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Order",{"unitPrice":169,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},5.6,3204,{"slug":172,"cid":173,"imgSvg":174,"name":175,"nameZh":175,"cas":176,"formula":177,"iupac":175,"mdl":21,"mw":178,"category":179,"categoryName":180,"categoryEnName":181,"industry":21,"tags":182,"synonyms":183,"properties":189,"ghs":228,"offers":229,"activity":230,"upstream":246,"downstream":265,"customs":266,"safetyRows":267,"toxicity":286,"msds":287,"updatedAt":288,"isProhibited":289,"related":290,"__ts":327,"__lang":328,"__slug":173},"785880948972457984","J-1975288-0","\u002Fimages\u002Fchem_structures_svg\u002F399\u002F90-69-7.svg","洛贝林","90-69-7","C22H27NO2","337.455","organic","有机化合物","Organic Compounds",[],[184,185,186,187,188],"山梗菜碱","祛痰菜碱","L-洛贝林","山梗菜碱\u002F洛贝林","山梗菜鹼",[190,194,198,202,206,210,213,216,220,224],{"label":191,"labelZh":191,"value":192,"prop":193},"Melting Point","130-131°","meltingPoint",{"label":195,"labelZh":195,"value":196,"prop":197},"Boiling Point","485.6±15.0 °C at 760 mmHg","boilingPoint",{"label":199,"labelZh":199,"value":200,"prop":201},"Density","1.1±0.1 g\u002Fcm3","density",{"label":203,"labelZh":203,"value":204,"prop":205},"Flash Point","247.5±20.4 °C","flashPoint",{"label":207,"labelZh":208,"value":209},"Exact Mass","精确质量","337.204193",{"label":211,"labelZh":211,"value":212},"PSA","40.54000",{"label":214,"labelZh":214,"value":215},"LogP","3.61",{"label":217,"labelZh":218,"value":219},"Vapor Pressure","蒸汽压","0.0±1.3 mmHg at 25°C",{"label":221,"labelZh":222,"value":223},"Refractive Index","折射率","1.563",{"label":225,"labelZh":226,"value":227},"Storage Conditions","储存条件","库房低温通风干燥,与食品原料分开存放",null,[],[231,234,237,240,243],{"key":232,"value":233},"描述","洛贝林(α-洛贝林；L-洛贝林)是一种亲脂性生物碱,是一种烟碱受体激动剂。洛贝林抑制d-甲基苯丙胺自我给药,无多巴胺毒性。洛贝琳挽救了滥用d-苯丙胺导致的成瘾效应。洛贝林通过抑制DA摄取到突触小泡中并改变突触前DA储存来增加多巴胺(DA)释放[1][2][3]。",{"key":235,"value":236},"相关类别","信号通路\n>>\n跨膜转运\n>>\n胆碱受体\n信号通路\n>>\n神经信号通路\n>>\n胆碱受体\n信号通路\n>>\n神经信号通路\n>>\n多巴胺转运蛋白\n研究领域\n>>\n神经疾病",{"key":238,"value":239},"体外研究","洛贝林(0.1-100μM)诱导 [3H]天溢出呈非钙依赖性[1]。 洛贝琳牌手表抑制 [3H]天被突触小体 (IC50=80μM)和囊泡 (IC50=0.88μM)摄取[1]。 洛贝林(0.1-1μM；1小时)抑制 1μM d-甲基苯丙胺诱导的纹状体切片释放多巴胺[2]。",{"key":241,"value":242},"体内研究","洛贝林(0.3-3.0 mg\u002Fkg；皮下注射; 单剂量) 降低模型大鼠 d-去氧麻黄碱的自我给药能力[3]。 洛贝林(3 mg\u002Fkg；皮下注射; 7.个周期,共 7.次) 以非竞争性的方式特别降低大鼠对 d-去氧麻黄碱的反应,并增加耐受性发展[3]。  动物模型：Sprague-Dawley大鼠(200-250 g)[3]剂量：0.3 mg\u002Fkg、1.0 mg\u002Fkg和3.0 mg\u002Fkg用于急性给药；慢性给药3 mg\u002Fkg给药：皮下注射；测量前15分钟,或每15分钟进行7次；间隔2个干预维持日的d-甲基苯丙胺(0.05 mg\u002Fkg输注)自我给药结果：d-甲基苯甲酯自我给药减少。",{"key":244,"value":245},"参考文献","[1].\nTeng L, et al. Lobeline and nicotine evoke [3H]overflow from rat striatal slices preloaded with [3H]dopamine: differential inhibition of synaptosomal and vesicular [3H]dopamine uptake. J Pharmacol Exp Ther. 1997 Mar;280(3):1432-44.\n[2].\nMiller DK, et al. Lobeline inhibits the neurochemical and behavioral effects of amphetamine. J Pharmacol Exp Ther. 2001 Mar;296(3):1023-34.\n[3].\nHarrod SB, et al. Lobeline attenuates d-methamphetamine self-administration in rats. J Pharmacol Exp Ther. 2001 Jul;298(1):172-9.",[247,253,259],{"slug":248,"cid":249,"name":250,"nameZh":250,"cas":251,"imgSvg":252},"785883706760892400","J-8863-5","盐酸洛贝林","134-63-4","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F439\u002F134-63-4.svg",{"slug":254,"cid":255,"name":256,"nameZh":256,"cas":257,"imgSvg":258},"785875910824824800","J-11233-0","N-甲基-N-甲基苯甲酰胺","6919-61-5","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F009\u002F6919-61-5.svg",{"slug":260,"cid":261,"name":262,"nameZh":262,"cas":263,"imgSvg":264},"785897342048931800","J-1520529-4","1-苯基-3-丁烯-1-醇","80735-94-0","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F142\u002F80735-94-0.svg",[],[],[268,271,274,277,280,283],{"key":269,"value":270},"危害码 (欧洲)","T",{"key":272,"value":273},"风险声明 (欧洲)","23\u002F24\u002F25",{"key":275,"value":276},"安全声明 (欧洲)","36\u002F37\u002F39-45",{"key":278,"value":279},"危险品运输编码","UN 1544",{"key":281,"value":282},"包装等级","III",{"key":284,"value":285},"危险类别","6.1(b)","\u003Ctd>\n\n\u003Cp>\u003Ca href=\"\u002Fen\u002Fcas\u002F90-69-7_261882.html#duXinDiv\">洛贝林毒性英文版\u003C\u002Fa>\u003C\u002Fp>\n\n\u003C\u002Ftd>","\u003Ctd>\n\r\n                                        \r\n                                        Date Updated: 13\u002FFEB\u002F2006\n\u003Cbr \u002F> Version 1.2\n\u003Cbr \u002F> Regulation (EC) No 1907\u002F2006\n\u003Cbr \u002F> ________________________________________________________________________\n\u003Cbr \u002F> 1 - Product and Company Information\n\u003Cbr \u002F> ________________________________________________________________________\n\u003Cbr \u002F> Product NameL-LOBELINE FREE BASE\n\u003Cbr \u002F> Product NumberL7149\n\u003Cbr \u002F> Company\n\u003Cbr \u002F> Century Ba-Shi Building 22A-B,\n\u003Cbr \u002F> 200020 Shanghai\n\u003Cbr \u002F> Technical Phone #86-21-61415566\n\u003Cbr \u002F> Fax 86-21-61415567\n\u003Cbr \u002F> E-mail Address\n\u003Cbr \u002F> ________________________________________________________________________\n\u003Cbr \u002F> 2 - Hazards Identification\n\u003Cbr \u002F> ________________________________________________________________________\n\u003Cbr \u002F> SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT\n\u003Cbr \u002F> Toxic by inhalation, in contact with skin and if swallowed.\n\u003Cbr \u002F> ________________________________________________________________________\n\u003Cbr \u002F> 3 - Composition\u002FInformation on Ingredients\n\u003Cbr \u002F> ________________________________________________________________________\n\u003Cbr \u002F> Product NameCAS #EC noAnnex I\n\u003Cbr \u002F> Index Number\n\u003Cbr \u002F> L-LOBELINE FREE BASE90-69-7202-012-3 None\n\u003Cbr \u002F> FormulaC22H27NO2\n\u003Cbr \u002F> Molecular Weight 337,5000 AMU\n\u003Cbr \u002F> Synonyms8,10-Diphenyllobelionol *\n\u003Cbr \u002F> 2-(6-(beta-Hydroxy-phenethyl)-1-methyl-2-piperidy\n\u003Cbr \u002F> l)acetophenone *\n\u003Cbr \u002F> 2-(6-(2-Hydroxy-2-phenylethyl)-1-methyl-2-piperid\n\u003Cbr \u002F> inyl)-1-phenylethanone * Inflatine * Lobelin *\n\u003Cbr \u002F> (-)-Lobeline * alpha-Lobeline * Lobnico\n\u003Cbr \u002F> ________________________________________________________________________\n\u003Cbr \u002F> 4 - First Aid Measures\n\u003Cbr \u002F> ________________________________________________________________________\n\u003Cbr \u002F> AFTER INHALATION\n\u003Cbr \u002F> If inhaled, remove to fresh air. If breathing becomes difficult,\n\u003Cbr \u002F> call a physician.\n\u003Cbr \u002F> AFTER SKIN CONTACT\n\u003Cbr \u002F> In case of skin contact, flush with copious amounts of water for\n\u003Cbr \u002F> at least 15 minutes. Remove contaminated clothing and shoes.\n\u003Cbr \u002F> Call a physician.\n\u003Cbr \u002F> AFTER EYE CONTACT\n\u003Cbr \u002F> In case of contact with eyes, flush with copious amounts of\n\u003Cbr \u002F> water for at least 15 minutes. Assure adequate flushing by\n\u003Cbr \u002F> separating the eyelids with fingers. Call a physician.\n\u003Cbr \u002F> AFTER INGESTION\n\u003Cbr \u002F> If swallowed, wash out mouth with water provided person is\n\u003Cbr \u002F> conscious. Call a physician.\n\u003Cbr \u002F> ________________________________________________________________________\n\u003Cbr \u002F> 5 - Fire Fighting Measures\n\u003Cbr \u002F> ________________________________________________________________________\n\u003Cbr \u002F> EXTINGUISHING MEDIA\n\u003Cbr \u002F> Suitable: Carbon dioxide, dry chemical powder, or appropriate\n\u003Cbr \u002F> foam.\n\u003Cbr \u002F> SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS\n\u003Cbr \u002F> Wear self-contained breathing apparatus and protective clothing\n\u003Cbr \u002F> to prevent contact with skin and eyes.\n\u003Cbr \u002F> ________________________________________________________________________\n\u003Cbr \u002F> 6 - Accidental Release Measures\n\u003Cbr \u002F> ________________________________________________________________________\n\u003Cbr \u002F> PROCEDURE(S) OF PERSONAL PRECAUTION(S)\n\u003Cbr \u002F> Wear respirator, chemical safety goggles, rubber boots, and\n\u003Cbr \u002F> heavy rubber gloves.\n\u003Cbr \u002F> METHODS FOR CLEANING UP\n\u003Cbr \u002F> Sweep up, place in a bag and hold for waste disposal. Avoid\n\u003Cbr \u002F> raising dust. Ventilate area and wash spill site after material\n\u003Cbr \u002F> pickup is complete.\n\u003Cbr \u002F> ________________________________________________________________________\n\u003Cbr \u002F> 7 - Handling and Storage\n\u003Cbr \u002F> ________________________________________________________________________\n\u003Cbr \u002F> ________________________________________________________________________\n\u003Cbr \u002F> 8 - Exposure Controls \u002F Personal Protection\n\u003Cbr \u002F> ________________________________________________________________________\n\u003Cbr \u002F> ENGINEERING CONTROLS\n\u003Cbr \u002F> Mechanical exhaust.\n\u003Cbr \u002F> PERSONAL PROTECTIVE EQUIPMENT\n\u003Cbr \u002F> Respiratory Protection: Use respirators and components tested and\n\u003Cbr \u002F> approved under appropriate government standards such as NIOSH (US)\n\u003Cbr \u002F> or CEN (EU). Where risk assessment shows air-purifying respirators\n\u003Cbr \u002F> are appropriate use a full-face particle respirator type N99 (US)\n\u003Cbr \u002F> or type P2 (EN 143) respirator cartridges as a backup to\n\u003Cbr \u002F> engineering controls. If the respirator is the sole means of\n\u003Cbr \u002F> protection, use a full-face supplied air respirator.\n\u003Cbr \u002F> Hand Protection: Compatible chemical-resistant gloves.\n\u003Cbr \u002F> Eye Protection: Chemical safety goggles.\n\u003Cbr \u002F> ________________________________________________________________________\n\u003Cbr \u002F> 9 - Physical and Chemical Properties\n\u003Cbr \u002F> ________________________________________________________________________\n\u003Cbr \u002F> AppearancePhysical State: Solid\n\u003Cbr \u002F> PropertyValueAt Temperature or Pressure\n\u003Cbr \u002F> pHN\u002FA\n\u003Cbr \u002F> BP\u002FBP RangeN\u002FA\n\u003Cbr \u002F> MP\u002FMP RangeN\u002FA\n\u003Cbr \u002F> Flash PointN\u002FA\n\u003Cbr \u002F> FlammabilityN\u002FA\n\u003Cbr \u002F> Autoignition TempN\u002FA\n\u003Cbr \u002F> Oxidizing PropertiesN\u002FA\n\u003Cbr \u002F> Explosive PropertiesN\u002FA\n\u003Cbr \u002F> Explosion LimitsN\u002FA\n\u003Cbr \u002F> Vapor PressureN\u002FA\n\u003Cbr \u002F> Partition CoefficientN\u002FA\n\u003Cbr \u002F> ViscosityN\u002FA\n\u003Cbr \u002F> Vapor DensityN\u002FA\n\u003Cbr \u002F> Saturated Vapor Conc. N\u002FA\n\u003Cbr \u002F> Evaporation RateN\u002FA\n\u003Cbr \u002F> Bulk DensityN\u002FA\n\u003Cbr \u002F> Decomposition Temp.N\u002FA\n\u003Cbr \u002F> Solvent ContentN\u002FA\n\u003Cbr \u002F> Water ContentN\u002FA\n\u003Cbr \u002F> Surface TensionN\u002FA\n\u003Cbr \u002F> ConductivityN\u002FA\n\u003Cbr \u002F> Miscellaneous DataN\u002FA\n\u003Cbr \u002F> SolubilityN\u002FA\n\u003Cbr \u002F> ________________________________________________________________________\n\u003Cbr \u002F> 10 - Stability and Reactivity\n\u003Cbr \u002F> ________________________________________________________________________\n\u003Cbr \u002F> STABILITY\n\u003Cbr \u002F> Stable: Stable.\n\u003Cbr \u002F> HAZARDOUS DECOMPOSITION PRODUCTS\n\u003Cbr \u002F> Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,\n\u003Cbr \u002F> Nitrogen oxides.\n\u003Cbr \u002F> HAZARDOUS POLYMERIZATION\n\u003Cbr \u002F> Hazardous Polymerization: Will not occur\n\u003Cbr \u002F> ________________________________________________________________________\n\u003Cbr \u002F> 11 - Toxicological Information\n\u003Cbr \u002F> ________________________________________________________________________\n\u003Cbr \u002F> RTECS NUMBER: OJ8480000\n\u003Cbr \u002F> ACUTE TOXICITY\n\u003Cbr \u002F> LD50\n\u003Cbr \u002F> Intraperitoneal\n\u003Cbr \u002F> Mouse\n\u003Cbr \u002F> 43500 UG\u002FKG\n\u003Cbr \u002F> LD50\n\u003Cbr \u002F> Intravenous\n\u003Cbr \u002F> Mouse\n\u003Cbr \u002F> 6300 UG\u002FKG\n\u003Cbr \u002F> LD50\n\u003Cbr \u002F> Subcutaneous\n\u003Cbr \u002F> Rabbit\n\u003Cbr \u002F> 35 MG\u002FKG\n\u003Cbr \u002F> SIGNS AND SYMPTOMS OF EXPOSURE\n\u003Cbr \u002F> Stomach pains, vomiting, diarrhea. Exposure can cause:\n\u003Cbr \u002F> ROUTE OF EXPOSURE\n\u003Cbr \u002F> Multiple Routes: Harmful if swallowed, inhaled, or absorbed\n\u003Cbr \u002F> through skin. May cause irritation.\n\u003Cbr \u002F> TARGET ORGAN INFORMATION\n\u003Cbr \u002F> Central nervous system. Peripheral nervous system.\n\u003Cbr \u002F> ________________________________________________________________________\n\u003Cbr \u002F> 12 - Ecological Information\n\u003Cbr \u002F> ________________________________________________________________________\n\u003Cbr \u002F> No data available.\n\u003Cbr \u002F> ________________________________________________________________________\n\u003Cbr \u002F> 13 - Disposal Considerations\n\u003Cbr \u002F> ________________________________________________________________________\n\u003Cbr \u002F> SUBSTANCE DISPOSAL\n\u003Cbr \u002F> Dissolve or mix the material with a combustible solvent and burn\n\u003Cbr \u002F> in a chemical incinerator equipped with an afterburner and\n\u003Cbr \u002F> scrubber. Observe all federal, state, and local environmental\n\u003Cbr \u002F> regulations.\n\u003Cbr \u002F> ________________________________________________________________________\n\u003Cbr \u002F> 14 - Transport Information\n\u003Cbr \u002F> ________________________________________________________________________\n\u003Cbr \u002F> RID\u002FADR\n\u003Cbr \u002F> UN#: 1544\n\u003Cbr \u002F> Class: 6.1\n\u003Cbr \u002F> PG: III\n\u003Cbr \u002F> Proper Shipping Name: Alkaloids, solid, n.o.s.\n\u003Cbr \u002F> IMDG\n\u003Cbr \u002F> UN#: 1544\n\u003Cbr \u002F> Class: 6.1\n\u003Cbr \u002F> PG: III\n\u003Cbr \u002F> Proper Shipping Name: Alkaloids, solid, n.o.s.\n\u003Cbr \u002F> Marine Pollutant: No\n\u003Cbr \u002F> Severe Marine Pollutant: No\n\u003Cbr \u002F> Technical Name: Required\n\u003Cbr \u002F> IATA\n\u003Cbr \u002F> UN#: 1544\n\u003Cbr \u002F> Class: 6.1\n\u003Cbr \u002F> PG: III\n\u003Cbr \u002F> Proper Shipping Name: Alkaloids, solid, n.o.s.\n\u003Cbr \u002F> Inhalation Packing Group I: No\n\u003Cbr \u002F> Technical Name: Required\n\u003Cbr \u002F> ________________________________________________________________________\n\u003Cbr \u002F> 15 - Regulatory Information\n\u003Cbr \u002F> ________________________________________________________________________\n\u003Cbr \u002F> CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES\n\u003Cbr \u002F> INDICATION OF DANGER: T\n\u003Cbr \u002F> Toxic.\n\u003Cbr \u002F> R-PHRASES: 23\u002F24\u002F25\n\u003Cbr \u002F> Toxic by inhalation, in contact with skin and if swallowed.\n\u003Cbr \u002F> S-PHRASES: 36\u002F37\u002F39-45\n\u003Cbr \u002F> Wear suitable protective clothing, gloves, and eye\u002Fface\n\u003Cbr \u002F> protection. In case of accident or if you feel unwell, seek\n\u003Cbr \u002F> medical advice immediately (show the label where possible).\n\u003Cbr \u002F> COUNTRY SPECIFIC INFORMATION\n\u003Cbr \u002F> Germany\n\u003Cbr \u002F> WGK: 3\n\u003Cbr \u002F> Self-Classification\n\u003Cbr \u002F> ________________________________________________________________________\n\u003Cbr \u002F> 16 - Other Information\n\u003Cbr \u002F> ________________________________________________________________________\n\u003Cbr \u002F> WARRANTY\n\u003Cbr \u002F> The above information is believed to be correct but does not\n\u003Cbr \u002F> purport to be all inclusive and shall be used only as a guide. The\n\u003Cbr \u002F> information in this document is based on the present state of our\n\u003Cbr \u002F> knowledge and is applicable to the product with regard to\n\u003Cbr \u002F> appropriate safety precautions. It does not represent any\n\u003Cbr \u002F> shall not be held liable for any damage resulting from handling or\n\u003Cbr \u002F> from contact with the above product. See reverse side of invoice\n\u003Cbr \u002F> or packing slip for additional terms and conditions of sale.\n\u003Cbr \u002F> unlimitedpaper copies for internal use only.\n\u003Cbr \u002F> DISCLAIMER\n\u003Cbr \u002F> For R&D use only. Not for drug, household or other uses.\n\u003Cbr \u002F>\n\u003Cbr \u002F>\n\n\u003Cstrong> 模块 15 - 法规信息 \u003C\u002Fstrong>\n\u003Cbr \u002F>N\u002FA\n\u003Cbr \u002F>\n\u003Cbr \u002F>\n\n\u003Cstrong> 模块16 - 其他信息 \u003C\u002Fstrong>\n\u003Cbr \u002F>N\u002FA\n\u003Cbr \u002F>\n\u003Cbr \u002F>\u003Cbr \u002F>\u003Cbr \u002F>\n\u003C\u002Ftd>","2026-08-21T07:51:12.859463Z",false,[291,297,303,309,315,321],{"slug":292,"cid":293,"name":294,"nameZh":295,"cas":296},"785883191893299200","J-1367925-3","Pigment Yellow 150","颜料黄150","68511-62-6",{"slug":298,"cid":299,"name":300,"nameZh":301,"cas":302},"785897850759286784","J-48149-6","Carboxyethylgermanium sesquioxide","羧乙基锗倍半氧化物","12758-40-6",{"slug":304,"cid":305,"name":306,"nameZh":307,"cas":308},"785891538591813632","J-30130-7","Alizarin Red S","茜素红S","130-22-3",{"slug":310,"cid":311,"name":312,"nameZh":313,"cas":314},"785897801883062272","J-47964-0","Fluorescein","荧光素","2321-07-5",{"slug":316,"cid":317,"name":318,"nameZh":319,"cas":320},"785891622826020864","J-30487-2","Gibberellic acid","赤霉素","77-06-5",{"slug":322,"cid":323,"name":324,"nameZh":325,"cas":326},"785872688496250880","J-1992713-2","Acediasulfone sodium","醋地砜钠","127-60-6",1792634001428,"zh-CN",[]]