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Ramelteon与持续睡眠潜伏期,睡眠效率和总睡眠时间的改善有关[3]。在L：D周期的暗期中点附近施用Ramelteon(10mg\u002Fkg,i\u002Fp),显着降低NREM睡眠潜伏期(从注射到NREM睡眠出现的时间)。 Ramelteon也会使NREM睡眠持续时间短暂增加,但NREM功率谱不会改变[4]。",{"key":263,"value":264},"激酶实验","将编码人MT1基因的cDNA导入CHO细胞。在含有5mM EDTA的Ca 2+和Mg 2+游离的Hanks平衡盐溶液中汇合收获细胞，并通过离心收集。将细胞在冰冷的50mM Tris-HCl缓冲液中匀浆，洗涤两次，沉淀，并在-30℃下储存直至进行结合测定。将测试化合物和40pM 2- [125I]褪黑激素与解冻的匀浆混合，总体积为1mL，并在25℃下孵育150分钟。通过加入3mL冰冷缓冲液终止反应，然后在Whatman GF \u002F B上真空过滤。将滤器洗涤两次，用g计数器计数放射性[1]。",{"key":266,"value":267},"动物实验","大鼠：将Ramelteon以200mg \u002F mL的浓度溶解在DMSO中，并在使用前立即在生理盐水中稀释100倍。给予不同组的六只植入大鼠载体或ramelteon（10mg \u002F kg ip）。在注射前记录EEG和EMG 1小时，然后再记录3.5小时。所有治疗均在24:00小时（接近L：D周期的暗期中点）施用，在同一动物中分开注射最少72小时。每只大鼠都采用完全随机，平衡的交叉设计接受两种治疗，减少了研究所需的动物数量[4]。",{"key":269,"value":270},"参考文献","[1].\nKato K, et al. Neurochemical properties of ramelteon (TAK-375), a selective MT1\u002FMT2 receptor agonist. Neuropharmacology. 2005 Feb;48(2):301-10.\n[2].\nMiyamoto M, et al. The sleep-promoting action of ramelteon (TAK-375) in freely moving cats. Sleep. 2004 Nov 1;27(7):1319-25.\n[3].\nKuriyama A, et al. Ramelteon for the treatment of insomnia in adults: a systematic review and meta-analysis. Sleep Med. 2014 Apr;15(4):385-92.\n[4].\nFisher SP, et al. Acute sleep-promoting action of the melatonin agonist, ramelteon, in the rat. 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