81g,收率66%.\u003C\u002Fp>\u003Cp>3. 3-(4-氯-5-氟嘧啶-6-基)-2-(2,4-二氟苯基)-1-(1H-1,2,4-三唑-1-基)丁-2-醇的制备\u003C\u002Fp>\u003Cp> 在反应瓶中加入干燥的THF 60ml和二异丙胺2.02g(20mmol),搅拌下冷至-60 ºC,于N2保护下滴加正丁基锂12.50ml(20mmol)溶于己烷溶液(溶液浓度1.6mol\u002FL).加毕,自然升温至-20 ºC,再将其冷至-70 ºC,结果得到二异丙氨基锂(LDA)(20mmol)的THF液,于-70 ºC搅拌下滴加4-氯-6-乙基-5-氟嘧啶 3.2g(20mmol)溶于THF30ml溶液,于15min内滴完,滴毕,在同温度下(-70 ºC)搅拌反应3h.向反应液中再加入1-(2,4-二氟苯基)-2-(1H-1,2,4-三唑-1-基)乙酮4.46g(20mmol)溶于THF 50ml溶液,加毕,于-70 ºC搅拌反应1h.然后在-50 ºC再搅拌反应1h(全过程均要N2保护).然后向反应混合物中加入冰醋酸(1.2g)的水(10ml)溶液终止反应.让其自然升至室温,分出有机相,水相用乙酸乙酯20ml提取,合并有机相,用无水MgSO4干燥,过滤,滤液减压浓缩,剩余物用硅胶柱色谱分离,用乙酸乙酯\u002F乙醚(3:2)洗脱,首先流出目的液合并蒸除溶剂,剩余物用乙醚捣碎,过滤抽干,得对映体对B(enantiomericpair B)3-(4-氯-5-氟嘧啶-6-基)-2-(2,4-二氟苯基)-1-(1H-1,2,4-三唑-1-基)丁-2-醇0.94g,收率12%,mp92 ºC.\u003C\u002Fp>\u003Cp>进一步洗脱,合并流出液进行蒸除溶剂,剩余物用乙醚重结晶得到对映体对A,mp132 ºC(可作为副产物).\u003C\u002Fp>\u003Cp>4. 2-(2,4- 二氟苯基)-3-(5-氟嘧啶-4-基)-1-(1H-1,2,4-三唑-1-基)丁-2-醇的制备\u003C\u002Fp>\u003Cp>在加氢反应瓶中加入Enantiomeric B 3-(4-氯-5-氟嘧啶-6-基)-2-(2,4-二氟苯基)-1-(1H-1,2,4-三唑-1-基)丁-2-醇0.307g(0.8mmol)和乙醇20ml,搅拌溶解,再加入10%Pd\u002FC 30mg和乙酸钠0.082g(1mmol),常温常压通H2反应,5h后补加10%Pd\u002FC 10mg,再通H2反应1h.过滤回收催化剂,液真空浓缩,剩余物经“闪式”色谱分离[用乙酸乙酯\u002F甲醇（97：3）洗脱]纯化，得（2R，3S）\u002F(2S,3R)2-(2,4- 二氟苯基)-3-(5-氟嘧啶-4-基)-1-(1H-1,2,4-三唑-1-基)丁-2-醇0.249g,收率89%,mp127 ºC .\u003C\u002Fp>\u003Cp>5. (2R,3S)-2-(2,4-二氟苯基)-3-(5-氟嘧啶-4-基)-1-(1H-1,2,4-三唑-1-基)丁-2-醇(伏立康唑)的合成\u003C\u002Fp>\u003Cp>在反应瓶中加入(2R,3S)\u002F(2S,3R)(051-5)0.105g(0.3mmol)和(1R)-(--)-10-樟脑磺酸0.07g(0.3mmol)和甲醇4ml,拌溶解,在2h内冷却至0 ºC .将产生的结晶过滤收集,则得到(2R,3S)-2-(2,4-二氟苯基)-3-(5-氟嘧啶-4-基)-1-(1H-1,2,4-三唑-1-基)-丁-2-醇-(1R)-(--)-10-樟脑磺酸盐.0.5甲醇0.06g,mp176 ºC \u003C\u002Fp>\u003Cp>上述的过滤母液经减压蒸除溶剂,加入二氯甲烷10ml和NaHCO3饱和水溶液5ml,室温下充分振摇,静置分层,取有机层用无水MgSO4干燥,过滤,滤液减压浓缩,剩余物中加入(1S)-(+)-10樟脑磺酸0.046g(0.2mmol)和甲醇3ml,然后搅拌溶解,在2h内冷至0 ºC ,析出结晶过滤收集,得到(2S,3R)-2-(2,4- 二氟苯基)-3-(5-氟嘧啶-4-基)-1-(1H-1,2,4-三唑-1-基)丁-2-醇(1S)-(+)-10-樟脑磺酸盐.0.5甲醇0.052g,mp176 ºC .此可作\u003C\u002Fp>\u003Cp>为副产物回收.\u003C\u002Fp>\u003Cp>在反应瓶中加入(2R,3S)-2-(2,4- 二氟苯基)-3-(5-氟嘧啶-4-基)-1-(1H-1,2,4-三唑-1-基)丁-2-醇-1R-(--)-10-樟脑磺酸盐1.22g(2.1mmol)、二氯甲烷20ml和饱和NaHCO3水溶液3ml,充分振摇后,静置分层,有机层用水5ml洗涤,用无水MgSO4干燥,过滤,滤液真空蒸发掉溶剂得(2R,3S)-(051)(伏立康唑)0.64g,mp127 ºC .\u003C\u002Fp>\u003Cp>(2S,3R)-2-(2,4- 二氟苯基)-3-(5-氟嘧啶-4-基)-1-(1H-1,2,4-三唑-1-基)丁-2-醇-(1S)-(+)樟脑磺酸盐1.17g(0.2mmol)按上述同样方法处理则得(2S,3R)-2-(2,4- 二氟苯基)-3-(5-氟嘧啶-4-基)-1-(1H-1,2,4-三唑-1-基)丁-2-醇0.63g.\u003C\u002Fp>\u003Cp>\u003C\u002Fp>","\u003Ctd>\n\r\n                                        \r\n                                        伏立康唑\n\u003Cb>修改号码：4\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块1. 化学品\u003C\u002Fstrong>\n\u003Cbr \u002F> 产品名称：\n\u003Cb>Voriconazole\u003C\u002Fb>\n\u003Cbr \u002F> 修改号码：\n\u003Cb>4\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块2. 危险性概述\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>GHS分类\u003C\u002Fb>\n\u003Cbr \u002F> 　物理性危害未分类\n\u003Cbr \u002F> 　健康危害\n\u003Cbr \u002F> 急性毒性（经口）\n\u003Cb>第3级\u003C\u002Fb>\n\u003Cbr \u002F> 生殖毒性\n\u003Cb>1B类\u003C\u002Fb>\n\u003Cbr \u002F> 　环境危害未分类\n\u003Cbr \u002F>\n\u003Cb>GHS标签元素\u003C\u002Fb>\n\u003Cbr \u002F> 　图标或危害标志\n\u003Cbr \u002F> 　信号词危险\n\u003Cbr \u002F> 　危险描述吞咽会中毒。\n\u003Cbr \u002F> 可能损害生育能力或胎儿\n\u003Cbr \u002F> 　防范说明\n\u003Cbr \u002F>\n\u003Cb>[预防]\u003C\u002Fb>使用前获取特定手册。\n\u003Cbr \u002F> 处理前必须阅读并理解所有安全措施。\n\u003Cbr \u002F> 使用本产品时切勿吃东西，喝水或吸烟。\n\u003Cbr \u002F> 处理后要彻底清洗双手。\n\u003Cbr \u002F> 使用个人所需的防护用具。\n\u003Cbr \u002F>\n\u003Cb>[急救措施]\u003C\u002Fb>\n\u003Cb>食入：立即呼叫解毒中心\u002F医生。\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>如接触到或相关接触：求医\u002F就诊。\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>[储存]\u003C\u002Fb>存放处须加锁。\n\u003Cbr \u002F>\n\u003Cb>[废弃处置]\u003C\u002Fb>\n\u003Cb>根据当地政府规定把物品\u002F容器交与工业废弃处理机构。\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块3. 成分\u002F组成信息\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>单一物质\u002F混和物\u003C\u002Fb>单一物质\n\u003Cbr \u002F>\n\u003Cb>化学名(中文名)：\u003C\u002Fb>伏立康唑\n\u003Cbr \u002F> 百分比：\n\u003Cb>>98.0%(LC)\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>CAS编码：\u003C\u002Fb>\n\u003Cb>137234-62-9\u003C\u002Fb>\n\u003Cbr \u002F> 伏立康唑\n\u003Cb>修改号码：4\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块3. 成分\u002F组成信息\u003C\u002Fstrong>\n\u003Cbr \u002F> 俗名：\n\u003Cb>(2R,3S)-2-(2,4-Difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>triazol-1-yl)-2-butanol\u003C\u002Fb>\n\u003Cbr \u002F> 分子式：\n\u003Cb>C16H14F3N5O\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块4. 急救措施\u003C\u002Fstrong>\n\u003Cbr \u002F> 吸入：\n\u003Cb>将受害者移到新鲜空气处，保持呼吸通畅，休息。求医\u002F就诊。\u003C\u002Fb>\n\u003Cbr \u002F> 皮肤接触：\n\u003Cb>立即去除\u002F脱掉所有被污染的衣物。用大量肥皂和水轻轻洗。\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>求医\u002F就诊。\u003C\u002Fb>\n\u003Cbr \u002F> 眼睛接触：用水小心清洗几分钟。如果方便，易操作，摘除隐形眼镜。\n\u003Cbr \u002F>\n\u003Cb>求医\u002F就诊。\u003C\u002Fb>\n\u003Cbr \u002F> 食入：\n\u003Cb>立即呼叫解毒中心\u002F医生。漱口。\u003C\u002Fb>\n\u003Cbr \u002F> 紧急救助者的防护：救援者需要穿戴个人防护用品，比如橡胶手套和气密性护目镜。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块5. 消防措施\u003C\u002Fstrong>\n\u003Cbr \u002F> 合适的灭火剂：干粉，泡沫，雾状水，二氧化碳\n\u003Cbr \u002F> 特殊危险性：小心，燃烧或高温下可能分解产生毒烟。\n\u003Cbr \u002F> 特定方法：从上风处灭火，根据周围环境选择合适的灭火方法。\n\u003Cbr \u002F> 非相关人员应该撤离至安全地方。\n\u003Cbr \u002F> 周围一旦着火：如果安全，移去可移动容器。\n\u003Cbr \u002F> 消防员的特殊防护用具：灭火时，一定要穿戴个人防护用品。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块6. 泄漏应急处理\u003C\u002Fstrong>\n\u003Cbr \u002F> 个人防护措施，防护用具，\n\u003Cb>使用特殊的个人防护用品（针对有毒颗粒的P3过滤式空气呼吸器）。远离溢出物\u002F泄露\u003C\u002Fb>\n\u003Cbr \u002F> 紧急措施：处并处在上风处。\n\u003Cbr \u002F> 泄露区应该用安全带等圈起来，控制非相关人员进入。\n\u003Cbr \u002F> 环保措施：防止进入下水道。\n\u003Cbr \u002F> 控制和清洗的方法和材料：清扫收集粉尘，封入密闭容器。注意切勿分散。附着物或收集物应该立即根据合适的\n\u003Cbr \u002F> 法律法规处置。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块7. 操作处置与储存\u003C\u002Fstrong>\n\u003Cbr \u002F> 处理\n\u003Cbr \u002F> 技术措施：在通风良好处进行处理。穿戴合适的防护用具。防止粉尘扩散。处理后彻底清洗双手\n\u003Cbr \u002F> 和脸。\n\u003Cbr \u002F> 注意事项：如果可能，使用封闭系统。如果粉尘或浮质产生，使用局部排气。\n\u003Cbr \u002F> 操作处置注意事项：避免所有部位的接触！\n\u003Cbr \u002F> 贮存\n\u003Cbr \u002F> 储存条件：保持容器密闭。存放于凉爽、阴暗处。\n\u003Cbr \u002F> 存放处须加锁。\n\u003Cbr \u002F> 远离不相容的材料比如氧化剂存放。\n\u003Cbr \u002F> 包装材料：依据法律。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块8. 接触控制和个体防护\u003C\u002Fstrong>\n\u003Cbr \u002F> 工程控制：尽可能安装封闭体系或局部排风系统。同时安装淋浴器和洗眼器。\n\u003Cbr \u002F> 个人防护用品\n\u003Cbr \u002F> 　呼吸系统防护：\n\u003Cb>防尘面具，自携式呼吸器（SCBA），供气呼吸器等。使用通过政府标准的呼吸器。依\u003C\u002Fb>\n\u003Cbr \u002F> 据当地和政府法规。\n\u003Cbr \u002F> 　手部防护：防渗手套。\n\u003Cbr \u002F> 　眼睛防护：护目镜。如果情况需要，佩戴面具。\n\u003Cbr \u002F> 　皮肤和身体防护：防渗防护服。如果情况需要，穿戴防护靴。\n\u003Cbr \u002F> 伏立康唑\n\u003Cb>修改号码：4\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块9. 理化特性\u003C\u002Fstrong>\n\u003Cbr \u002F> 固体\n\u003Cbr \u002F>\n\u003Cb>外形（20°C）：\u003C\u002Fb>\n\u003Cbr \u002F> 外观：\n\u003Cb>晶体-粉末\u003C\u002Fb>\n\u003Cbr \u002F> 颜色：白色类白色\n\u003Cbr \u002F> 气味：无资料\n\u003Cbr \u002F>\n\u003Cb>pH:\u003C\u002Fb>无数据资料\n\u003Cbr \u002F> 熔点：\n\u003Cb>132°C\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>沸点\u002F沸程\u003C\u002Fb>无资料\n\u003Cbr \u002F> 闪点：无资料\n\u003Cbr \u002F> 爆炸特性\n\u003Cbr \u002F> 　爆炸下限：无资料\n\u003Cbr \u002F> 　爆炸上限：无资料\n\u003Cbr \u002F> 密度：无资料\n\u003Cbr \u002F> 溶解度：溶于： 甲醇 乙腈\n\u003Cbr \u002F> 不溶于： 水\n\u003Cbr \u002F>\n\u003Cb>log水分配系数 =\u003C\u002Fb>\n\u003Cb>1.69\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块10. 稳定性和反应性\u003C\u002Fstrong>\n\u003Cbr \u002F> 化学稳定性：一般情况下稳定。\n\u003Cbr \u002F> 危险反应的可能性：未报道特殊反应性。\n\u003Cbr \u002F> 须避免接触的物质氧化剂\n\u003Cbr \u002F>\n\u003Cb>危险的分解产物:\u003C\u002Fb>\n\u003Cb>一氧化碳, 二氧化碳, 氮氧化物 (NOx), 氟化氢\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块11. 毒理学信息\u003C\u002Fstrong>\n\u003Cbr \u002F> 急性毒性：无资料\n\u003Cbr \u002F> 对皮肤腐蚀或刺激：无资料\n\u003Cbr \u002F> 对眼睛严重损害或刺激：无资料\n\u003Cbr \u002F> 生殖细胞变异原性：无资料\n\u003Cbr \u002F> 致癌性：\n\u003Cbr \u002F>\n\u003Cb>IARC =\u003C\u002Fb>无资料\n\u003Cbr \u002F>\n\u003Cb>NTP =\u003C\u002Fb>无资料\n\u003Cbr \u002F> 生殖毒性：无资料\n\u003Cbr \u002F>\n\n\u003Cstrong>模块12. 生态学信息\u003C\u002Fstrong>\n\u003Cbr \u002F> 生态毒性：\n\u003Cbr \u002F> 鱼类：无资料\n\u003Cbr \u002F> 甲壳类：无资料\n\u003Cbr \u002F> 藻类：无资料\n\u003Cbr \u002F>\n\u003Cb>残留性 \u002F 降解性：\u003C\u002Fb>无资料\n\u003Cbr \u002F>\n\u003Cb>潜在生物累积 （BCF):\u003C\u002Fb>无资料\n\u003Cbr \u002F> 土壤中移动性\n\u003Cbr \u002F>\n\u003Cb>　log水分配系数：\u003C\u002Fb>\n\u003Cb>1.69\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>　土壤吸收系数 （Koc）：\u003C\u002Fb>无资料\n\u003Cbr \u002F> 　亨利定律无资料\n\u003Cbr \u002F>\n\u003Cb>constant(PaM3\u002Fmol):\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块13. 废弃处置\u003C\u002Fstrong>\n\u003Cbr \u002F> 如果可能，回收处理。请咨询当地管理部门。建议在可燃溶剂中溶解混合，在装有后燃和洗涤装置的化学焚烧炉中\n\u003Cbr \u002F> 焚烧。废弃处置时请遵守国家、地区和当地的所有法规。\n\u003Cbr \u002F> 伏立康唑\n\u003Cb>修改号码：4\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块14. 运输信息\u003C\u002Fstrong>\n\u003Cbr \u002F> 联合国分类：\n\u003Cb>第1项 毒害品。\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>UN编号：\u003C\u002Fb>\n\u003Cb>2811\u003C\u002Fb>\n\u003Cbr \u002F> 正式运输名称：\n\u003Cb>有毒固体, 有机物, 不另作详细说明\u003C\u002Fb>\n\u003Cbr \u002F> 包装等级：\n\u003Cb>III\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块15. 法规信息\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>《危险化学品安全管理条例》（2002年1月26日国务院发布，2011年2月16日修订）: 针对危险化学品的安全使用、\u003C\u002Fb>\n\u003Cbr \u002F> 生产、储存、运输、装卸等方面均作了相应的规定。\n\u003Cbr \u002F>\n\u003Cbr \u002F>\n\n\u003Cstrong> 模块16 - 其他信息 \u003C\u002Fstrong>\n\u003Cbr \u002F>N\u002FA\n\u003Cbr \u002F>\u003Cbr \u002F>\u003Cbr \u002F>\u003Cbr \u002F>\u003Cbr \u002F>\n\u003Cbr \u002F>\n\u003C\u002Ftd>","2026-08-21T07:51:12.859463Z",false,[335,341,347,353,359,365],{"slug":336,"cid":337,"name":338,"nameZh":339,"cas":340},"785875939618721792","J-11381-4","Ampicillin","氨苄西林","69-53-4",{"slug":342,"cid":343,"name":344,"nameZh":345,"cas":346},"785892740264103936","J-33551-7","Milneb","代森环","3773-49-7",{"slug":348,"cid":349,"name":350,"nameZh":351,"cas":352},"785880379465666560","J-15087-1","Safranine T","藏红T","477-73-6",{"slug":354,"cid":355,"name":356,"nameZh":357,"cas":358},"785891622826020864","J-30487-2","Gibberellic acid","赤霉素","77-06-5",{"slug":360,"cid":361,"name":362,"nameZh":363,"cas":364},"785897799970459648","J-1987055-5","Sudan III","苏丹红Ⅲ","85-86-9",{"slug":366,"cid":367,"name":368,"nameZh":369,"cas":370},"785937076037095424","J-587118-0","Lead, [3-mercapto-D-valinato(2-)-N,O,S]-","[3-巯基-D-缬氨酰基(2-)-N,O,S]铅","53513-80-7",1792625921499,"zh-CN",[]]