[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"currency-rates":3,"$fyk2oeqxpb7bd":8,"compound-J-1979168-5":169,"verified-suppliers-J-1979168-5":368},{"rates":4,"source":7},{"USD":5,"CNY":6},1,6.679814,"live",{"rows":9,"total":167,"current":5,"size":168},[10,33,45,60,73,84,96,111,121,133,145,156],{"slug":11,"cid":12,"imgSvg":13,"name":14,"nameZh":15,"cas":16,"formula":17,"iupac":14,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":22,"offersCount":24,"supplierCount":25,"bestOffer":26},"843627791009189888","J-1971488-6","\u002Fimages\u002Fchem_structures_svg\u002F399\u002F65845-61-6.svg","N-Methylcyclohexanamine hydrochloride","N-甲基环己胺盐酸盐","65845-61-6","C7H16ClN","acids","有机酸","Organic Acids","",[23],"In Stock",4,2,{"unitPrice":27,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},2.64,"500g","CNY","China","CN","in-stock",{"slug":34,"cid":35,"imgSvg":36,"name":37,"nameZh":38,"cas":39,"formula":40,"iupac":37,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":41,"offersCount":24,"supplierCount":5,"bestOffer":42},"785882541994283008","J-1323843-2","\u002Fimages\u002Fchem_structures_svg\u002F104\u002F67627-18-3.svg","Potassium indigotrisulfonate","靛蓝三磺酸钾","67627-18-3","C16H7K3N2O11S3",[23],{"unitPrice":43,"pack":44,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},180,"5g",{"slug":46,"cid":47,"imgSvg":48,"name":49,"nameZh":50,"cas":51,"formula":52,"iupac":49,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":56,"offersCount":57,"supplierCount":25,"bestOffer":58},"785889752443260928","J-28559-6","\u002Fimages\u002Fchem_structures_svg\u002F292\u002F15060-55-6.svg","Ammonium tetrathiomolybdate","四硫钼酸铵","15060-55-6","H8MoN2S4","inorganic","无机化合物","Inorganic Chemicals",[23],10,{"unitPrice":59,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},24,{"slug":61,"cid":62,"imgSvg":63,"name":64,"nameZh":65,"cas":66,"formula":67,"iupac":64,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":68,"offersCount":69,"supplierCount":25,"bestOffer":70},"855452191530422272","J-1994428-6","\u002Fimages\u002Fchem_structures_svg\u002F500\u002F16350-96-2.svg","N-benzylcyclohexanamine.hydrochloride","N-苄基环己胺盐酸盐","16350-96-2","C13H20ClN",[23],5,{"unitPrice":71,"pack":28,"currency":29,"origin":72,"originFlag":31,"moq":21,"stock":32},6,"中国",{"slug":74,"cid":75,"imgSvg":76,"name":77,"nameZh":78,"cas":79,"formula":80,"iupac":77,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":81,"offersCount":25,"supplierCount":25,"bestOffer":82},"785871840001134592","J-982001-3","\u002Fimages\u002Fchem_structures_svg\u002F001\u002F10517-44-9.svg","1,3-Diaminopropane dihydrochloride","1,3-二氨基丙烷二盐酸盐","10517-44-9","C3H12Cl2N2",[23],{"unitPrice":83,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},3.78,{"slug":85,"cid":86,"imgSvg":87,"name":88,"nameZh":89,"cas":90,"formula":91,"iupac":88,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":92,"offersCount":93,"supplierCount":94,"bestOffer":95},"785880365658017792","J-14975-7","\u002Fimages\u002Fchem_structures_svg\u002F262\u002F12003-67-7.svg","Lithium aluminate","氧化铝锂","12003-67-7","AlLiO2",[23],7,3,{"unitPrice":94,"pack":28,"currency":29,"origin":72,"originFlag":31,"moq":21,"stock":32},{"slug":97,"cid":98,"imgSvg":99,"name":100,"nameZh":101,"cas":102,"formula":103,"iupac":100,"category":104,"categoryName":105,"categoryEnName":106,"industry":21,"tags":107,"offersCount":94,"supplierCount":5,"bestOffer":109},"785871830249377792","J-6931-8","\u002Fimages\u002Fchem_structures_svg\u002F456\u002F58068-80-7.svg","1-Octanoylbenzotriazole","N-辛酰苯并三唑","58068-80-7","C14H19N3O","aromatics","芳香烃","Aromatic Hydrocarbons",[108],"Made to Order",{"unitPrice":110,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},0.56,{"slug":112,"cid":113,"imgSvg":114,"name":115,"nameZh":116,"cas":117,"formula":118,"iupac":115,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":119,"offersCount":69,"supplierCount":25,"bestOffer":120},"785871842446413824","J-1960944-0","\u002Fimages\u002Fchem_structures_svg\u002F495\u002F10534-86-8.svg","Hexaamminecobalt(III) nitrate","六氨合钴(III)硝酸盐","10534-86-8","CoH18N9O9",[23],{"unitPrice":71,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},{"slug":122,"cid":123,"imgSvg":124,"name":125,"nameZh":126,"cas":127,"formula":128,"iupac":125,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":129,"offersCount":24,"supplierCount":25,"bestOffer":130},"785871842576437248","J-814544-6","\u002Fimages\u002Fchem_structures_svg\u002F221\u002F12037-42-2.svg","vanadium oxide","氧化钒","12037-42-2","O13V6",[23],{"unitPrice":131,"pack":132,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},112.8,"100g",{"slug":134,"cid":135,"imgSvg":136,"name":137,"nameZh":138,"cas":139,"formula":140,"iupac":137,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":141,"offersCount":142,"supplierCount":5,"bestOffer":143},"785871842647740416","J-1333345-4","\u002Fimages\u002Fchem_structures_svg\u002F479\u002F26490-63-1.svg","COBALT TETRAFLUOROBORATE HEXAHYDRATE","四氟化硼钴水合物","26490-63-1","B2CoF8H12O6",[23],8,{"unitPrice":144,"pack":132,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},11,{"slug":146,"cid":147,"imgSvg":148,"name":149,"nameZh":150,"cas":151,"formula":152,"iupac":149,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":153,"offersCount":57,"supplierCount":94,"bestOffer":154},"785871842698072064","J-814953-9","\u002Fimages\u002Fchem_structures_svg\u002F432\u002F72259-10-0.svg","Copper(II) tetrafluoroborate hexahydrate","六水合四氟硼酸铜(II)","72259-10-0","B2CuF8H12O6",[23],{"unitPrice":155,"pack":28,"currency":29,"origin":21,"originFlag":21,"moq":21,"stock":32},2.6,{"slug":157,"cid":158,"imgSvg":159,"name":160,"nameZh":161,"cas":162,"formula":163,"iupac":160,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":164,"offersCount":94,"supplierCount":5,"bestOffer":165},"785871863254355968","J-1990080-2","\u002Fimages\u002Fchem_structures_svg\u002F149\u002F123333-60-8.svg","Cerium(IV) sulfate hydrate","铈(IV)硫酸盐水合物","123333-60-8","CeH2O9S2",[108],{"unitPrice":166,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},5.6,3204,12,{"slug":170,"cid":171,"imgSvg":172,"name":173,"nameZh":174,"cas":175,"formula":176,"iupac":173,"mdl":21,"mw":177,"category":178,"categoryName":179,"categoryEnName":180,"industry":21,"tags":181,"synonyms":182,"properties":187,"ghs":233,"offers":238,"activity":239,"upstream":264,"downstream":265,"customs":266,"safetyRows":267,"updatedAt":291,"isProhibited":292,"related":293,"__ts":366,"__lang":367,"__slug":171},"785895326786523136","J-1979168-5","\u002Fimages\u002Fchem_structures_svg\u002F166\u002F155270-99-8.svg","Istradefylline","伊曲茶碱","155270-99-8","C20H24N4O4","384.429","bases","有机碱","Organic Bases",[],[183,184,185,186],"8-[(E)-2-(3,4-二甲氧基苯基)乙烯基]-1,3-二乙基-7-甲基嘌呤-2,6-二酮","(E)-8-(3,4-二甲氧基苯乙烯基)-1,3-二乙基-7-甲基-1H-嘌呤-2,6(3H,7H)-二酮","(E)-8-(3,4-二甲氧基苯乙烯基)-1,3-二乙基-7-甲基-3,7-二氢-1H-嘌呤-2,6-二酮","KW-6002",[188,193,198,203,207,210,213,217,221,225,229],{"label":189,"labelZh":190,"value":191,"prop":192},"Boiling Point","沸点","601.0±65.0 °C at 760 mmHg","boilingPoint",{"label":194,"labelZh":195,"value":196,"prop":197},"Density","密度","1.2±0.1 g\u002Fcm3","density",{"label":199,"labelZh":200,"value":201,"prop":202},"Flash Point","闪点","317.3±34.3 °C","flashPoint",{"label":204,"labelZh":205,"value":206},"Exact Mass","精确质量","384.179749",{"label":208,"labelZh":208,"value":209},"PSA","80.28000",{"label":211,"labelZh":211,"value":212},"LogP","2.84",{"label":214,"labelZh":215,"value":216},"Appearance","外观性状","white to beige",{"label":218,"labelZh":219,"value":220},"Vapor Pressure","蒸汽压","0.0±1.7 mmHg at 25°C",{"label":222,"labelZh":223,"value":224},"Refractive Index","折射率","1.598",{"label":226,"labelZh":227,"value":228},"Storage Conditions","储存条件","2-8°C",{"label":230,"labelZh":231,"value":232},"Additional Property","水溶解性","DMSO: soluble5mg\u002FmL (clear solution)",{"pictogram":234,"signal":235,"hazards":236},"Acute Toxicity","Danger",[237],"H301 — Toxic if swallowed \u002F 吞咽会中毒",[],[240,243,246,249,252,255,258,261],{"key":241,"value":242},"描述","Istradefylline 是一种有效的,选择性的,可口服的 adenosine A2A receptor 拮抗剂,在帕金森疾病模型试验中,Ki 值为 2.2 nM。",{"key":244,"value":245},"相关类别","信号通路\n>>\nG 蛋白偶联受体\u002FG 蛋白\n>>\n腺苷受体\n研究领域\n>>\n神经疾病",{"key":247,"value":248},"靶点","Ki: 2.2 nM (adenosine A2A receptor)",{"key":250,"value":251},"体外研究","Istradefylline对A2AR的亲和力比A1受体高70倍,Ki为2.2 nM,而150 nM [1]。 Istradefylline导致原代大鼠纹状体星形胶质细胞中bFGF诱导星形胶质细胞增生的浓度依赖性消除[4]。 Istradefylline与人类A1受体,A2A受体和A3受体结合,Kis> 287 nM,9.12 nM,> 681 nM,大鼠的A1受体和A2A受体分别为50.9 nM和1.57 nM,105.02 nM和1.87 nM分别为小鼠的A1受体和A2A受体[5]。",{"key":253,"value":254},"体内研究","在单剂量MPTP之前,Istradefylline(3.3 mg\u002Fkg,ip)治疗减弱1周后在纹状体中测量的部分多巴胺和DOPAC消耗[1]。 Istradefylline可逆转CGS21680诱导的和利血平诱导的强直性昏厥,ED50分别为0.05 mg\u002Fkg和0.26 mg\u002Fkg。与其他腺苷拮抗剂和多巴胺激动剂药物相比,Istradefylline在这些模型中的效力超过10倍。 Istradefylline联合L-dopa可对氟哌啶醇诱导和利血平诱导的强直性昏厥有潜在作用[2]。 Istradefylline(10 mg\u002Fkg,po)导致运动活性增加至对照的约两倍,并改善MPTP处理的普通mar猴的运动功能障碍。 Istradefylline(10 mg\u002Fkg,po)与SKF80723,喹吡罗或L-DOPA联合使用可对运动活动和运动功能障碍的改善产生显着的累加效应,但不会导致运动障碍[3]。",{"key":256,"value":257},"细胞实验","永久表达人腺苷A1或A2A受体的CHO细胞系在补充有10％（v \u002F v）胎牛血清，50U \u002F mL青霉素和50μg\u002F mL链霉素的α-MEM中培养。细胞在37℃，5％CO 2的环境中生长。将这些细胞以15,000个细胞\u002F孔的密度接种在黑色96孔测定板上，然后培养24小时。",{"key":259,"value":260},"动物实验","在标准条件下，在24-26℃和50-60％相对湿度的温度下，使用12小时光暗循环，将动物成对或单独饲养。饮食包括标准食物颗粒，新鲜水果和Mazuri Marmoset果冻。用MPTP以每天2.0mg \u002F kg sc的剂量处理动物5天。在MPTP处理后，允许动物在约6-8周的时间内从急性效应中恢复。在MPTP治疗期间以及随后的几周内，动物用Mazuri mar猴果冻和新鲜水果泥手工喂养，直到它们能够维持它们自身为止。在进行行为测试之前，暴露于MPTP后6-8周至8个月，所有动物均表现出基础运动活动明显减少，运动速度减慢且协调性较差，身体某些部位姿势异常，以及减少的checKing运动和眼睛闪烁。将Istradefylline（KW-6002）悬浮于0.3％吐温-80和10％蔗糖溶液中，并通过口服强饲法以2.0mL \u002F kg体重的最终体积给药。",{"key":262,"value":263},"参考文献","[1].\nChen JF, et al. Neuroprotection by caffeine and A(2A) adenosine receptor inactivation in a model of Parkinson's disease. J Neurosci. 2001 May 15;21(10):RC143.\n[2].\nShiozaki S, et al. Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP. Psychopharmacology (Berl). 1999 Nov;147(1):90-5.\n[3].\nKanda T, et al. Combined use of the adenosine A(2A) antagonist KW-6002 with L-DOPA or with selective D1 or D2 dopamine agonists increases antiparkinsonian activity but not dyskinesia in MPTP-treated monkeys. Exp Neurol. 2000 Apr;162(2):321-7.\n[4].\nBrambilla R, et al. Blockade of A2A adenosine receptors prevents basic fibroblast growth factor-induced reactive astrogliosis in rat striatal primary astrocytes. Glia. 2003 Aug;43(2):190-4.\n[5].\nMihara T, et al. Pharmacological characterization of a novel, potent adenosine A1 and A2A receptor dual antagonist, 5-[5-amino-3-(4-fluorophenyl)pyrazin-2-yl]-1-isopropylpyridine-2(1H)-one (ASP5854), in models of Parkinson's disease and cognition. J Pharm",[],[],[],[268,271,273,276,279,282,285,288],{"key":269,"value":270},"符号","GHS06",{"key":272,"value":235},"信号词",{"key":274,"value":275},"危害声明","H301",{"key":277,"value":278},"警示性声明","P301 + P310",{"key":280,"value":281},"危害码 (欧洲)","T",{"key":283,"value":284},"风险声明 (欧洲)","25",{"key":286,"value":287},"安全声明 (欧洲)","45",{"key":289,"value":290},"危险品运输编码","UN 2811 6.1 \u002F PGIII","2026-08-21T07:51:12.859463Z",false,[294,300,306,312,318,324,330,336,342,348,354,360],{"slug":295,"cid":296,"name":297,"nameZh":298,"cas":299},"785872803055276032","J-979062-9","N,N-bis(2-ethylhexyl)-4-methyl-1H-benzotriazole-1-methylamine","N,N-二(2-乙基己基)-4-甲基-1H-苯并三唑-1-甲胺","80584-90-3",{"slug":301,"cid":302,"name":303,"nameZh":304,"cas":305},"785881272906944512","J-18533-1","Tris(ethylenediamine)cobalt(III) chloride dihydrate","三(乙二胺)合氯化钴(III)二水合物","207802-43-5",{"slug":307,"cid":308,"name":309,"nameZh":310,"cas":311},"785876670308421632","J-13996-8","2,2-Diphenyl-1-picrylhydrazyl","2,2-联苯基-1-苦基肼基","1898-66-4",{"slug":313,"cid":314,"name":315,"nameZh":316,"cas":317},"785912332868915200","J-1929537-5","copper;[(1R,2R)-2-azanidylcyclohexyl]azanide;bromide","溴化[(1R,2R)-1,2-环己二胺]合铜(II)","388580-24-3",{"slug":319,"cid":320,"name":321,"nameZh":322,"cas":323},"785898832582938624","J-1839293-3","N-[4-(2-Naphthalenyl)phenyl]-[1,1'-biphenyl]-4-amine","N-[4-(2-萘基)苯基]-[1,1'-联苯]-4-胺","897921-60-7",{"slug":325,"cid":326,"name":327,"nameZh":328,"cas":329},"785884690279043072","J-23887-9","Perfluorotriethylamine","全氟三乙胺","359-70-6",{"slug":331,"cid":332,"name":333,"nameZh":334,"cas":335},"785875602539286528","J-10557-7","Tris(ethylenediamine)cobalt(III) chloride trihydrate","三(乙二胺)氯化钴(III)三水合物","14883-80-8",{"slug":337,"cid":338,"name":339,"nameZh":340,"cas":341},"785891782276681728","J-1435600-4","N-([1,1'-biphenyl]-4-yl)-9,9-dimethyl-9H-fluoren-2-amine","N-[1,1'-联苯-4-基]-9,9-二甲基-9H-芴-2-胺","897671-69-1",{"slug":343,"cid":344,"name":345,"nameZh":346,"cas":347},"785895156179013632","J-1507619-4","N-[1,1'-Biphenyl]-2-yl-9,9-dimethyl-9H-fluoren-2-amine","N-[1,1'-联苯]-2-基-9,9-二甲基-9H-芴-2-胺","1198395-24-2",{"slug":349,"cid":350,"name":351,"nameZh":352,"cas":353},"785880932870524928","J-1975254-6","Chloro[N,N'-ethylenebis(salicylideneaminato)]manganese(III)","N,N'-双(亚水杨基)-1,2-乙二胺氯化锰(III)","53177-12-1",{"slug":355,"cid":356,"name":357,"nameZh":358,"cas":359},"785898498833780736","J-1528294-7","Cesium(I) bis(trifluoromethanesulfonyl)imide","双(三氟甲基磺酰基)酰亚胺铯(I)","91742-16-4",{"slug":361,"cid":362,"name":363,"nameZh":364,"cas":365},"785895093797130240","J-1116686-2","Nile Blue chloride","碱性蓝12","2381-85-3",1794263011549,"zh-CN",[]]