[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"currency-rates":3,"$fyk2oeqxpb7bd":8,"compound-J-28961-6":171,"verified-suppliers-J-28961-6":412},{"rates":4,"source":7},{"USD":5,"CNY":6},1,6.691314,"live",{"rows":9,"total":170,"current":5,"size":145},[10,33,45,60,74,85,96,113,123,135,146,158],{"slug":11,"cid":12,"imgSvg":13,"name":14,"nameZh":15,"cas":16,"formula":17,"iupac":14,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":22,"offersCount":24,"supplierCount":25,"bestOffer":26},"843627791009189888","J-1971488-8","\u002Fimages\u002Fchem_structures_svg\u002F399\u002F65845-61-6.svg","N-Methylcyclohexanamine hydrochloride","N-甲基环己胺盐酸盐","65845-61-6","C7H16ClN","acids","有机酸","Organic Acids","",[23],"In Stock",4,2,{"unitPrice":27,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},2.64,"500g","CNY","China","CN","in-stock",{"slug":34,"cid":35,"imgSvg":36,"name":37,"nameZh":38,"cas":39,"formula":40,"iupac":37,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":41,"offersCount":24,"supplierCount":5,"bestOffer":42},"785882541994283008","J-1323843-4","\u002Fimages\u002Fchem_structures_svg\u002F104\u002F67627-18-3.svg","Potassium indigotrisulfonate","靛蓝三磺酸钾","67627-18-3","C16H7K3N2O11S3",[23],{"unitPrice":43,"pack":44,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},180,"5g",{"slug":46,"cid":47,"imgSvg":48,"name":49,"nameZh":50,"cas":51,"formula":52,"iupac":49,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":56,"offersCount":57,"supplierCount":25,"bestOffer":58},"785889752443260928","J-28559-9","\u002Fimages\u002Fchem_structures_svg\u002F292\u002F15060-55-6.svg","Ammonium tetrathiomolybdate","四硫钼酸铵","15060-55-6","H8MoN2S4","inorganic","无机化合物","Inorganic Chemicals",[23],7,{"unitPrice":59,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},24,{"slug":61,"cid":62,"imgSvg":63,"name":64,"nameZh":65,"cas":66,"formula":67,"iupac":64,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":68,"offersCount":69,"supplierCount":25,"bestOffer":70},"855452191530422272","J-1994428-7","\u002Fimages\u002Fchem_structures_svg\u002F500\u002F16350-96-2.svg","N-benzylcyclohexanamine.hydrochloride","N-苄基环己胺盐酸盐","16350-96-2","C13H20ClN",[23],5,{"unitPrice":71,"pack":72,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},6,"1000g","中国",{"slug":75,"cid":76,"imgSvg":77,"name":78,"nameZh":79,"cas":80,"formula":81,"iupac":78,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":82,"offersCount":25,"supplierCount":25,"bestOffer":83},"785871840001134592","J-982001-0","\u002Fimages\u002Fchem_structures_svg\u002F001\u002F10517-44-9.svg","1,3-Diaminopropane dihydrochloride","1,3-二氨基丙烷二盐酸盐","10517-44-9","C3H12Cl2N2",[23],{"unitPrice":84,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},3.78,{"slug":86,"cid":87,"imgSvg":88,"name":89,"nameZh":90,"cas":91,"formula":92,"iupac":89,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":93,"offersCount":57,"supplierCount":94,"bestOffer":95},"785880365658017792","J-14975-6","\u002Fimages\u002Fchem_structures_svg\u002F262\u002F12003-67-7.svg","Lithium aluminate","氧化铝锂","12003-67-7","AlHLiO2",[23],3,{"unitPrice":94,"pack":28,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},{"slug":97,"cid":98,"imgSvg":99,"name":100,"nameZh":101,"cas":102,"formula":103,"iupac":100,"category":104,"categoryName":105,"categoryEnName":106,"industry":21,"tags":107,"offersCount":108,"supplierCount":108,"bestOffer":109},"785871830249377792","J-6931-9","\u002Fimages\u002Fchem_structures_svg\u002F456\u002F58068-80-7.svg","1-Octanoylbenzotriazole","N-辛酰苯并三唑","58068-80-7","C14H19N3O","aromatics","芳香烃","Aromatic Hydrocarbons",[],0,{"unitPrice":110,"pack":21,"currency":111,"origin":21,"originFlag":21,"moq":21,"stock":112},9007199254740991,"USD","made-to-order",{"slug":114,"cid":115,"imgSvg":116,"name":117,"nameZh":118,"cas":119,"formula":120,"iupac":117,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":121,"offersCount":69,"supplierCount":25,"bestOffer":122},"785871842446413824","J-1960944-3","\u002Fimages\u002Fchem_structures_svg\u002F495\u002F10534-86-8.svg","Hexaamminecobalt(III) nitrate","六氨合钴(III)硝酸盐","10534-86-8","CoH18N9O9",[23],{"unitPrice":71,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},{"slug":124,"cid":125,"imgSvg":126,"name":127,"nameZh":128,"cas":129,"formula":130,"iupac":127,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":131,"offersCount":24,"supplierCount":25,"bestOffer":132},"785871842576437248","J-814544-6","\u002Fimages\u002Fchem_structures_svg\u002F221\u002F12037-42-2.svg","vanadium oxide","氧化钒","12037-42-2","O13V6",[23],{"unitPrice":133,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},112.8,"100g",{"slug":136,"cid":137,"imgSvg":138,"name":139,"nameZh":140,"cas":141,"formula":142,"iupac":139,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":143,"offersCount":57,"supplierCount":5,"bestOffer":144},"785871842647740416","J-1333345-2","\u002Fimages\u002Fchem_structures_svg\u002F479\u002F26490-63-1.svg","COBALT TETRAFLUOROBORATE HEXAHYDRATE","四氟化硼钴水合物","26490-63-1","B2CoF8H12O6",[23],{"unitPrice":145,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},12,{"slug":147,"cid":148,"imgSvg":149,"name":150,"nameZh":151,"cas":152,"formula":153,"iupac":150,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":154,"offersCount":155,"supplierCount":94,"bestOffer":156},"785871842698072064","J-814953-0","\u002Fimages\u002Fchem_structures_svg\u002F432\u002F72259-10-0.svg","Copper(II) tetrafluoroborate hexahydrate","六水合四氟硼酸铜(II)","72259-10-0","B2CuF8H12O6",[23],10,{"unitPrice":157,"pack":28,"currency":29,"origin":21,"originFlag":21,"moq":21,"stock":32},2.6,{"slug":159,"cid":160,"imgSvg":161,"name":162,"nameZh":163,"cas":164,"formula":165,"iupac":162,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":166,"offersCount":25,"supplierCount":5,"bestOffer":168},"785871863254355968","J-1990080-7","\u002Fimages\u002Fchem_structures_svg\u002F149\u002F123333-60-8.svg","Cerium(IV) sulfate hydrate","铈(IV)硫酸盐水合物","123333-60-8","CeH2O9S2",[167],"Made to Order",{"unitPrice":169,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},5.6,3204,{"slug":172,"cid":173,"imgSvg":174,"name":175,"nameZh":175,"cas":176,"formula":177,"iupac":175,"mdl":21,"mw":178,"category":179,"categoryName":180,"categoryEnName":181,"industry":21,"tags":182,"synonyms":183,"properties":190,"ghs":249,"offers":256,"activity":257,"upstream":282,"downstream":295,"customs":326,"safetyRows":339,"toxicity":370,"updatedAt":371,"isProhibited":372,"related":373,"__ts":410,"__lang":411,"__slug":173},"785889899080323072","J-28961-6","\u002Fimages\u002Fchem_structures_svg\u002F124\u002F2627-69-2.svg","阿卡地新","2627-69-2","C9H14N4O5","258.231","organic","有机化合物","Organic Compounds",[],[184,185,186,187,188,189],"5-氨基咪唑-4-甲酰胺-1-β-D-呋喃核糖苷","5-氨基-1-β-D-呋喃核糖基咪唑-4-甲酰胺","5-氨基-1-β-D-呋喃核糖基-1H-咪唑-4-甲酰胺","阿卡地辛","AICAR","AMP活化蛋白激酶激活剂",[191,195,199,203,207,211,214,217,220,224,228,232,235,238,242,246],{"label":192,"labelZh":192,"value":193,"prop":194},"Melting Point","214-215 °C","meltingPoint",{"label":196,"labelZh":196,"value":197,"prop":198},"Boiling Point","726.3±60.0 °C at 760 mmHg","boilingPoint",{"label":200,"labelZh":200,"value":201,"prop":202},"Density","2.1±0.1 g\u002Fcm3","density",{"label":204,"labelZh":204,"value":205,"prop":206},"Flash Point","393.1±32.9 °C","flashPoint",{"label":208,"labelZh":209,"value":210},"Exact Mass","精确质量","258.096405",{"label":212,"labelZh":212,"value":213},"PSA","156.85000",{"label":215,"labelZh":215,"value":216},"LogP","-2.93",{"label":218,"labelZh":218,"value":219},"外观性状","固体",{"label":221,"labelZh":222,"value":223},"Vapor Pressure","蒸汽压","0.0±2.5 mmHg at 25°C",{"label":225,"labelZh":226,"value":227},"Refractive Index","折射率","1.821",{"label":229,"labelZh":230,"value":231},"Storage Conditions","储存条件","密封于-20ºC阴凉干燥环境。",{"label":233,"labelZh":233,"value":234},"稳定性","如果遵照规格使用和储存则不会分解。",{"label":236,"labelZh":236,"value":237},"水溶解性","H2O: >10 mg\u002FmL",{"label":239,"labelZh":240,"value":241},"Molecular Structure","分子结构","1、 摩尔折射率：54.55\n2、 摩尔体积（m\n3\n\u002Fmol）：125.2\n3、 等张比容（90.2K）：402.2\n4、 表面张力（dyne\u002Fcm）：106.5\n5、 极化率（10\n-24\ncm\n3\n）：21.62",{"label":243,"labelZh":244,"value":245},"Computational Chemistry","计算化学","1、 疏水参数计算参考值（XlogP）：-2.2\n2、 氢键供体数量：5\n3、 氢键受体数量：7\n4、 可旋转化学键数量：3\n5、 拓扑分子极性表面积（TPSA）：157\n6、 重原子数量：18\n7、 表面电荷：0\n8、 复杂度：330\n9、 同位素原子数量：0\n10、 确定原子立构中心数量：4\n11、 不确定原子立构中心数量：0\n12、 确定化学键立构中心数量：0\n13、 不确定化学键立构中心数量：0\n14、 共价键单元数量：1",{"label":247,"labelZh":247,"value":248},"更多","1. 性状：黄褐色粉末\n2. 密度（g\u002FmL,25\u002F4℃）：无可用\n3. 相对蒸汽密度（g\u002FmL,空气=1）：无可用\n4. 熔点（ºC）：214-215\n5. 沸点（ºC,常压）：无可用\n6. 沸点（ºC,5.2kPa）：无可用\n7. 折射率：无可用\n8. 闪点（ºC）：无可用\n9. 比旋光度（º）：无可用\n10. 自燃点或引燃温度（ºC）：无可用\n11. 蒸气压（kPa,25ºC）：无可用\n12. 饱和蒸气压（kPa,60ºC）：无可用\n13. 燃烧热（KJ\u002Fmol）：无可用\n14. 临界温度（ºC）：无可用\n15. 临界压力（KPa）：无可用\n16. 油水（辛醇\u002F水）分配系数的对数值：无可用\n17. 爆炸上限（%,V\u002FV）：无可用\n18. 爆炸下限（%,V\u002FV）： 无可用\n19. 溶解性：可溶于水",{"pictogram":250,"signal":251,"hazards":252},"Irritant","Warning",[253,254,255],"H315 — Causes skin irritation \u002F 造成皮肤刺激","H319 — Causes serious eye irritation \u002F 造成严重眼刺激","H335 — May cause respiratory irritation \u002F 可能造成呼吸道刺激",[],[258,261,264,267,270,273,276,279],{"key":259,"value":260},"描述","AICAR是一种可渗透细胞的AMP活化蛋白激酶 (AMPK) 激活剂。",{"key":262,"value":263},"相关类别","信号通路\n>>\n表观遗传学\n>>\nAMPK\n信号通路\n>>\nPI3K\u002FAkt\u002FmTOR 信号通路\n>>\nAMPK\n信号通路\n>>\n自噬\n>>\n自噬\n信号通路\n>>\n自噬\n>>\n自噬\n研究领域\n>>\n癌症",{"key":265,"value":266},"靶点","AMPK\nAutophagy\nMitophagy",{"key":268,"value":269},"体外研究","用不同浓度的AICAR(0.1-1.0mM)处理HepG2细胞12,24和48小时。 IR-β的表达水平在对照组的48小时至50％,53％和46％时分别以0.25,0.5和1.0mM的AICAR显着降低[1]。",{"key":271,"value":272},"体内研究","将14周龄雄性,瘦肉(L; 31.3g体重)野生型andob\u002Fob(O; 59.6g体重)小鼠注射AMP激活激酶(AMPK)激活剂AICAR(A)0.5mg\u002Fg \u002F天或盐水对照(C)14天。在最后一次注射后24小时(包括12小时禁食),杀死所有小鼠,切除足底屈肌复合肌(腓肠肌,比目鱼肌和跖肌)进行分析。 OC(159±12 mg)的肌肉质量低于LC,LA和OA(分别为176±10,178±9和166±16 mg)小鼠,与体重变化无关[2]。与运动和AICAR(0.5mg\u002Fg体重)组相比,未治疗组的肾重量显着更高。运动组的心脏重量高于其他组,而AICAR治疗组的肝脏重量显着高于运动组和未治疗组[3]。",{"key":274,"value":275},"细胞实验","将HepG2细胞（5×10 5个细胞）接种在6孔培养板培养皿中，然后在无血清培养基中培养12小时，然后转染。用FuGENE6转染试剂转染1微克质粒。转染5小时后，除去培养基，然后向每个孔中加入补充有或不含AICAR（0.1-1.0mM）的培养基。刺激介质每24小时更换一次[1]。",{"key":277,"value":278},"动物实验","小鼠[2]使用14周龄瘦（Lepob \u002F +或Lepob \u002F +）和ob \u002F ob（Lepob \u002F Lepob）雄性小鼠。经过14天的实验治疗（AICAR注射后24小时，包括12小时禁食），足底屈肌复合肌从4％异氟醚麻醉的小鼠切除干净（肌腱 - 肌腱）。快速称重肌肉，然后进行组织学处理或在液氮中冷冻并储存在-80℃。在通过针刺直接进入心脏采血后，通过隔膜横切和整个心脏的移除来杀死麻醉的小鼠，同时呼吸4％的异氟烷。将AICAR或盐水（对照）皮下注射到背部的侧向远侧部分。 AICAR以0.5mg \u002F g每天一次给药，持续14天。盐水（对照）以与AICAR治疗相同的方式注射，其用量与AICAR治疗相同。在死亡之前测量体重。大鼠[3]雄性5周龄ZDF大鼠皮下注射单剂量AICAR（0.5 mg \u002F g体重）或经历一次跑步机运行（60分钟，速度25 m \u002F min） 5％倾斜）。未处理的ZDF大鼠用作对照（每组n = 5）。皮下AICAR注射后1小时或在跑步机运行后立即，通过颈椎脱位将大鼠杀死。为了避免肌肉痉挛和缺氧的任何影响，在几秒钟内移除红色和白色腓肠肌并立即冷冻夹紧以便随后确定AMPK活性。",{"key":280,"value":281},"参考文献","[1].\nNakamaru K, et al. AICAR, an activator of AMP-activated protein kinase, down-regulates the insulin receptor expression in HepG2 cells. Biochem Biophys Res Commun. 2005 Mar 11;328(2):449-54\n[2].\nDrake JC, et al. AICAR treatment for 14 days normalizes obesity-induced dysregulation of TORC1 signaling and translational capacity in fasted skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2010 Dec;299(6):R1546-54.\n[3].\nPold R, et al. Long-term AICAR administration and exercise prevents diabetes in ZDF rats.Diabetes. 2005 Apr;54(4):928-34.\n[4].\nChen L, et al. Activating AMPK to Restore Tight Junction Assembly in Intestinal Epithelium and to Attenuate Experimental Colitis by Metformin. Front Pharmacol. 2018 Jul 16;9:761.",[283,289],{"slug":284,"cid":285,"name":286,"nameZh":286,"cas":287,"imgSvg":288},"785893717016842200","J-1104890-3","肌苷","58-63-9","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F415\u002F58-63-9.svg",{"slug":290,"cid":291,"name":292,"nameZh":292,"cas":293,"imgSvg":294},"785892642503266300","J-1601939-9","2',3',5'-三乙酰肌苷","3181-38-2","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F424\u002F3181-38-2.svg",[296,302,308,314,320],{"slug":297,"cid":298,"name":299,"nameZh":299,"cas":300,"imgSvg":301},"785889520515027000","J-1423830-1","N2-苯甲酰基-D-鸟苷","3676-72-0","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F477\u002F3676-72-0.svg",{"slug":303,"cid":304,"name":305,"nameZh":305,"cas":306,"imgSvg":307},"785892723986010100","J-1961667-6","咪唑立宾","50924-49-7","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F056\u002F50924-49-7.svg",{"slug":309,"cid":310,"name":311,"nameZh":311,"cas":312,"imgSvg":313},"785875433802436600","J-1118370-1","5-氨基-4-甲酰胺咪唑","360-97-4","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F469\u002F360-97-4.svg",{"slug":315,"cid":316,"name":317,"nameZh":317,"cas":318,"imgSvg":319},"785888315508265000","J-24649-5","5-氨基咪唑-4-甲酰胺-1-...","3031-94-5","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F385\u002F3031-94-5.svg",{"slug":321,"cid":322,"name":323,"nameZh":323,"cas":324,"imgSvg":325},"785888633780441100","J-1108846-8","鸟苷","118-00-3","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F347\u002F118-00-3.svg",[327,330,333,336],{"key":328,"value":329},"海关编码","2934999090",{"key":331,"value":332},"中文概述","2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%",{"key":334,"value":335},"申报要素","品名, 成分含量, 用途",{"key":337,"value":338},"Summary","2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%",[340,343,345,348,351,354,357,360,363,366,369],{"key":341,"value":342},"符号","GHS07",{"key":344,"value":251},"信号词",{"key":346,"value":347},"危害声明","H315-H319-H335",{"key":349,"value":350},"警示性声明","P261-P305 + P351 + P338",{"key":352,"value":353},"个人防护装备","dust mask type N95 (US);Eyeshields;Gloves",{"key":355,"value":356},"危害码 (欧洲)","Xi: Irritant;",{"key":358,"value":359},"风险声明 (欧洲)","R36\u002F37\u002F38",{"key":361,"value":362},"安全声明 (欧洲)","S26-S36",{"key":364,"value":365},"危险品运输编码","NONH for all modes of transport",{"key":367,"value":368},"WGK德国","3",{"key":328,"value":329},"\u003Ctd>\n\n\u003Cp>\u003Cstrong>阿卡地辛生态学数据:\u003C\u002Fstrong>\u003C\u002Fp>\n\u003Cp>\u003C\u002Fp>\u003Cp>该物质对环境可能有危害，对水体应给予特别注意。  \u003C\u002Fp>\n\u003Cp>\u003C\u002Fp>\n\u003Cp>\u003Ca href=\"\u002Fen\u002Fcas\u002F2627-69-2_684686.html#duXinDiv\">阿卡地辛毒性英文版\u003C\u002Fa>\u003C\u002Fp>\n\n\u003C\u002Ftd>","2026-08-21T07:51:12.859463Z",false,[374,380,386,392,398,404],{"slug":375,"cid":376,"name":377,"nameZh":378,"cas":379},"785892557803491328","J-1462491-7","Magneson I","镁试剂Ⅰ","74-39-5",{"slug":381,"cid":382,"name":383,"nameZh":384,"cas":385},"785884778195849216","J-1103278-2","Carbasalate calcium","卡巴匹林钙","5749-67-7",{"slug":387,"cid":388,"name":389,"nameZh":390,"cas":391},"785880701596602368","J-16821-8","Primaquine","伯氨喹","90-34-6",{"slug":393,"cid":394,"name":395,"nameZh":396,"cas":397},"785884673006899200","J-1306389-0","Nabam","代森钠","142-59-6",{"slug":399,"cid":400,"name":401,"nameZh":402,"cas":403},"785892637872754688","J-33227-7","Dithizone","双硫腙","60-10-6",{"slug":405,"cid":406,"name":407,"nameZh":408,"cas":409},"785898263868870656","J-50020-7","purpurin","吡啉","81-54-9",1792624351905,"zh-CN",[]]