[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"currency-rates":3,"$fyk2oeqxpb7bd":8,"compound-J-25428-4":169,"verified-suppliers-J-25428-4":388},{"rates":4,"source":7},{"USD":5,"CNY":6},1,6.679814,"live",{"rows":9,"total":167,"current":5,"size":168},[10,33,45,60,73,84,96,111,121,133,145,156],{"slug":11,"cid":12,"imgSvg":13,"name":14,"nameZh":15,"cas":16,"formula":17,"iupac":14,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":22,"offersCount":24,"supplierCount":25,"bestOffer":26},"843627791009189888","J-1971488-6","\u002Fimages\u002Fchem_structures_svg\u002F399\u002F65845-61-6.svg","N-Methylcyclohexanamine hydrochloride","N-甲基环己胺盐酸盐","65845-61-6","C7H16ClN","acids","有机酸","Organic Acids","",[23],"In Stock",4,2,{"unitPrice":27,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},2.64,"500g","CNY","China","CN","in-stock",{"slug":34,"cid":35,"imgSvg":36,"name":37,"nameZh":38,"cas":39,"formula":40,"iupac":37,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":41,"offersCount":24,"supplierCount":5,"bestOffer":42},"785882541994283008","J-1323843-2","\u002Fimages\u002Fchem_structures_svg\u002F104\u002F67627-18-3.svg","Potassium indigotrisulfonate","靛蓝三磺酸钾","67627-18-3","C16H7K3N2O11S3",[23],{"unitPrice":43,"pack":44,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},180,"5g",{"slug":46,"cid":47,"imgSvg":48,"name":49,"nameZh":50,"cas":51,"formula":52,"iupac":49,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":56,"offersCount":57,"supplierCount":25,"bestOffer":58},"785889752443260928","J-28559-6","\u002Fimages\u002Fchem_structures_svg\u002F292\u002F15060-55-6.svg","Ammonium tetrathiomolybdate","四硫钼酸铵","15060-55-6","H8MoN2S4","inorganic","无机化合物","Inorganic Chemicals",[23],10,{"unitPrice":59,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},24,{"slug":61,"cid":62,"imgSvg":63,"name":64,"nameZh":65,"cas":66,"formula":67,"iupac":64,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":68,"offersCount":69,"supplierCount":25,"bestOffer":70},"855452191530422272","J-1994428-6","\u002Fimages\u002Fchem_structures_svg\u002F500\u002F16350-96-2.svg","N-benzylcyclohexanamine.hydrochloride","N-苄基环己胺盐酸盐","16350-96-2","C13H20ClN",[23],5,{"unitPrice":71,"pack":28,"currency":29,"origin":72,"originFlag":31,"moq":21,"stock":32},6,"中国",{"slug":74,"cid":75,"imgSvg":76,"name":77,"nameZh":78,"cas":79,"formula":80,"iupac":77,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":81,"offersCount":25,"supplierCount":25,"bestOffer":82},"785871840001134592","J-982001-3","\u002Fimages\u002Fchem_structures_svg\u002F001\u002F10517-44-9.svg","1,3-Diaminopropane dihydrochloride","1,3-二氨基丙烷二盐酸盐","10517-44-9","C3H12Cl2N2",[23],{"unitPrice":83,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},3.78,{"slug":85,"cid":86,"imgSvg":87,"name":88,"nameZh":89,"cas":90,"formula":91,"iupac":88,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":92,"offersCount":93,"supplierCount":94,"bestOffer":95},"785880365658017792","J-14975-7","\u002Fimages\u002Fchem_structures_svg\u002F262\u002F12003-67-7.svg","Lithium aluminate","氧化铝锂","12003-67-7","AlLiO2",[23],7,3,{"unitPrice":94,"pack":28,"currency":29,"origin":72,"originFlag":31,"moq":21,"stock":32},{"slug":97,"cid":98,"imgSvg":99,"name":100,"nameZh":101,"cas":102,"formula":103,"iupac":100,"category":104,"categoryName":105,"categoryEnName":106,"industry":21,"tags":107,"offersCount":94,"supplierCount":5,"bestOffer":109},"785871830249377792","J-6931-8","\u002Fimages\u002Fchem_structures_svg\u002F456\u002F58068-80-7.svg","1-Octanoylbenzotriazole","N-辛酰苯并三唑","58068-80-7","C14H19N3O","aromatics","芳香烃","Aromatic Hydrocarbons",[108],"Made to Order",{"unitPrice":110,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},0.56,{"slug":112,"cid":113,"imgSvg":114,"name":115,"nameZh":116,"cas":117,"formula":118,"iupac":115,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":119,"offersCount":69,"supplierCount":25,"bestOffer":120},"785871842446413824","J-1960944-0","\u002Fimages\u002Fchem_structures_svg\u002F495\u002F10534-86-8.svg","Hexaamminecobalt(III) nitrate","六氨合钴(III)硝酸盐","10534-86-8","CoH18N9O9",[23],{"unitPrice":71,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},{"slug":122,"cid":123,"imgSvg":124,"name":125,"nameZh":126,"cas":127,"formula":128,"iupac":125,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":129,"offersCount":24,"supplierCount":25,"bestOffer":130},"785871842576437248","J-814544-6","\u002Fimages\u002Fchem_structures_svg\u002F221\u002F12037-42-2.svg","vanadium oxide","氧化钒","12037-42-2","O13V6",[23],{"unitPrice":131,"pack":132,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},112.8,"100g",{"slug":134,"cid":135,"imgSvg":136,"name":137,"nameZh":138,"cas":139,"formula":140,"iupac":137,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":141,"offersCount":142,"supplierCount":5,"bestOffer":143},"785871842647740416","J-1333345-4","\u002Fimages\u002Fchem_structures_svg\u002F479\u002F26490-63-1.svg","COBALT TETRAFLUOROBORATE HEXAHYDRATE","四氟化硼钴水合物","26490-63-1","B2CoF8H12O6",[23],8,{"unitPrice":144,"pack":132,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},11,{"slug":146,"cid":147,"imgSvg":148,"name":149,"nameZh":150,"cas":151,"formula":152,"iupac":149,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":153,"offersCount":57,"supplierCount":94,"bestOffer":154},"785871842698072064","J-814953-9","\u002Fimages\u002Fchem_structures_svg\u002F432\u002F72259-10-0.svg","Copper(II) tetrafluoroborate hexahydrate","六水合四氟硼酸铜(II)","72259-10-0","B2CuF8H12O6",[23],{"unitPrice":155,"pack":28,"currency":29,"origin":21,"originFlag":21,"moq":21,"stock":32},2.6,{"slug":157,"cid":158,"imgSvg":159,"name":160,"nameZh":161,"cas":162,"formula":163,"iupac":160,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":164,"offersCount":94,"supplierCount":5,"bestOffer":165},"785871863254355968","J-1990080-2","\u002Fimages\u002Fchem_structures_svg\u002F149\u002F123333-60-8.svg","Cerium(IV) sulfate hydrate","铈(IV)硫酸盐水合物","123333-60-8","CeH2O9S2",[108],{"unitPrice":166,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},5.6,3204,12,{"slug":170,"cid":171,"imgSvg":172,"name":173,"nameZh":174,"cas":175,"formula":176,"iupac":173,"mdl":21,"mw":177,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":178,"synonyms":179,"properties":184,"ghs":238,"offers":246,"activity":247,"upstream":266,"downstream":273,"customs":281,"safetyRows":282,"toxicity":309,"msds":310,"updatedAt":311,"isProhibited":312,"related":313,"__ts":386,"__lang":387,"__slug":171},"785888642391347200","J-25428-4","\u002Fimages\u002Fchem_structures_svg\u002F499\u002F2646-38-0.svg","Sodium chenodeoxycholate","鹅去氧胆酸钠","2646-38-0","C24H39NaO4","414.55",[],[180,181,182,183],"鹅脱氧胆酸钠","鹅去氧胆酸钠盐","3α,7α-二羟基-5β-胆烷酸钠","5β-胆烷酸-3α,7α-二醇钠",[185,190,195,200,204,207,210,214,218,222,226,230,234],{"label":186,"labelZh":187,"value":188,"prop":189},"Melting Point","熔点","298 °C(dec.)","meltingPoint",{"label":191,"labelZh":192,"value":193,"prop":194},"Boiling Point","沸点","547.1ºC at 760mmHg","boilingPoint",{"label":196,"labelZh":197,"value":198,"prop":199},"Flash Point","闪点","298.8ºC","flashPoint",{"label":201,"labelZh":202,"value":203},"Exact Mass","精确质量","414.274597",{"label":205,"labelZh":205,"value":206},"PSA","80.59000",{"label":208,"labelZh":208,"value":209},"LogP","3.14320",{"label":211,"labelZh":212,"value":213},"Appearance","外观性状","固体;White to Almost white powder to crystal",{"label":215,"labelZh":216,"value":217},"Vapor Pressure","蒸汽压","2.98E-14mmHg at 25°C",{"label":219,"labelZh":220,"value":221},"Storage Conditions","储存条件","密封于阴凉干燥环境。",{"label":223,"labelZh":224,"value":225},"Stability","稳定性","如果遵照规格使用和储存则不会分解。",{"label":227,"labelZh":228,"value":229},"Molecular Structure","分子结构","1、摩尔折射率：无可用\n2、 摩尔体积（cm\n3\n\u002Fmol）： 无可用\n3、 等张比容（90.2K）：无可用\n4、 表面张力（dyne\u002Fcm）：无可用\n5、 极化率：无可用",{"label":231,"labelZh":232,"value":233},"Computational Chemistry","计算化学","1、 疏水参数计算参考值（XlogP）：无可用\n2、 氢键供体数量：2\n3、 氢键受体数量：4\n4、 可旋转化学键数量：4\n5、 拓扑分子极性表面积（TPSA）：80.6\n6、 重原子数量：29\n7、 表面电荷：0\n8、 复杂度：612\n9、 同位素原子数量：0\n10、 确定原子立构中心数量：0\n11、 不确定原子立构中心数量：4\n12、 确定化学键立构中心数量：0\n13、 不确定化学键立构中心数量：0\n14、 共价键单元数量：2",{"label":235,"labelZh":236,"value":237},"Additional Property","更多","1. 性状：无可用\n2. 密度（g\u002FmL,25\u002F4℃）：无可用\n3. 相对蒸汽密度（g\u002FmL,空气=1）：无可用\n4. 熔点（ºC）：无可用\n5. 沸点（ºC,常压）：无可用\n6. 沸点（ºC,5.2kPa）：无可用\n7. 折射率：无可用\n8. 闪点（ºC）：无可用\n9. 比旋光度（º）：无可用\n10. 自燃点或引燃温度（ºC）：无可用\n11. 蒸气压（kPa,25ºC）：无可用\n12. 饱和蒸气压（kPa,60ºC）：无可用\n13. 燃烧热（KJ\u002Fmol）：无可用\n14. 临界温度（ºC）：无可用\n15. 临界压力（KPa）：无可用\n16. 油水（辛醇\u002F水）分配系数的对数值：无可用\n17. 爆炸上限（%,V\u002FV）：无可用\n18. 爆炸下限（%,V\u002FV）： 无可用\n19. 溶解性：无可用",{"pictogram":239,"signal":240,"hazards":241},"Irritant \u002F Health Hazard","Warning",[242,243,244,245],"H302 — Harmful if swallowed \u002F 吞咽有害","H312 — Harmful in contact with skin \u002F 皮肤接触有害","H332 — Harmful if inhaled \u002F 吸入有害","H351 — Suspected of causing cancer \u002F 怀疑致癌",[],[248,251,254,257,260,263],{"key":249,"value":250},"描述","鹅去氧胆酸钠是一种疏水性初级胆汁酸,可激活参与胆固醇代谢的核受体(FXR)。",{"key":252,"value":253},"相关类别","研究领域\n>>\n癌症\n信号通路\n>>\n代谢酶\u002F蛋白酶\n>>\nFXR\n信号通路\n>>\n自噬\n>>\n自噬\n研究领域\n>>\n代谢疾病",{"key":255,"value":256},"体外研究","鹅去氧胆酸钠(CDCA)和脱氧胆酸(DCA)均抑制11β-HSD2,IC50值分别为22 mM和38 mM,并导致皮质醇依赖性核转位,增加盐皮质激素受体(MR)的转录活性[1]。鹅去氧胆酸钠能够通过激活膜G蛋白偶联受体(TGR5)依赖性途径,诱导细胞周期蛋白D1蛋白和mRNA表达显著增加,从而刺激石川细胞生长[2]。在培养的人肝母细胞瘤细胞系Hep G2中,鹅去氧胆酸钠(CDCA)诱导LDL受体mRNA水平约为4倍,HMG-CoA还原酶和HMG-CoA合成酶的mRNA水平为2倍[3]。鹅去氧胆酸钠诱导的Isc被布美他奈、BaCl2和囊性纤维化跨膜电导调节剂(CFTR)抑制剂CFTRin-172抑制(≥67%)。腺苷酸环化酶抑制剂MDL12330A使鹅去氧胆酸钠刺激的Isc降低43%,鹅去氧胆酸盐增加细胞内cAMP浓度[4]。鹅去氧胆酸钠处理激活C\u002FEBPβ,如其磷酸化、核积累和在HepG2细胞中表达的增加所示。鹅去氧胆酸钠增强来自含有-1.65-kb GSTA2启动子的构建体的萤光素酶基因转录,该构建体含有C\u002FEBP应答元件(pGL-1651)。鹅去氧胆酸钠处理激活AMP活化蛋白激酶(AMPK),导致细胞外信号调节激酶1\u002F2(ERK1\u002F2)激活,使用AMPKα显性阴性突变体和化学抑制剂的实验结果证明了这一点[5]。",{"key":258,"value":259},"激酶实验","简言之，转染的HEK-293细胞在木炭处理的Dulbecco改良的Eagle培养基中孵育24小时，用Hanks溶液洗涤一次，并重悬于含有100mM NaCl、1mM MgCl2、1mM EDTA、1mM EGTA、250mM蔗糖、20mM Tris-HCl、pH 7.4的缓冲液中。细胞通过在液氮中冷冻而裂解。在含有适当浓度胆汁酸、30nCi[3H]皮质醇和最终浓度为50nM的未标记皮质醇的20μL最终体积中测量脱氢酶活性。通过将细胞裂解物与反应混合物混合来开始反应。或者，由转染的HEK-293细胞制备内质网微粒体，并与含有不同浓度皮质醇和CDCA的反应混合物孵育。培养20分钟，通过薄层色谱法（TLC）测定皮质醇向可的松的转化率。由于TLC方法在低转化率下的不准确性，以及11βHSD2在转化率高于60-70%时的最终产物抑制性，因此仅考虑10%至60%的转化率进行计算。使用曲线拟合程序来评估抑制常数IC50。结果用平均值±S.E.表示，至少由四个独立的测量值组成。",{"key":261,"value":262},"细胞实验","通过用相应浓度的胆汁酸孵育转染的HEK-293细胞和CHO细胞1小时并用台盼蓝染色来分析细胞活力。根据细胞增殖试剂盒I，使用四唑盐MTT（3-（4,5-二甲基噻唑-2-基）-2,5-二苯基四唑溴化物）分析胆汁酸的毒性。在两种测试中，对照和胆汁酸处理的细胞之间没有显著差异。",{"key":264,"value":265},"参考文献","[1].\nStauffer AT, et al. Chenodeoxycholic acid and deoxycholic acid inhibit 11 beta-hydroxysteroid dehydrogenase type 2 and cause cortisol-induced transcriptional activation of the mineralocorticoid receptor. J Biol Chem. 2002 Jul 19;277(29):26286-92\n[2].\nNoh K, et al. Farnesoid X receptor activation by chenodeoxycholic acid induces detoxifying enzymes through AMP-activated protein kinase and extracellular signal-regulated kinase 1\u002F2-mediated phosphorylation of CCAAT\u002Fenhancer binding protein β. Drug Metab\n[3].\nCasaburi I, et al. Chenodeoxycholic acid through a TGR5-dependent CREB signaling activation enhances cyclin D1 expression and promotes human endometrial cancer cell proliferation. Cell Cycle. 2012 Jul 15;11(14):2699-710\n[4].\nAo M, et al. Chenodeoxycholic acid stimulates Cl(-) secretion via cAMP signaling and increases cystic fibrosis transmembrane conductance regulator phosphorylation in T84 cells. Am J Physiol Cell Physiol. 2013 Aug 15;305(4):C447-56\n[5].\nKawabe Y, et al. The molecular mechanism of the induction of the low density lipoprotein receptor by chenodeoxycholic acid in cultured human cells. Biochem Biophys Res Commun. 1995 Mar 8;208(1):405-11.",[267],{"slug":268,"cid":269,"name":270,"nameZh":270,"cas":271,"imgSvg":272},"785872758071365600","J-1992829-1","鹅去氧胆酸； 鹅脱氧胆酸","474-25-9","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F339\u002F474-25-9.svg",[274,280],{"slug":275,"cid":276,"name":277,"nameZh":277,"cas":278,"imgSvg":279},"785891814065311700","J-31202-7","3α-羟基-7-氧代-5β-胆烷酸","4651-67-6","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F213\u002F4651-67-6.svg",{"slug":268,"cid":269,"name":270,"nameZh":270,"cas":271,"imgSvg":272},[],[283,286,288,291,294,297,300,303,306],{"key":284,"value":285},"符号","GHS07, GHS08",{"key":287,"value":240},"信号词",{"key":289,"value":290},"危害声明","H302-H312-H332-H351",{"key":292,"value":293},"警示性声明","P280-P281",{"key":295,"value":296},"危害码 (欧洲)","Xn: Harmful;",{"key":298,"value":299},"风险声明 (欧洲)","20\u002F21\u002F22-40",{"key":301,"value":302},"安全声明 (欧洲)","S22;S36",{"key":304,"value":305},"危险品运输编码","NONH for all modes of transport",{"key":307,"value":308},"RTECS号","FZ2231000","\u003Ctd>\n\n\u003Cp>\u003Cstrong>鹅去氧胆酸钠生态学数据:\u003C\u002Fstrong>\u003C\u002Fp>\n\u003Cp>\u003C\u002Fp>\u003Cp>该物质对环境可能有危害，对水体应给予特别注意。  \u003C\u002Fp>\n\u003Cp>\u003C\u002Fp>\n\u003Cp>\u003Ca href=\"\u002Fen\u002Fcas\u002F2646-38-0_594674.html#duXinDiv\">鹅去氧胆酸钠毒性英文版\u003C\u002Fa>\u003C\u002Fp>\n\n\u003C\u002Ftd>","\u003Ctd>\n\n\u003Ca href=\"\u002Fen\u002Fcas\u002F2646-38-0_594674.html#MSDSDiv\">鹅去氧胆酸钠MSDS英文版\u003C\u002Fa>\n\n\u003C\u002Ftd>","2026-08-21T07:51:12.859463Z",false,[314,320,326,332,338,344,350,356,362,368,374,380],{"slug":315,"cid":316,"name":317,"nameZh":318,"cas":319},"785875946644180992","J-1111581-4","Ambroxol hydrochloride","盐酸氨溴索","23828-92-4",{"slug":321,"cid":322,"name":323,"nameZh":324,"cas":325},"785904290802700288","J-1311939-6","Calcium 4-hydroxy-3-methylbenzenesulfonate","4-羟基-3-甲基苯磺酸钙","74220-17-0",{"slug":327,"cid":328,"name":329,"nameZh":330,"cas":331},"785895977000112128","J-1512742-1","Cholesterol Formate","甲酸胆固醇酯","4351-55-7",{"slug":333,"cid":334,"name":335,"nameZh":336,"cas":337},"785884377224581120","J-1910990-1","Tris(5-oxo-L-prolinato-N1,O2)aluminium","三(5-氧代-L-脯氨酸)铝","59792-81-3",{"slug":339,"cid":340,"name":341,"nameZh":342,"cas":343},"785902216895533056","J-1047603-6","Dilanthanum oxydicarbonate","碱式碳酸镧","77242-85-4",{"slug":345,"cid":346,"name":347,"nameZh":348,"cas":349},"785946571446423552","J-758217-4","Ammonium 2,3,3,3-tetrafluoro-2-[1,1,2,3,3,3-hexafluoro-2-(trifluoromethoxy)propoxy]propanoate","2,3,3,3-四氟-2-[1,1,2,3,3,3-六氟-2-(三氟甲氧基)丙氧基]丙酸铵","510774-77-3",{"slug":351,"cid":352,"name":353,"nameZh":354,"cas":355},"785924061908701184","J-1217478-6","Piperazine edetate calcium","依地酸钙哌嗪","12002-30-1",{"slug":357,"cid":358,"name":359,"nameZh":360,"cas":361},"785873652494110720","J-1027825-8","Erbium(III) acetate tetrahydrate","醋酸铒(III)四水合物","15280-57-6",{"slug":363,"cid":364,"name":365,"nameZh":366,"cas":367},"785882354366287872","J-3302-3","Anthraquinone-2,7-disulfonic acid disodium salt","蒽醌-2,7-二磺酸二钠盐","853-67-8",{"slug":369,"cid":370,"name":371,"nameZh":372,"cas":373},"785882424050454528","J-1159158-5","Anthraquinone-2,6-disulfonic acid disodium salt","蒽醌-2,6-二磺酸二钠","853-68-9",{"slug":375,"cid":376,"name":377,"nameZh":378,"cas":379},"785872493972819968","J-1992190-5","Neodymium(III) acetate hydrate","醋酸钕","6192-13-8",{"slug":381,"cid":382,"name":383,"nameZh":384,"cas":385},"785883574720008192","J-8293-9","Fmoc-Asp(OtBu)-OH","Fmoc-L-天冬氨酸-4-叔丁酯","71989-14-5",1794256147216,"zh-CN",[]]