[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"currency-rates":3,"$fyk2oeqxpb7bd":8,"compound-J-1986485-1":171,"verified-suppliers-J-1986485-1":345},{"rates":4,"source":7},{"USD":5,"CNY":6},1,6.689327,"live",{"rows":9,"total":170,"current":5,"size":145},[10,33,45,60,74,85,96,113,123,135,146,158],{"slug":11,"cid":12,"imgSvg":13,"name":14,"nameZh":15,"cas":16,"formula":17,"iupac":14,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":22,"offersCount":24,"supplierCount":25,"bestOffer":26},"843627791009189888","J-1971488-8","\u002Fimages\u002Fchem_structures_svg\u002F399\u002F65845-61-6.svg","N-Methylcyclohexanamine hydrochloride","N-甲基环己胺盐酸盐","65845-61-6","C7H16ClN","acids","有机酸","Organic Acids","",[23],"In Stock",4,2,{"unitPrice":27,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},2.64,"500g","CNY","China","CN","in-stock",{"slug":34,"cid":35,"imgSvg":36,"name":37,"nameZh":38,"cas":39,"formula":40,"iupac":37,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":41,"offersCount":24,"supplierCount":5,"bestOffer":42},"785882541994283008","J-1323843-4","\u002Fimages\u002Fchem_structures_svg\u002F104\u002F67627-18-3.svg","Potassium indigotrisulfonate","靛蓝三磺酸钾","67627-18-3","C16H7K3N2O11S3",[23],{"unitPrice":43,"pack":44,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},180,"5g",{"slug":46,"cid":47,"imgSvg":48,"name":49,"nameZh":50,"cas":51,"formula":52,"iupac":49,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":56,"offersCount":57,"supplierCount":25,"bestOffer":58},"785889752443260928","J-28559-9","\u002Fimages\u002Fchem_structures_svg\u002F292\u002F15060-55-6.svg","Ammonium tetrathiomolybdate","四硫钼酸铵","15060-55-6","H8MoN2S4","inorganic","无机化合物","Inorganic Chemicals",[23],7,{"unitPrice":59,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},24,{"slug":61,"cid":62,"imgSvg":63,"name":64,"nameZh":65,"cas":66,"formula":67,"iupac":64,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":68,"offersCount":69,"supplierCount":25,"bestOffer":70},"855452191530422272","J-1994428-7","\u002Fimages\u002Fchem_structures_svg\u002F500\u002F16350-96-2.svg","N-benzylcyclohexanamine.hydrochloride","N-苄基环己胺盐酸盐","16350-96-2","C13H20ClN",[23],5,{"unitPrice":71,"pack":72,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},6,"1000g","中国",{"slug":75,"cid":76,"imgSvg":77,"name":78,"nameZh":79,"cas":80,"formula":81,"iupac":78,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":82,"offersCount":25,"supplierCount":25,"bestOffer":83},"785871840001134592","J-982001-0","\u002Fimages\u002Fchem_structures_svg\u002F001\u002F10517-44-9.svg","1,3-Diaminopropane dihydrochloride","1,3-二氨基丙烷二盐酸盐","10517-44-9","C3H12Cl2N2",[23],{"unitPrice":84,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},3.78,{"slug":86,"cid":87,"imgSvg":88,"name":89,"nameZh":90,"cas":91,"formula":92,"iupac":89,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":93,"offersCount":57,"supplierCount":94,"bestOffer":95},"785880365658017792","J-14975-6","\u002Fimages\u002Fchem_structures_svg\u002F262\u002F12003-67-7.svg","Lithium aluminate","氧化铝锂","12003-67-7","AlHLiO2",[23],3,{"unitPrice":94,"pack":28,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},{"slug":97,"cid":98,"imgSvg":99,"name":100,"nameZh":101,"cas":102,"formula":103,"iupac":100,"category":104,"categoryName":105,"categoryEnName":106,"industry":21,"tags":107,"offersCount":108,"supplierCount":108,"bestOffer":109},"785871830249377792","J-6931-9","\u002Fimages\u002Fchem_structures_svg\u002F456\u002F58068-80-7.svg","1-Octanoylbenzotriazole","N-辛酰苯并三唑","58068-80-7","C14H19N3O","aromatics","芳香烃","Aromatic Hydrocarbons",[],0,{"unitPrice":110,"pack":21,"currency":111,"origin":21,"originFlag":21,"moq":21,"stock":112},9007199254740991,"USD","made-to-order",{"slug":114,"cid":115,"imgSvg":116,"name":117,"nameZh":118,"cas":119,"formula":120,"iupac":117,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":121,"offersCount":69,"supplierCount":25,"bestOffer":122},"785871842446413824","J-1960944-3","\u002Fimages\u002Fchem_structures_svg\u002F495\u002F10534-86-8.svg","Hexaamminecobalt(III) nitrate","六氨合钴(III)硝酸盐","10534-86-8","CoH18N9O9",[23],{"unitPrice":71,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},{"slug":124,"cid":125,"imgSvg":126,"name":127,"nameZh":128,"cas":129,"formula":130,"iupac":127,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":131,"offersCount":24,"supplierCount":25,"bestOffer":132},"785871842576437248","J-814544-6","\u002Fimages\u002Fchem_structures_svg\u002F221\u002F12037-42-2.svg","vanadium oxide","氧化钒","12037-42-2","O13V6",[23],{"unitPrice":133,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},112.8,"100g",{"slug":136,"cid":137,"imgSvg":138,"name":139,"nameZh":140,"cas":141,"formula":142,"iupac":139,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":143,"offersCount":57,"supplierCount":5,"bestOffer":144},"785871842647740416","J-1333345-2","\u002Fimages\u002Fchem_structures_svg\u002F479\u002F26490-63-1.svg","COBALT TETRAFLUOROBORATE HEXAHYDRATE","四氟化硼钴水合物","26490-63-1","B2CoF8H12O6",[23],{"unitPrice":145,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},12,{"slug":147,"cid":148,"imgSvg":149,"name":150,"nameZh":151,"cas":152,"formula":153,"iupac":150,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":154,"offersCount":155,"supplierCount":94,"bestOffer":156},"785871842698072064","J-814953-0","\u002Fimages\u002Fchem_structures_svg\u002F432\u002F72259-10-0.svg","Copper(II) tetrafluoroborate hexahydrate","六水合四氟硼酸铜(II)","72259-10-0","B2CuF8H12O6",[23],10,{"unitPrice":157,"pack":28,"currency":29,"origin":21,"originFlag":21,"moq":21,"stock":32},2.6,{"slug":159,"cid":160,"imgSvg":161,"name":162,"nameZh":163,"cas":164,"formula":165,"iupac":162,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":166,"offersCount":25,"supplierCount":5,"bestOffer":168},"785871863254355968","J-1990080-7","\u002Fimages\u002Fchem_structures_svg\u002F149\u002F123333-60-8.svg","Cerium(IV) sulfate hydrate","铈(IV)硫酸盐水合物","123333-60-8","CeH2O9S2",[167],"Made to Order",{"unitPrice":169,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},5.6,3204,{"slug":172,"cid":173,"imgSvg":174,"name":175,"nameZh":175,"cas":176,"formula":177,"iupac":175,"mdl":21,"mw":178,"category":179,"categoryName":180,"categoryEnName":181,"industry":21,"tags":182,"synonyms":183,"properties":188,"ghs":236,"offers":237,"activity":238,"upstream":260,"downstream":279,"customs":286,"safetyRows":299,"updatedAt":304,"isProhibited":305,"related":306,"__ts":343,"__lang":344,"__slug":173},"785897259488251904","J-1986485-1","\u002Fimages\u002Fchem_structures_svg\u002F169\u002F218600-53-4.svg","甲基巴多索隆","218600-53-4","C32H43NO4","505.688","organic","有机化合物","Organic Compounds",[],[184,185,186,187],"2-氰基-3,12-二氧代齐墩果-1,9(11)-二烯-28-酸甲酯","CDDO甲基酯","RTA 402","NSC 713200",[189,194,199,204,209,213,217,220,224,228,232],{"label":190,"labelZh":191,"value":192,"prop":193},"Melting Point","熔点","215-223 °C","meltingPoint",{"label":195,"labelZh":196,"value":197,"prop":198},"Boiling Point","沸点","600.8±55.0 °C at 760 mmHg","boilingPoint",{"label":200,"labelZh":201,"value":202,"prop":203},"Density","密度","1.2±0.1 g\u002Fcm3","density",{"label":205,"labelZh":206,"value":207,"prop":208},"Flash Point","闪点","256.5±21.7 °C","flashPoint",{"label":210,"labelZh":211,"value":212},"Exact Mass","精确质量","505.319214",{"label":214,"labelZh":215,"value":216},"PSA","其他信息","84.23000",{"label":218,"labelZh":218,"value":219},"LogP","6.22",{"label":221,"labelZh":222,"value":223},"Appearance","外观性状","固体",{"label":225,"labelZh":226,"value":227},"Vapor Pressure","蒸汽压","0.0±1.7 mmHg at 25°C",{"label":229,"labelZh":230,"value":231},"Refractive Index","折射率","1.559",{"label":233,"labelZh":234,"value":235},"Storage Conditions","储存条件","-20 °C",null,[],[239,242,245,248,251,254,257],{"key":240,"value":241},"描述","Bardoxolone是一种合成的三萜类化合物,具有潜在的抗肿瘤和抗炎活性,作为 Nrf2 通路的激活剂和 NF-κB 途径的抑制剂。",{"key":243,"value":244},"相关类别","信号通路\n>>\n自噬\n>>\n自噬\n信号通路\n>>\nNF-κB信号通路\n>>\nKEAP1-Nrf2\n研究领域\n>>\n癌症",{"key":246,"value":247},"靶点","Nrf2[1]",{"key":249,"value":250},"体内研究","Bardoxolone Methyl(30 mg\u002Fkg,po)可降低巨蛋白的肾脏表达,但不会降低cubilin,提高肌酐清除率和尿白蛋白与肌酐的比值,并诱导食蟹猴的Nrf2细胞保护作用[1]。在动物模型和临床试验中,Bardoxolone Methyl通过改善eGFR可以对心脏产生总体有利影响[2]。",{"key":252,"value":253},"激酶实验","将来自28天猴研究的肾组织在液氮中快速冷冻，并储存在-80℃直至分析。将肾组织在含有2mM乙二胺四乙酸（EDTA）的250mg组织\u002F mL冰冷PBS（pH7.2）中匀浆。然后将匀浆物在4℃下以10,000×g离心10分钟。收集上清液并储存在-80℃直至分析。使用来自Pierce Biotechnology的Bicinchoninic Acid（BCA）Protein Assay Kit测定组织匀浆的蛋白质浓度。通过定量2,6-二氯苯酚 - 靛酚（DCPIP）的还原速率来确定NQO1酶活性。使用市售试剂盒测定Gsr酶活性。将所有酶活性标准化为蛋白质并呈现为折叠载体对照。",{"key":255,"value":256},"动物实验","在食蟹猴中进行了两项独立的生命研究。在一项研究中，使用芝麻油作为载体，通过口服强饲法给予食蟹猴（n = 9 \u002F性别\u002F剂量组）无定形的bardoxolone甲基，在GLP中以5,30和300mg \u002F kg每天一次，持续12个月。环境。对于所有动物，每天两次对发病率，死亡率，损伤以及食物和水的可用性进行观察。每周进行临床观察和体重测量并记录。通过使用线性梯形方法计算重量 - 时间曲线下的面积来分析重量数据。在中期（6个月）和终末期（12个月）尸检前，从所有动物预测试和所有动物收集用于临床化学评估的血液样品。使每个剂量组的另一组猴子恢复4周。",{"key":258,"value":259},"参考文献","[1].\nReisman SA, et al. Bardoxolone Methyl Decreases Megalin and Activates Nrf2 in the Kidney. J Am Soc Nephrol. 2012 Aug 2.\n[2].\nMcCullough PA, et al. Cardiac and renal function in patients with type 2 diabetes who have chronic kidney disease: potential effects of bardoxolone methyl. Drug Des Devel Ther. 2012;6:141-9.",[261,267,273],{"slug":262,"cid":263,"name":264,"nameZh":264,"cas":265,"imgSvg":266},"785894563683242000","J-38026-9","齐墩果酸","508-02-1","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F334\u002F508-02-1.svg",{"slug":268,"cid":269,"name":270,"nameZh":270,"cas":271,"imgSvg":272},"785884648054984700","J-1320549-4","齐墩果酸甲酯","1724-17-0","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F090\u002F1724-17-0.svg",{"slug":274,"cid":275,"name":276,"nameZh":276,"cas":277,"imgSvg":278},"785875690846163000","J-1039256-6","3,12-二氧代齐墩果-9(1...","218600-50-1","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F283\u002F218600-50-1.svg",[280],{"slug":281,"cid":282,"name":283,"nameZh":283,"cas":284,"imgSvg":285},"785897241545019400","J-1986451-4","2-氰基-3,12-二氧代齐墩...","218600-44-3","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F338\u002F218600-44-3.svg",[287,290,293,296],{"key":288,"value":289},"海关编码","2926909090",{"key":291,"value":292},"中文概述","2926909090 其他腈基化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%",{"key":294,"value":295},"申报要素","品名, 成分含量, 用途",{"key":297,"value":298},"Summary","HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%",[300,303],{"key":301,"value":302},"危险品运输编码","NONH for all modes of transport",{"key":288,"value":289},"2026-08-21T07:51:12.859463Z",false,[307,313,319,325,331,337],{"slug":308,"cid":309,"name":310,"nameZh":311,"cas":312},"785892233441185792","J-1960577-5","Mupirocin lithium","莫匹罗星锂","73346-79-9",{"slug":314,"cid":315,"name":316,"nameZh":317,"cas":318},"785898319007191040","J-50207-4","Cellulase","纤维素酶","9012-54-8",{"slug":320,"cid":321,"name":322,"nameZh":323,"cas":324},"785875919876132864","J-11268-8","Bis(tri-tert-butylphosphine)palladium(0)","双(三叔丁基膦)钯(0)","53199-31-8",{"slug":326,"cid":327,"name":328,"nameZh":329,"cas":330},"785875803232538624","J-1044195-4","Copper(II) ionophore I","铜(II) 离子载体 I","125769-67-7",{"slug":332,"cid":333,"name":334,"nameZh":335,"cas":336},"785883051367337984","J-6801-5","Chromotrope 2B","铬变素2B","548-80-1",{"slug":338,"cid":339,"name":340,"nameZh":341,"cas":342},"785884049620078592","J-22716-8","Cobalt phthalocyanine","酞菁钴","3317-67-7",1792658345913,"zh-CN",[]]