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2]。",{"key":258,"value":259},"激酶实验","FPT活性通过测量[3H]法呢基从[3H]法呢基PPi向三氯乙酸可沉淀的Ha-Ras-CVLS的转移来确定。使用[3H]香叶基香叶基二磷酸和Ha-Ras-CVLL作为底物类似地测定GGPT-1活性[1]。",{"key":261,"value":262},"细胞实验","使用CellTiter96水性测定试剂盒。在96孔组织培养板中以5000个细胞\u002F孔进行测定。在药物暴露后24小时照射平板并在XRT后96小时测定，每天施用新的药物处理。为了定量，将染料直接添加到每个孔中，根据制造商的建议洗涤板，并通过光密度确定细胞活力。使用学生T检验分析显着性。将12孔板接种100,000个细胞\u002F孔。在接种后24小时开始药物治疗，并且每24小时更换培养基，总共96小时的药物暴露。在药物暴露24小时后照射平板。将来自一式三份处理组的细胞用胰蛋白酶消化并在照射后48小时使用Z1系列库尔特计数器计数，并与来自第1天计数的孔的细胞数（药物处理开始当天）进行比较。药物处理后的增殖相对于对照孔标准化，并表示为对照处理的％。使用学生T检验分析显着性[2]。",{"key":264,"value":265},"动物实验","小鼠[2] Lonafarnib每天给予一次，剂量为80mg \u002F kg，每周两次称重，以确保准确给药。在XRT之前90分钟通过管饲法以5mg \u002F kg给予替莫唑胺（Tem）。对于照射，将麻醉的小鼠置于铅屏蔽装置中，该装置仅限制对头部的辐射暴露。使用Gammacell 40辐照器以100rad \u002F min的速度递送治疗（2.5Gy \u002F天，持续两天）。对于体内组合实验，选择次优剂量的XRT \u002F Tem以允许鉴定Lonafarnib的协同作用。",{"key":267,"value":268},"参考文献","[1].\nLiu M, et al. 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