[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"currency-rates":3,"$fyk2oeqxpb7bd":8,"compound-J-28151-6":169,"verified-suppliers-J-28151-6":396},{"rates":4,"source":7},{"USD":5,"CNY":6},1,6.679814,"live",{"rows":9,"total":167,"current":5,"size":168},[10,33,45,60,73,84,96,111,121,133,145,156],{"slug":11,"cid":12,"imgSvg":13,"name":14,"nameZh":15,"cas":16,"formula":17,"iupac":14,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":22,"offersCount":24,"supplierCount":25,"bestOffer":26},"843627791009189888","J-1971488-6","\u002Fimages\u002Fchem_structures_svg\u002F399\u002F65845-61-6.svg","N-Methylcyclohexanamine hydrochloride","N-甲基环己胺盐酸盐","65845-61-6","C7H16ClN","acids","有机酸","Organic Acids","",[23],"In Stock",4,2,{"unitPrice":27,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},2.64,"500g","CNY","China","CN","in-stock",{"slug":34,"cid":35,"imgSvg":36,"name":37,"nameZh":38,"cas":39,"formula":40,"iupac":37,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":41,"offersCount":24,"supplierCount":5,"bestOffer":42},"785882541994283008","J-1323843-2","\u002Fimages\u002Fchem_structures_svg\u002F104\u002F67627-18-3.svg","Potassium indigotrisulfonate","靛蓝三磺酸钾","67627-18-3","C16H7K3N2O11S3",[23],{"unitPrice":43,"pack":44,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},180,"5g",{"slug":46,"cid":47,"imgSvg":48,"name":49,"nameZh":50,"cas":51,"formula":52,"iupac":49,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":56,"offersCount":57,"supplierCount":25,"bestOffer":58},"785889752443260928","J-28559-6","\u002Fimages\u002Fchem_structures_svg\u002F292\u002F15060-55-6.svg","Ammonium tetrathiomolybdate","四硫钼酸铵","15060-55-6","H8MoN2S4","inorganic","无机化合物","Inorganic Chemicals",[23],10,{"unitPrice":59,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},24,{"slug":61,"cid":62,"imgSvg":63,"name":64,"nameZh":65,"cas":66,"formula":67,"iupac":64,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":68,"offersCount":69,"supplierCount":25,"bestOffer":70},"855452191530422272","J-1994428-6","\u002Fimages\u002Fchem_structures_svg\u002F500\u002F16350-96-2.svg","N-benzylcyclohexanamine.hydrochloride","N-苄基环己胺盐酸盐","16350-96-2","C13H20ClN",[23],5,{"unitPrice":71,"pack":28,"currency":29,"origin":72,"originFlag":31,"moq":21,"stock":32},6,"中国",{"slug":74,"cid":75,"imgSvg":76,"name":77,"nameZh":78,"cas":79,"formula":80,"iupac":77,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":81,"offersCount":25,"supplierCount":25,"bestOffer":82},"785871840001134592","J-982001-3","\u002Fimages\u002Fchem_structures_svg\u002F001\u002F10517-44-9.svg","1,3-Diaminopropane dihydrochloride","1,3-二氨基丙烷二盐酸盐","10517-44-9","C3H12Cl2N2",[23],{"unitPrice":83,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},3.78,{"slug":85,"cid":86,"imgSvg":87,"name":88,"nameZh":89,"cas":90,"formula":91,"iupac":88,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":92,"offersCount":93,"supplierCount":94,"bestOffer":95},"785880365658017792","J-14975-7","\u002Fimages\u002Fchem_structures_svg\u002F262\u002F12003-67-7.svg","Lithium aluminate","氧化铝锂","12003-67-7","AlLiO2",[23],7,3,{"unitPrice":94,"pack":28,"currency":29,"origin":72,"originFlag":31,"moq":21,"stock":32},{"slug":97,"cid":98,"imgSvg":99,"name":100,"nameZh":101,"cas":102,"formula":103,"iupac":100,"category":104,"categoryName":105,"categoryEnName":106,"industry":21,"tags":107,"offersCount":94,"supplierCount":5,"bestOffer":109},"785871830249377792","J-6931-8","\u002Fimages\u002Fchem_structures_svg\u002F456\u002F58068-80-7.svg","1-Octanoylbenzotriazole","N-辛酰苯并三唑","58068-80-7","C14H19N3O","aromatics","芳香烃","Aromatic Hydrocarbons",[108],"Made to Order",{"unitPrice":110,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},0.56,{"slug":112,"cid":113,"imgSvg":114,"name":115,"nameZh":116,"cas":117,"formula":118,"iupac":115,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":119,"offersCount":69,"supplierCount":25,"bestOffer":120},"785871842446413824","J-1960944-0","\u002Fimages\u002Fchem_structures_svg\u002F495\u002F10534-86-8.svg","Hexaamminecobalt(III) nitrate","六氨合钴(III)硝酸盐","10534-86-8","CoH18N9O9",[23],{"unitPrice":71,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},{"slug":122,"cid":123,"imgSvg":124,"name":125,"nameZh":126,"cas":127,"formula":128,"iupac":125,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":129,"offersCount":24,"supplierCount":25,"bestOffer":130},"785871842576437248","J-814544-6","\u002Fimages\u002Fchem_structures_svg\u002F221\u002F12037-42-2.svg","vanadium oxide","氧化钒","12037-42-2","O13V6",[23],{"unitPrice":131,"pack":132,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},112.8,"100g",{"slug":134,"cid":135,"imgSvg":136,"name":137,"nameZh":138,"cas":139,"formula":140,"iupac":137,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":141,"offersCount":142,"supplierCount":5,"bestOffer":143},"785871842647740416","J-1333345-4","\u002Fimages\u002Fchem_structures_svg\u002F479\u002F26490-63-1.svg","COBALT TETRAFLUOROBORATE HEXAHYDRATE","四氟化硼钴水合物","26490-63-1","B2CoF8H12O6",[23],8,{"unitPrice":144,"pack":132,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},11,{"slug":146,"cid":147,"imgSvg":148,"name":149,"nameZh":150,"cas":151,"formula":152,"iupac":149,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":153,"offersCount":57,"supplierCount":94,"bestOffer":154},"785871842698072064","J-814953-9","\u002Fimages\u002Fchem_structures_svg\u002F432\u002F72259-10-0.svg","Copper(II) tetrafluoroborate hexahydrate","六水合四氟硼酸铜(II)","72259-10-0","B2CuF8H12O6",[23],{"unitPrice":155,"pack":28,"currency":29,"origin":21,"originFlag":21,"moq":21,"stock":32},2.6,{"slug":157,"cid":158,"imgSvg":159,"name":160,"nameZh":161,"cas":162,"formula":163,"iupac":160,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":164,"offersCount":94,"supplierCount":5,"bestOffer":165},"785871863254355968","J-1990080-2","\u002Fimages\u002Fchem_structures_svg\u002F149\u002F123333-60-8.svg","Cerium(IV) sulfate hydrate","铈(IV)硫酸盐水合物","123333-60-8","CeH2O9S2",[108],{"unitPrice":166,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},5.6,3204,12,{"slug":170,"cid":171,"imgSvg":172,"name":173,"nameZh":174,"cas":175,"formula":176,"iupac":173,"mdl":21,"mw":177,"category":178,"categoryName":179,"categoryEnName":180,"industry":21,"tags":181,"synonyms":182,"properties":187,"ghs":233,"offers":234,"activity":235,"upstream":260,"downstream":303,"customs":304,"safetyRows":317,"updatedAt":319,"isProhibited":320,"related":321,"__ts":394,"__lang":395,"__slug":171},"785889581206605824","J-28151-6","\u002Fimages\u002Fchem_structures_svg\u002F402\u002F1143-70-0.svg","Urolithin A","尿石素A","1143-70-0","C13H8O4","228.20000","organic","有机化合物","Organic Compounds",[],[183,184,185,186],"3,8-二羟基-6H-二苯并[B,D]吡喃-6-酮","3,8-二羟基-6H-苯并[C]色烯-6-酮","3,8-二羟基-6H-苯并[C]苯并吡喃-6-酮","3,8-二羟基-6H-二苯并(二,四)吡喃-6-酮",[188,193,198,203,207,210,213,217,221,225,229],{"label":189,"labelZh":190,"value":191,"prop":192},"Boiling Point","沸点","527.9ºC at 760 mmHg","boilingPoint",{"label":194,"labelZh":195,"value":196,"prop":197},"Density","密度","1.516g\u002Fcm3","density",{"label":199,"labelZh":200,"value":201,"prop":202},"Flash Point","闪点","214.2ºC","flashPoint",{"label":204,"labelZh":205,"value":206},"Exact Mass","精确质量","228.04200",{"label":208,"labelZh":208,"value":209},"PSA","70.67000",{"label":211,"labelZh":211,"value":212},"LogP","2.35740",{"label":214,"labelZh":215,"value":216},"Appearance","外观性状","固体;White to Light yellow powder to crystal",{"label":218,"labelZh":219,"value":220},"Vapor Pressure","蒸汽压","9.24E-12mmHg at 25°C",{"label":222,"labelZh":223,"value":224},"Refractive Index","折射率","1.717",{"label":226,"labelZh":227,"value":228},"Storage Conditions","储存条件","0-10°C;避免加热",{"label":230,"labelZh":231,"value":232},"Computational Chemistry","计算化学","1.疏水参数计算参考值（XlogP）:2.3\n2.氢键供体数量:2\n3.氢键受体数量:4\n4.可旋转化学键数量:0\n5.互变异构体数量:16\n6.拓扑分子极性表面积66.8\n7.重原子数量:17\n8.表面电荷:0\n9.复杂度:317\n10.同位素原子数量:0\n11.确定原子立构中心数量:0\n12.不确定原子立构中心数量:0\n13.确定化学键立构中心数量:0\n14.不确定化学键立构中心数量:0\n15.共价键单元数量:1",null,[],[236,239,242,245,248,251,254,257],{"key":237,"value":238},"描述","Urolithin A是具有抗氧化和抗增殖作用的鞣花酸的肠代谢物; 抑制T24和Caco-2细胞的生长的IC50值分别为43.9和49 μM。",{"key":240,"value":241},"相关类别","信号通路\n>>\n其他\n>>\n其他\n研究领域\n>>\n癌症",{"key":243,"value":244},"靶点","IC50: 43.9 μM (T24 cell)[1], 49 μM (Caco-2cell)[2]",{"key":246,"value":247},"体外研究","尿石素可主要抑制前列腺癌和结肠癌细胞的生长。尿石素A增加Phospho-p38 MAPK的mRNA和蛋白质表达,并降低T24细胞中MEKK1和Phospho-c-Jun的mRNA和蛋白质表达。 Caspase-3也被激活,PPAR-γ蛋白表达在药物诱导的细胞凋亡中增加[1]。与对照细胞相比,尿石素A在24和48小时处理50和100μM后在G2\u002FM和S期发挥剂量和时间依赖性显着停滞。它诱导50和100μM的细胞凋亡[2]。尿石素A对HepG2细胞显示出有效的抗增殖活性。当尿石素A诱导细胞死亡时,β-连环蛋白,c-Myc和细胞周期蛋白D1的表达降低,TCF\u002FLEF转录激活显着下调。尿石素A还可增加p53,p38-MAPK和caspase-3的蛋白表达,但抑制NF-κBp65和其他炎症介质的表达[3]。",{"key":249,"value":250},"体内研究","口服尿石素A后1小时爪水肿体积减少。此外,治疗小鼠血浆显示出显着的氧自由基抗氧化能力(ORAC)评分,口服尿石素后1小时血浆中未结合形式的高水平A [4]。",{"key":252,"value":253},"细胞实验","将人结肠癌细胞HT-29在100和50μM的尿石素A和Iso尿石素A糖苷配基及其葡糖苷酸结合物处理24和48小时。使用TC10自动细胞计数器测量细胞活力和增殖，添加台盼蓝用于活力测定。 IC50值通过MTT测定法确定[2]。",{"key":255,"value":256},"动物实验","小鼠：通过在生理盐水（50μL）中皮下注射1％λ-角叉菜胶，在ICR小鼠的右后爪中诱导爪水肿。炎症水平通过爪水肿的量来量化。溶解在0.5％羧甲基纤维素悬浮液中的尿石素A在角叉菜胶注射前1或6小时口服给予小鼠。分析尿石素A对角叉菜胶诱导的小鼠水肿的抗炎作用[4]。",{"key":258,"value":259},"参考文献","[1].\nQiu Z, et al. In vitro antioxidant and antiproliferative effects of ellagic acid and its colonic metabolite, urolithins, on human bladder cancer T24 cells. Food Chem Toxicol. 2013 Sep;59:428-37.\n[2].\nGonzález-Sarrías A, et al. Antiproliferative activity of the ellagic acid-derived gut microbiota isourolithin A and comparison with its urolithin A isomer: the role of cell metabolism.Eur J Nutr. 2017 Mar;56(2):831-841.\n[3].\nWang Y, et al. In vitro antiproliferative and antioxidant effects of urolithin A, the colonic metabolite of ellagic acid, on hepatocellular carcinomas HepG2 cells. Toxicol In Vitro. 2015 Aug;29(5):1107-15.\n[4].\nIshimoto H, et al. In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5901-4.",[261,267,273,279,285,291,297],{"slug":262,"cid":263,"name":264,"nameZh":264,"cas":265,"imgSvg":266},"785883604533121000","J-1169386-0","3-羟基-8-甲氧基-6H-苯...","35233-17-1","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F319\u002F35233-17-1.svg",{"slug":268,"cid":269,"name":270,"nameZh":270,"cas":271,"imgSvg":272},"785892914050895900","J-1410155-4","2-溴-5-羟基苯甲酸","58380-11-3","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F443\u002F58380-11-3.svg",{"slug":274,"cid":275,"name":276,"nameZh":276,"cas":277,"imgSvg":278},"785896533118685200","J-44398-1","间苯二酚","108-46-3","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F096\u002F108-46-3.svg",{"slug":280,"cid":281,"name":282,"nameZh":282,"cas":283,"imgSvg":284},"785888544903139300","J-25135-4","顺式-5,8,11,14,17...","10417-94-4","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F412\u002F10417-94-4.svg",{"slug":286,"cid":287,"name":288,"nameZh":288,"cas":289,"imgSvg":290},"785883299225538600","J-7756-5","二十二碳六烯酸","6217-54-5","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F342\u002F6217-54-5.svg",{"slug":292,"cid":293,"name":294,"nameZh":294,"cas":295,"imgSvg":296},"785881592240279600","J-20211-9","3-甲氧基苄醇","6971-51-3","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F298\u002F6971-51-3.svg",{"slug":298,"cid":299,"name":300,"nameZh":300,"cas":301,"imgSvg":302},"785896653813977100","J-44854-4","3-甲氧基苯甲酸","586-38-9","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F331\u002F586-38-9.svg",[],[305,308,311,314],{"key":306,"value":307},"海关编码","2914400090",{"key":309,"value":310},"中文概述","2914400090 其他酮醇及酮醛。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%",{"key":312,"value":313},"申报要素","品名, 成分含量, 用途, 丙酮报明包装",{"key":315,"value":316},"Summary","2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%",[318],{"key":306,"value":307},"2026-08-21T07:51:12.859463Z",false,[322,328,334,340,346,352,358,364,370,376,382,388],{"slug":323,"cid":324,"name":325,"nameZh":326,"cas":327},"785896826338283520","J-1517312-3","Acetylferrocene","乙酰基二茂铁","1271-55-2",{"slug":329,"cid":330,"name":331,"nameZh":332,"cas":333},"785881992800505856","J-21744-7","(1R)-(-)-(10-Camphorsulfonyl)oxaziridine","(1R)-(-)-10-樟脑磺哑嗪","104372-31-8",{"slug":335,"cid":336,"name":337,"nameZh":338,"cas":339},"785898057500725248","J-49067-5","(1S)-(+)-(10-Camphorsulfonyl)oxaziridine","(1S)-(+)-10-樟脑磺哑嗪","104322-63-6",{"slug":341,"cid":342,"name":343,"nameZh":344,"cas":345},"785897353302249472","J-47153-4","1,3,4-Thiadiazole-2,5-dithiol dipotassium salt","2,5-二巯基-1,3,4-噻二唑二钾盐","4628-94-8",{"slug":347,"cid":348,"name":349,"nameZh":350,"cas":351},"785881174261108736","J-1361630-3","1-Decylpiperazine","1-癸哌嗪","63207-03-4",{"slug":353,"cid":354,"name":355,"nameZh":356,"cas":357},"785889959323111424","J-1392181-8","Neocuproine hydrate","新亚铜试剂水合物","654054-57-6",{"slug":359,"cid":360,"name":361,"nameZh":362,"cas":363},"785888446215360512","J-24921-8","1-Pyrenecarboxaldehyde","1-芘甲醛","3029-19-4",{"slug":365,"cid":366,"name":367,"nameZh":368,"cas":369},"785876747198402560","J-14318-0","Ruthenocene","二茂钌","1287-13-4",{"slug":371,"cid":372,"name":373,"nameZh":374,"cas":375},"785898736533377024","J-1441023-2","2-Methoxy-9,9-dimethyl-9H-fluorene","2-甲氧基-9,9-二甲基-9H-芴","1514864-84-6",{"slug":377,"cid":378,"name":379,"nameZh":380,"cas":381},"785880457651687424","J-1106117-9","1-Methoxypyrene","1-甲氧基芘","34246-96-3",{"slug":383,"cid":384,"name":385,"nameZh":386,"cas":387},"785894653474902016","J-1102218-7","Chitin","甲壳素","1398-61-4",{"slug":389,"cid":390,"name":391,"nameZh":392,"cas":393},"853289900257054720","J-1116487-7","Chitooctaose Octahydrochloride","壳八糖","98632-70-3",1794250759723,"zh-CN",[]]