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治疗组肿瘤体积在第1天的平均值）\u002F（平均值）对照组肿瘤体积对第1天对照组肿瘤体积的评价日均值]]×100。大鼠[3]雌性Wistar白化大鼠，体重226-243g（平均体重，241.09g），用于本研究。以吲哚美辛给药的同一天开始，通过口胃管向Nilotinib组大鼠（n = 7）施用尼罗替尼，以两个分剂量施用20mg \u002F kg \u002F d，持续13天。在13-d期结束时，在乙醚麻醉下从所有大鼠获得用于病理学检查的血液和组织样品。然后通过断头处死所有动物。",{"key":240,"value":241},"参考文献","[1].\nWeisberg E, et al. Beneficial effects of combining nilotinib and imatinib in preclinical models of BCR-ABL+ leukemias. Blood. 2007 Mar 1;109(5):2112-20.\n[2].\nSako H, et al. Antitumor effect of the tyrosine kinase inhibitor Nilotinib on gastrointestinal stromal tumor (GIST) and Imatinib-resistant GIST cells. PLoS One. 2014 Sep 15;9(9):e107613.\n[3].\nDervis Hakim G, et al. Mucosal healing effect of nilotinib in indomethacin-induced enterocolitis: A rat model. World J Gastroenterol. 2015 Nov 28;21(44):12576-85.\n[4].\nFujita KI, et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites. J Pharm Sci. 2017 Sep;106(9):2632-2641.\n[5].\nMeirson T, et al. Targeting invadopodia-mediated breast cancer metastasis by using ABL kinase inhibitors. 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