[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"currency-rates":3,"$fyk2oeqxpb7bd":8,"compound-J-1988978-2":169,"verified-suppliers-J-1988978-2":329},{"rates":4,"source":7},{"USD":5,"CNY":6},1,6.679814,"live",{"rows":9,"total":167,"current":5,"size":168},[10,33,45,60,73,84,96,111,121,133,145,156],{"slug":11,"cid":12,"imgSvg":13,"name":14,"nameZh":15,"cas":16,"formula":17,"iupac":14,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":22,"offersCount":24,"supplierCount":25,"bestOffer":26},"843627791009189888","J-1971488-6","\u002Fimages\u002Fchem_structures_svg\u002F399\u002F65845-61-6.svg","N-Methylcyclohexanamine hydrochloride","N-甲基环己胺盐酸盐","65845-61-6","C7H16ClN","acids","有机酸","Organic Acids","",[23],"In Stock",4,2,{"unitPrice":27,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},2.64,"500g","CNY","China","CN","in-stock",{"slug":34,"cid":35,"imgSvg":36,"name":37,"nameZh":38,"cas":39,"formula":40,"iupac":37,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":41,"offersCount":24,"supplierCount":5,"bestOffer":42},"785882541994283008","J-1323843-2","\u002Fimages\u002Fchem_structures_svg\u002F104\u002F67627-18-3.svg","Potassium indigotrisulfonate","靛蓝三磺酸钾","67627-18-3","C16H7K3N2O11S3",[23],{"unitPrice":43,"pack":44,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},180,"5g",{"slug":46,"cid":47,"imgSvg":48,"name":49,"nameZh":50,"cas":51,"formula":52,"iupac":49,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":56,"offersCount":57,"supplierCount":25,"bestOffer":58},"785889752443260928","J-28559-6","\u002Fimages\u002Fchem_structures_svg\u002F292\u002F15060-55-6.svg","Ammonium tetrathiomolybdate","四硫钼酸铵","15060-55-6","H8MoN2S4","inorganic","无机化合物","Inorganic Chemicals",[23],10,{"unitPrice":59,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},24,{"slug":61,"cid":62,"imgSvg":63,"name":64,"nameZh":65,"cas":66,"formula":67,"iupac":64,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":68,"offersCount":69,"supplierCount":25,"bestOffer":70},"855452191530422272","J-1994428-6","\u002Fimages\u002Fchem_structures_svg\u002F500\u002F16350-96-2.svg","N-benzylcyclohexanamine.hydrochloride","N-苄基环己胺盐酸盐","16350-96-2","C13H20ClN",[23],5,{"unitPrice":71,"pack":28,"currency":29,"origin":72,"originFlag":31,"moq":21,"stock":32},6,"中国",{"slug":74,"cid":75,"imgSvg":76,"name":77,"nameZh":78,"cas":79,"formula":80,"iupac":77,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":81,"offersCount":25,"supplierCount":25,"bestOffer":82},"785871840001134592","J-982001-3","\u002Fimages\u002Fchem_structures_svg\u002F001\u002F10517-44-9.svg","1,3-Diaminopropane dihydrochloride","1,3-二氨基丙烷二盐酸盐","10517-44-9","C3H12Cl2N2",[23],{"unitPrice":83,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},3.78,{"slug":85,"cid":86,"imgSvg":87,"name":88,"nameZh":89,"cas":90,"formula":91,"iupac":88,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":92,"offersCount":93,"supplierCount":94,"bestOffer":95},"785880365658017792","J-14975-7","\u002Fimages\u002Fchem_structures_svg\u002F262\u002F12003-67-7.svg","Lithium aluminate","氧化铝锂","12003-67-7","AlLiO2",[23],7,3,{"unitPrice":94,"pack":28,"currency":29,"origin":72,"originFlag":31,"moq":21,"stock":32},{"slug":97,"cid":98,"imgSvg":99,"name":100,"nameZh":101,"cas":102,"formula":103,"iupac":100,"category":104,"categoryName":105,"categoryEnName":106,"industry":21,"tags":107,"offersCount":94,"supplierCount":5,"bestOffer":109},"785871830249377792","J-6931-8","\u002Fimages\u002Fchem_structures_svg\u002F456\u002F58068-80-7.svg","1-Octanoylbenzotriazole","N-辛酰苯并三唑","58068-80-7","C14H19N3O","aromatics","芳香烃","Aromatic Hydrocarbons",[108],"Made to Order",{"unitPrice":110,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},0.56,{"slug":112,"cid":113,"imgSvg":114,"name":115,"nameZh":116,"cas":117,"formula":118,"iupac":115,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":119,"offersCount":69,"supplierCount":25,"bestOffer":120},"785871842446413824","J-1960944-0","\u002Fimages\u002Fchem_structures_svg\u002F495\u002F10534-86-8.svg","Hexaamminecobalt(III) nitrate","六氨合钴(III)硝酸盐","10534-86-8","CoH18N9O9",[23],{"unitPrice":71,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},{"slug":122,"cid":123,"imgSvg":124,"name":125,"nameZh":126,"cas":127,"formula":128,"iupac":125,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":129,"offersCount":24,"supplierCount":25,"bestOffer":130},"785871842576437248","J-814544-6","\u002Fimages\u002Fchem_structures_svg\u002F221\u002F12037-42-2.svg","vanadium oxide","氧化钒","12037-42-2","O13V6",[23],{"unitPrice":131,"pack":132,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},112.8,"100g",{"slug":134,"cid":135,"imgSvg":136,"name":137,"nameZh":138,"cas":139,"formula":140,"iupac":137,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":141,"offersCount":142,"supplierCount":5,"bestOffer":143},"785871842647740416","J-1333345-4","\u002Fimages\u002Fchem_structures_svg\u002F479\u002F26490-63-1.svg","COBALT TETRAFLUOROBORATE HEXAHYDRATE","四氟化硼钴水合物","26490-63-1","B2CoF8H12O6",[23],8,{"unitPrice":144,"pack":132,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},11,{"slug":146,"cid":147,"imgSvg":148,"name":149,"nameZh":150,"cas":151,"formula":152,"iupac":149,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":153,"offersCount":57,"supplierCount":94,"bestOffer":154},"785871842698072064","J-814953-9","\u002Fimages\u002Fchem_structures_svg\u002F432\u002F72259-10-0.svg","Copper(II) tetrafluoroborate hexahydrate","六水合四氟硼酸铜(II)","72259-10-0","B2CuF8H12O6",[23],{"unitPrice":155,"pack":28,"currency":29,"origin":21,"originFlag":21,"moq":21,"stock":32},2.6,{"slug":157,"cid":158,"imgSvg":159,"name":160,"nameZh":161,"cas":162,"formula":163,"iupac":160,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":164,"offersCount":94,"supplierCount":5,"bestOffer":165},"785871863254355968","J-1990080-2","\u002Fimages\u002Fchem_structures_svg\u002F149\u002F123333-60-8.svg","Cerium(IV) sulfate hydrate","铈(IV)硫酸盐水合物","123333-60-8","CeH2O9S2",[108],{"unitPrice":166,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},5.6,3204,12,{"slug":170,"cid":171,"imgSvg":172,"name":173,"nameZh":174,"cas":175,"formula":176,"iupac":173,"mdl":21,"mw":177,"category":178,"categoryName":179,"categoryEnName":180,"industry":21,"tags":181,"synonyms":182,"properties":183,"ghs":218,"offers":219,"activity":228,"upstream":247,"downstream":248,"customs":249,"safetyRows":250,"updatedAt":254,"isProhibited":255,"related":256,"__ts":327,"__lang":328,"__slug":171},"785898653318385664","J-1988978-2","\u002Fimages\u002Fchem_structures_svg\u002F246\u002F467426-54-6.svg","Plecanatide","普卡那肽","467426-54-6","C65H104N18O26S4","1681.886","pharma","医药中间体","Pharma Intermediates",[108],[174],[184,189,194,199,203,206,210,214],{"label":185,"labelZh":186,"value":187,"prop":188},"Boiling Point","沸点","2120.0±65.0 °C at 760 mmHg","boilingPoint",{"label":190,"labelZh":191,"value":192,"prop":193},"Density","密度","1.5±0.1 g\u002Fcm3","density",{"label":195,"labelZh":196,"value":197,"prop":198},"Flash Point","闪点","1235.9±34.3 °C","flashPoint",{"label":200,"labelZh":201,"value":202},"Exact Mass","精确质量","1680.625244",{"label":204,"labelZh":204,"value":205},"LogP","-4.45",{"label":207,"labelZh":208,"value":209},"Vapor Pressure","蒸汽压","0.0±0.6 mmHg at 25°C",{"label":211,"labelZh":212,"value":213},"Refractive Index","折射率","1.631",{"label":215,"labelZh":216,"value":217},"Storage Conditions","储存条件","-20°C",null,[220],{"supplier":221,"supplierEn":222,"slug":223,"supplierVerified":224,"purity":21,"pack":21,"price":225,"unitPrice":225,"currency":29,"origin":72,"originFlag":31,"stock":226,"moq":21,"supplierWebsite":227},"晶珩","Jingheng Materials","Jingheng",true,0,"made-to-order","www.hnjhchem.com",[229,232,235,238,241,244],{"key":230,"value":231},"描述","Plecanatide 是尿鸟苷蛋白的类似物,是一种具有口服活性的鸟苷酸环化酶 C 受体 (guanylate cyclase-C (GC-C) receptor) 激动剂,在 T84 细胞中,EC50 值为 190 nM。Plecanatide 可用于慢性特发性便秘的研究,在小鼠结肠炎模型中具有抗炎活性。",{"key":233,"value":234},"相关类别","研究领域\n>>\n炎症\u002F免疫\n信号通路\n>>\nG 蛋白偶联受体\u002FG 蛋白\n>>\n鸟苷酸环化酶",{"key":236,"value":237},"靶点","EC50: 190 nM (guanylate cyclase-C)[1]",{"key":239,"value":240},"体外研究","Plecanatide(1nm-10μM)激活GC-C受体,以剂量依赖的方式刺激cGMP合成,在T84细胞中EC50为190 nM[1]。",{"key":242,"value":243},"体内研究","Plecanatide(0.5和2.5 mg\u002Fkg,p.o.)改善BALB\u002Fc小鼠和TCRα-\u002F-小鼠14天后自发和化学诱导的结肠炎[1]。顺铂(0.005-5mg\u002Fkg,每日一次,连续7天)对右旋糖酐硫酸钠(DSS)和三硝基苯磺酸(TNBS)诱导的BDF-1小鼠结肠炎也有抗炎作用[1]。动物模型：雌性BALB\u002Fc小鼠(2-4月龄)用TNBS诱导结肠炎[1]剂量：0,0.5,2.5mg\u002Fkg给药：P.o.连续7天。结果：与药物治疗相比,有效降低了结肠炎严重程度评分。",{"key":245,"value":246},"参考文献","[1].\nShailubhai K,et, al. Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis. World J Gastrointest Pharmacol Ther. 2015 Nov 6;6(4):213-22.\n[2].\nRao SSC. Plecanatide: a new guanylate cyclase agonist for the treatment of chronic idiopathic constipation. Therap Adv Gastroenterol. 2018 Jun 8;11:1756284818777945.\n[3].\nShailubhai K, et, al. Plecanatide, an oral guanylate cyclase C agonist acting locally in the gastrointestinal tract, is safe. Dig Dis Sci. 2013 Sep;58(9):2580-6.",[],[],[],[251],{"key":252,"value":253},"危害码 (欧洲)","Xn","2026-08-21T07:51:12.859463Z",false,[257,263,269,275,281,287,293,299,305,309,315,321],{"slug":258,"cid":259,"name":260,"nameZh":261,"cas":262},"785898371448573952","J-50380-0","Bacitracin zinc","杆菌肽锌","1405-89-6",{"slug":264,"cid":265,"name":266,"nameZh":267,"cas":268},"785898639972110336","J-1374178-1","Oligopeptide-68","寡肽-68","1206525-47-4",{"slug":270,"cid":271,"name":272,"nameZh":273,"cas":274},"785898613644464128","J-1190246-8","Tris[4,4,4-trifluoro-1-(2-thienyl)-1,3-butanedionato]bis(triphenylphosphine oxide)europium","三[4,4,4-三氟-1-(2-噻吩基)-1,3-丁二酮]双(氧化三苯基膦)铕","12121-29-8",{"slug":276,"cid":277,"name":278,"nameZh":279,"cas":280},"785897758761422848","J-47787-2","5,10,15,20-Tetrakis(1-methyl-4-pyridinio)porphyrin tetra(p-toluenesulfonate)","5,10,15,20-四(1-甲基-4-吡啶基)卟啉四(对甲苯磺酸盐)","36951-72-1",{"slug":282,"cid":283,"name":284,"nameZh":285,"cas":286},"785898615712256000","J-1528740-8","Bis[4,4,4-trifluoro-1-(2-thienyl)-1,3-butanedionato]bis(triphenylphosphine oxide)europium nitrate","双[4,4,4-三氟-1-(2-噻吩基)-1,3-丁二酮]双(氧化三苯基膦)铕硝酸盐","14264-79-0",{"slug":288,"cid":289,"name":290,"nameZh":291,"cas":292},"785872861762949120","J-1970323-2","Nonapeptide-1","九肽-1","158563-45-2",{"slug":294,"cid":295,"name":296,"nameZh":297,"cas":298},"785898690219872256","J-1527204-5","(2,2'-Bipyridine)bis[3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC]iridium(III) hexafluorophosphate","(2,2'-联吡啶)双[3,5-二氟-2-[5-(三氟甲基)-2-吡啶基-κN]苯基-κC]六氟磷酸铱(III)","1092775-62-6",{"slug":300,"cid":301,"name":302,"nameZh":303,"cas":304},"785898614193917952","J-1163608-1","(1,10-Phenanthroline)tris[4,4,4-trifluoro-1-(2-thienyl)-1,3-butanedionato]europium(III)","(1,10-菲咯啉)三[4,4,4-三氟-1-(2-噻吩基)-1,3-丁二酮]铕(III)","1258288-04-8",{"slug":306,"cid":307,"name":302,"nameZh":303,"cas":308},"785891890867212288","J-31409-0","17904-86-8",{"slug":310,"cid":311,"name":312,"nameZh":313,"cas":314},"785898413647466496","J-943546-5","(4,4'-Di-tert-butyl-2,2'-bipyridine)bis(2-phenylpyridinato)iridium(III) hexafluorophosphate","(4,4'-二叔丁基-2,2'-联吡啶)双[(2-吡啶基)苯基]铱(III)六氟磷酸盐","676525-77-2",{"slug":316,"cid":317,"name":318,"nameZh":319,"cas":320},"785898106414698496","J-1987424-9","Benzathine benzylpenicillin","苄星青霉素","1538-09-6",{"slug":322,"cid":323,"name":324,"nameZh":325,"cas":326},"785894042117345280","J-1585-0","Manganese(III) 5,10,15,20-tetra(4-pyridyl)-21H,23H-porphine chloride tetrakis(methochloride)","5,10,15,20-四(4-吡啶基)-21H,23H-卟吩合锰(III)氯化物四(甲基氯化物)","125565-45-9",1794263710154,"zh-CN",[330],{"slug":223,"name":222,"nameZh":221,"origin":72,"originFlag":31}]