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7.4的250μL\u002F孔Hanks'平衡盐溶液交换培养基。将细胞与每种化合物（异丙肾上腺素，Mirabegron，BRL37344和CL316,243，终浓度10-10至10-4M）在37℃温育10分钟，然后通过加入250μL终止温育。 0.2M HCl。使用γ计数器，使用125I-cAMP测定系统，通过放射免疫测定法测量反应混合物中的cAMP浓度。将50微升反应混合物与50μL琥珀酰试剂在室温下孵育10分钟，之后通过加入400μL缓冲溶液终止反应。将50微升琥珀酰化的样品与50μL的125 I-cAMP和50μL的抗cAMP抗体在4℃温育24小时。在孵育期结束时，加入250μL活性炭悬浮液，并在4℃下以2800g离心10分钟。将250微升上清液转移到管中并使用γ计数器计数1分钟。使用每种化合物的最大反应计算每种β-肾上腺素受体激动剂相对于异丙肾上腺素的内在活性（IA）[1]。",{"key":258,"value":259},"动物实验","大鼠[1]使用雄性（350至400g）和雌性（225至290g）Wistar大鼠。 Mirabegron的自由形式剂量为0.03,0.1,0.3,1和3mg \u002F kg，奥昔布宁为0.0272,0.0907,0.272,0.907和2.72mg \u002F kg。",{"key":261,"value":262},"参考文献","[1].\nTakasu T, et al. 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