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Incompatible with strong oxidizing agents.",{"label":242,"labelZh":243,"value":244},"Additional Property","水溶解性","Very slightly soluble in water, soluble in ethanol (96 per cent).",null,[],[248,251,254,257,260],{"key":249,"value":250},"描述","青霉素V(苯氧甲基青霉素)是一种有效的口服抗生素。青霉素V对链球菌、艰难梭菌和金黄色葡萄球菌具有抗菌活性。青霉素V具有研究中耳炎、鼻窦炎、咽炎和扁桃体炎的潜力[1][2][3][4]。",{"key":252,"value":253},"相关类别","研究领域\n>>\n感染\n信号通路\n>>\n抗感染\n>>\n细菌",{"key":255,"value":256},"体外研究","青霉素V(0.002-8.0mg\u002FL)抑制链球菌的生长,最低抑制浓度(MIC)为0.004-0.008mg\u002FL[2]。青霉素V(0.002-8.0 mg\u002FL)对艰难梭菌具有抗菌活性,MIC50值为4.0 mg\u002FL,MIC90值为8.0 g\u002FL[3]。青霉素V(0.004-0.063 mg\u002FL；18 h)抑制金黄色葡萄球菌的生长,MIC值为0.016 mg\u002FL[4]。",{"key":258,"value":259},"体内研究","青霉素V(0.063-0.25mg\u002Fkg；s.c.)抑制小鼠大腿肌肉中金黄色葡萄球菌的生长[4]。青霉素V(2 mg\u002Fkg；s.c.)的血浆半衰期(61 min)和平均AUC(0.47 mg\u002FL·h)[4]。青霉素V(100mg\u002Fkg；每天一次,持续5天)可避免大鼠急性化脓性中耳炎(AOM)的暴发性感染[5]。动物模型：无特异性病原体(SPF)雄性瑞士小鼠(20-25 g)接种金黄色葡萄球菌[4]剂量：0.063、0.13、0.25 mg\u002Fkg给药：S.c.结果：与对照组(3.5×107计数\u002FmL)相比,0.25 g\u002Fkg剂量下的CFU数量(1.34×107计数\u002FmL)减少。",{"key":261,"value":262},"参考文献","[1].\nSabath LD. Et, al. Phenoxymethylpenicillin (penicillin V) and phenethicillin. Med Clin North Am. 1970 Sep;54(5):1101-11.\n[2].\nKamme C, et, al. In vitro effect on group A streptococci of loracarbef versus cefadroxil, cefaclor and penicillin V. Scand J Infect Dis. 1993;25(1):37-42.\n[3].\nNorén T, et, al. In vitro susceptibility to 17 antimicrobials of clinical Clostridium difficile isolates collected in 1993-2007 in Sweden. Clin Microbiol Infect. 2010 Aug;16(8):1104-10.\n[4].\nOverbosch D, et, al. Comparative pharmacodynamics and clinical pharmacokinetics of phenoxymethylpenicillin and pheneticillin. Br J Clin Pharmacol. 1985 May;19(5):657-68.\n[5].\nHermansson A, et, al. Prevention of experimental acute otitis media with penicillin V. Acta Otolaryngol. Jan-Feb 1990;109(1-2):119-23.\n[6].\nTimm A, et al. Photolysis of four β‑lactam antibiotics under simulated environmental conditions: Degradation, transformation products and antibacterial activity. 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