[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"currency-rates":3,"$fyk2oeqxpb7bd":8,"compound-J-1983556-7":171,"verified-suppliers-J-1983556-7":417},{"rates":4,"source":7},{"USD":5,"CNY":6},1,6.691314,"live",{"rows":9,"total":170,"current":5,"size":145},[10,33,45,60,74,85,96,113,123,135,146,158],{"slug":11,"cid":12,"imgSvg":13,"name":14,"nameZh":15,"cas":16,"formula":17,"iupac":14,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":22,"offersCount":24,"supplierCount":25,"bestOffer":26},"843627791009189888","J-1971488-8","\u002Fimages\u002Fchem_structures_svg\u002F399\u002F65845-61-6.svg","N-Methylcyclohexanamine hydrochloride","N-甲基环己胺盐酸盐","65845-61-6","C7H16ClN","acids","有机酸","Organic Acids","",[23],"In Stock",4,2,{"unitPrice":27,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},2.64,"500g","CNY","China","CN","in-stock",{"slug":34,"cid":35,"imgSvg":36,"name":37,"nameZh":38,"cas":39,"formula":40,"iupac":37,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":41,"offersCount":24,"supplierCount":5,"bestOffer":42},"785882541994283008","J-1323843-4","\u002Fimages\u002Fchem_structures_svg\u002F104\u002F67627-18-3.svg","Potassium indigotrisulfonate","靛蓝三磺酸钾","67627-18-3","C16H7K3N2O11S3",[23],{"unitPrice":43,"pack":44,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},180,"5g",{"slug":46,"cid":47,"imgSvg":48,"name":49,"nameZh":50,"cas":51,"formula":52,"iupac":49,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":56,"offersCount":57,"supplierCount":25,"bestOffer":58},"785889752443260928","J-28559-9","\u002Fimages\u002Fchem_structures_svg\u002F292\u002F15060-55-6.svg","Ammonium tetrathiomolybdate","四硫钼酸铵","15060-55-6","H8MoN2S4","inorganic","无机化合物","Inorganic Chemicals",[23],7,{"unitPrice":59,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},24,{"slug":61,"cid":62,"imgSvg":63,"name":64,"nameZh":65,"cas":66,"formula":67,"iupac":64,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":68,"offersCount":69,"supplierCount":25,"bestOffer":70},"855452191530422272","J-1994428-7","\u002Fimages\u002Fchem_structures_svg\u002F500\u002F16350-96-2.svg","N-benzylcyclohexanamine.hydrochloride","N-苄基环己胺盐酸盐","16350-96-2","C13H20ClN",[23],5,{"unitPrice":71,"pack":72,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},6,"1000g","中国",{"slug":75,"cid":76,"imgSvg":77,"name":78,"nameZh":79,"cas":80,"formula":81,"iupac":78,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":82,"offersCount":25,"supplierCount":25,"bestOffer":83},"785871840001134592","J-982001-0","\u002Fimages\u002Fchem_structures_svg\u002F001\u002F10517-44-9.svg","1,3-Diaminopropane dihydrochloride","1,3-二氨基丙烷二盐酸盐","10517-44-9","C3H12Cl2N2",[23],{"unitPrice":84,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},3.78,{"slug":86,"cid":87,"imgSvg":88,"name":89,"nameZh":90,"cas":91,"formula":92,"iupac":89,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":93,"offersCount":57,"supplierCount":94,"bestOffer":95},"785880365658017792","J-14975-6","\u002Fimages\u002Fchem_structures_svg\u002F262\u002F12003-67-7.svg","Lithium aluminate","氧化铝锂","12003-67-7","AlHLiO2",[23],3,{"unitPrice":94,"pack":28,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},{"slug":97,"cid":98,"imgSvg":99,"name":100,"nameZh":101,"cas":102,"formula":103,"iupac":100,"category":104,"categoryName":105,"categoryEnName":106,"industry":21,"tags":107,"offersCount":108,"supplierCount":108,"bestOffer":109},"785871830249377792","J-6931-9","\u002Fimages\u002Fchem_structures_svg\u002F456\u002F58068-80-7.svg","1-Octanoylbenzotriazole","N-辛酰苯并三唑","58068-80-7","C14H19N3O","aromatics","芳香烃","Aromatic Hydrocarbons",[],0,{"unitPrice":110,"pack":21,"currency":111,"origin":21,"originFlag":21,"moq":21,"stock":112},9007199254740991,"USD","made-to-order",{"slug":114,"cid":115,"imgSvg":116,"name":117,"nameZh":118,"cas":119,"formula":120,"iupac":117,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":121,"offersCount":69,"supplierCount":25,"bestOffer":122},"785871842446413824","J-1960944-3","\u002Fimages\u002Fchem_structures_svg\u002F495\u002F10534-86-8.svg","Hexaamminecobalt(III) nitrate","六氨合钴(III)硝酸盐","10534-86-8","CoH18N9O9",[23],{"unitPrice":71,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},{"slug":124,"cid":125,"imgSvg":126,"name":127,"nameZh":128,"cas":129,"formula":130,"iupac":127,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":131,"offersCount":24,"supplierCount":25,"bestOffer":132},"785871842576437248","J-814544-6","\u002Fimages\u002Fchem_structures_svg\u002F221\u002F12037-42-2.svg","vanadium oxide","氧化钒","12037-42-2","O13V6",[23],{"unitPrice":133,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},112.8,"100g",{"slug":136,"cid":137,"imgSvg":138,"name":139,"nameZh":140,"cas":141,"formula":142,"iupac":139,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":143,"offersCount":57,"supplierCount":5,"bestOffer":144},"785871842647740416","J-1333345-2","\u002Fimages\u002Fchem_structures_svg\u002F479\u002F26490-63-1.svg","COBALT TETRAFLUOROBORATE HEXAHYDRATE","四氟化硼钴水合物","26490-63-1","B2CoF8H12O6",[23],{"unitPrice":145,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},12,{"slug":147,"cid":148,"imgSvg":149,"name":150,"nameZh":151,"cas":152,"formula":153,"iupac":150,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":154,"offersCount":155,"supplierCount":94,"bestOffer":156},"785871842698072064","J-814953-0","\u002Fimages\u002Fchem_structures_svg\u002F432\u002F72259-10-0.svg","Copper(II) tetrafluoroborate hexahydrate","六水合四氟硼酸铜(II)","72259-10-0","B2CuF8H12O6",[23],10,{"unitPrice":157,"pack":28,"currency":29,"origin":21,"originFlag":21,"moq":21,"stock":32},2.6,{"slug":159,"cid":160,"imgSvg":161,"name":162,"nameZh":163,"cas":164,"formula":165,"iupac":162,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":166,"offersCount":25,"supplierCount":5,"bestOffer":168},"785871863254355968","J-1990080-7","\u002Fimages\u002Fchem_structures_svg\u002F149\u002F123333-60-8.svg","Cerium(IV) sulfate hydrate","铈(IV)硫酸盐水合物","123333-60-8","CeH2O9S2",[167],"Made to Order",{"unitPrice":169,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},5.6,3204,{"slug":172,"cid":173,"imgSvg":174,"name":175,"nameZh":175,"cas":176,"formula":177,"iupac":175,"mdl":21,"mw":178,"category":179,"categoryName":180,"categoryEnName":181,"industry":21,"tags":182,"synonyms":183,"properties":190,"ghs":246,"offers":251,"activity":252,"upstream":277,"downstream":319,"customs":326,"safetyRows":339,"toxicity":373,"synthesis":374,"msds":375,"updatedAt":376,"isProhibited":377,"related":378,"__ts":415,"__lang":416,"__slug":173},"785896515653603328","J-1983556-7","\u002Fimages\u002Fchem_structures_svg\u002F486\u002F71125-38-7.svg","美洛昔康","71125-38-7","C14H13N3O4S2","351.401","organic","有机化合物","Organic Compounds",[],[184,185,186,187,188,189],"4-羟基-2-甲基-N-(5-甲基-2-噻唑基)-2H-1,2-苯并噻嗪-3-甲酰胺-1,1-二氧化物","4-羟基-2-甲基-N-(5-甲基-2-噻唑)-2H-1,2-苯并噻嗪-3-甲酰胺 1,1-二氧化物","2-甲基-4-羟基-N-(5-甲基-2-噻唑基)-2H-苯并[E][1,2]噻嗪-3-甲酰胺-1,1-二氧化物","4-羟-2-甲基-N-(5-甲基-2-噻唑)-2H-1,2-苯并噻唑-3-酰胺-1,1-二氧化物","4-羟基-2-甲基-N-(5-甲基-2-噻唑基)-2H-1,2-苯并噻嗪-3-羧酰胺1,1-二氧化物","美罗昔康",[191,195,199,203,207,211,214,217,220,224,228,232,235,239,243],{"label":192,"labelZh":192,"value":193,"prop":194},"Melting Point","255ºC","meltingPoint",{"label":196,"labelZh":196,"value":197,"prop":198},"Boiling Point","581.3±60.0 °C at 760 mmHg","boilingPoint",{"label":200,"labelZh":200,"value":201,"prop":202},"Density","1.6±0.1 g\u002Fcm3","density",{"label":204,"labelZh":204,"value":205,"prop":206},"Flash Point","305.4±32.9 °C","flashPoint",{"label":208,"labelZh":209,"value":210},"Exact Mass","精确质量","351.034760",{"label":212,"labelZh":212,"value":213},"PSA","136.22000",{"label":215,"labelZh":215,"value":216},"LogP","3.35",{"label":218,"labelZh":218,"value":219},"外观性状","淡黄色固体",{"label":221,"labelZh":222,"value":223},"Vapor Pressure","蒸汽压","0.0±1.7 mmHg at 25°C",{"label":225,"labelZh":226,"value":227},"Refractive Index","折射率","1.735",{"label":229,"labelZh":230,"value":231},"Storage Conditions","储存条件","存放在密封容器内，并放在阴凉，干燥处。储存的地方必须远离氧化剂。",{"label":233,"labelZh":233,"value":234},"水溶解性","DMSO: soluble",{"label":236,"labelZh":237,"value":238},"Molecular Structure","分子结构","1、 摩尔折射率：85.95\n2、 摩尔体积（cm\n3\n\u002Fmol）：217.7\n3、 等张比容（90.2K）：661.7\n4、 表面张力（dyne\u002Fcm）：85.3\n5、 极化率（10\n-24\ncm\n3\n）：34.07",{"label":240,"labelZh":241,"value":242},"Computational Chemistry","计算化学","1.疏水参数计算参考值（XlogP）:无\n2.氢键供体数量:2\n3.氢键受体数量:7\n4.可旋转化学键数量:2\n5.互变异构体数量:8\n6.拓扑分子极性表面积136\n7.重原子数量:23\n8.表面电荷:0\n9.复杂度:628\n10.同位素原子数量:0\n11.确定原子立构中心数量:0\n12.不确定原子立构中心数量:0\n13.确定化学键立构中心数量:0\n14.不确定化学键立构中心数量:0\n15.共价键单元数量:1",{"label":244,"labelZh":244,"value":245},"更多","1. 性状：浅黄色粉末。\n2. 密度（g\u002FmL,25\u002F4℃）：1.613\n3. 相对蒸汽密度（g\u002FmL,空气=1）：未确定\n4. 熔点（ºC）：254\n5. 沸点（ºC,常压）：未确定\n6. 沸点（ºC,5.2kPa）：未确定\n7. 折射率：未确定\n8. 闪点（ºC）：未确定\n9. 比旋光度（º）：未确定\n10. 自燃点或引燃温度（ºC）：未确定\n11. 蒸气压（kPa,25ºC）：未确定\n12. 饱和蒸气压（kPa,60ºC）：未确定\n13. 燃烧热（KJ\u002Fmol）：未确定\n14. 临界温度（ºC）：未确定\n15. 临界压力（KPa）：未确定\n16. 油水（辛醇\u002F水）分配系数的对数值：未确定\n17. 爆炸上限（%,V\u002FV）：未确定\n18. 爆炸下限（%,V\u002FV）：未确定\n19. 溶解性：未确定。",{"pictogram":247,"signal":248,"hazards":249},"Acute Toxicity","Danger",[250],"H301 — Toxic if swallowed \u002F 吞咽会中毒",[],[253,256,259,262,265,268,271,274],{"key":254,"value":255},"描述","Meloxicam 是一种非甾体类抗炎剂,能够有效抑制 COX 的活性,对 COX-2 和 COX-1 的 IC50 值分别为 0.49 µM 和 36.6 µM。",{"key":257,"value":258},"相关类别","信号通路\n>>\n自噬\n>>\n自噬\n信号通路\n>>\n免疫及炎症\n>>\nCOX\n研究领域\n>>\n炎症\u002F免疫",{"key":260,"value":261},"靶点","COX-2:0.49 μM (IC50)\nCOX-1:36.6 μM (IC50)",{"key":263,"value":264},"体外研究","美洛昔康(化合物5)是一种非甾体抗炎药,抑制COX活性,COX-2和COX-1的IC50分别为0.49μM和36.6μM[1]。美洛昔康抑制COX +肿瘤细胞,但对0.25-2μg\u002F mL的CF41.Mg或MDCK细胞没有显示出细胞毒性。此外,美洛昔康与多柔比星组合,对CF41.Mg细胞没有协同作用。美洛昔康(0.25μg\u002F mL)降低CF41.Mg细胞迁移和侵袭,诱导MMP-2表达下降,并增加CF41.Mg细胞中β-catenin的磷酸化,但不影响CF41.Mg细胞凋亡[2]。",{"key":266,"value":267},"体内研究","与福尔马林治疗组相比,单用或与芦丁联合使用的美洛昔康(10mg\u002Fkg)显着减少第1天的爪子喜好时间分别为55％和49％,但是该组合在第3天减少了小鼠的时间。 。单用或与芦丁联合使用的美洛昔康还可降低相对肝脏重量,降低MDA含量,诱导肝脏SOD活性,阻碍IL-1β含量,并显着降低小鼠中阳性caspase-3免疫反应细胞的数量[3]。",{"key":269,"value":270},"细胞实验","将CF41.Mg和MDCK细胞以1.5×10 3个细胞\u002F孔的密度接种到96孔板中，培养24小时，然后单独或与多柔比星组合暴露于0-25μg\u002F mL美洛昔康。为了评价协同作用和致敏作用，分别在24小时后和24小时后加入多柔比星。 MDCK细胞仅作为非肿瘤阴性对照暴露于美洛昔康。对照组在没有美洛昔康和多柔比星的情况下培养，但是将相应量的DMSO加入培养基中。在24和48小时的温育期后，使用MTS测定法测量细胞生长，使用酶标仪测定490nm处的吸光度。每个实验一式三份进行3次[2]。",{"key":272,"value":273},"动物实验","小鼠[3]将32只小鼠随机分成4组，每组8只。在施用1％DMSO（组1;阳性对照组），60mg \u002F kg芦丁后1小时第1天和第3天，给小组接受20μL2.5％福尔马林注射到小鼠右后足的足底区域，口服（第2组），口服10mg \u002F kg美洛昔康（第3组），以及芦丁和美洛昔康的联合治疗（第4组）。在所有组中，药物每天施用一次，持续7天。在第7天，对小鼠实施安乐死，立即切除右后爪加肝脏，用冰冷的盐水洗涤，吸干并称重。将它们储存在-80℃直至分析时。然后将用过的动物冷冻直至焚烧[3]。",{"key":275,"value":276},"参考文献","[1].\nLazer ES, et al. Effect of structural modification of enol-carboxamide-type nonsteroidal antiinflammatory drugs on COX-2\u002FCOX-1 selectivity. J Med Chem. 1997 Mar 14;40(6):980-9.\n[2].\nIturriaga MP, et al. Meloxicam decreases the migration and invasion of CF41.Mg canine mammary carcinoma cells. Oncol Lett. 2017 Aug;14(2):2198-2206.\n[3].\nFikry EM, et al. Rutin and meloxicam attenuate paw inflammation in mice: Affecting sorbitol dehydrogenase activity. J Biochem Mol Toxicol. 2018 Feb;32(2).",[278,284,290,295,301,307,313],{"slug":279,"cid":280,"name":281,"nameZh":281,"cas":282,"imgSvg":283},"785884450192887800","J-23436-8","2-氨基-5-甲基噻唑","7305-71-7","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F432\u002F7305-71-7.svg",{"slug":285,"cid":286,"name":287,"nameZh":287,"cas":288,"imgSvg":289},"785872171904798700","J-996503-2","4-羟基-2-甲基-2H-1,...","35511-15-0","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F237\u002F35511-15-0.svg",{"slug":291,"cid":292,"name":287,"nameZh":287,"cas":293,"imgSvg":294},"785875433060044800","J-9721-9","24683-26-9","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F482\u002F24683-26-9.svg",{"slug":296,"cid":297,"name":298,"nameZh":298,"cas":299,"imgSvg":300},"785891657043152900","J-30613-3","邻二氯苯","95-50-1","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F208\u002F95-50-1.svg",{"slug":302,"cid":303,"name":304,"nameZh":304,"cas":305,"imgSvg":306},"785876239578566700","J-1071522-8","2,3-二氢-3-氧代-1,2...","6639-62-9","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F127\u002F6639-62-9.svg",{"slug":308,"cid":309,"name":310,"nameZh":310,"cas":311,"imgSvg":312},"785881486447349800","J-1092319-5","4-羟基-2H-1,2-苯并噻...","35511-14-9","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F285\u002F35511-14-9.svg",{"slug":314,"cid":315,"name":316,"nameZh":316,"cas":317,"imgSvg":318},"785876036330983400","J-11888-6","糖精","81-07-2","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F196\u002F81-07-2.svg",[320],{"slug":321,"cid":322,"name":323,"nameZh":323,"cas":324,"imgSvg":325},"785888839175508000","J-1958479-3","美洛昔康钠","71125-39-8","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F448\u002F71125-39-8.svg",[327,330,333,336],{"key":328,"value":329},"海关编码","2934999090",{"key":331,"value":332},"中文概述","2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%",{"key":334,"value":335},"申报要素","品名, 成分含量, 用途",{"key":337,"value":338},"Summary","2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%",[340,343,345,348,351,354,357,360,363,366,369,372],{"key":341,"value":342},"符号","GHS06",{"key":344,"value":248},"信号词",{"key":346,"value":347},"危害声明","H301",{"key":349,"value":350},"警示性声明","P301 + P310",{"key":352,"value":353},"危害码 (欧洲)","Xn: Harmful;",{"key":355,"value":356},"风险声明 (欧洲)","R22",{"key":358,"value":359},"安全声明 (欧洲)","26",{"key":361,"value":362},"危险品运输编码","UN 2811 6.1\u002FPG 3",{"key":364,"value":365},"WGK德国","3",{"key":367,"value":368},"RTECS号","DL0702000",{"key":370,"value":371},"包装等级","III",{"key":328,"value":329},"\u003Ctd>\n\n\u003Cp>\u003Cstrong>美洛昔康毒理学数据:\u003C\u002Fstrong>\u003C\u002Fp>\n\u003Cp>\u003C\u002Fp>\u003Cp> 口服- 大鼠 LD50 84 毫克\u002F 公斤; 口服- 小鼠 LD50: 470 毫克\u002F公斤 \u003C\u002Fp>\n\u003Cp>\u003C\u002Fp>\n\u003Cp>\u003Ca href=\"\u002Fen\u002Fcas\u002F71125-38-7_1083007.html#duXinDiv\">美洛昔康毒性英文版\u003C\u002Fa>\u003C\u002Fp>\n\n\u003C\u002Ftd>","\u003Cp>1. 4-羟基-2-甲基-2H-1，2-苯并噻嗪-3-羧酸甲酯1，1-二氧化物和2-氨基-5-甲基噻唑在二甲苯中回流，得到美洛昔康，收率74%。\u003C\u002Fp>\u003Cp>2. 3-氧代-1,2-苯并异噻唑-2-乙酸甲酯-1,1-二氧化物的制备\u003C\u002Fp>\u003Cp>在反应瓶中加入DMF45ml和邻磺酰苯酰亚胺钠盐(即市售的含2分子结晶水的糖精钠)24.1g(0.10mol),搅拌溶解,再在搅拌下加入氯乙酸甲酯16.3g(0.15mol),回流反应3~4h.反应毕,冷却至室温,加入冷水85ml, 析出固体过滤,水洗,抽干,干燥得白色固体3-氧代-1,2-苯并异噻唑-2-乙酸甲酯-1,1-二氧化物24.0g,收率94.1%,mp114.5~116 ºC.\u003C\u002Fp>\u003Cp>3. 4-羟基-2H-1,2-苯并噻嗪-3-羧酸甲酯-1,1-二氧化物的制备\u003C\u002Fp>\u003Cp>在反应瓶中加入无水甲醇60ml,然后在冰浴冷却和搅拌下分批加入金属钠6.5g(0.28mol)到加完后可稍加热,金属钠全溶后,加热至回流温度,于强烈搅拌下,快速加入3-氧代-1,2-苯并异噻唑-2-乙酸甲酯-1,1-二氧化物的粉状物18g(0.07mol),瞬间反应得到橙黄色浆状物.移去油浴,加入冰72g和浓盐酸28ml混合液,搅拌,用冰浴冷却至10以ºC下,析出白色固体,过滤,水洗,干燥,得白色固体4-羟基-2H-1,2-苯并噻嗪-3-羧酸甲酯-1,1-二氧化物14.4g, 收率80%,mp160~166 ºC.\u003C\u002Fp>\u003Cp>4. 4-羟基-2-甲基-2H-1,2-苯并噻嗪-3-羧酸甲酯-1,1-二氧化物的制备\u003C\u002Fp>\u003Cp>在反应瓶中加入乙醇72ml和4-羟基-2H-1,2-苯并噻嗪-3-羧酸甲酯-1,1-二氧化物14.4g(56.47mmol),搅拌,再加入氢氧化钠3.16g溶于72ml水溶液.放热反应,固体完全溶解后,降温至20ºC以下,滴加硫酸二甲酯11.81g(93.74mmol),滴加过程反应混合物温度保持不超过25ºC,几分钟后析出大量固体,再于25ºC搅拌反应15h.反应毕,冷却至10 ºC以下,过滤,50%乙醇洗涤,抽干,得白色固体4-羟基-2-甲基-2H-1,2-苯并噻嗪-3-羧酸甲酯-1,1-二氧化物粗品,mp168~169ºC.将其溶于乙醇72ml、水72ml、氢氧化钠3.16g的混合液中,过滤,\u003C\u002Fp>\u003Cp>滤液用稀盐酸调pH至6~7,过滤,50%乙醇洗涤,真空干燥(60 ºC下),得白色固体4-羟基-2-甲基-2H-1,2-苯并噻嗪-3-羧酸甲酯-1,1-二氧化物12.2g,收率80%,mp171~172 ºC.\u003C\u002Fp>\u003Cp>5. 美洛昔康的合成\u003C\u002Fp>\u003Cp>在反应瓶中加入4-羟基-2-甲基-2H-1,2-苯并噻嗪-3-羧酸甲酯-1,1-二氧化物5.38g(0.02mol)和2-氨基-5-甲基噻唑2.5g(0.22mol),再加入二甲苯800mol,搅拌溶解,然后升温搅拌回流24h,在回流过程通氮气保护.反应毕,减压蒸馏去大部分二甲苯,冷至室温,过滤,得美洛昔康粗品6.4g,将粗品溶于二氯乙烷100ml,加入活性炭0.5g, 回流30min.趁热过滤,滤液冷却至10 ºC,析出晶体过滤,干燥,得到白色固体5.62g,收率80%,mp254~255ºC (分解)\u003C\u002Fp>\u003Cp>\u003C\u002Fp>","\u003Ctd>\n\r\n                                        \r\n                                        美洛昔康\n\u003Cb>修改号码：5\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块1. 化学品\u003C\u002Fstrong>\n\u003Cbr \u002F> 产品名称：\n\u003Cb>Meloxicam\u003C\u002Fb>\n\u003Cbr \u002F> 修改号码：\n\u003Cb>5\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块2. 危险性概述\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>GHS分类\u003C\u002Fb>\n\u003Cbr \u002F> 　物理性危害未分类\n\u003Cbr \u002F> 　健康危害\n\u003Cbr \u002F> 急性毒性（经口）\n\u003Cb>第3级\u003C\u002Fb>\n\u003Cbr \u002F> 　环境危害未分类\n\u003Cbr \u002F>\n\u003Cb>GHS标签元素\u003C\u002Fb>\n\u003Cbr \u002F> 　图标或危害标志\n\u003Cbr \u002F> 　信号词危险\n\u003Cbr \u002F> 　危险描述吞咽会中毒。\n\u003Cbr \u002F> 　防范说明\n\u003Cbr \u002F>\n\u003Cb>[预防]\u003C\u002Fb>使用本产品时切勿吃东西，喝水或吸烟。\n\u003Cbr \u002F> 处理后要彻底清洗双手。\n\u003Cbr \u002F>\n\u003Cb>[急救措施]\u003C\u002Fb>\n\u003Cb>食入：立即呼叫解毒中心\u002F医生。\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>[储存]\u003C\u002Fb>存放处须加锁。\n\u003Cbr \u002F>\n\u003Cb>[废弃处置]\u003C\u002Fb>\n\u003Cb>根据当地政府规定把物品\u002F容器交与工业废弃处理机构。\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块3. 成分\u002F组成信息\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>单一物质\u002F混和物\u003C\u002Fb>单一物质\n\u003Cbr \u002F>\n\u003Cb>化学名(中文名)：\u003C\u002Fb>美洛昔康\n\u003Cbr \u002F> 百分比：\n\u003Cb>>96.0%(LC)(T)\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>CAS编码：\u003C\u002Fb>\n\u003Cb>71125-38-7\u003C\u002Fb>\n\u003Cbr \u002F> 俗名：\n\u003Cb>4-Hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>carboxamide 1,1-Dioxide\u003C\u002Fb>\n\u003Cbr \u002F> 分子式：\n\u003Cb>C14H13N3O4S2\u003C\u002Fb>\n\u003Cbr \u002F> 美洛昔康\n\u003Cb>修改号码：5\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块4. 急救措施\u003C\u002Fstrong>\n\u003Cbr \u002F> 吸入：\n\u003Cb>将受害者移到新鲜空气处，保持呼吸通畅，休息。若感不适请求医\u002F就诊。\u003C\u002Fb>\n\u003Cbr \u002F> 皮肤接触：\n\u003Cb>立即去除\u002F脱掉所有被污染的衣物。用水清洗皮肤\u002F淋浴。\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>若皮肤刺激或发生皮疹：求医\u002F就诊。\u003C\u002Fb>\n\u003Cbr \u002F> 眼睛接触：用水小心清洗几分钟。如果方便，易操作，摘除隐形眼镜。继续清洗。\n\u003Cbr \u002F>\n\u003Cb>如果眼睛刺激：求医\u002F就诊。\u003C\u002Fb>\n\u003Cbr \u002F> 食入：\n\u003Cb>立即呼叫解毒中心\u002F医生。漱口。\u003C\u002Fb>\n\u003Cbr \u002F> 紧急救助者的防护：救援者需要穿戴个人防护用品，比如橡胶手套和气密性护目镜。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块5. 消防措施\u003C\u002Fstrong>\n\u003Cbr \u002F> 合适的灭火剂：干粉，泡沫，雾状水，二氧化碳\n\u003Cbr \u002F> 特殊危险性：小心，燃烧或高温下可能分解产生毒烟。\n\u003Cbr \u002F> 特定方法：从上风处灭火，根据周围环境选择合适的灭火方法。\n\u003Cbr \u002F> 非相关人员应该撤离至安全地方。\n\u003Cbr \u002F> 周围一旦着火：如果安全，移去可移动容器。\n\u003Cbr \u002F> 消防员的特殊防护用具：灭火时，一定要穿戴个人防护用品。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块6. 泄漏应急处理\u003C\u002Fstrong>\n\u003Cbr \u002F> 个人防护措施，防护用具，\n\u003Cb>使用特殊的个人防护用品（针对有毒颗粒的P3过滤式空气呼吸器）。远离溢出物\u002F泄露\u003C\u002Fb>\n\u003Cbr \u002F> 紧急措施：处并处在上风处。\n\u003Cbr \u002F> 泄露区应该用安全带等圈起来，控制非相关人员进入。\n\u003Cbr \u002F> 环保措施：防止进入下水道。\n\u003Cbr \u002F> 控制和清洗的方法和材料：清扫收集粉尘，封入密闭容器。注意切勿分散。附着物或收集物应该立即根据合适的\n\u003Cbr \u002F> 法律法规处置。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块7. 操作处置与储存\u003C\u002Fstrong>\n\u003Cbr \u002F> 处理\n\u003Cbr \u002F> 技术措施：在通风良好处进行处理。穿戴合适的防护用具。防止粉尘扩散。处理后彻底清洗双手\n\u003Cbr \u002F> 和脸。\n\u003Cbr \u002F> 注意事项：如果可能，使用封闭系统。如果粉尘或浮质产生，使用局部排气。\n\u003Cbr \u002F> 操作处置注意事项：避免接触皮肤、眼睛和衣物。\n\u003Cbr \u002F> 贮存\n\u003Cbr \u002F> 储存条件：保持容器密闭。冷藏储存。\n\u003Cbr \u002F> 存放处须加锁。\n\u003Cbr \u002F> 远离不相容的材料比如氧化剂存放。\n\u003Cbr \u002F> 热敏\n\u003Cbr \u002F> 包装材料：依据法律。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块8. 接触控制和个体防护\u003C\u002Fstrong>\n\u003Cbr \u002F> 工程控制：尽可能安装封闭体系或局部排风系统。同时安装淋浴器和洗眼器。\n\u003Cbr \u002F> 个人防护用品\n\u003Cbr \u002F> 　呼吸系统防护：\n\u003Cb>防尘面具，自携式呼吸器（SCBA），供气呼吸器等。使用通过政府标准的呼吸器。依\u003C\u002Fb>\n\u003Cbr \u002F> 据当地和政府法规。\n\u003Cbr \u002F> 　手部防护：防渗手套。\n\u003Cbr \u002F> 　眼睛防护：护目镜。如果情况需要，佩戴面具。\n\u003Cbr \u002F> 　皮肤和身体防护：防渗防护服。如果情况需要，穿戴防护靴。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块9. 理化特性\u003C\u002Fstrong>\n\u003Cbr \u002F> 固体\n\u003Cbr \u002F>\n\u003Cb>外形（20°C）：\u003C\u002Fb>\n\u003Cbr \u002F> 外观：\n\u003Cb>晶体-粉末\u003C\u002Fb>\n\u003Cbr \u002F> 美洛昔康\n\u003Cb>修改号码：5\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块9. 理化特性\u003C\u002Fstrong>\n\u003Cbr \u002F> 颜色：\n\u003Cb>微浅黄色-浅黄绿色\u003C\u002Fb>\n\u003Cbr \u002F> 气味：无资料\n\u003Cbr \u002F>\n\u003Cb>pH:\u003C\u002Fb>无数据资料\n\u003Cbr \u002F> 熔点：\n\u003Cbr \u002F>\n\u003Cb>255°C\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>沸点\u002F沸程\u003C\u002Fb>无资料\n\u003Cbr \u002F> 闪点：无资料\n\u003Cbr \u002F> 爆炸特性\n\u003Cbr \u002F> 　爆炸下限：无资料\n\u003Cbr \u002F> 　爆炸上限：无资料\n\u003Cbr \u002F> 密度：无资料\n\u003Cbr \u002F> 溶解度：\n\u003Cbr \u002F>\n\u003Cb>[水]\u003C\u002Fb>无资料\n\u003Cbr \u002F>\n\u003Cb>[其他溶剂]\u003C\u002Fb>无资料\n\u003Cbr \u002F>\n\n\u003Cstrong>模块10. 稳定性和反应性\u003C\u002Fstrong>\n\u003Cbr \u002F> 化学稳定性：一般情况下稳定。\n\u003Cbr \u002F> 危险反应的可能性：未报道特殊反应性。\n\u003Cbr \u002F> 须避免接触的物质氧化剂\n\u003Cbr \u002F>\n\u003Cb>危险的分解产物:\u003C\u002Fb>\n\u003Cb>一氧化碳, 二氧化碳, 氮氧化物 (NOx), 硫氧化物\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块11. 毒理学信息\u003C\u002Fstrong>\n\u003Cbr \u002F> 急性毒性：\n\u003Cb>orl-rat LDLo:7.5 mg\u002Fkg\u003C\u002Fb>\n\u003Cbr \u002F> 对皮肤腐蚀或刺激：无资料\n\u003Cbr \u002F> 对眼睛严重损害或刺激：无资料\n\u003Cbr \u002F> 生殖细胞变异原性：无资料\n\u003Cbr \u002F> 致癌性：\n\u003Cbr \u002F>\n\u003Cb>IARC =\u003C\u002Fb>无资料\n\u003Cbr \u002F>\n\u003Cb>NTP =\u003C\u002Fb>无资料\n\u003Cbr \u002F> 生殖毒性：无资料\n\u003Cbr \u002F>\n\u003Cb>RTECS 号码:\u003C\u002Fb>\n\u003Cb>DL0702000\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块12. 生态学信息\u003C\u002Fstrong>\n\u003Cbr \u002F> 生态毒性：\n\u003Cbr \u002F> 鱼类：无资料\n\u003Cbr \u002F> 甲壳类：无资料\n\u003Cbr \u002F> 藻类：无资料\n\u003Cbr \u002F>\n\u003Cb>残留性 \u002F 降解性：\u003C\u002Fb>无资料\n\u003Cbr \u002F>\n\u003Cb>潜在生物累积 （BCF):\u003C\u002Fb>无资料\n\u003Cbr \u002F> 土壤中移动性\n\u003Cbr \u002F>\n\u003Cb>　log水分配系数：\u003C\u002Fb>无资料\n\u003Cbr \u002F>\n\u003Cb>　土壤吸收系数 （Koc）：\u003C\u002Fb>无资料\n\u003Cbr \u002F> 　亨利定律无资料\n\u003Cbr \u002F>\n\u003Cb>constant(PaM3\u002Fmol):\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块13. 废弃处置\u003C\u002Fstrong>\n\u003Cbr \u002F> 如果可能，回收处理。请咨询当地管理部门。建议在可燃溶剂中溶解混合，在装有后燃和洗涤装置的化学焚烧炉中\n\u003Cbr \u002F> 焚烧。废弃处置时请遵守国家、地区和当地的所有法规。\n\u003Cbr \u002F> 美洛昔康\n\u003Cb>修改号码：5\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块14. 运输信息\u003C\u002Fstrong>\n\u003Cbr \u002F> 联合国分类：\n\u003Cb>第1项 毒害品。\u003C\u002Fb>\n\u003Cbr \u002F>\n\u003Cb>UN编号：\u003C\u002Fb>\n\u003Cb>2811\u003C\u002Fb>\n\u003Cbr \u002F> 正式运输名称：\n\u003Cb>有毒固体, 有机物, 不另作详细说明\u003C\u002Fb>\n\u003Cbr \u002F> 包装等级：\n\u003Cb>III\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块15. 法规信息\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>《危险化学品安全管理条例》（2002年1月26日国务院发布，2011年2月16日修订）: 针对危险化学品的安全使用、\u003C\u002Fb>\n\u003Cbr \u002F> 生产、储存、运输、装卸等方面均作了相应的规定。\n\u003Cbr \u002F>\n\u003Cbr \u002F>\n\n\u003Cstrong> 模块16 - 其他信息 \u003C\u002Fstrong>\n\u003Cbr \u002F>N\u002FA\n\u003Cbr \u002F>\u003Cbr \u002F>\u003Cbr \u002F>\n\u003Cbr \u002F>\u003Cbr \u002F>\n\u003C\u002Ftd>","2026-08-21T07:51:12.859463Z",false,[379,385,391,397,403,409],{"slug":380,"cid":381,"name":382,"nameZh":383,"cas":384},"785880379465666560","J-15087-1","Safranine T","藏红T","477-73-6",{"slug":386,"cid":387,"name":388,"nameZh":389,"cas":390},"785892740264103936","J-33551-7","Milneb","代森环","3773-49-7",{"slug":392,"cid":393,"name":394,"nameZh":395,"cas":396},"785897799970459648","J-1987055-5","Sudan III","苏丹红Ⅲ","85-86-9",{"slug":398,"cid":399,"name":400,"nameZh":401,"cas":402},"785875939618721792","J-11381-4","Ampicillin","氨苄西林","69-53-4",{"slug":404,"cid":405,"name":406,"nameZh":407,"cas":408},"785937076037095424","J-587118-0","Lead, [3-mercapto-D-valinato(2-)-N,O,S]-","[3-巯基-D-缬氨酰基(2-)-N,O,S]铅","53513-80-7",{"slug":410,"cid":411,"name":412,"nameZh":413,"cas":414},"785881207576465408","J-18377-6","Reinecke salt","利英钠克盐","13573-16-5",1792626713029,"zh-CN",[]]