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I(1,10,100μM)通过EOC细胞中的MyD88依赖性TLR4信号传导下调紫杉醇诱导的VEGF和survivin的表达[4]。",{"key":253,"value":254},"体内研究","白术内酯I(5,10或20mg\u002Fkg,po)恢复经历慢性不可预测的轻度应激(CUMS)的小鼠体重减轻。 Atractylenolide I减轻CUMS诱导的抑郁样行为,减轻CUMS诱导的海马神经递质水平失衡,并减少CUMS诱导的海马促炎细胞因子水平增加和小鼠海马NLRP3炎症小体的增加[2]。",{"key":256,"value":257},"细胞实验","简而言之，用指定浓度的白术内酯I预处理血清饥饿的VSMC 1小时，然后用Ox-LDL刺激24小时。加入MTT后形成的紫色甲crystals晶体溶解在DMSO中，在540nm处测量吸光度。活力或增殖率计算为对照（未治疗的VSMC）的百分比[3]。",{"key":259,"value":260},"动物实验","小鼠[2]适应一周后，将48只雄性ICR小鼠随机分成6组（每组8只小鼠）：对照组（无应激+盐水载体），模型组（CUMS +盐水载体），三种Atractylenolide I治疗组（CUMS + Atractylenolide I）和氟西汀组（CUMS + FLU）。从第4周起，每天通过口服强饲法给予Atractylenolide I（5,10或20mg \u002F kg）或氟西汀（20mg \u002F kg）3周。在最后一次施用Atractylenolide I或氟西汀后，进行行为测试[2]。",{"key":262,"value":263},"参考文献","[1].\nAtractylenolide I, et al. 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