[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"currency-rates":3,"$fyk2oeqxpb7bd":8,"compound-J-1975437-1":169,"verified-suppliers-J-1975437-1":341},{"rates":4,"source":7},{"USD":5,"CNY":6},1,6.679814,"live",{"rows":9,"total":167,"current":5,"size":168},[10,33,45,60,73,84,96,111,121,133,145,156],{"slug":11,"cid":12,"imgSvg":13,"name":14,"nameZh":15,"cas":16,"formula":17,"iupac":14,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":22,"offersCount":24,"supplierCount":25,"bestOffer":26},"843627791009189888","J-1971488-6","\u002Fimages\u002Fchem_structures_svg\u002F399\u002F65845-61-6.svg","N-Methylcyclohexanamine hydrochloride","N-甲基环己胺盐酸盐","65845-61-6","C7H16ClN","acids","有机酸","Organic Acids","",[23],"In Stock",4,2,{"unitPrice":27,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},2.64,"500g","CNY","China","CN","in-stock",{"slug":34,"cid":35,"imgSvg":36,"name":37,"nameZh":38,"cas":39,"formula":40,"iupac":37,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":41,"offersCount":24,"supplierCount":5,"bestOffer":42},"785882541994283008","J-1323843-2","\u002Fimages\u002Fchem_structures_svg\u002F104\u002F67627-18-3.svg","Potassium indigotrisulfonate","靛蓝三磺酸钾","67627-18-3","C16H7K3N2O11S3",[23],{"unitPrice":43,"pack":44,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},180,"5g",{"slug":46,"cid":47,"imgSvg":48,"name":49,"nameZh":50,"cas":51,"formula":52,"iupac":49,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":56,"offersCount":57,"supplierCount":25,"bestOffer":58},"785889752443260928","J-28559-6","\u002Fimages\u002Fchem_structures_svg\u002F292\u002F15060-55-6.svg","Ammonium tetrathiomolybdate","四硫钼酸铵","15060-55-6","H8MoN2S4","inorganic","无机化合物","Inorganic Chemicals",[23],10,{"unitPrice":59,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},24,{"slug":61,"cid":62,"imgSvg":63,"name":64,"nameZh":65,"cas":66,"formula":67,"iupac":64,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":68,"offersCount":69,"supplierCount":25,"bestOffer":70},"855452191530422272","J-1994428-6","\u002Fimages\u002Fchem_structures_svg\u002F500\u002F16350-96-2.svg","N-benzylcyclohexanamine.hydrochloride","N-苄基环己胺盐酸盐","16350-96-2","C13H20ClN",[23],5,{"unitPrice":71,"pack":28,"currency":29,"origin":72,"originFlag":31,"moq":21,"stock":32},6,"中国",{"slug":74,"cid":75,"imgSvg":76,"name":77,"nameZh":78,"cas":79,"formula":80,"iupac":77,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":81,"offersCount":25,"supplierCount":25,"bestOffer":82},"785871840001134592","J-982001-3","\u002Fimages\u002Fchem_structures_svg\u002F001\u002F10517-44-9.svg","1,3-Diaminopropane dihydrochloride","1,3-二氨基丙烷二盐酸盐","10517-44-9","C3H12Cl2N2",[23],{"unitPrice":83,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},3.78,{"slug":85,"cid":86,"imgSvg":87,"name":88,"nameZh":89,"cas":90,"formula":91,"iupac":88,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":92,"offersCount":93,"supplierCount":94,"bestOffer":95},"785880365658017792","J-14975-7","\u002Fimages\u002Fchem_structures_svg\u002F262\u002F12003-67-7.svg","Lithium aluminate","氧化铝锂","12003-67-7","AlLiO2",[23],7,3,{"unitPrice":94,"pack":28,"currency":29,"origin":72,"originFlag":31,"moq":21,"stock":32},{"slug":97,"cid":98,"imgSvg":99,"name":100,"nameZh":101,"cas":102,"formula":103,"iupac":100,"category":104,"categoryName":105,"categoryEnName":106,"industry":21,"tags":107,"offersCount":94,"supplierCount":5,"bestOffer":109},"785871830249377792","J-6931-8","\u002Fimages\u002Fchem_structures_svg\u002F456\u002F58068-80-7.svg","1-Octanoylbenzotriazole","N-辛酰苯并三唑","58068-80-7","C14H19N3O","aromatics","芳香烃","Aromatic Hydrocarbons",[108],"Made to Order",{"unitPrice":110,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},0.56,{"slug":112,"cid":113,"imgSvg":114,"name":115,"nameZh":116,"cas":117,"formula":118,"iupac":115,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":119,"offersCount":69,"supplierCount":25,"bestOffer":120},"785871842446413824","J-1960944-0","\u002Fimages\u002Fchem_structures_svg\u002F495\u002F10534-86-8.svg","Hexaamminecobalt(III) nitrate","六氨合钴(III)硝酸盐","10534-86-8","CoH18N9O9",[23],{"unitPrice":71,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},{"slug":122,"cid":123,"imgSvg":124,"name":125,"nameZh":126,"cas":127,"formula":128,"iupac":125,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":129,"offersCount":24,"supplierCount":25,"bestOffer":130},"785871842576437248","J-814544-6","\u002Fimages\u002Fchem_structures_svg\u002F221\u002F12037-42-2.svg","vanadium oxide","氧化钒","12037-42-2","O13V6",[23],{"unitPrice":131,"pack":132,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},112.8,"100g",{"slug":134,"cid":135,"imgSvg":136,"name":137,"nameZh":138,"cas":139,"formula":140,"iupac":137,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":141,"offersCount":142,"supplierCount":5,"bestOffer":143},"785871842647740416","J-1333345-4","\u002Fimages\u002Fchem_structures_svg\u002F479\u002F26490-63-1.svg","COBALT TETRAFLUOROBORATE HEXAHYDRATE","四氟化硼钴水合物","26490-63-1","B2CoF8H12O6",[23],8,{"unitPrice":144,"pack":132,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},11,{"slug":146,"cid":147,"imgSvg":148,"name":149,"nameZh":150,"cas":151,"formula":152,"iupac":149,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":153,"offersCount":57,"supplierCount":94,"bestOffer":154},"785871842698072064","J-814953-9","\u002Fimages\u002Fchem_structures_svg\u002F432\u002F72259-10-0.svg","Copper(II) tetrafluoroborate hexahydrate","六水合四氟硼酸铜(II)","72259-10-0","B2CuF8H12O6",[23],{"unitPrice":155,"pack":28,"currency":29,"origin":21,"originFlag":21,"moq":21,"stock":32},2.6,{"slug":157,"cid":158,"imgSvg":159,"name":160,"nameZh":161,"cas":162,"formula":163,"iupac":160,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":164,"offersCount":94,"supplierCount":5,"bestOffer":165},"785871863254355968","J-1990080-2","\u002Fimages\u002Fchem_structures_svg\u002F149\u002F123333-60-8.svg","Cerium(IV) sulfate hydrate","铈(IV)硫酸盐水合物","123333-60-8","CeH2O9S2",[108],{"unitPrice":166,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},5.6,3204,12,{"slug":170,"cid":171,"imgSvg":172,"name":173,"nameZh":174,"cas":175,"formula":176,"iupac":173,"mdl":21,"mw":177,"category":178,"categoryName":179,"categoryEnName":180,"industry":21,"tags":181,"synonyms":182,"properties":185,"ghs":218,"offers":219,"activity":220,"upstream":248,"downstream":255,"customs":256,"safetyRows":257,"updatedAt":264,"isProhibited":265,"related":266,"__ts":339,"__lang":340,"__slug":171},"785881274014240768","J-1975437-1","\u002Fimages\u002Fchem_structures_svg\u002F476\u002F497839-62-0.svg","AEE788","6-[4-[(4-乙基-1-哌嗪)甲基]苯基]-N-[(1R)-1-苯基乙基]-7H-吡咯并[2,3-d]嘧啶-4-胺","497839-62-0","C27H32N6","440.583","pharma","医药中间体","Pharma Intermediates",[],[173,183,184],"NVP-AEE788","(R)-6-(4-((4-乙基哌嗪-1-基)甲基)苯基)-N-(1-苯基乙基)-7H-吡咯并[2,3-d]嘧啶-4-胺",[186,191,196,200,203,206,210,214],{"label":187,"labelZh":188,"value":189,"prop":190},"Melting Point","熔点","247 °C","meltingPoint",{"label":192,"labelZh":193,"value":194,"prop":195},"Density","密度","1.2±0.1 g\u002Fcm3","density",{"label":197,"labelZh":198,"value":199},"Exact Mass","精确质量","440.268860",{"label":201,"labelZh":201,"value":202},"PSA","63.31000",{"label":204,"labelZh":204,"value":205},"LogP","4.76",{"label":207,"labelZh":208,"value":209},"Appearance","外观性状","固体;White to Light yellow powder to crystal",{"label":211,"labelZh":212,"value":213},"Refractive Index","折射率","1.665",{"label":215,"labelZh":216,"value":217},"Storage Conditions","储存条件","-20°C;存放于惰性气体之中;避免空气,加热",null,[],[221,224,227,230,233,236,239,242,245],{"key":222,"value":223},"描述","AEE788是EGFR和ErbB2的抑制剂,IC50值分别为2和6 nM。",{"key":225,"value":226},"相关类别","研究领域\n>>\n癌症",{"key":228,"value":229},"靶点","EGFR:2 nM (IC50)\nErbB2:6 nM (IC50)",{"key":231,"value":232},"体外研究","AEE788在nM范围内抑制EGFR和VEGF受体酪氨酸激酶(IC50：EGFR 2nm,ErbB2 6nm,KDR 77nm和Flt-1 59nm)。在细胞中,生长因子诱导的EGFR和ErbB2磷酸化也被有效抑制(分别为IC50：11和220nm)。 AEE788表现出抗一系列EGFR和ErbB2过表达细胞系(包括EGFRvIII依赖性细胞系)的抗增殖活性,并抑制表皮生长因子和VEGF刺激的人脐静脉内皮细胞的增殖[1]。用AEE788处理皮肤SCC细胞导致EGFR和VEGFR-2磷酸化,生长抑制和诱导细胞凋亡的剂量依赖性抑制[2]。",{"key":234,"value":235},"体内研究","AEE788有效抑制肿瘤中生长因子诱导的EGFR和ErbB2磷酸化> 72 h。 AEE788还在小鼠植入模型中抑制VEGF诱导的血管生成[1]。在用AEE788处理的小鼠中,与对照小鼠相比,在治疗开始后21天肿瘤生长被抑制54％[2]。",{"key":237,"value":238},"激酶实验","使用重组谷胱甘肽S-转移酶 - 融合的激酶结构域（4-100ng，取决于比活性），在环境温度下在96孔板（30μL）中进行体外激酶测定15-45分钟。 [γ33P] ATP用作磷酸供体和polyGluTyr-（4：1）肽作为受体。使用以下ATP浓度针对每种激酶优化测定：1.0μM（c-Kit，c-Met，c-Fms，c-Raf-1和RET），2.0μM（EGFR，ErbB2，ErbB3和ErbB4）， 5.0μM（c-Abl），8.0μM（Flt-1，Flt-3，Flt-4，Flk，KDR，FGFR-1和Tek），10.0μM（PDGF受体-β，蛋白激酶C-α和细胞周期蛋白依赖性激酶1）和20.0μM（c-Src和蛋白激酶A）。加入20μL125mMEDTA终止反应。将30μL（c-Abl，c-Src，胰岛素样生长因子-1R，RET-Men2A和RET-Men2B）或40μL（所有其他激酶）的反应混合物转移至预先浸渍的Immobilon-polyvinylidene difluoride膜上。用0.5％H3PO4并安装在真空歧管上。然后施加真空并用200μL0.5％H 3 PO 4冲洗每个孔。取出膜并洗涤四次。计算干膜。 IC50通过抑制百分比的线性回归分析计算，并且是至少三次测定的平均值[1]。",{"key":240,"value":241},"细胞实验","将AEE788溶于90％聚乙二醇300加10％1-甲基-2-吡咯烷酮中至浓度为6.25mg \u002F mL。将肿瘤细胞接种到96孔板中的完全培养基中并使其附着24小时。用含有2％血清的培养基重新培养培养物。 24小时后，用不同浓度（0-2μM）的AEE788（单独使用DMSO的阴性对照）处理细胞72小时。在含有0.42mg \u002F mL MTT的培养基中孵育2小时后，将细胞在100μLDMSO中裂解。在570nm的吸光度下测量MTT向甲amount的转化[2]",{"key":243,"value":244},"动物实验","小鼠：将AEE788在DMSO中稀释并在最佳培养基中稀释。携带scA-431鳞状肿瘤（3只动物\u002F组）或HC11-NeuT驱动的乳腺肿瘤（2只动物\u002F组）的BALB \u002F c小鼠每天一次口服30mg \u002F kg AEE788或载体，持续5天。在化合物处理结束后和处死动物之前的不同时间点，给予小鼠静脉内500μgEG\u002F kg体重或0.2ml 0.9％w \u002F v NaCl作为载体对照。 EGF给药后5分钟，处死小鼠，取出肿瘤[1]。",{"key":246,"value":247},"参考文献","[1].\nTraxler P, et al. AEE788: a dual family epidermal growth factor receptor\u002FErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity. Cancer Res. 2004 Jul 15;64(14):4931-4941.\n[2].\nPark et al. AEE788, a dual tyrosine kinase receptor inhibitor, induces endothelial cell apoptosis in human cutaneous squamous cell carcinoma xenografts in nude mice. Clin Cancer Res. 2005 Mar 1;11(5):1963-1973.",[249],{"slug":250,"cid":251,"name":252,"nameZh":252,"cas":253,"imgSvg":254},"785882399639605200","J-3561-0","N-乙基哌嗪","5308-25-8","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F405\u002F5308-25-8.svg",[],[],[258,261],{"key":259,"value":260},"危险品运输编码","NONH for all modes of transport",{"key":262,"value":263},"RTECS号","UY8836200","2026-08-21T07:51:12.859463Z",false,[267,273,279,285,291,297,303,309,315,321,327,333],{"slug":268,"cid":269,"name":270,"nameZh":271,"cas":272},"785921713975070720","J-388070-4","6-Nitro-1,3-benzothiazol-2-amine;trichlorostibane;hydroxide","6-硝基-1,3-苯并噻唑-2-胺;三氯化锑;氢氧化物","32798-53-1",{"slug":274,"cid":275,"name":276,"nameZh":277,"cas":278},"853302420485181440","J-1135399-4","2-(2-Aminoacetamido)-N-methyl-N-(2-oxo-2-((6-(trifluoromethoxy)benzo[d]thiazol-2-yl)amino)ethyl)acetamide hydrochloride","2-(2-氨基乙酰胺基)-N-甲基-N-(2-氧代-2-((6-(三氟甲氧基)苯并[d]噻唑-2-基)氨基)乙基)乙酰胺盐酸盐","1926204-76-3",{"slug":280,"cid":281,"name":282,"nameZh":283,"cas":284},"785881404205436928","J-1090131-2","Tetraethyl ([2,2'-bipyridine]-4,4'-diylbis(methylene))bis(phosphonate)","四乙基([2,2'-联吡啶]-4,4'-二基双(亚甲基))双(膦酸酯)","176220-38-5",{"slug":286,"cid":287,"name":288,"nameZh":289,"cas":290},"785940547456995328","J-652336-0","Pyrithione lead","吡啶硫酮铅","88685-10-3",{"slug":292,"cid":293,"name":294,"nameZh":295,"cas":296},"785897952517296128","J-48494-6","Tris(8-hydroxyquinolinato)aluminum","8-羟基喹啉铝","2085-33-8",{"slug":298,"cid":299,"name":300,"nameZh":301,"cas":302},"785893989369778176","J-36832-1","Perfluoro-2-butyltetrahydrofuran","全氟(2-丁基四氢呋喃)","335-36-4",{"slug":304,"cid":305,"name":306,"nameZh":307,"cas":308},"785876076013293568","J-12038-7","Thiazolyl Blue","噻唑蓝","298-93-1",{"slug":310,"cid":311,"name":312,"nameZh":313,"cas":314},"785898927399374848","J-1530255-3","Dichloro[2,2'-dithiobis[benzothiazole]]zinc","二氯[2,2'-二硫代双[苯并噻唑]]锌","22405-83-0",{"slug":316,"cid":317,"name":318,"nameZh":319,"cas":320},"785892833549619200","J-1493550-3","Methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxy-1H-benzimidazole-7-carboxylate","1-[(2'-氰基联苯-4-基)甲基]-2-乙氧基-1H-苯并咪唑-7-甲酸甲酯","139481-44-0",{"slug":322,"cid":323,"name":324,"nameZh":325,"cas":326},"785873249509576704","J-1015386-3","Fmoc-Gly-Gly-Gly-OH","Fmoc-三甘肽","170941-79-4",{"slug":328,"cid":329,"name":330,"nameZh":331,"cas":332},"785894733439307776","J-38841-0","Chloro(pyridine)bis(dimethylglyoximato)cobalt(III)","氯双(二甲基乙二肟)吡啶钴(III)","23295-32-1",{"slug":334,"cid":335,"name":336,"nameZh":337,"cas":338},"785918166327889920","J-831479-2","2-(8-Bromodibenzo[b,d]furan-1-yl)-4,6-diphenyl-1,3,5-triazine","2-(8-溴二苯并[b,d]呋喃-1-基)-4,6-二苯基-1,3,5-三嗪","1822310-63-3",1794266912113,"zh-CN",[]]