[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"$fyk2oeqxpb7bd":3,"currency-rates":167,"compound-J-1986971-1":171,"verified-suppliers-J-1986971-1":323},{"rows":4,"total":166,"current":37,"size":141},[5,28,41,56,70,81,92,109,119,131,142,154],{"slug":6,"cid":7,"imgSvg":8,"name":9,"nameZh":10,"cas":11,"formula":12,"iupac":9,"category":13,"categoryName":14,"categoryEnName":15,"industry":16,"tags":17,"offersCount":19,"supplierCount":20,"bestOffer":21},"843627791009189888","J-1971488-8","\u002Fimages\u002Fchem_structures_svg\u002F399\u002F65845-61-6.svg","N-Methylcyclohexanamine hydrochloride","N-甲基环己胺盐酸盐","65845-61-6","C7H16ClN","acids","有机酸","Organic Acids","",[18],"In Stock",4,2,{"unitPrice":22,"pack":23,"currency":24,"origin":25,"originFlag":26,"moq":16,"stock":27},2.64,"500g","CNY","China","CN","in-stock",{"slug":29,"cid":30,"imgSvg":31,"name":32,"nameZh":33,"cas":34,"formula":35,"iupac":32,"category":13,"categoryName":14,"categoryEnName":15,"industry":16,"tags":36,"offersCount":19,"supplierCount":37,"bestOffer":38},"785882541994283008","J-1323843-4","\u002Fimages\u002Fchem_structures_svg\u002F104\u002F67627-18-3.svg","Potassium indigotrisulfonate","靛蓝三磺酸钾","67627-18-3","C16H7K3N2O11S3",[18],1,{"unitPrice":39,"pack":40,"currency":24,"origin":25,"originFlag":26,"moq":16,"stock":27},180,"5g",{"slug":42,"cid":43,"imgSvg":44,"name":45,"nameZh":46,"cas":47,"formula":48,"iupac":45,"category":49,"categoryName":50,"categoryEnName":51,"industry":16,"tags":52,"offersCount":53,"supplierCount":20,"bestOffer":54},"785889752443260928","J-28559-9","\u002Fimages\u002Fchem_structures_svg\u002F292\u002F15060-55-6.svg","Ammonium tetrathiomolybdate","四硫钼酸铵","15060-55-6","H8MoN2S4","inorganic","无机化合物","Inorganic Chemicals",[18],7,{"unitPrice":55,"pack":23,"currency":24,"origin":25,"originFlag":26,"moq":16,"stock":27},24,{"slug":57,"cid":58,"imgSvg":59,"name":60,"nameZh":61,"cas":62,"formula":63,"iupac":60,"category":13,"categoryName":14,"categoryEnName":15,"industry":16,"tags":64,"offersCount":65,"supplierCount":20,"bestOffer":66},"855452191530422272","J-1994428-7","\u002Fimages\u002Fchem_structures_svg\u002F500\u002F16350-96-2.svg","N-benzylcyclohexanamine.hydrochloride","N-苄基环己胺盐酸盐","16350-96-2","C13H20ClN",[18],5,{"unitPrice":67,"pack":68,"currency":24,"origin":69,"originFlag":26,"moq":16,"stock":27},6,"1000g","中国",{"slug":71,"cid":72,"imgSvg":73,"name":74,"nameZh":75,"cas":76,"formula":77,"iupac":74,"category":13,"categoryName":14,"categoryEnName":15,"industry":16,"tags":78,"offersCount":20,"supplierCount":20,"bestOffer":79},"785871840001134592","J-982001-0","\u002Fimages\u002Fchem_structures_svg\u002F001\u002F10517-44-9.svg","1,3-Diaminopropane dihydrochloride","1,3-二氨基丙烷二盐酸盐","10517-44-9","C3H12Cl2N2",[18],{"unitPrice":80,"pack":23,"currency":24,"origin":25,"originFlag":26,"moq":16,"stock":27},3.78,{"slug":82,"cid":83,"imgSvg":84,"name":85,"nameZh":86,"cas":87,"formula":88,"iupac":85,"category":49,"categoryName":50,"categoryEnName":51,"industry":16,"tags":89,"offersCount":53,"supplierCount":90,"bestOffer":91},"785880365658017792","J-14975-6","\u002Fimages\u002Fchem_structures_svg\u002F262\u002F12003-67-7.svg","Lithium aluminate","氧化铝锂","12003-67-7","AlHLiO2",[18],3,{"unitPrice":90,"pack":23,"currency":24,"origin":69,"originFlag":26,"moq":16,"stock":27},{"slug":93,"cid":94,"imgSvg":95,"name":96,"nameZh":97,"cas":98,"formula":99,"iupac":96,"category":100,"categoryName":101,"categoryEnName":102,"industry":16,"tags":103,"offersCount":104,"supplierCount":104,"bestOffer":105},"785871830249377792","J-6931-9","\u002Fimages\u002Fchem_structures_svg\u002F456\u002F58068-80-7.svg","1-Octanoylbenzotriazole","N-辛酰苯并三唑","58068-80-7","C14H19N3O","aromatics","芳香烃","Aromatic Hydrocarbons",[],0,{"unitPrice":106,"pack":16,"currency":107,"origin":16,"originFlag":16,"moq":16,"stock":108},9007199254740991,"USD","made-to-order",{"slug":110,"cid":111,"imgSvg":112,"name":113,"nameZh":114,"cas":115,"formula":116,"iupac":113,"category":49,"categoryName":50,"categoryEnName":51,"industry":16,"tags":117,"offersCount":65,"supplierCount":20,"bestOffer":118},"785871842446413824","J-1960944-3","\u002Fimages\u002Fchem_structures_svg\u002F495\u002F10534-86-8.svg","Hexaamminecobalt(III) nitrate","六氨合钴(III)硝酸盐","10534-86-8","CoH18N9O9",[18],{"unitPrice":67,"pack":23,"currency":24,"origin":25,"originFlag":26,"moq":16,"stock":27},{"slug":120,"cid":121,"imgSvg":122,"name":123,"nameZh":124,"cas":125,"formula":126,"iupac":123,"category":49,"categoryName":50,"categoryEnName":51,"industry":16,"tags":127,"offersCount":19,"supplierCount":20,"bestOffer":128},"785871842576437248","J-814544-6","\u002Fimages\u002Fchem_structures_svg\u002F221\u002F12037-42-2.svg","vanadium oxide","氧化钒","12037-42-2","O13V6",[18],{"unitPrice":129,"pack":130,"currency":24,"origin":25,"originFlag":26,"moq":16,"stock":27},112.8,"100g",{"slug":132,"cid":133,"imgSvg":134,"name":135,"nameZh":136,"cas":137,"formula":138,"iupac":135,"category":49,"categoryName":50,"categoryEnName":51,"industry":16,"tags":139,"offersCount":53,"supplierCount":37,"bestOffer":140},"785871842647740416","J-1333345-2","\u002Fimages\u002Fchem_structures_svg\u002F479\u002F26490-63-1.svg","COBALT TETRAFLUOROBORATE HEXAHYDRATE","四氟化硼钴水合物","26490-63-1","B2CoF8H12O6",[18],{"unitPrice":141,"pack":130,"currency":24,"origin":25,"originFlag":26,"moq":16,"stock":27},12,{"slug":143,"cid":144,"imgSvg":145,"name":146,"nameZh":147,"cas":148,"formula":149,"iupac":146,"category":49,"categoryName":50,"categoryEnName":51,"industry":16,"tags":150,"offersCount":151,"supplierCount":90,"bestOffer":152},"785871842698072064","J-814953-0","\u002Fimages\u002Fchem_structures_svg\u002F432\u002F72259-10-0.svg","Copper(II) tetrafluoroborate hexahydrate","六水合四氟硼酸铜(II)","72259-10-0","B2CuF8H12O6",[18],10,{"unitPrice":153,"pack":23,"currency":24,"origin":16,"originFlag":16,"moq":16,"stock":27},2.6,{"slug":155,"cid":156,"imgSvg":157,"name":158,"nameZh":159,"cas":160,"formula":161,"iupac":158,"category":49,"categoryName":50,"categoryEnName":51,"industry":16,"tags":162,"offersCount":20,"supplierCount":37,"bestOffer":164},"785871863254355968","J-1990080-7","\u002Fimages\u002Fchem_structures_svg\u002F149\u002F123333-60-8.svg","Cerium(IV) sulfate hydrate","铈(IV)硫酸盐水合物","123333-60-8","CeH2O9S2",[163],"Made to Order",{"unitPrice":165,"pack":23,"currency":24,"origin":25,"originFlag":26,"moq":16,"stock":27},5.6,3204,{"rates":168,"source":170},{"USD":37,"CNY":169},6.691314,"live",{"slug":172,"cid":173,"imgSvg":174,"name":175,"nameZh":175,"cas":176,"formula":177,"iupac":175,"mdl":16,"mw":178,"category":179,"categoryName":180,"categoryEnName":181,"industry":16,"tags":182,"synonyms":183,"properties":192,"ghs":215,"offers":216,"activity":217,"upstream":239,"downstream":276,"customs":277,"safetyRows":278,"updatedAt":282,"isProhibited":283,"related":284,"__ts":321,"__lang":322,"__slug":173},"785897731628470272","J-1986971-1","\u002Fimages\u002Fchem_structures_svg\u002F312\u002F394730-60-0.svg","波普瑞韦","394730-60-0","C27H45N5O5","519.677","organic","有机化合物","Organic Compounds",[],[184,185,186,187,188,189,190,191],"伯克匹韦","博赛泼维","博塞匹韦","波西普韦","博赛匹韦","博普瑞韦","波塞普韦","波普瑞伟",[193,197,201,204,207,211],{"label":194,"labelZh":194,"value":195,"prop":196},"Density","1.2±0.1 g\u002Fcm3","density",{"label":198,"labelZh":199,"value":200},"Exact Mass","精确质量","519.342041",{"label":202,"labelZh":202,"value":203},"PSA","150.70000",{"label":205,"labelZh":205,"value":206},"LogP","2.05",{"label":208,"labelZh":209,"value":210},"Refractive Index","折射率","1.533",{"label":212,"labelZh":213,"value":214},"Storage Conditions","储存条件","-20℃",null,[],[218,221,224,227,230,233,236],{"key":219,"value":220},"描述","Boceprevir 是一种口服有效的选择性的 HCV NS3 protease 抑制剂,酶实验中Ki 为 14 nM,在含细胞体系的复制实验中,EC90 为 350 nM。",{"key":222,"value":223},"相关类别","信号通路\n>>\n代谢酶\u002F蛋白酶\n>>\nHCV蛋白酶\n信号通路\n>>\n抗感染\n>>\nHCV\n研究领域\n>>\n感染",{"key":225,"value":226},"靶点","Ki: 14 nM (HCV NS3 protease)[1]",{"key":228,"value":229},"体外研究","在HCV NS3蛋白酶连续测定中,Boceprevir(SCH 503034)在大量运行中具有14nM(Ki)平均效力。在HuH-7细胞中的72小时双顺反子亚基因组细胞复制子测定中,EC 50和EC 90值分别确定为0.20μM和0.35μM。 Boceprevir也被发现是一种非常弱的HNE抑制剂(Ki =26μM),代表选择性为2200 [1]。",{"key":231,"value":232},"体内研究","Boceprevir,一种用于治疗丙型肝炎病毒感染的HCV蛋白酶抑制剂。在几种动物物种中评估了Boceprevir的药代动力学特征。口服给药后,Boceprevir在大鼠(10mg\u002Fkg),狗(3mg\u002Fkg)和猴子(3mg\u002Fkg)中适度吸收。狗的吸收相对较快,但小鼠(10 mg\u002Fkg),大鼠和猴子的吸收较慢,平均吸收时间(MAT)为0.5至1.4小时。 AUC在狗和大鼠中是好的,在小鼠中是适中的,在猴中是低的。绝对口服生物利用度在小鼠,大鼠和狗中是适度的(26-34％),但在猴子中是低的(4％)[1]。 Boceprevir(100 mg\u002Fkg,口服)抑制三转基因小鼠的HCV NS3\u002F4A蛋白酶活性[2]。",{"key":234,"value":235},"动物实验","小鼠[2] Boceprevir购自MedChem Express。为了评估Boceprevir的效果，用强力霉素（Dox）诱导三转基因小鼠10天（每组n = 5）。在Dox诱导后的第三天，当血浆Gluc活性达到其峰值时，通过口服管饲法每天两次给予小鼠Boceprevir（100mg \u002F kg）或DMSO，持续7天。在此期间，每天从尾静脉采集血液以检测血浆Gluc活性。",{"key":237,"value":238},"参考文献","[1].\nNjoroge FG, et al. Challenges in modern drug discovery: a case study of boceprevir, an HCV protease inhibitor for the treatment of hepatitis C virus infection. Acc Chem Res. 2008 Jan;41(1):50-9.\n[2].\nYao M, et al. Conditional Inducible Triple-Transgenic Mouse Model for Rapid Real-Time Detection of HCV NS3\u002F4A ProteaseActivity. PLoS One. 2016 Mar 4;11(3):e0150894.\n[3].\nCoilly A, et al. Practical management of boceprevir and immunosuppressive therapy in liver transplant recipients with hepatitis C virus recurrence. Antimicrob Agents Chemother. 2012 Nov;56(11):5728-34.\n[4].\nBerenguer M, et al. New developments in the management of hepatitis C virus infection: focus on boceprevir. Biologics. 2012;6:249-56.\n[5].\nBurton MJ, et al. Telaprevir and boceprevir in african americans with genotype 1 chronic hepatitis C: implications for patients and providers. South Med J. 2012 Aug;105(8):431-6.",[240,246,252,258,264,270],{"slug":241,"cid":242,"name":243,"nameZh":243,"cas":244,"imgSvg":245},"785896549518413800","J-1516098-0","(1R,2S,5S)-3-[(...","816444-90-3","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F175\u002F816444-90-3.svg",{"slug":247,"cid":248,"name":249,"nameZh":249,"cas":250,"imgSvg":251},"785872448842108900","J-1330948-8","2-羰基-3-氨基-4环丁烷丁酰胺盐酸盐","817169-86-1","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F093\u002F817169-86-1.svg",{"slug":253,"cid":254,"name":255,"nameZh":255,"cas":256,"imgSvg":257},"785882047418732500","J-1123332-5","(1-环丁基-3-氧代丙烷-2...","394735-19-4","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F265\u002F394735-19-4.svg",{"slug":259,"cid":260,"name":261,"nameZh":261,"cas":262,"imgSvg":263},"785894270283288600","J-1501788-0","1-氰基-3-环丁基-1-羟基...","394735-20-7","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F410\u002F394735-20-7.svg",{"slug":265,"cid":266,"name":267,"nameZh":267,"cas":268,"imgSvg":269},"785893297099903000","J-1428885-6","BOC-DL-环丁基丙氨酸","565456-75-9","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F106\u002F565456-75-9.svg",{"slug":271,"cid":272,"name":273,"nameZh":273,"cas":274,"imgSvg":275},"785876567774466000","J-1052702-7","2-氨基-3-环丁基丙酸乙酯","394735-17-2","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F341\u002F394735-17-2.svg",[],[],[279],{"key":280,"value":281},"危害码 (欧洲)","Xi","2026-08-21T07:51:12.859463Z",false,[285,291,297,303,309,315],{"slug":286,"cid":287,"name":288,"nameZh":289,"cas":290},"785897816206610432","J-1946922-3","Carmine alum lake","胭脂红铝","1328-60-5",{"slug":292,"cid":293,"name":294,"nameZh":295,"cas":296},"785884049620078592","J-22716-8","Cobalt phthalocyanine","酞菁钴","3317-67-7",{"slug":298,"cid":299,"name":300,"nameZh":301,"cas":302},"785883051367337984","J-6801-5","Chromotrope 2B","铬变素2B","548-80-1",{"slug":304,"cid":305,"name":306,"nameZh":307,"cas":308},"785882767572340736","J-5720-4","Dilithium phthalocyanine-29,30-diide","酞菁二锂","25510-41-2",{"slug":310,"cid":311,"name":312,"nameZh":313,"cas":314},"785875803232538624","J-1044195-4","Copper(II) ionophore I","铜(II) 离子载体 I","125769-67-7",{"slug":316,"cid":317,"name":318,"nameZh":319,"cas":320},"785875919876132864","J-11268-8","Bis(tri-tert-butylphosphine)palladium(0)","双(三叔丁基膦)钯(0)","53199-31-8",1792619923576,"zh-CN",[]]