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饱和蒸气压（kPa,60ºC）：未确定\n13. 燃烧热（KJ\u002Fmol）：未确定\n14. 临界温度（ºC）：未确定\n15. 临界压力（KPa）：未确定\n16. 油水（辛醇\u002F水）分配系数的对数值：未确定\n17. 爆炸上限（%,V\u002FV）：未确定\n18. 爆炸下限（%,V\u002FV）：未确定\n19. 溶解性：溶于水、低级醇、酯、酮和氯仿，微溶于苯、甲苯和己烷。室温时水溶液在很宽的pH范围内稳定。",{"pictogram":254,"signal":255,"hazards":256},"Acute Toxicity","Danger",[257],"H301 — Toxic if swallowed \u002F 吞咽会中毒",[],[260,263,266,269,272,275,278,281],{"key":261,"value":262},"描述","Anisomycin是一种有效的蛋白质合成抑制剂,它通过抑制肽基转移酶或80S核糖体系统干扰蛋白质和DNA合成。",{"key":264,"value":265},"相关类别","信号通路\n>>\n细胞周期\u002FDNA损伤\n>>\nDNA\u002FRNA合成\n研究领域\n>>\n癌症",{"key":267,"value":268},"靶点","DNA synthesis[1]",{"key":270,"value":271},"体外研究","为了检查JNK是否在PC-12细胞中的粘菌素诱导的神经毒性中具有核心作用,在该研究中使用SP600125(JNK的高选择性抑制剂)和Anisomycin(强效激活剂)。为了选择合适的浓度,分别用一系列SP600125(0-80μM)和Anisomycin(0-20μM)处理PC-12细胞24小时。结果显示,SP600125处理以浓度依赖性方式显着降低细胞存活率,在大于20μM的浓度下观察到(p \u003C0.01)。类似地,通过Anisomycin处理(≥8μM)抑制细胞活力(p \u003C0.05)[1]。",{"key":273,"value":274},"体内研究","TNFRp55\u002Fp75的破坏减弱了Anisomycin诱导的心室功能改善。 Anisomycin导致左心室发展压力(LVDP)的改善,其在TNFR p55\u002Fp75破坏的动物中消失。此外,通过删除TNFR p55\u002Fp75消除了野生型动物中的Anisomycin诱导的LVEDP改善。同样地,TNFR p55\u002Fp75的破坏消除了通过预处理Anisomycin引起的速率压力产物(RPP)的回收。与对照野生型小鼠相比,没有使用Anisomycin处理的TNFR p55\u002Fp75 -\u002F-小鼠在心脏功能恢复方面没有显示出差异。野生型和TNFR p55\u002Fp75缺陷小鼠的心率没有显着差异。为了观察Nox2是否参与Anisomycin诱导的心肌保护,用Anisomycin处理Nox2缺陷型小鼠。与野生型小鼠相比,在Nox2 -\u002F-小鼠中消除了在Anisomycin处理的小鼠中LVEDP的改善。此外,在Nox2 -\u002F-小鼠中减轻了用Anisomycin处理的野生型小鼠中RPP的恢复。与野生型对照小鼠相比,没有使用Anisomycin处理的Nox2 -\u002F-小鼠在心脏功能恢复方面没有显示出差异[2]。",{"key":276,"value":277},"细胞实验","将PC-12细胞以1×10 4个细胞\u002F孔的浓度接种于96孔板中，并在37℃，5％CO 2的培养箱中培养至少12小时，然后暴露于不同浓度的SP600125（0- 80μM）或Anisomycin（0-20μM）24小时。随后，将培养基加入20μL5mg\u002F mL MTT工作溶液中，并将板在37℃下温育2小时。除去培养上清液，将甲crystals晶体溶于150μLDMSO中。最后，通过酶标仪在490nm处测量每个孔的吸光度。细胞活力表示为对照组的百分比，设定为100％[1]。",{"key":279,"value":280},"动物实验","小鼠[2]在该研究中使用成年雄性TNFRp55 \u002F p75小鼠，成年雄性野生型C57 \u002F BL和纯合型Nox2  -  \u002F  - 小鼠。将小鼠随机分成六个实验组，进行以下治疗。将动物分为六组：第1组：对照缺血\u002F再灌注，向野生型小鼠注射DMSO（0.1mL）;第2组：Anisomycin 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Colistin-induced autophagy and apoptosis involves the JNK-Bcl2-Bax signaling pathway and JNK-p53-ROS positive feedback loop in PC-12 cells.\n[2].\nZhao TC, et al. Disruption of Nox2 and TNFRp55\u002Fp75 eliminates cardioprotection induced by Anisomycin. Am J Physiol Heart Circ Physiol. 2012 Nov 15;303(10):H1263-72.",[],[],[287,290,293,296],{"key":288,"value":289},"海关编码","2933990090",{"key":291,"value":292},"中文概述","2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%",{"key":294,"value":295},"申报要素","品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期",{"key":297,"value":298},"Summary","2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. 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