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TNP-470将KKU-M213的迁移细胞减少至26％,将KKU-M214迁移至11％(P \u003C0.01)。同样,TNP-470也显着影响细胞侵袭,入侵细胞数量在KKU-M213中降低至25％(P \u003C0.01),在KKU-M214中降至15％(P \u003C0.01)。与载体处理的细胞相比,TNP-470处理的细胞中MMP2,MMP9和c-MYC的相对表达被显着抑制[1]。",{"key":232,"value":233},"体内研究","与高脂肪喂养(HFF)小鼠相比,用TNP-470处理减弱(P \u003C0.05)肝脏脂质积累。到第5天,TNP-470处理的小鼠比载体处理的HFF小鼠消耗显着更少克的高脂肪食物。在治疗的第15天,尽管提供了高脂肪饮食,但TNP-470小鼠消耗的热量与食物喂养的小鼠相当。与喂食食物和高脂肪的对照相比,用TNP-470处理增加(P \u003C0.05)脂肪组织LPL mRNA的表达。 TNP-470减少能量摄入并增加能量消耗[2]。",{"key":235,"value":236},"细胞实验","MTT测定用于测试细胞活力。简而言之，将每孔3×103个细胞接种在96孔板中，并与不同浓度的TNP-470在37℃，5％CO 2下孵育24,48和72小时。为了比较，将在不存在TNP-470的情况下培养的细胞用作对照。孵育期后，向每个孔中加入10μLMTT（0.5mg \u002F mL终浓度）。再孵育4小时后，加入100μL的0.01N HCl的异丙醇溶液以溶解晶体。通过ELISA板读数器[1]测定570nm处的吸收。",{"key":238,"value":239},"动物实验","在本研究中使用单独饲养的4周龄雄性C57BL \u002F 6小鼠。在1周适应期后，将小鼠随机分配接受标准饲料或高脂肪饮食6.5周。在整个高脂肪喂养期间，小鼠用20mg \u002F kg体重剂量的TNP-470治疗，每隔一天皮下注射（TNP; n = 7）或等体积的载体注射（HFF对照; N = 7）。载体注射在磷酸盐缓冲盐水中含有3％乙醇。假饲喂对照小鼠（食物; n = 8）进行假注射。随意喂食小鼠，每2或3天更换一次食物。每周收集三次体重。喂食6.5周后，将动物禁食16小时并处死。测量最终的身体，肝脏和附睾脂肪组织重量。将肝脏和脂肪组织样品在液氮中冷冻并储存在-80℃下用于后续分析[2]。",{"key":241,"value":242},"参考文献","[1].\nKidoikhammouan S, et al. 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