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T细胞中幼稚T细胞的比例[2]。与未治疗的小鼠相比,他米巴罗汀(2.5mg\u002Fkg,口服)不会导致牙周炎攻击小鼠的AST,ALT或ALP血清水平的任何显着改变。他米巴罗通改善牙槽骨吸收,显着减少小鼠牙龈卟啉单胞菌诱导的破骨细胞数量。与EPD小鼠相比,他米巴罗汀可测量地增加CD4 + Foxp3 + Treg细胞的百分比。他米巴罗汀还有效降低牙龈卟啉单胞菌感染的牙龈组织和CLN中CD4 + ROR-γt+(Th17)细胞的表达[3]。他米巴罗汀(1 mg\u002Fkg,po)可增加大鼠球囊损伤动脉的apelin表达,与培养的VSMCs结果一致[4]。在老年SAMP8小鼠中,在施用他米巴罗汀(1mg\u002Fkg \u002F天)后海马ADAM10水平改善。在Tamibarotene给药后,Hes5和Ki67恢复,空间工作记忆也得到改善[5]。",{"key":266,"value":267},"细胞实验","CellTiter水性非放射性细胞增殖测定试剂盒用于评估细胞生长。简言之，将每孔10,000个细胞接种在96孔板中，并在含有2％活性炭剥离的FBS的RPMI中培养，并指示类视黄醇浓度72小时。在处理期结束时，加入MTS试剂，将细胞再孵育2-4小时，并在490纳米下测量吸光度。",{"key":269,"value":270},"动物实验","对于感染，给小鼠口服悬浮液中的磺胺甲恶唑和甲氧苄氨嘧啶10mL去离子水10天，以减少天然菌群并支持牙龈卟啉单胞菌W83的定植。抗生素治疗结束后4天，通过口服接种建立牙周感染，使用悬浮在100μL4％羧甲基纤维素（CMC）中的1010菌落形成单位的牙龈卟啉单胞菌7天。在第一次口服接种后4周对小鼠实施安乐死。将他米巴罗汀（2.5mg \u002F kg）悬浮在0.5％羧甲基纤维素溶液中。每天以0.1mL \u002F 10g体重的体积将药物口服加入食道。在诱导牙周炎之前1小时施用他米巴罗汀，然后按照方案每天给予直至第28天。患有牙周病的对照小鼠接受相同体积的0.5％羧甲基纤维素溶液。每3天测量每只小鼠的体重。",{"key":272,"value":273},"参考文献","[1].\nWang X, et al. Retinoic acid receptor alpha drives cell cycle progression and is associated with increased sensitivity to retinoids in T-cell lymphoma. Oncotarget. 2017 Apr 18;8(16):26245-26255.\n[2].\nToyama T, et al. Tamibarotene Ameliorates Bleomycin-Induced Dermal Fibrosis by Modulating Phenotypes of Fibroblasts, Endothelial Cells, and Immune Cells. J Invest Dermatol. 2016 Feb;136(2):387-98.\n[3].\nJin Y, et al. Tamibarotene modulates the local immune response in experimental periodontitis. Int Immunopharmacol. 2014 Dec;23(2):537-45.\n[4].\nLv XR, et al. Synthetic retinoid Am80 up-regulates apelin expression by promoting interaction of RARα with KLF5 and Sp1 in vascular smooth muscle cells. Biochem J. 2013 Nov 15;456(1):35-46.\n[5].\nKitaoka K, et al. The retinoic acid receptor agonist Am80 increases hippocampal ADAM10 in aged SAMP8 mice. 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