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Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis. J Nat Prod. 1998 Jan;61(1):2-7.\n[2].\nPalayoor ST, et al. Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen. Oncogene. 1999 Dec 2;18(51):7389-94.\n[3].\nKhwaja F, et al. Ibuprofen inhibits survival of bladder cancer cells by induced expression of the p75NTR tumor suppressor protein. Cancer Res. 2004 Sep 1;64(17):6207-13.\n[4].\nRao GH, et al. Ibuprofen protects platelet cyclooxygenase from irreversible inhibition by aspirin. Arteriosclerosis. 1983 Jul-Aug;3(4):383-8.\n[5].\nDriban JB, et al. Joint inflammation and early degeneration induced by high-force reaching are attenuated by ibuprofen in an animal model of work-related musculoskeletal disorder. J Biomed Biotechnol. 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2-(4-甲酰基苯基)...","43153-07-7","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F482\u002F43153-07-7.svg",{"slug":302,"cid":303,"name":304,"nameZh":304,"cas":305,"imgSvg":306},{"slug":365,"cid":366,"name":367,"nameZh":367,"cas":368,"imgSvg":369},"785880409027121200","J-1974628-7","布洛芬杂质","65813-55-0","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F397\u002F65813-55-0.svg",[371,374,377,380],{"key":372,"value":373},"海关编码","2916392000",{"key":375,"value":376},"中文概述","2916392000 布洛芬。监管条件:无。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:30.0%",{"key":378,"value":379},"申报要素","品名, 成分含量, 用途, 丙烯酸、丙烯酸盐或酯应报明包装",{"key":381,"value":382},"Summary","2916392000 2-(4-isobutylphenyl)propanoic acid。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。Lowest tariff:6.5%。General tariff:30.0%",[384,387,389,392,395,398,401,404,407,410,413,416,419,422],{"key":385,"value":386},"符号","GHS07",{"key":388,"value":259},"信号词",{"key":390,"value":391},"危害声明","H302",{"key":393,"value":394},"警示性声明","P301 + P312 + P330",{"key":396,"value":397},"个人防护装备","dust mask type N95 (US);Eyeshields;Gloves",{"key":399,"value":400},"危害码 (欧洲)","Xn:Harmful",{"key":402,"value":403},"风险声明 (欧洲)","R22;R51\u002F53;R63",{"key":405,"value":406},"安全声明 (欧洲)","S36-S61-S36\u002F37",{"key":408,"value":409},"危险品运输编码","2811",{"key":411,"value":412},"WGK德国","3",{"key":414,"value":415},"RTECS号","MU6640000",{"key":417,"value":418},"包装等级","III",{"key":420,"value":421},"危险类别","6.1(b)",{"key":372,"value":423},"2924299090","\u003Ctd>\n\n\u003Cp>\u003Cstrong>布洛芬生态学数据:\u003C\u002Fstrong>\u003C\u002Fp>\n\u003Cp>\u003C\u002Fp>\u003Cp>通常对水体是稍微有害的，不要将未稀释或大量产品接触地下水，水道或污水系统，未经政府许可勿将材料排入周围环境。  \u003C\u002Fp>\n\u003Cp>\u003C\u002Fp>\n\u003Cp>\u003Ca href=\"\u002Fen\u002Fcas\u002F15687-27-1_832290.html#duXinDiv\">布洛芬毒性英文版\u003C\u002Fa>\u003C\u002Fp>\n\n\u003C\u002Ftd>","\u003Cp>异丁基苯乙酮经缩合、水解、消除、氧化、中和而得。  \u003C\u002Fp>","\u003Ctd>\n\n\u003Cb>2-(4-异丁苯基)丙酸\u003C\u002Fb>\n\u003Cb>修改号码：5\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块1. 化学品\u003C\u002Fstrong>\n\u003Cbr \u002F> 产品名称：\n\u003Cb>2-(4-Isobutylphenyl)propionic Acid\u003C\u002Fb>\n\u003Cbr \u002F> 修改号码：\n\u003Cb>5\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块2. 危险性概述\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>GHS分类\u003C\u002Fb>\n\u003Cbr \u002F> 　物理性危害未分类\n\u003Cbr \u002F> 　健康危害\n\u003Cbr \u002F> 急性毒性（经口）\n\u003Cb>第4级\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>皮肤腐蚀\u002F刺激\u003C\u002Fb>\n\u003Cb>第2级\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>严重损伤\u002F刺激眼睛\u003C\u002Fb>\n\u003Cb>2A类\u003C\u002Fb>\n\u003Cbr \u002F> 　环境危害未分类\n\u003Cbr \u002F>\n\u003Cb>GHS标签元素\u003C\u002Fb>\n\u003Cbr \u002F> 　图标或危害标志\n\u003Cbr \u002F> 　信号词警告\n\u003Cbr \u002F> 　危险描述吞咽有害。\n\u003Cbr \u002F> 造成皮肤刺激\n\u003Cbr \u002F> 造成严重眼刺激\n\u003Cbr \u002F> 　防范说明\n\u003Cbr \u002F>\n\u003Cb>[预防]\u003C\u002Fb>使用本产品时切勿吃东西，喝水或吸烟。\n\u003Cbr \u002F> 处理后要彻底清洗双手。\n\u003Cbr \u002F>\n\u003Cb>穿戴防护手套\u002F护目镜\u002F防护面具。\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>[急救措施]\u003C\u002Fb>\n\u003Cb>食入：若感不适，呼叫解毒中心\u002F医生。漱口。\u003C\u002Fb>\n\u003Cbr \u002F> 眼睛接触：用水小心清洗几分钟。如果方便，易操作，摘除隐形眼镜。继续冲洗。\n\u003Cbr \u002F>\n\u003Cb>眼睛接触：求医\u002F就诊\u003C\u002Fb>\n\u003Cbr \u002F> 皮肤接触：用大量肥皂和水轻轻洗。\n\u003Cbr \u002F>\n\u003Cb>若皮肤刺激：求医\u002F就诊。\u003C\u002Fb>\n\u003Cbr \u002F> 脱掉被污染的衣物，清洗后方可重新使用。\n\u003Cbr \u002F>\n\u003Cb>[废弃处置]\u003C\u002Fb>\n\u003Cb>根据当地政府规定把物品\u002F容器交与工业废弃处理机构。\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>2-(4-异丁苯基)丙酸\u003C\u002Fb>\n\u003Cb>修改号码：5\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块3. 成分\u002F组成信息\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>单一物质\u002F混和物\u003C\u002Fb>单一物质\n\u003Cbr \u002F>\n\u003Cb>化学名(中文名)：\u003C\u002Fb>\n\u003Cb>2-(4-异丁苯基)丙酸\u003C\u002Fb>\n\u003Cbr \u002F> 百分比：\n\u003Cb>>98.0%(GC)(T)\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>CAS编码：\u003C\u002Fb>\n\u003Cb>15687-27-1\u003C\u002Fb>\n\u003Cbr \u002F> 俗名：\n\u003Cb>Ibuprofen , 4-Isobutyl-α-methylphenylacetic Acid\u003C\u002Fb>\n\u003Cbr \u002F> 分子式：\n\u003Cb>C13H18O2\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块4. 急救措施\u003C\u002Fstrong>\n\u003Cbr \u002F> 吸入：\n\u003Cb>将受害者移到新鲜空气处，保持呼吸通畅，休息。若感不适请求医\u002F就诊。\u003C\u002Fb>\n\u003Cbr \u002F> 皮肤接触：\n\u003Cb>立即去除\u002F脱掉所有被污染的衣物。用大量肥皂和水轻轻洗。\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>若皮肤刺激或发生皮疹：求医\u002F就诊。\u003C\u002Fb>\n\u003Cbr \u002F> 眼睛接触：用水小心清洗几分钟。如果方便，易操作，摘除隐形眼镜。继续清洗。\n\u003Cbr \u002F>\n\u003Cb>如果眼睛刺激：求医\u002F就诊。\u003C\u002Fb>\n\u003Cbr \u002F> 食入：\n\u003Cb>若感不适，呼叫解毒中心\u002F医生。漱口。\u003C\u002Fb>\n\u003Cbr \u002F> 危害迹象：\n\u003Cb>发烧, 肝炎, 月经周期异常, 复视, 过敏, 肿胀, 皮炎\u003C\u002Fb>\n\u003Cbr \u002F> 紧急救助者的防护：救援者需要穿戴个人防护用品，比如橡胶手套和气密性护目镜。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块5. 消防措施\u003C\u002Fstrong>\n\u003Cbr \u002F> 合适的灭火剂：干粉，泡沫，雾状水，二氧化碳\n\u003Cbr \u002F> 特定方法：从上风处灭火，根据周围环境选择合适的灭火方法。\n\u003Cbr \u002F> 非相关人员应该撤离至安全地方。\n\u003Cbr \u002F> 周围一旦着火：如果安全，移去可移动容器。\n\u003Cbr \u002F> 消防员的特殊防护用具：灭火时，一定要穿戴个人防护用品。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块6. 泄漏应急处理\u003C\u002Fstrong>\n\u003Cbr \u002F> 个人防护措施，防护用具，\n\u003Cb>使用个人防护用品。远离溢出物\u002F泄露处并处在上风处。\u003C\u002Fb>\n\u003Cbr \u002F> 紧急措施：泄露区应该用安全带等圈起来，控制非相关人员进入。\n\u003Cbr \u002F> 环保措施：防止进入下水道。\n\u003Cbr \u002F> 控制和清洗的方法和材料：清扫收集粉尘，封入密闭容器。注意切勿分散。附着物或收集物应该立即根据合适的\n\u003Cbr \u002F> 法律法规处置。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块7. 操作处置与储存\u003C\u002Fstrong>\n\u003Cbr \u002F> 处理\n\u003Cbr \u002F> 技术措施：在通风良好处进行处理。穿戴合适的防护用具。防止粉尘扩散。处理后彻底清洗双手\n\u003Cbr \u002F> 和脸。\n\u003Cbr \u002F> 注意事项：如果粉尘或浮质产生，使用局部排气。\n\u003Cbr \u002F> 操作处置注意事项：避免接触皮肤、眼睛和衣物。\n\u003Cbr \u002F> 贮存\n\u003Cbr \u002F> 储存条件：保持容器密闭。存放于凉爽、阴暗处。\n\u003Cbr \u002F> 远离不相容的材料比如氧化剂存放。\n\u003Cbr \u002F> 包装材料：依据法律。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块8. 接触控制和个体防护\u003C\u002Fstrong>\n\u003Cbr \u002F> 工程控制：尽可能安装封闭体系或局部排风系统，操作人员切勿直接接触。同时安装淋浴器和洗\n\u003Cbr \u002F> 眼器。\n\u003Cbr \u002F> 个人防护用品\n\u003Cbr \u002F> 　呼吸系统防护：防尘面具。依据当地和政府法规。\n\u003Cbr \u002F> 　手部防护：防护手套。\n\u003Cbr \u002F> 　眼睛防护：安全防护镜。如果情况需要，佩戴面具。\n\u003Cbr \u002F>\n\u003Cb>2-(4-异丁苯基)丙酸\u003C\u002Fb>\n\u003Cb>修改号码：5\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块8. 接触控制和个体防护\u003C\u002Fstrong>\n\u003Cbr \u002F> 　皮肤和身体防护：防护服。如果情况需要，穿戴防护靴。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块9. 理化特性\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>外形（20°C）：\u003C\u002Fb>固体\n\u003Cbr \u002F> 外观：\n\u003Cb>晶体-粉末\u003C\u002Fb>\n\u003Cbr \u002F> 颜色：白色类白色\n\u003Cbr \u002F> 气味：特殊味\n\u003Cbr \u002F>\n\u003Cb>pH:\u003C\u002Fb>无数据资料\n\u003Cbr \u002F> 熔点：\n\u003Cb>76°C\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>沸点\u002F沸程\u003C\u002Fb>\n\u003Cb>157 °C\u002F0.5kPa\u003C\u002Fb>\n\u003Cbr \u002F> 闪点：无资料\n\u003Cbr \u002F> 爆炸特性\n\u003Cbr \u002F> 　爆炸下限：无资料\n\u003Cbr \u002F> 　爆炸上限：无资料\n\u003Cbr \u002F> 蒸气压：\n\u003Cb>6.32x10-3Pa\u002F25°C\u003C\u002Fb>\n\u003Cbr \u002F> 密度：无资料\n\u003Cbr \u002F> 溶解度：\n\u003Cbr \u002F>\n\u003Cb>[水]\u003C\u002Fb>\n\u003Cb>不溶于(21mg\u002FL, 25°C)\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>[其他溶剂]\u003C\u002Fb>\n\u003Cbr \u002F> 易溶于：酒精\n\u003Cbr \u002F> 溶于：许多有机溶剂\n\u003Cbr \u002F>\n\u003Cb>log水分配系数 =\u003C\u002Fb>\n\u003Cb>3.97\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块10. 稳定性和反应性\u003C\u002Fstrong>\n\u003Cbr \u002F> 化学稳定性：一般情况下稳定。\n\u003Cbr \u002F> 危险反应的可能性：未报道特殊反应性。\n\u003Cbr \u002F> 须避免接触的物质氧化剂\n\u003Cbr \u002F>\n\u003Cb>危险的分解产物:\u003C\u002Fb>\n\u003Cb>一氧化碳, 二氧化碳\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块11. 毒理学信息\u003C\u002Fstrong>\n\u003Cbr \u002F> 急性毒性：\n\u003Cb>orl-chd LDLo:469 mg\u002Fkg\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>orl-man LDLo:171 mg\u002Fkg\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>orl-rat LD50:636 mg\u002Fkg\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>orl-wmn TDLo:8 mg\u002Fkg\u003C\u002Fb>\n\u003Cbr \u002F> 对皮肤腐蚀或刺激：\n\u003Cb>skn-hmn 2%\u002F2D\u003C\u002Fb>\n\u003Cbr \u002F> 对眼睛严重损害或刺激：无资料\n\u003Cbr \u002F> 生殖细胞变异原性：\n\u003Cb>cyt-mus-orl 1470 mg\u002Fkg\u002F7D\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>sce-mus-ipr 50 mg\u002Fkg\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>sce-mus-orl 270 mg\u002Fkg\u003C\u002Fb>\n\u003Cbr \u002F> 致癌性：\n\u003Cbr \u002F>\n\u003Cb>IARC =\u003C\u002Fb>无资料\n\u003Cbr \u002F>\n\u003Cb>NTP =\u003C\u002Fb>无资料\n\u003Cbr \u002F> 生殖毒性：\n\u003Cb>rec-rat TDLo:270 mg\u002Fkg(17-21D preg)\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>orl-rat TDLo:9750 mg\u002Fkg(65D male)\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>orl-wmn TDLo:8 mg\u002Fkg(1D pre)\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>orl-mus TDLo:1260 mg\u002Fkg(7-13D preg)\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>RTECS 号码:\u003C\u002Fb>\n\u003Cb>MU6640000\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块12. 生态学信息\u003C\u002Fstrong>\n\u003Cbr \u002F> 生态毒性：\n\u003Cbr \u002F>\n\u003Cb>2-(4-异丁苯基)丙酸\u003C\u002Fb>\n\u003Cb>修改号码：5\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块12. 生态学信息\u003C\u002Fstrong>\n\u003Cbr \u002F> 鱼类：无资料\n\u003Cbr \u002F> 甲壳类：无资料\n\u003Cbr \u002F> 藻类：无资料\n\u003Cbr \u002F>\n\u003Cb>残留性 \u002F 降解性：\u003C\u002Fb>无资料\n\u003Cbr \u002F>\n\u003Cb>潜在生物累积 （BCF):\u003C\u002Fb>\n\u003Cb>3\u003C\u002Fb>\n\u003Cbr \u002F> 土壤中移动性\n\u003Cbr \u002F>\n\u003Cb>　log水分配系数：\u003C\u002Fb>\n\u003Cb>3.97\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>1.5 x 10-2\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>　土壤吸收系数 （Koc）：\u003C\u002Fb>\n\u003Cbr \u002F> 　亨利定律\n\u003Cb>3400\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>constant(PaM3\u002Fmol):\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块13. 废弃处置\u003C\u002Fstrong>\n\u003Cbr \u002F> 如果可能，回收处理。请咨询当地管理部门。建议在可燃溶剂中溶解混合，在装有后燃和洗涤装置的化学焚烧炉中\n\u003Cbr \u002F> 焚烧。废弃处置时请遵守国家、地区和当地的所有法规。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块14. 运输信息\u003C\u002Fstrong>\n\u003Cbr \u002F> 联合国分类：与联合国分类标准不一致\n\u003Cbr \u002F>\n\u003Cb>UN编号：\u003C\u002Fb>未列明\n\u003Cbr \u002F>\n\n\u003Cstrong>模块15. 法规信息\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>《危险化学品安全管理条例》（2002年1月26日国务院发布，2011年2月16日修订）: 针对危险化学品的安全使用、\u003C\u002Fb>\n\u003Cbr \u002F> 生产、储存、运输、装卸等方面均作了相应的规定。\n\u003Cbr \u002F>\n\u003Cbr \u002F>\n\n\u003Cstrong> 模块16 - 其他信息 \u003C\u002Fstrong>\n\u003Cbr \u002F>N\u002FA\n\u003Cbr \u002F>\u003Cbr \u002F>\u003Cbr \u002F>\u003Cbr \u002F>\u003Cbr \u002F>\u003Cbr \u002F>\u003Cbr \u002F>\u003Cbr \u002F>\u003Cbr \u002F>\u003Cbr \u002F>\n\n\u003C\u002Ftd>","2026-08-21T07:51:12.859463Z",false,[430,436,442,448,454,460],{"slug":431,"cid":432,"name":433,"nameZh":434,"cas":435},"785892359601655808","J-32348-0","Neocupferron","新铜铁灵","1013-20-3",{"slug":437,"cid":438,"name":439,"nameZh":440,"cas":441},"785876513881853952","J-1128133-9","1,10-Phenanthroline-2-carbaldehyde","1,10-菲啰啉-2-甲醛","33795-37-8",{"slug":443,"cid":444,"name":445,"nameZh":446,"cas":447},"785881511617368064","J-19814-3","Neocuproine","新铜试剂","484-11-7",{"slug":449,"cid":450,"name":451,"nameZh":452,"cas":453},"785883452506378240","J-1580556-0","2-Amino-9,9-dimethylfluorene","2-氨基-9,9-二甲基芴","108714-73-4",{"slug":455,"cid":456,"name":457,"nameZh":458,"cas":459},"785892494209454080","J-810358-5","4-Aminoantipyrine","4-氨基安替比林","83-07-8",{"slug":461,"cid":462,"name":463,"nameZh":464,"cas":465},"785893636008054784","J-35795-9","Methyldopa","甲基多巴","555-30-6",1792678561017,"zh-CN",[]]