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HMGB1 的拮抗剂,具有抗肿瘤、抗糖尿病等功效。",{"key":259,"value":260},"相关类别","信号通路\n>>\n其他\n>>\n其他\n研究领域\n>>\n代谢疾病\n天然产物\n>>\n萜类化合物和糖苷\n研究领域\n>>\n癌症",{"key":262,"value":263},"体外研究","甘草酸具有一系列抗癌相关的药理活性,如广谱抗癌能力,化疗和放射引起的组织毒性抵抗,药物吸收增强作用和抗多药耐药(MDR)机制,如药物输送系统中的载体材料[1]。在分泌GLP-1的肠NCI-H716细胞中,甘草酸促进GLP-1分泌,钙水平显着升高。甘草酸可通过TGR5活化增强GLP-1的分泌[2]。",{"key":265,"value":266},"体内研究","在由链脲佐菌素(STZ处理的大鼠)诱导的1型糖尿病大鼠中,甘草酸增加血浆GLP-1的水平,其以足以抑制武田G蛋白偶联受体5(TGR5)的剂量被氨苯喋呤阻断。 [1]。甘草酸(Glycyrrhizic acid; 50 mg\u002Fkg,ip)显着降低小鼠的TgAb,HMGB1,TNF-α,IL-6,IL-1β水平[3]。",{"key":268,"value":269},"动物实验","将小鼠[3] NOD.H-2h4小鼠喂养在动物房中直至4周龄。然后将总共24只雄性小鼠随机分成三个不同的组（每组n = 8）。对照组小鼠给予无菌水，无需补充。碘补充剂（NaI）组中的小鼠在饮用水中给予0.005％NaI。 NaI +甘草酸组中的小鼠每天一次用50mg \u002F kg甘草酸处理4周，在碘补充8周后通过腹膜内注射给药。在麻醉下通过外科手术取出甲状腺组织，用冷盐水洗涤，在滤纸上吸干并使用电子天平称重。然后将甲状腺组织储存在-80°C直至使用[3]。",{"key":271,"value":272},"参考文献","[1].\nSu X, et al. Glycyrrhizic acid: A promising carrier material for anticancer therapy. Biomed Pharmacother. 2017 Sep 5;95:670-678\n[2].\nWang LY, et al. Glycyrrhizic acid increases glucagon like peptide-1 secretion via TGR5 activation in type 1-like diabetic rats. Biomed Pharmacother. 2017 Sep 4;95:599-604.\n[3].\nLi C, et al. Glycyrrhizin, a Direct HMGB1 Antagonist, Ameliorates Inflammatory Infiltration in a Model of Autoimmune Thyroiditis via Inhibition of TLR2-HMGB1 Signaling. Thyroid. 2017 May;27(5):722-731.",[],[275,281,287],{"slug":276,"cid":277,"name":278,"nameZh":278,"cas":279,"imgSvg":280},"785888695092777000","J-25528-2","D-葡萄糖醛酸","6556-12-3","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F240\u002F6556-12-3.svg",{"slug":282,"cid":283,"name":284,"nameZh":284,"cas":285,"imgSvg":286},"785896066393313300","J-43520-4","甘草次酸; beta-甘草亭酸","471-53-4","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F332\u002F471-53-4.svg",{"slug":288,"cid":289,"name":290,"nameZh":290,"cas":291,"imgSvg":292},"785881818707529700","J-21204-9","2-乙酰氨基氟","53-96-3","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F410\u002F53-96-3.svg",[294],{"key":295,"value":296},"海关编码","1211903600",[298,301,304,307,310],{"key":299,"value":300},"危害码 (欧洲)","Xi",{"key":302,"value":303},"安全声明 (欧洲)","S22-S24\u002F25",{"key":305,"value":306},"危险品运输编码","NONH for all modes of transport",{"key":308,"value":309},"RTECS号","MD2025000",{"key":295,"value":296},"\u003Ctd>\n\n\u003Cp>\u003Cstrong>甘草酸毒理学数据:\u003C\u002Fstrong>\u003C\u002Fp>\n\u003Cp>\u003C\u002Fp>\u003Cp> 急性毒性：人体口经TDLo：280mg\u002Fkg\u002F4W；小鼠口经LCLo：3gm\u002Fkg；小鼠腹经LCLo：2gm\u002Fkg；小鼠静脉LC：>300mg\u002Fkg \u003C\u002Fp>\n\u003Cp>\u003C\u002Fp>\n\u003Cp>\u003Cstrong>甘草酸生态学数据:\u003C\u002Fstrong>\u003C\u002Fp>\n\u003Cp>\u003C\u002Fp>\u003Cp>对是水稍微有危害的不要让未稀释或大量的产品接触地下水、水道或者污水系统，若无政府许可，勿将材料排入周围环境。\u003C\u002Fp>\n\u003Cp>\u003C\u002Fp>\n\u003Cp>\u003Ca href=\"\u002Fen\u002Fcas\u002F1405-86-3_402118.html#duXinDiv\">甘草酸毒性英文版\u003C\u002Fa>\u003C\u002Fp>\n\n\u003C\u002Ftd>","\u003Cp>1.本品具有特殊的甜味，其甜度约砂糖的250倍，从甘草中提取出来的甘草酸钠盐，即使稀释4000倍的水溶液也有甜味。但直接作为食品的甜味剂，对某些食品不合适，一般可与砂糖，葡萄糖、糖稀等天然糖类并用或与糖精、甘氨酸、丙二醇等适当配合，方可获得较为可口的甜味。日本1978年生产甘草酸240吨，原料甘草从我国和俄罗斯进口，最高年份，进口甘草12000吨，1978年销售总量中，用于医药、化妆品的占26%，用于食品的占70%，用于卷烟及其他的占4%，在食品方面主要用途是：1.酱油 除了可改善咸味以提高酱油固有味道外，可消除糖精的苦味，对化学调味剂有增效作用。2.咸菜类 与糖精并用腌制咸菜的卤法中，可消除糖精的苦味。在腌制过程中，可克服少加糖而出现的发酵败、变色、硬化等缺点。3.调味 本品可添加腌渍调味液，调味粉或饮食时的临时调味，可增加甜味，得到敌视芭的咸味，季低其他化学调味剂的怪味。4.豆酱 腌制小酱鲱鱼采用本品可起到增加甜味、使味道均匀的作用。在甘草提取的过程中，得到甘草酸铵溶解在含有讲学算量碳酸钠的水溶液中，减压浓缩即得甘草酸二钠（C42H60Na3O16）、甘草酸三钠（C42H59Na3O16）。也用作食品添加剂，作为豆酱、酱油的甜味剂。二钠盐对小鼠腹腔注射LD50为1.44克\u002F公斤，三钠盐对小鼠皮下注射LD50为1.54克\u002F公斤。\u003C\u002Fp>\u003Cp>2.将干燥甘草根粉碎，用水煮沸提取3次，合并提取液过滤后浓缩至原体积的1／5，搅拌下加入浓硫酸至不再析出沉淀为止，静置过夜。收集棕色沉淀，水洗，并在60℃以下干燥磨粉。粉末用丙酮回流提取3次，滤除不溶于丙酮的杂质，丙酮液放冷加20%氢氧化钾溶液至弱碱性，析出晶体为甘草酸三钾盐，其水溶液加酸即可生成游离甘草酸。\u003C\u002Fp>\u003Cp>3.超临界CO2萃取法　本法在超临界萃取状态下，用CO2做萃取剂，用水 乙醇作挟带剂从甘草中萃取甘草苷，最佳萃取温度为40℃，压力为35MPa，萃取体系与物料的质量比为4～5，萃取时间为5h。提取中CO2不与提取物有效成分发生化学反应，无毒、无污染、无致癌性、沸点低，便于从产品中清除。\u003C\u002Fp>\u003Cp>4. 从甘草根中提取，在热水中溶解。\u003C\u002Fp>","\u003Ctd>\n\n\u003Ca href=\"\u002Fen\u002Fcas\u002F1405-86-3_402118.html#MSDSDiv\">甘草酸MSDS英文版\u003C\u002Fa>\n\n\u003C\u002Ftd>","2026-08-21T07:51:12.859463Z",false,[317,323,329,335,341,347],{"slug":318,"cid":319,"name":320,"nameZh":321,"cas":322},"785898580933087232","J-913894-4","Dibasic lead phthalate","二盐基邻苯二甲酸铅","69011-06-9",{"slug":324,"cid":325,"name":326,"nameZh":327,"cas":328},"785897512778076160","J-1986767-4","Chitotetraose Tetrahydrochloride Hydrate","壳四糖四盐酸盐水合物","117399-50-5",{"slug":330,"cid":331,"name":332,"nameZh":333,"cas":334},"785876311598960640","J-13043-1","Tripalmitin","三棕榈酸甘油酯","555-44-2",{"slug":336,"cid":337,"name":338,"nameZh":339,"cas":340},"785891434392719360","J-29699-5","Dimethylanilinium tetrakis(pentafluorophenyl)borate","N,N-二甲基苯铵四(五氟苯基)硼酸盐","118612-00-3",{"slug":342,"cid":343,"name":344,"nameZh":345,"cas":346},"785942980035874816","J-698524-4","Tris(dithiophosphoric acid O,O-dibutyl) antimony salt","三(O,O-二丁基二硫代磷酸)锑","30927-36-7",{"slug":348,"cid":349,"name":350,"nameZh":351,"cas":352},"785876135899566080","J-1094587-4","Sodium Hyaluronate","透明质酸钠","9067-32-7",1792676524124,"zh-CN",[]]