[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"currency-rates":3,"$fyk2oeqxpb7bd":8,"compound-J-27726-9":169,"verified-suppliers-J-27726-9":372},{"rates":4,"source":7},{"USD":5,"CNY":6},1,6.679814,"live",{"rows":9,"total":167,"current":5,"size":168},[10,33,45,60,73,84,96,111,121,133,145,156],{"slug":11,"cid":12,"imgSvg":13,"name":14,"nameZh":15,"cas":16,"formula":17,"iupac":14,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":22,"offersCount":24,"supplierCount":25,"bestOffer":26},"843627791009189888","J-1971488-6","\u002Fimages\u002Fchem_structures_svg\u002F399\u002F65845-61-6.svg","N-Methylcyclohexanamine hydrochloride","N-甲基环己胺盐酸盐","65845-61-6","C7H16ClN","acids","有机酸","Organic Acids","",[23],"In Stock",4,2,{"unitPrice":27,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},2.64,"500g","CNY","China","CN","in-stock",{"slug":34,"cid":35,"imgSvg":36,"name":37,"nameZh":38,"cas":39,"formula":40,"iupac":37,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":41,"offersCount":24,"supplierCount":5,"bestOffer":42},"785882541994283008","J-1323843-2","\u002Fimages\u002Fchem_structures_svg\u002F104\u002F67627-18-3.svg","Potassium indigotrisulfonate","靛蓝三磺酸钾","67627-18-3","C16H7K3N2O11S3",[23],{"unitPrice":43,"pack":44,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},180,"5g",{"slug":46,"cid":47,"imgSvg":48,"name":49,"nameZh":50,"cas":51,"formula":52,"iupac":49,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":56,"offersCount":57,"supplierCount":25,"bestOffer":58},"785889752443260928","J-28559-6","\u002Fimages\u002Fchem_structures_svg\u002F292\u002F15060-55-6.svg","Ammonium tetrathiomolybdate","四硫钼酸铵","15060-55-6","H8MoN2S4","inorganic","无机化合物","Inorganic Chemicals",[23],10,{"unitPrice":59,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},24,{"slug":61,"cid":62,"imgSvg":63,"name":64,"nameZh":65,"cas":66,"formula":67,"iupac":64,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":68,"offersCount":69,"supplierCount":25,"bestOffer":70},"855452191530422272","J-1994428-6","\u002Fimages\u002Fchem_structures_svg\u002F500\u002F16350-96-2.svg","N-benzylcyclohexanamine.hydrochloride","N-苄基环己胺盐酸盐","16350-96-2","C13H20ClN",[23],5,{"unitPrice":71,"pack":28,"currency":29,"origin":72,"originFlag":31,"moq":21,"stock":32},6,"中国",{"slug":74,"cid":75,"imgSvg":76,"name":77,"nameZh":78,"cas":79,"formula":80,"iupac":77,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":81,"offersCount":25,"supplierCount":25,"bestOffer":82},"785871840001134592","J-982001-3","\u002Fimages\u002Fchem_structures_svg\u002F001\u002F10517-44-9.svg","1,3-Diaminopropane dihydrochloride","1,3-二氨基丙烷二盐酸盐","10517-44-9","C3H12Cl2N2",[23],{"unitPrice":83,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},3.78,{"slug":85,"cid":86,"imgSvg":87,"name":88,"nameZh":89,"cas":90,"formula":91,"iupac":88,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":92,"offersCount":93,"supplierCount":94,"bestOffer":95},"785880365658017792","J-14975-7","\u002Fimages\u002Fchem_structures_svg\u002F262\u002F12003-67-7.svg","Lithium aluminate","氧化铝锂","12003-67-7","AlLiO2",[23],7,3,{"unitPrice":94,"pack":28,"currency":29,"origin":72,"originFlag":31,"moq":21,"stock":32},{"slug":97,"cid":98,"imgSvg":99,"name":100,"nameZh":101,"cas":102,"formula":103,"iupac":100,"category":104,"categoryName":105,"categoryEnName":106,"industry":21,"tags":107,"offersCount":94,"supplierCount":5,"bestOffer":109},"785871830249377792","J-6931-8","\u002Fimages\u002Fchem_structures_svg\u002F456\u002F58068-80-7.svg","1-Octanoylbenzotriazole","N-辛酰苯并三唑","58068-80-7","C14H19N3O","aromatics","芳香烃","Aromatic Hydrocarbons",[108],"Made to Order",{"unitPrice":110,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},0.56,{"slug":112,"cid":113,"imgSvg":114,"name":115,"nameZh":116,"cas":117,"formula":118,"iupac":115,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":119,"offersCount":69,"supplierCount":25,"bestOffer":120},"785871842446413824","J-1960944-0","\u002Fimages\u002Fchem_structures_svg\u002F495\u002F10534-86-8.svg","Hexaamminecobalt(III) nitrate","六氨合钴(III)硝酸盐","10534-86-8","CoH18N9O9",[23],{"unitPrice":71,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},{"slug":122,"cid":123,"imgSvg":124,"name":125,"nameZh":126,"cas":127,"formula":128,"iupac":125,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":129,"offersCount":24,"supplierCount":25,"bestOffer":130},"785871842576437248","J-814544-6","\u002Fimages\u002Fchem_structures_svg\u002F221\u002F12037-42-2.svg","vanadium oxide","氧化钒","12037-42-2","O13V6",[23],{"unitPrice":131,"pack":132,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},112.8,"100g",{"slug":134,"cid":135,"imgSvg":136,"name":137,"nameZh":138,"cas":139,"formula":140,"iupac":137,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":141,"offersCount":142,"supplierCount":5,"bestOffer":143},"785871842647740416","J-1333345-4","\u002Fimages\u002Fchem_structures_svg\u002F479\u002F26490-63-1.svg","COBALT TETRAFLUOROBORATE HEXAHYDRATE","四氟化硼钴水合物","26490-63-1","B2CoF8H12O6",[23],8,{"unitPrice":144,"pack":132,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},11,{"slug":146,"cid":147,"imgSvg":148,"name":149,"nameZh":150,"cas":151,"formula":152,"iupac":149,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":153,"offersCount":57,"supplierCount":94,"bestOffer":154},"785871842698072064","J-814953-9","\u002Fimages\u002Fchem_structures_svg\u002F432\u002F72259-10-0.svg","Copper(II) tetrafluoroborate hexahydrate","六水合四氟硼酸铜(II)","72259-10-0","B2CuF8H12O6",[23],{"unitPrice":155,"pack":28,"currency":29,"origin":21,"originFlag":21,"moq":21,"stock":32},2.6,{"slug":157,"cid":158,"imgSvg":159,"name":160,"nameZh":161,"cas":162,"formula":163,"iupac":160,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":164,"offersCount":94,"supplierCount":5,"bestOffer":165},"785871863254355968","J-1990080-2","\u002Fimages\u002Fchem_structures_svg\u002F149\u002F123333-60-8.svg","Cerium(IV) sulfate hydrate","铈(IV)硫酸盐水合物","123333-60-8","CeH2O9S2",[108],{"unitPrice":166,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},5.6,3204,12,{"slug":170,"cid":171,"imgSvg":172,"name":173,"nameZh":174,"cas":175,"formula":176,"iupac":173,"mdl":21,"mw":177,"category":178,"categoryName":179,"categoryEnName":180,"industry":21,"tags":181,"synonyms":182,"properties":186,"ghs":223,"offers":224,"activity":225,"upstream":235,"downstream":271,"customs":272,"safetyRows":276,"toxicity":293,"synthesis":294,"updatedAt":295,"isProhibited":296,"related":297,"__ts":370,"__lang":371,"__slug":171},"785889452294672384","J-27726-9","\u002Fimages\u002Fchem_structures_svg\u002F344\u002F87239-81-4.svg","Cefpodoxime Proxetil","头孢泊肟酯","87239-81-4","C21H27N5O9S2","557.597","esters","酯类","Esters",[],[183,184,185],"先福吡兰","头孢波肟酯","头孢泊肟",[187,192,197,201,204,207,211,215,219],{"label":188,"labelZh":189,"value":190,"prop":191},"Melting Point","熔点","111-113°C","meltingPoint",{"label":193,"labelZh":194,"value":195,"prop":196},"Density","密度","1.6±0.1 g\u002Fcm3","density",{"label":198,"labelZh":199,"value":200},"Exact Mass","精确质量","557.125000",{"label":202,"labelZh":202,"value":203},"PSA","234.51000",{"label":205,"labelZh":205,"value":206},"LogP","2.17",{"label":208,"labelZh":209,"value":210},"Appearance","外观性状","一种白色或近乎于白色结晶粉末",{"label":212,"labelZh":213,"value":214},"Refractive Index","折射率","1.671",{"label":216,"labelZh":217,"value":218},"Storage Conditions","储存条件","-20?C Freezer",{"label":220,"labelZh":221,"value":222},"Additional Property","更多","1.性状：白色至淡褐白色粉末，无臭或稍有异气味，味苦。\n2.溶解度：极易溶于甲醇或乙腈，易溶于乙醇，微溶于乙醚，极微溶于水。",null,[],[226,229,232],{"key":227,"value":228},"描述","Cefpodoxime Proxetil 是第一种口服的广谱型抗生素,属于第三代头孢菌素。Cefpodoxime Proxetil 与青霉素结合蛋白 (penicillin binding proteins) 结合,抑制肽聚糖的合成,最终干扰细菌细胞壁的生物合成。",{"key":230,"value":231},"相关类别","研究领域\n>>\n感染\n信号通路\n>>\n抗感染\n>>\n细菌",{"key":233,"value":234},"参考文献","[1].\nIqbal S, et al. In vitro Spectroscopic studies on drug interaction of cefpodoxime proxetil and H2 receptor blockers. Pak J Pharm Sci. 2019 Mar;32(2 (Supplementary)):881-887.",[236,242,247,253,259,265],{"slug":237,"cid":238,"name":239,"nameZh":239,"cas":240,"imgSvg":241},"785892704138563600","J-1411359-8","1-碘乙基异丙基碳酸酯","84089-73-6","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F305\u002F84089-73-6.svg",{"slug":243,"cid":244,"name":185,"nameZh":185,"cas":245,"imgSvg":246},"785893498074173400","J-1962779-3","80210-62-4","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F151\u002F80210-62-4.svg",{"slug":248,"cid":249,"name":250,"nameZh":250,"cas":251,"imgSvg":252},"785894541952553000","J-1106256-9","7-氨基头孢烷酸","957-68-6","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F353\u002F957-68-6.svg",{"slug":254,"cid":255,"name":256,"nameZh":256,"cas":257,"imgSvg":258},"785894537397538800","J-2193-2","头孢噻肟","63527-52-6","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F226\u002F63527-52-6.svg",{"slug":260,"cid":261,"name":262,"nameZh":262,"cas":263,"imgSvg":264},"785896580866641900","J-44499-5","1-氯乙基异丙基碳酸酯","98298-66-9","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F039\u002F98298-66-9.svg",{"slug":266,"cid":267,"name":268,"nameZh":268,"cas":269,"imgSvg":270},"785875417654366200","J-1117128-1","头孢曲松杂质D","80756-85-0","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F029\u002F80756-85-0.svg",[],[273],{"key":274,"value":275},"海关编码","2941905990",[277,280,283,286,289,292],{"key":278,"value":279},"危害码 (欧洲)","Xi",{"key":281,"value":282},"风险声明 (欧洲)","R36\u002F37\u002F38",{"key":284,"value":285},"安全声明 (欧洲)","S26-S36",{"key":287,"value":288},"危险品运输编码","NONH for all modes of transport",{"key":290,"value":291},"WGK德国","3",{"key":274,"value":275},"\u003Ctd>\n\n\u003Cp>\u003Cstrong>头孢泊肟酯毒理学数据:\u003C\u002Fstrong>\u003C\u002Fp>\n\u003Cp>\u003C\u002Fp>\u003Cp>  急性毒性LD\u003Csup>50\u003C\u002Fsup>雄、雌小鼠，雄、雌大鼠(mg／kg)：＞10000，＞10000，＞2000，＞2000皮下注射；3502，2535，＞4000，＞4000腹腔注射；＞8000，＞8000，＞4000，＞4000口服。 \u003C\u002Fp>\n\u003Cp>\u003C\u002Fp>\n\u003Cp>\u003Ca href=\"\u002Fen\u002Fcas\u002F87239-81-4_670625.html#duXinDiv\">头孢泊肟酯毒性英文版\u003C\u002Fa>\u003C\u002Fp>\n\n\u003C\u002Ftd>","\u003Cp> 侧链的制备 280ml氯甲酸乙酯和260ml硫酰氯混合，在室温下加入1.0g过氧化苯甲酰。回流7.5h后，蒸馏得到217g1-氯乙基氯甲酸酯(沸点119～140℃。将317g该酯溶于2000ml二氯甲烷，在冷却和搅拌下加入397g异丙醇。在20min内滴加230ml吡啶，加毕再搅拌30min。反应液依次用500ml水、500ml盐水和5%硫酸氢钾水溶液洗，无水硫酸镁干燥。蒸去溶剂后再减压蒸馏，得228g 1-氯乙基异丙基碳酸酯，沸点92～94℃\u002F7.33MPa。102g该碳酸酯溶于1000ml苯，加入200g碘化钠和5g 18-冠醚-6，回流过夜。反应液用水和5%硫代硫酸钠洗，有机层用无水硫酸镁干燥。减压浓缩得144g所需的侧链，即1-碘乙基异丙基碳酸酯。\u003Cbr \u002F> 7-ACA经酰化得化合物(I)。\u003Cbr \u002F> 26g化合物(Ⅰ)和4.1g碳酸氢钠溶于80ml水，在室温下依次加入1.70ml甲醇和375g二氯化钙二水合物，再在70℃搅拌75min。将反应液倾入500ml冰水，用10ml浓盐酸酸化，再用乙酸乙酯提取(2×500m1)。提取液合并，用盐水洗后，再用10％磷酸单氢钾水溶液提取(依次350，150和100m1)。该水溶性提取液合并，用盐酸酸化后再用乙酸乙酯提取(2×500m1)。乙酸乙酯提取液用盐水洗，无水硫酸镁干燥，浓缩至1\u002F5体积时出现沉淀。在室温下放置3h，过滤收集沉淀，得15.97g化合物(Ⅱ)，收率64.8%。\u003Cbr \u002F> 8g化合物(Ⅱ)和4g碳酸氢钠溶于20ml水，在室温下加入1.82g硫脲。在室温搅拌14h后，过滤除去产生的沉淀，在冰浴冷却和搅拌下，加入20ml浓盐酸。再过滤除去产生的沉淀。滤液用氢氧化钠水溶液调至Ph=2～3。过滤收集产生的沉淀，得5.12g化合物(Ⅲ)，收率75.5%。\u003Cbr \u002F> 427mg化合物(Ⅲ)溶于20ml N，N-二甲基乙酰胺(DMA)，在冷却下，依次加入200mg二环己胺和310mg 1-碘乙基异丙基碳酸酯。搅拌30min后，加入100ml乙酸乙酯。过滤除去产生的沉淀，滤液依次用稀盐酸、碳酸氢钠水溶液和盐水洗。有机层用无水硫酸镁干燥，减压浓缩得黄色固体。该固体用硅胶柱层析，乙酸乙酯-环己烷(3：1)洗脱，得50lmg头孢泊肟酯，收率89.9%。 \u003C\u002Fp>","2026-08-21T07:51:12.859463Z",false,[298,304,310,316,322,328,334,340,346,352,358,364],{"slug":299,"cid":300,"name":301,"nameZh":302,"cas":303},"785880917334822912","J-1094636-8","Polysorbate 80","聚山梨酯80","9005-65-6",{"slug":305,"cid":306,"name":307,"nameZh":308,"cas":309},"785893769781186560","J-36209-4","Sodium methylparaben","尼泊金甲酯钠","5026-62-0",{"slug":311,"cid":312,"name":313,"nameZh":314,"cas":315},"785872476956528640","J-1339868-0","beta-Butyrolactone","β-丁内酯","3068-88-0",{"slug":317,"cid":318,"name":319,"nameZh":320,"cas":321},"785898646079016960","J-1364495-6","Cefpodoxime Proxetil EP Impurity C","头孢泊肟酯EP杂质C","339528-86-8",{"slug":323,"cid":324,"name":325,"nameZh":326,"cas":327},"785898646552973312","J-1528913-1","Cefpodoxime Proxetil Impurity D","头孢泊肟酯杂质D","947692-13-9",{"slug":329,"cid":330,"name":331,"nameZh":332,"cas":333},"785894927593639936","J-1977217-9","4-Hydroxyatorvastatin lactone","对羟基阿托伐他汀内酯","163217-70-7",{"slug":335,"cid":336,"name":337,"nameZh":338,"cas":339},"785892778264498176","J-33661-8","Olmesartan medoxomil","奥美沙坦酯","144689-63-4",{"slug":341,"cid":342,"name":343,"nameZh":344,"cas":345},"785912949679067136","J-276978-0","SchisantherinG","五味子酯G","117047-86-6",{"slug":347,"cid":348,"name":349,"nameZh":350,"cas":351},"785913708894228480","J-1443525-7","HenridilactoneB","亨里内酯B","682745-24-0",{"slug":353,"cid":354,"name":355,"nameZh":356,"cas":357},"785930022157291520","J-1436490-0","Yadanziolide U","鸦胆子内酯U","1346764-99-5",{"slug":359,"cid":360,"name":361,"nameZh":362,"cas":363},"785898657089064960","J-1529012-7","Ethyl-Tianeptine-I","噻奈普汀乙酯碘代物","1809277-99-3",{"slug":365,"cid":366,"name":367,"nameZh":368,"cas":369},"785892437137559552","J-1601252-5","Ceftazidime methyl ester","头孢他啶甲基酯","1354396-23-8",1794254221003,"zh-CN",[]]