[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"currency-rates":3,"$fyk2oeqxpb7bd":8,"compound-J-2337-5":171,"verified-suppliers-J-2337-5":320},{"rates":4,"source":7},{"USD":5,"CNY":6},1,6.689327,"live",{"rows":9,"total":170,"current":5,"size":145},[10,33,45,60,74,85,96,113,123,135,146,158],{"slug":11,"cid":12,"imgSvg":13,"name":14,"nameZh":15,"cas":16,"formula":17,"iupac":14,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":22,"offersCount":24,"supplierCount":25,"bestOffer":26},"843627791009189888","J-1971488-8","\u002Fimages\u002Fchem_structures_svg\u002F399\u002F65845-61-6.svg","N-Methylcyclohexanamine hydrochloride","N-甲基环己胺盐酸盐","65845-61-6","C7H16ClN","acids","有机酸","Organic Acids","",[23],"In Stock",4,2,{"unitPrice":27,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},2.64,"500g","CNY","China","CN","in-stock",{"slug":34,"cid":35,"imgSvg":36,"name":37,"nameZh":38,"cas":39,"formula":40,"iupac":37,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":41,"offersCount":24,"supplierCount":5,"bestOffer":42},"785882541994283008","J-1323843-4","\u002Fimages\u002Fchem_structures_svg\u002F104\u002F67627-18-3.svg","Potassium indigotrisulfonate","靛蓝三磺酸钾","67627-18-3","C16H7K3N2O11S3",[23],{"unitPrice":43,"pack":44,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},180,"5g",{"slug":46,"cid":47,"imgSvg":48,"name":49,"nameZh":50,"cas":51,"formula":52,"iupac":49,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":56,"offersCount":57,"supplierCount":25,"bestOffer":58},"785889752443260928","J-28559-9","\u002Fimages\u002Fchem_structures_svg\u002F292\u002F15060-55-6.svg","Ammonium tetrathiomolybdate","四硫钼酸铵","15060-55-6","H8MoN2S4","inorganic","无机化合物","Inorganic Chemicals",[23],7,{"unitPrice":59,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},24,{"slug":61,"cid":62,"imgSvg":63,"name":64,"nameZh":65,"cas":66,"formula":67,"iupac":64,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":68,"offersCount":69,"supplierCount":25,"bestOffer":70},"855452191530422272","J-1994428-7","\u002Fimages\u002Fchem_structures_svg\u002F500\u002F16350-96-2.svg","N-benzylcyclohexanamine.hydrochloride","N-苄基环己胺盐酸盐","16350-96-2","C13H20ClN",[23],5,{"unitPrice":71,"pack":72,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},6,"1000g","中国",{"slug":75,"cid":76,"imgSvg":77,"name":78,"nameZh":79,"cas":80,"formula":81,"iupac":78,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":82,"offersCount":25,"supplierCount":25,"bestOffer":83},"785871840001134592","J-982001-0","\u002Fimages\u002Fchem_structures_svg\u002F001\u002F10517-44-9.svg","1,3-Diaminopropane dihydrochloride","1,3-二氨基丙烷二盐酸盐","10517-44-9","C3H12Cl2N2",[23],{"unitPrice":84,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},3.78,{"slug":86,"cid":87,"imgSvg":88,"name":89,"nameZh":90,"cas":91,"formula":92,"iupac":89,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":93,"offersCount":57,"supplierCount":94,"bestOffer":95},"785880365658017792","J-14975-6","\u002Fimages\u002Fchem_structures_svg\u002F262\u002F12003-67-7.svg","Lithium aluminate","氧化铝锂","12003-67-7","AlHLiO2",[23],3,{"unitPrice":94,"pack":28,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},{"slug":97,"cid":98,"imgSvg":99,"name":100,"nameZh":101,"cas":102,"formula":103,"iupac":100,"category":104,"categoryName":105,"categoryEnName":106,"industry":21,"tags":107,"offersCount":108,"supplierCount":108,"bestOffer":109},"785871830249377792","J-6931-9","\u002Fimages\u002Fchem_structures_svg\u002F456\u002F58068-80-7.svg","1-Octanoylbenzotriazole","N-辛酰苯并三唑","58068-80-7","C14H19N3O","aromatics","芳香烃","Aromatic Hydrocarbons",[],0,{"unitPrice":110,"pack":21,"currency":111,"origin":21,"originFlag":21,"moq":21,"stock":112},9007199254740991,"USD","made-to-order",{"slug":114,"cid":115,"imgSvg":116,"name":117,"nameZh":118,"cas":119,"formula":120,"iupac":117,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":121,"offersCount":69,"supplierCount":25,"bestOffer":122},"785871842446413824","J-1960944-3","\u002Fimages\u002Fchem_structures_svg\u002F495\u002F10534-86-8.svg","Hexaamminecobalt(III) nitrate","六氨合钴(III)硝酸盐","10534-86-8","CoH18N9O9",[23],{"unitPrice":71,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},{"slug":124,"cid":125,"imgSvg":126,"name":127,"nameZh":128,"cas":129,"formula":130,"iupac":127,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":131,"offersCount":24,"supplierCount":25,"bestOffer":132},"785871842576437248","J-814544-6","\u002Fimages\u002Fchem_structures_svg\u002F221\u002F12037-42-2.svg","vanadium oxide","氧化钒","12037-42-2","O13V6",[23],{"unitPrice":133,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},112.8,"100g",{"slug":136,"cid":137,"imgSvg":138,"name":139,"nameZh":140,"cas":141,"formula":142,"iupac":139,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":143,"offersCount":57,"supplierCount":5,"bestOffer":144},"785871842647740416","J-1333345-2","\u002Fimages\u002Fchem_structures_svg\u002F479\u002F26490-63-1.svg","COBALT TETRAFLUOROBORATE HEXAHYDRATE","四氟化硼钴水合物","26490-63-1","B2CoF8H12O6",[23],{"unitPrice":145,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},12,{"slug":147,"cid":148,"imgSvg":149,"name":150,"nameZh":151,"cas":152,"formula":153,"iupac":150,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":154,"offersCount":155,"supplierCount":94,"bestOffer":156},"785871842698072064","J-814953-0","\u002Fimages\u002Fchem_structures_svg\u002F432\u002F72259-10-0.svg","Copper(II) tetrafluoroborate hexahydrate","六水合四氟硼酸铜(II)","72259-10-0","B2CuF8H12O6",[23],10,{"unitPrice":157,"pack":28,"currency":29,"origin":21,"originFlag":21,"moq":21,"stock":32},2.6,{"slug":159,"cid":160,"imgSvg":161,"name":162,"nameZh":163,"cas":164,"formula":165,"iupac":162,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":166,"offersCount":25,"supplierCount":5,"bestOffer":168},"785871863254355968","J-1990080-7","\u002Fimages\u002Fchem_structures_svg\u002F149\u002F123333-60-8.svg","Cerium(IV) sulfate hydrate","铈(IV)硫酸盐水合物","123333-60-8","CeH2O9S2",[167],"Made to Order",{"unitPrice":169,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},5.6,3204,{"slug":172,"cid":173,"imgSvg":174,"name":175,"nameZh":175,"cas":176,"formula":177,"iupac":175,"mdl":21,"mw":178,"category":179,"categoryName":180,"categoryEnName":181,"industry":21,"tags":182,"synonyms":183,"properties":188,"ghs":236,"offers":237,"activity":238,"upstream":263,"downstream":276,"customs":277,"safetyRows":278,"updatedAt":279,"isProhibited":280,"related":281,"__ts":318,"__lang":319,"__slug":173},"785894564006203392","J-2337-5","\u002Fimages\u002Fchem_structures_svg\u002F380\u002F572924-54-0.svg","42-(二甲基亚膦酰)雷帕霉素","572924-54-0","C53H84NO14P","990.206","organic","有机化合物","Organic Compounds",[],[184,185,175,186,187],"Deforolimus","(二甲基亚膦酰)雷帕霉素","MTOR抑制剂(DEFOROLIMUS)","雷帕霉素衍生物",[189,194,199,204,209,213,217,220,224,228,232],{"label":190,"labelZh":191,"value":192,"prop":193},"Melting Point","熔点","95-98ºC","meltingPoint",{"label":195,"labelZh":196,"value":197,"prop":198},"Boiling Point","沸点","996.2±75.0 °C at 760 mmHg","boilingPoint",{"label":200,"labelZh":201,"value":202,"prop":203},"Density","密度","1.2±0.1 g\u002Fcm3","density",{"label":205,"labelZh":206,"value":207,"prop":208},"Flash Point","闪点","556.3±37.1 °C","flashPoint",{"label":210,"labelZh":211,"value":212},"Exact Mass","精确质量","989.562927",{"label":214,"labelZh":215,"value":216},"PSA","其他信息","211.31000",{"label":218,"labelZh":218,"value":219},"LogP","3.12",{"label":221,"labelZh":222,"value":223},"Appearance","外观性状","灰白色固体",{"label":225,"labelZh":226,"value":227},"Vapor Pressure","蒸汽压","0.0±0.6 mmHg at 25°C",{"label":229,"labelZh":230,"value":231},"Refractive Index","折射率","1.539",{"label":233,"labelZh":234,"value":235},"Storage Conditions","储存条件","Hygroscopic, -20?C Freezer, Under Inert Atmosphere",null,[],[239,242,245,248,251,254,257,260],{"key":240,"value":241},"描述","Deforolimus (AP23573; MK-8669) 是一种有效和选择性的 mTOR 抑制剂,在 HT-1080 细胞中抑制 S6磷酸化的 IC50 值为 0.2 nM。",{"key":243,"value":244},"相关类别","研究领域\n>>\n癌症",{"key":246,"value":247},"靶点","mTOR",{"key":249,"value":250},"体外研究","用deforolimus处理HT-1080纤维肉瘤细胞导致S6和4E-BP1的磷酸化的剂量依赖性抑制,IC50分别为0.2和5.6nM,EC50分别为0.2和1.0nM。在HT-1080细胞中,抑制细胞增殖的EC50(0.5nM)类似于抑制S6和4E-BP1磷酸化的EC50。暴露于deforolimus可减少代表多种肿瘤类型的细胞系的增殖。在体外给予肿瘤细胞的deforolimus引起mTOR活性的剂量依赖性抑制,伴随对细胞生长和分裂的影响。 Deforolimus表现出主要的细胞抑制作用模式,与其他mTOR抑制剂的发现一致。对血管内皮生长因子分泌,内皮细胞生长和葡萄糖代谢有强效抑制作用[1]。",{"key":252,"value":253},"体内研究","Deforolimus抑制携带PC-3(前列腺),HCT-116(结肠),MCF7(乳腺),PANC-1(胰腺)或A549(肺)异种移植物的小鼠中的肿瘤生长。 Deforolimus以剂量依赖性方式抑制肿瘤生长,0.3 mg\u002Fkg是抑制肿瘤生长的最低剂量,3和10 mg\u002Fkg剂量达到最大抑制[1]。",{"key":255,"value":256},"细胞实验","用10倍连续稀释的deforolimus（1,000至0.0001nM）或载体（乙醇）处理细胞。在37℃培养72小时后，吸出平板并储存在-80℃用于增殖分析[1]。",{"key":258,"value":259},"动物实验","小鼠：选择具有适当大小范围的肿瘤的动物被分配到各种治疗组。在2个不同的治疗方案中腹膜内施用剂量为3和10mg \u002F kg的Deforolimus：（a）每天，每隔一周连续5天和（b）每周一次。对照组未经治疗[1]。",{"key":261,"value":262},"参考文献","[1].\nRivera VM, et al. Deforolimus (AP23573; MK-8669), a potent mTOR inhibitor, has broad antitumor activity and can be optimally administered using intermittent dosing regimens. Mol Cancer Ther. 2011 Jun;10(6):1059-71.\n[2].\nBrandt M, et al. mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis. Cell Metab. 2018 Jan 9;27(1):118-135.e8.",[264,270],{"slug":265,"cid":266,"name":267,"nameZh":267,"cas":268,"imgSvg":269},"785881289805795300","J-18598-1","雷帕霉素","53123-88-9","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F225\u002F53123-88-9.svg",{"slug":271,"cid":272,"name":273,"nameZh":273,"cas":274,"imgSvg":275},"785892824011771900","J-33911-7","二甲基氯氧化磷","1111-92-8","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F069\u002F1111-92-8.svg",[],[],[],"2026-08-21T07:51:12.859463Z",false,[282,288,294,300,306,312],{"slug":283,"cid":284,"name":285,"nameZh":286,"cas":287},"785893849972084736","J-1499066-5","Ferrocholinate","铁胆盐","1336-80-7",{"slug":289,"cid":290,"name":291,"nameZh":292,"cas":293},"785880529122627584","J-16039-9","Triarachidin","三花生精","620-64-4",{"slug":295,"cid":296,"name":297,"nameZh":298,"cas":299},"785898371561820160","J-50381-7","Hemicellulase","半纤维素酶","9025-56-3",{"slug":301,"cid":302,"name":303,"nameZh":304,"cas":305},"785883052164255744","J-6807-1","Rose Bengal sodium salt","虎红钠盐","632-69-9",{"slug":307,"cid":308,"name":309,"nameZh":310,"cas":311},"785883052394942464","J-1108833-4","Trypan Blue","台盼蓝","72-57-1",{"slug":313,"cid":314,"name":315,"nameZh":316,"cas":317},"785880403549360128","J-1103503-3","lead,[c,c,c,c-tetrakis(1,1-dimethylethyl)-29h,31h-phthalocyaninato(2-)-kn29,kn30,kn31,kn32]- (9ci)","四叔丁基酞菁铅(Ⅱ)","158335-62-7",1792678572144,"zh-CN",[]]