[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"currency-rates":3,"$fyk2oeqxpb7bd":8,"compound-J-1982579-1":171,"verified-suppliers-J-1982579-1":300},{"rates":4,"source":7},{"USD":5,"CNY":6},1,6.691314,"live",{"rows":9,"total":170,"current":5,"size":145},[10,33,45,60,74,85,96,113,123,135,146,158],{"slug":11,"cid":12,"imgSvg":13,"name":14,"nameZh":15,"cas":16,"formula":17,"iupac":14,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":22,"offersCount":24,"supplierCount":25,"bestOffer":26},"843627791009189888","J-1971488-8","\u002Fimages\u002Fchem_structures_svg\u002F399\u002F65845-61-6.svg","N-Methylcyclohexanamine hydrochloride","N-甲基环己胺盐酸盐","65845-61-6","C7H16ClN","acids","有机酸","Organic Acids","",[23],"In Stock",4,2,{"unitPrice":27,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},2.64,"500g","CNY","China","CN","in-stock",{"slug":34,"cid":35,"imgSvg":36,"name":37,"nameZh":38,"cas":39,"formula":40,"iupac":37,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":41,"offersCount":24,"supplierCount":5,"bestOffer":42},"785882541994283008","J-1323843-4","\u002Fimages\u002Fchem_structures_svg\u002F104\u002F67627-18-3.svg","Potassium indigotrisulfonate","靛蓝三磺酸钾","67627-18-3","C16H7K3N2O11S3",[23],{"unitPrice":43,"pack":44,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},180,"5g",{"slug":46,"cid":47,"imgSvg":48,"name":49,"nameZh":50,"cas":51,"formula":52,"iupac":49,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":56,"offersCount":57,"supplierCount":25,"bestOffer":58},"785889752443260928","J-28559-9","\u002Fimages\u002Fchem_structures_svg\u002F292\u002F15060-55-6.svg","Ammonium tetrathiomolybdate","四硫钼酸铵","15060-55-6","H8MoN2S4","inorganic","无机化合物","Inorganic Chemicals",[23],7,{"unitPrice":59,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},24,{"slug":61,"cid":62,"imgSvg":63,"name":64,"nameZh":65,"cas":66,"formula":67,"iupac":64,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":68,"offersCount":69,"supplierCount":25,"bestOffer":70},"855452191530422272","J-1994428-7","\u002Fimages\u002Fchem_structures_svg\u002F500\u002F16350-96-2.svg","N-benzylcyclohexanamine.hydrochloride","N-苄基环己胺盐酸盐","16350-96-2","C13H20ClN",[23],5,{"unitPrice":71,"pack":72,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},6,"1000g","中国",{"slug":75,"cid":76,"imgSvg":77,"name":78,"nameZh":79,"cas":80,"formula":81,"iupac":78,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":82,"offersCount":25,"supplierCount":25,"bestOffer":83},"785871840001134592","J-982001-0","\u002Fimages\u002Fchem_structures_svg\u002F001\u002F10517-44-9.svg","1,3-Diaminopropane dihydrochloride","1,3-二氨基丙烷二盐酸盐","10517-44-9","C3H12Cl2N2",[23],{"unitPrice":84,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},3.78,{"slug":86,"cid":87,"imgSvg":88,"name":89,"nameZh":90,"cas":91,"formula":92,"iupac":89,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":93,"offersCount":57,"supplierCount":94,"bestOffer":95},"785880365658017792","J-14975-6","\u002Fimages\u002Fchem_structures_svg\u002F262\u002F12003-67-7.svg","Lithium aluminate","氧化铝锂","12003-67-7","AlHLiO2",[23],3,{"unitPrice":94,"pack":28,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},{"slug":97,"cid":98,"imgSvg":99,"name":100,"nameZh":101,"cas":102,"formula":103,"iupac":100,"category":104,"categoryName":105,"categoryEnName":106,"industry":21,"tags":107,"offersCount":108,"supplierCount":108,"bestOffer":109},"785871830249377792","J-6931-9","\u002Fimages\u002Fchem_structures_svg\u002F456\u002F58068-80-7.svg","1-Octanoylbenzotriazole","N-辛酰苯并三唑","58068-80-7","C14H19N3O","aromatics","芳香烃","Aromatic Hydrocarbons",[],0,{"unitPrice":110,"pack":21,"currency":111,"origin":21,"originFlag":21,"moq":21,"stock":112},9007199254740991,"USD","made-to-order",{"slug":114,"cid":115,"imgSvg":116,"name":117,"nameZh":118,"cas":119,"formula":120,"iupac":117,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":121,"offersCount":69,"supplierCount":25,"bestOffer":122},"785871842446413824","J-1960944-3","\u002Fimages\u002Fchem_structures_svg\u002F495\u002F10534-86-8.svg","Hexaamminecobalt(III) nitrate","六氨合钴(III)硝酸盐","10534-86-8","CoH18N9O9",[23],{"unitPrice":71,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},{"slug":124,"cid":125,"imgSvg":126,"name":127,"nameZh":128,"cas":129,"formula":130,"iupac":127,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":131,"offersCount":24,"supplierCount":25,"bestOffer":132},"785871842576437248","J-814544-6","\u002Fimages\u002Fchem_structures_svg\u002F221\u002F12037-42-2.svg","vanadium oxide","氧化钒","12037-42-2","O13V6",[23],{"unitPrice":133,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},112.8,"100g",{"slug":136,"cid":137,"imgSvg":138,"name":139,"nameZh":140,"cas":141,"formula":142,"iupac":139,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":143,"offersCount":57,"supplierCount":5,"bestOffer":144},"785871842647740416","J-1333345-2","\u002Fimages\u002Fchem_structures_svg\u002F479\u002F26490-63-1.svg","COBALT TETRAFLUOROBORATE HEXAHYDRATE","四氟化硼钴水合物","26490-63-1","B2CoF8H12O6",[23],{"unitPrice":145,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},12,{"slug":147,"cid":148,"imgSvg":149,"name":150,"nameZh":151,"cas":152,"formula":153,"iupac":150,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":154,"offersCount":155,"supplierCount":94,"bestOffer":156},"785871842698072064","J-814953-0","\u002Fimages\u002Fchem_structures_svg\u002F432\u002F72259-10-0.svg","Copper(II) tetrafluoroborate hexahydrate","六水合四氟硼酸铜(II)","72259-10-0","B2CuF8H12O6",[23],10,{"unitPrice":157,"pack":28,"currency":29,"origin":21,"originFlag":21,"moq":21,"stock":32},2.6,{"slug":159,"cid":160,"imgSvg":161,"name":162,"nameZh":163,"cas":164,"formula":165,"iupac":162,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":166,"offersCount":25,"supplierCount":5,"bestOffer":168},"785871863254355968","J-1990080-7","\u002Fimages\u002Fchem_structures_svg\u002F149\u002F123333-60-8.svg","Cerium(IV) sulfate hydrate","铈(IV)硫酸盐水合物","123333-60-8","CeH2O9S2",[167],"Made to Order",{"unitPrice":169,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},5.6,3204,{"slug":172,"cid":173,"imgSvg":174,"name":175,"nameZh":175,"cas":176,"formula":177,"iupac":175,"mdl":21,"mw":178,"category":179,"categoryName":180,"categoryEnName":181,"industry":21,"tags":182,"synonyms":183,"properties":187,"ghs":210,"offers":211,"activity":212,"upstream":237,"downstream":256,"customs":257,"safetyRows":258,"updatedAt":259,"isProhibited":260,"related":261,"__ts":298,"__lang":299,"__slug":173},"785896222849241088","J-1982579-1","\u002Fimages\u002Fchem_structures_svg\u002F374\u002F1174043-16-3.svg","4-[4-氟-3-[(4-甲氧基哌啶-1-基)羰基]苄基]酞嗪-1(2H)-酮","1174043-16-3","C22H22FN3O3","395.427","pharma","医药中间体","Pharma Intermediates",[],[184,185,186],"AZD2461抑制剂","化合物AZD2461","PARP抑制剂(AZD-2461)",[188,192,196,199,202,206],{"label":189,"labelZh":189,"value":190,"prop":191},"Density","1.3±0.1 g\u002Fcm3","density",{"label":193,"labelZh":194,"value":195},"Exact Mass","精确质量","395.164520",{"label":197,"labelZh":197,"value":198},"PSA","75.55000",{"label":200,"labelZh":200,"value":201},"LogP","0.53",{"label":203,"labelZh":204,"value":205},"Refractive Index","折射率","1.640",{"label":207,"labelZh":208,"value":209},"Storage Conditions","储存条件","-20°C",null,[],[213,216,219,222,225,228,231,234],{"key":214,"value":215},"描述","AZD-2461 是一种有效的 PARP 抑制剂,可抑制 PARP1,PARP2 和 PARP3 的活性,IC50 值分别为 5 nM,2 nM 和 200 nM。",{"key":217,"value":218},"相关类别","研究领域\n>>\n癌症",{"key":220,"value":221},"靶点","PARP2:2 nM (IC50)\nPARP1:5 nM (IC50)\nPARP3:200 nM (IC50)",{"key":223,"value":224},"体外研究","AZD-2461是一种有效的PARP抑制剂,PARP1,PARP2和PARP3的IC50分别为5 nM,2 nM和200 nM。 AZD-2461(500nM)显示出对人A459细胞中DNA单链断裂修复的抑制活性。 AZD-2461在BRCA2缺陷型小鼠乳腺癌细胞系KB2P3.4中表现出抗性和高P-gp表达水平[1]。 AZD-2461对BT-20细胞具有细胞毒性(5-50μM),增加了S期和G2期BT-20细胞的比例(5-20μM),并且对SKBr-3细胞周期的进展产生微弱影响细胞(5-20μM)[2]。",{"key":226,"value":227},"体内研究","AZD-2461(10mg\u002Fkg,口服)增强了替莫唑胺在小鼠结肠直肠异种移植物中的抗肿瘤活性,并且对小鼠骨髓细胞显示出低效果。然而,在大鼠模型中没有观察到AZD-2461的骨髓耐受性增加[1]。 AZD-2461(0.5％v\u002Fw HPMC,po)在短期治疗后增加了携带KB1P肿瘤的小鼠的存活率,并且长期治疗耐受性良好,但不能导致肿瘤根除[3]。",{"key":229,"value":230},"细胞实验","在测定中使用BT-20和SKBr-3人原发性乳腺癌细胞系。将SKBr-3细胞在含有10％FCS和BT-20的DMEM培养基中在含有5％CO 2的气氛下在RPMI培养基中培养。接种后24小时（60-70％汇合），细胞用PARP-1抑制剂NU1025，AZD-2461，iniparib，olaparib和rucaparib处理，浓度范围为50至200μM，5至50μM，分别为5至50μM，1至10μM和0.3至10μM，持续时间如图1-7所示[2]。",{"key":232,"value":233},"动物实验","从移植到小鼠后2周开始，每周至少监测3次肿瘤大小。当肿瘤达到约200mm 3的尺寸时，开始所有治疗。除非另有说明，否则给予Olaparib（50mg \u002F kg腹膜内）和AZD-2461（100mg \u002F kg口服）连续28天。如果肿瘤未缩小至初始体积的50％以下，则继续治疗28天;否则，当复发肿瘤达到原始体积的100％时，开始28天的新治疗周期。将AZD-2461在去离子水中用0.5％w \u002F v羟丙基甲基纤维素稀释至浓度为10mg \u002F mL [3]。",{"key":235,"value":236},"参考文献","[1].\nOplustil O'Connor L, et al. The PARP Inhibitor AZD2461 Provides Insights into the Role of PARP3 Inhibition for Both Synthetic Lethality and Tolerability with Chemotherapy in Preclinical Models. Cancer Res. 2016 Oct 15;76(20):6084-6094. Epub 2016 Aug 22.\n[2].\nWęsierska-Gądek J, et al. Differential Potential of Pharmacological PARP Inhibitors for Inhibiting Cell Proliferation and Inducing Apoptosis in Human Breast Cancer Cells. J Cell Biochem. 2015 Dec;116(12):2824-39.\n[3].\nJaspers JE, et al. Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors. Cancer Discov. 2013 Jan;3(1):68-81.",[238,244,250],{"slug":239,"cid":240,"name":241,"nameZh":241,"cas":242,"imgSvg":243},"785895140332933100","J-1087313-3","5-[(3,4-二氢-4-氧代...","763114-26-7","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F379\u002F763114-26-7.svg",{"slug":245,"cid":246,"name":247,"nameZh":247,"cas":248,"imgSvg":249},"785897086318022700","J-1518978-9","4-甲氧基哌啶盐酸盐","4045-25-4","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F130\u002F4045-25-4.svg",{"slug":251,"cid":252,"name":253,"nameZh":253,"cas":254,"imgSvg":255},"785872742925733900","J-1992805-4","4-甲氧基哌啶","4045-24-3","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F168\u002F4045-24-3.svg",[],[],[],"2026-08-21T07:51:12.859463Z",false,[262,268,274,280,286,292],{"slug":263,"cid":264,"name":265,"nameZh":266,"cas":267},"785894733439307776","J-38841-4","Chloro(pyridine)bis(dimethylglyoximato)cobalt(III)","氯双(二甲基乙二肟)吡啶钴(III)","23295-32-1",{"slug":269,"cid":270,"name":271,"nameZh":272,"cas":273},"785880888364765184","J-1084897-7","zinc bis(piperidine-1-carbodithioate)","(T-4)-双(1-哌啶二硫代羧酸-S,S’)-锌","13878-54-1",{"slug":275,"cid":276,"name":277,"nameZh":278,"cas":279},"785876809550925824","J-14681-0","Cetylpyridinium bromide","溴代十六烷基吡啶","140-72-7",{"slug":281,"cid":282,"name":283,"nameZh":284,"cas":285},"785873249509576704","J-1015386-4","Fmoc-Gly-Gly-Gly-OH","Fmoc-三甘肽","170941-79-4",{"slug":287,"cid":288,"name":289,"nameZh":290,"cas":291},"785892833549619200","J-1493550-7","Methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxy-1H-benzimidazole-7-carboxylate","1-[(2'-氰基联苯-4-基)甲基]-2-乙氧基-1H-苯并咪唑-7-甲酸甲酯","139481-44-0",{"slug":293,"cid":294,"name":295,"nameZh":296,"cas":297},"785876076013293568","J-12038-4","Thiazolyl Blue","噻唑蓝","298-93-1",1792629349484,"zh-CN",[]]