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mg\u002Fkg,IP,每日14天)不会改变CA3海马锥体神经元对应用5-HT的微离子电渗疗法的反应性[2]。内侧杏仁核(MeA)中的齐美利定(0.2、2和20 nmol\u002F100 nL)在禁食大鼠中引起剂量依赖性的吞咽减退作用[4]。动物模型：雄性Wistar白化大鼠(160-180 g,n=72)[3]剂量：15 mg\u002Fkg给药：IP,一次结果：显著减弱吗啡耐受的发展和表达。通过甩尾和热板试验,齐美利定组在60分钟测量时和吗啡耐受组在30分钟测量时获得了齐美利丁的最大抗伤害作用。齐美利定与吗啡联用显示出附加镇痛作用。动物模型：Sprague Dawley大鼠(150至250 g,10只,雄性)[2]剂量：5 mg\u002Fkg给药：IP,每日14天结果：未改变CA3海马锥体神经元对应用5-HT的微离子电渗疗法的反应性。",{"key":251,"value":252},"参考文献","[1].\nHeel RC, et al. Zimelidine: a review of its pharmacological properties and therapeutic efficacy in depressive illness. Drugs. 1982 Sep;24(3):169-206.\n[2].\nBlier P, et al. Electrophysiological investigations on the effect of repeated zimelidine administration on serotonergic neurotransmission in the rat. J Neurosci. 1983 Jun;3(6):1270-8.\n[3].\nOzdemir E, et al. Zimelidine attenuates the development of tolerance to morphine-induced antinociception. Indian J Pharmacol. 2012 Mar;44(2):215-8.\n[4].\nScopinho AA, et al. Medial amygdaloid nucleus 5-HT₂c receptors are involved in the hypophagic effect caused by zimelidine in rats. 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