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Order",{"unitPrice":169,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},5.6,3204,{"slug":172,"cid":173,"imgSvg":174,"name":175,"nameZh":175,"cas":176,"formula":177,"iupac":175,"mdl":21,"mw":178,"category":179,"categoryName":180,"categoryEnName":181,"industry":21,"tags":182,"synonyms":183,"properties":188,"ghs":240,"offers":241,"activity":242,"upstream":270,"downstream":313,"customs":314,"safetyRows":315,"toxicity":325,"updatedAt":326,"isProhibited":327,"related":328,"__ts":365,"__lang":366,"__slug":173},"785889335248424960","J-27364-2","\u002Fimages\u002Fchem_structures_svg\u002F116\u002F170632-47-0.svg","利非西呱","170632-47-0","C19H16N2O2","304.342","organic","有机化合物","Organic Compounds",[],[184,185,186,187],"3-(5-羟基甲基-2-呋喃基)-1-苯基吲哚","3-(5'-羟基甲基-2'-呋喃基)-1-苯基吲哚","(5-(1-苄基-1H-吲唑-3-基)呋喃-2-基)甲醇","YC-1",[189,193,197,201,205,208,211,214,218,222,226,229,233,237],{"label":190,"labelZh":190,"value":191,"prop":192},"Boiling Point","522.2±50.0 °C at 760 mmHg","boilingPoint",{"label":194,"labelZh":194,"value":195,"prop":196},"Density","1.2±0.1 g\u002Fcm3","density",{"label":198,"labelZh":198,"value":199,"prop":200},"Flash Point","269.6±30.1 °C","flashPoint",{"label":202,"labelZh":203,"value":204},"Exact Mass","精确质量","304.121185",{"label":206,"labelZh":206,"value":207},"PSA","51.19000",{"label":209,"labelZh":209,"value":210},"LogP","3.55",{"label":212,"labelZh":212,"value":213},"外观性状","粉末",{"label":215,"labelZh":216,"value":217},"Vapor Pressure","蒸汽压","0.0±1.4 mmHg at 25°C",{"label":219,"labelZh":220,"value":221},"Refractive Index","折射率","1.653",{"label":223,"labelZh":224,"value":225},"Storage Conditions","储存条件","密闭于阴凉干燥环境中",{"label":227,"labelZh":227,"value":228},"稳定性","遵照规定使用和储存则不会分解。",{"label":230,"labelZh":231,"value":232},"Molecular Structure","分子结构","1、 摩尔折射率：89.16\n2、 摩尔体积（m\n3\n\u002Fmol）：243.6\n3、 等张比容（90.2K）：647.4\n4、 表面张力（dyne\u002Fcm）：49.8\n5、 极化率（10\n-24\ncm\n3\n）：35.34",{"label":234,"labelZh":235,"value":236},"Computational Chemistry","计算化学","1.疏水参数计算参考值（XlogP）:3.1\n2.氢键供体数量:1\n3.氢键受体数量:3\n4.可旋转化学键数量:4\n5.互变异构体数量:无\n6.拓扑分子极性表面积51.2\n7.重原子数量:23\n8.表面电荷:0\n9.复杂度:386\n10.同位素原子数量:0\n11.确定原子立构中心数量:0\n12.不确定原子立构中心数量:0\n13.确定化学键立构中心数量:0\n14.不确定化学键立构中心数量:0\n15.共价键单元数量:1",{"label":238,"labelZh":238,"value":239},"更多","1. 性状：白色固体\n2. 密度（g\u002FmL,25\u002F4℃）：无可用\n3. 相对蒸汽密度（g\u002FmL,空气=1）：无可用\n4. 熔点（ºC）：无可用\n5. 沸点（ºC,常压）：无可用\n6. 沸点（ºC,5.2kPa）：无可用\n7. 折射率：无可用\n8. 闪点（ºC）：无可用\n9. 比旋光度（º）：无可用\n10. 自燃点或引燃温度（ºC）：无可用\n11. 蒸气压（kPa,25ºC）：无可用\n12. 饱和蒸气压（kPa,60ºC）：无可用\n13. 燃烧热（KJ\u002Fmol）：无可用\n14. 临界温度（ºC）：无可用\n15. 临界压力（KPa）：无可用\n16. 油水（辛醇\u002F水）分配系数的对数值：无可用\n17. 爆炸上限（%,V\u002FV）：无可用\n18. 爆炸下限（%,V\u002FV）：无可用\n19. 溶解性：DMSO: 12 mg\u002FmL",null,[],[243,246,249,252,255,258,261,264,267],{"key":244,"value":245},"描述","Lificiguat 结合到 可溶性鸟苷酸环化酶(sGC)的β亚基,在CO存在条件下,Kd 为 0.6-1.1 μM。",{"key":247,"value":248},"相关类别","信号通路\n>>\nG 蛋白偶联受体\u002FG 蛋白\n>>\n鸟苷酸环化酶\n研究领域\n>>\n癌症",{"key":250,"value":251},"靶点","Kd: 0.6-1.1 μM (sGC, in the presence of CO)[1]",{"key":253,"value":254},"体外研究","可溶性鸟苷酸环化酶(sGC)是异二聚体血红素蛋白和主要的NO受体。 Lificiguat(YC-1)在β亚基的含血红素结构域附近或直接结合。在不存在CO的情况下,Lificiguat(YC-1)以Kd =9-21μM结合,这取决于构建体。在CO存在下,这些值降低至0.6-1.1μM。如预期的那样,Lificiguat(YC-1)极大地增强了与异二聚体sGC的CO结合(Kd =1μM)。 Lificiguat(YC-1)在不存在NO的情况下刺激sGC 2至4倍,但与CO或NO协同作用以实现数百倍的活化。 Lificiguat(YC-1)的结合也可以克服sGC的抑制性磷酸化[1]。 Lificiguat(YC-1)是可溶性鸟苷酸环化酶(sGC)活化剂。将HCC细胞系HepG2,BEL-7402和HCCLM3与索拉非尼和\u002F或Lificiguat(YC-1)一起温育72小时。索拉非尼或Lificiguat(YC-1)单独以剂量依赖性方式抑制HCC细胞增殖。此外,索拉非尼和Lificiguat(YC-1)的组合以剂量依赖性方式显着抑制HCC细胞的增殖。此外,在索拉非尼和Lificiguat(YC-1)的ED50剂量下,HepG2中的组合指数值(CI)= 0.93,BEL-7402中的组合指数值(0.95)和HCCLM3中的0.72,表明索拉非尼和Lificiguat(YC-1)协同抑制HCC细胞的增殖[2]。",{"key":256,"value":257},"体内研究","Lificiguat(YC-1)(30或60mg\u002Fkg,ip)以剂量依赖性方式抑制MDA-MB-468肿瘤生长。还研究了Lificiguat(YC-1),YC-1-S的前药制剂在MDA-MB-468荷瘤小鼠中的作用。体内药代动力学分析表明YC-1-S迅速转化为其活性形式。给小鼠施用20,40或80mg\u002Fkg YC-1-S po YC-1-S还显示MDA-MB468肿瘤生长的剂量依赖性抑制。 Lificiguat(YC-1)和YC-1-S剂量依赖性地降低肿瘤重量。此外,与载体治疗组相比,Lificiguat(YC-1)或YC-1-S不影响小鼠的平均体重[3]。 Lificiguat(YC-1)是一种有效的NO-GC激活剂,据报道用Morris水迷宫(MWM)和回避试验检查可以改善啮齿动物的学习行为。 Lificiguat(YC-1)通过NO-cGMP-PKG依赖性途径增强海马Schafer侧支CA1突触的长时程增强(LTP),并增强杏仁核中LTP的诱导,增加ERK的活化,并增强ERK的表达。脑源性神经营养因子(BDNF)cAMP反应元件结合蛋白(CREB)响应恐惧记忆试验[4]。",{"key":259,"value":260},"激酶实验","通过将CO从饱和溶液滴定到sGC蛋白中并监测CO结合的Soret吸收带的出现来测量CO解离常数。在补充有过量连二亚硫酸盐的Ar吹扫缓冲液中制备MssGCβ1（1-380）和BtsGCβ1（1-197）样品。使用具有改良样品架的Cary 50分光光度计，在用于Ms sGC-β1（1-380）和Ms sGC-NT21的10cm光程比色皿中进行CO结合实验。使用SigmaPlot [1]中的单点饱和配体结合模型绘制在存在和不存在50μMLificiguat（YC-1）的情况下的结合数据。",{"key":262,"value":263},"细胞实验","使用细胞计数试剂盒-8（CCK-8）测量细胞增殖测定。简而言之，将细胞以3×10 3 \u002F孔的浓度在96孔板中培养，温育24小时，并用索拉非尼和\u002F或Lificiguat（YC-1）处理。处理72小时后，向每个孔中加入CCK-8试剂。使用自动ELISA板读数器在37℃温育2.5小时后在450nm处测量吸光度。使用Microsoft Excel软件测量由化合物组合产生的任何协同效应，以确定组合指数值（CI> 1：拮抗效应，CI = 1：加性效应，和CT \u003C1：协同效应）[2]。",{"key":265,"value":266},"动物实验","小鼠[3]使用58只雌性nu \u002F nu小鼠（4周龄）。将MDA-MB-468乳腺癌细胞（每只小鼠5×10 6个细胞）悬浮于0.1mL Matrigel溶液（50％v \u002F v Matrigel in PBS）中并接种到裸鼠的乳腺脂肪垫中。当肿瘤块达到100mm 3时，将携带肿瘤的小鼠随机分成组，用于不同Lificiguat（YC-1）\u002F YC-1-S剂量的治疗。给小鼠腹膜内注射YC-1（30或60mg \u002F kg）或给予YC-1-S po肿瘤大小，每3天测量一次小鼠体重，并使用下式计算肿瘤体积（mm3）：长度×（宽度）2×0.5。在实验结束时，杀死小鼠并解剖肿瘤结节并称重。对肿瘤组织进行Western印迹。使用大鼠[4] 4个月大（200-250g）和24个月大（550-600g）雄性Wistar-albino大鼠。 Lificiguat（YC-1）在使用前立即制备，腹膜内（ip）以每100g体重0.1mL的体积给药。所有大鼠接受1mg \u002F kg \u002F天的Lificiguat（YC-1），持续2周。将DMSO给予4个月大和24个月大的大鼠（每组n = 10）。选择剂量以确定选定的运动活动剂量;测量所有结果。",{"key":268,"value":269},"参考文献","[1].\nPurohit R, et al. YC-1 binding to the β subunit of soluble guanylyl cyclase overcomes allosteric inhibition by the α subunit. Biochemistry. 2014 Jan 14;53(1):101-14.\n[2].\nKong J, et al. YC-1 enhances the anti-tumor activity of sorafenib through inhibition of signal transducer and activator of transcription 3 (STAT3) in hepatocellular carcinoma. Mol Cancer. 2014 Jan 13;13:7.\n[3].\nChang LC, et al. YC-1 inhibits proliferation of breast cancer cells by down-regulating EZH2 expression via activation of c-Cbl and ERK. Br J Pharmacol. 2014 Sep;171(17):4010-25.\n[4].\nKomsuoglu Celikyurt I, et al. Effects of YC-1 on Learning and Memory Functions of Aged Rats. Med Sci Monit Basic Res. 2014 Aug 21;20:130-7.",[271,277,283,289,295,301,307],{"slug":272,"cid":273,"name":274,"nameZh":274,"cas":275,"imgSvg":276},"785897988919660500","J-48701-0","2-糠酸甲酯","611-13-2","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F046\u002F611-13-2.svg",{"slug":278,"cid":279,"name":280,"nameZh":280,"cas":281,"imgSvg":282},"785888479170007000","J-25015-3","吲唑","271-44-3","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F127\u002F271-44-3.svg",{"slug":284,"cid":285,"name":286,"nameZh":286,"cas":287,"imgSvg":288},"785895442125688800","J-1509677-5","1-苄基-3-碘-1H-吲唑","205643-28-3","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F283\u002F205643-28-3.svg",{"slug":290,"cid":291,"name":292,"nameZh":292,"cas":293,"imgSvg":294},"785894560764006400","J-877840-4","5-苯甲酰基呋喃-2-甲酸甲酯","58972-21-7","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F277\u002F58972-21-7.svg",{"slug":296,"cid":297,"name":298,"nameZh":298,"cas":299,"imgSvg":300},"785883249883746300","J-1362112-6","3-碘吲唑","66607-27-0","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F032\u002F66607-27-0.svg",{"slug":302,"cid":303,"name":304,"nameZh":304,"cas":305,"imgSvg":306},"785880754620993500","J-17041-3","5-溴-2-糠酸甲酯","2527-99-3","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F459\u002F2527-99-3.svg",{"slug":308,"cid":309,"name":310,"nameZh":310,"cas":311,"imgSvg":312},"785897276332576800","J-46875-0","1-苄基-3-羟基-1H-吲唑","2215-63-6","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F131\u002F2215-63-6.svg",[],[],[316,319,322],{"key":317,"value":318},"个人防护装备","Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter",{"key":320,"value":321},"危险品运输编码","NONH for all modes of transport",{"key":323,"value":324},"WGK德国","3","\u003Ctd>\n\n\u003Cp>\u003Cstrong>利非西呱生态学数据:\u003C\u002Fstrong>\u003C\u002Fp>\n\u003Cp>\u003C\u002Fp>\u003Cp>该物质对环境可能有危害，对水体应给予特别注意。 \u003C\u002Fp>\n\u003Cp>\u003C\u002Fp>\n\u003Cp>\u003Ca href=\"\u002Fen\u002Fcas\u002F170632-47-0_669266.html#duXinDiv\">利非西呱毒性英文版\u003C\u002Fa>\u003C\u002Fp>\n\n\u003C\u002Ftd>","2026-08-21T07:51:12.859463Z",false,[329,335,341,347,353,359],{"slug":330,"cid":331,"name":332,"nameZh":333,"cas":334},"785882574307201024","J-4791-1","Azure B","天青B","531-55-5",{"slug":336,"cid":337,"name":338,"nameZh":339,"cas":340},"847438775779856384","J-1134038-0","1,5-dimethyl-4-[[(Z)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]-2-phenylpyrazol-3-one","水杨醛缩4-氨基安替比林","30957-66-5",{"slug":342,"cid":343,"name":344,"nameZh":345,"cas":346},"785891737703813120","J-30957-4","Hispidulin","高车前素","1447-88-7",{"slug":348,"cid":349,"name":350,"nameZh":351,"cas":352},"785884688790065152","J-1109893-1","Alizarin yellow GG","茜素黄GG","584-42-9",{"slug":354,"cid":355,"name":356,"nameZh":357,"cas":358},"785898449647177728","J-50465-0","Ovalbumin","卵清蛋白","9006-59-1",{"slug":360,"cid":361,"name":362,"nameZh":363,"cas":364},"785875984183201792","J-11597-3","Aflatoxin B1","黄曲霉毒素B1","1162-65-8",1792618609107,"zh-CN",[]]