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1]。",{"key":235,"value":236},"细胞实验","在单药试验中，将Capan-1细胞（BRCA2缺陷型），MX-1（BRCA1缺陷型）细胞或其他培养细胞以密度接种，允许在96孔板中线性生长10-12天（通常500-3000个细胞\u002F孔）。将细胞在其推荐的含有不同浓度的PARP抑制剂（Veliparib，Rucaparib，Niraparib，Olaparib和Talazoparib）的生长培养基中处理10-12天（每5天用新鲜化合物更换培养基）。使用GraphPad Prism5 [1]计算IC50值。",{"key":238,"value":239},"动物实验","制备小鼠[1] MX-1肿瘤异种移植物。当肿瘤达到约150mm 3的平均体积时，以单剂量给予奥拉帕尼（100mg \u002F kg），他唑巴肽（1mg \u002F kg）或载体。在药物给药后2小时，8小时和24小时收获肿瘤并在液氮中快速冷冻。然后将肿瘤组织在PBS中在冰上匀浆并用裂解缓冲液（25mM Tris，pH 8.0,150mM NaCl，5mM EDTA，2mM EGTA，25mM NaF，2mM Na 3 VO 4,1mM Pefabloc，1％Triton X）提取。 -100，和含有1％SDS的蛋白酶抑制剂混合物）。使用PARP体内PD测定II试剂盒通过ELISA测定肿瘤裂解物中PAR的水平。",{"key":241,"value":242},"参考文献","[1].\nWang B, et al. 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