[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"$fyk2oeqxpb7bd":3,"currency-rates":167,"compound-J-1975052-9":171,"verified-suppliers-J-1975052-9":326},{"rows":4,"total":166,"current":37,"size":141},[5,28,41,56,70,81,92,109,119,131,142,154],{"slug":6,"cid":7,"imgSvg":8,"name":9,"nameZh":10,"cas":11,"formula":12,"iupac":9,"category":13,"categoryName":14,"categoryEnName":15,"industry":16,"tags":17,"offersCount":19,"supplierCount":20,"bestOffer":21},"843627791009189888","J-1971488-8","\u002Fimages\u002Fchem_structures_svg\u002F399\u002F65845-61-6.svg","N-Methylcyclohexanamine hydrochloride","N-甲基环己胺盐酸盐","65845-61-6","C7H16ClN","acids","有机酸","Organic Acids","",[18],"In Stock",4,2,{"unitPrice":22,"pack":23,"currency":24,"origin":25,"originFlag":26,"moq":16,"stock":27},2.64,"500g","CNY","China","CN","in-stock",{"slug":29,"cid":30,"imgSvg":31,"name":32,"nameZh":33,"cas":34,"formula":35,"iupac":32,"category":13,"categoryName":14,"categoryEnName":15,"industry":16,"tags":36,"offersCount":19,"supplierCount":37,"bestOffer":38},"785882541994283008","J-1323843-4","\u002Fimages\u002Fchem_structures_svg\u002F104\u002F67627-18-3.svg","Potassium indigotrisulfonate","靛蓝三磺酸钾","67627-18-3","C16H7K3N2O11S3",[18],1,{"unitPrice":39,"pack":40,"currency":24,"origin":25,"originFlag":26,"moq":16,"stock":27},180,"5g",{"slug":42,"cid":43,"imgSvg":44,"name":45,"nameZh":46,"cas":47,"formula":48,"iupac":45,"category":49,"categoryName":50,"categoryEnName":51,"industry":16,"tags":52,"offersCount":53,"supplierCount":20,"bestOffer":54},"785889752443260928","J-28559-9","\u002Fimages\u002Fchem_structures_svg\u002F292\u002F15060-55-6.svg","Ammonium tetrathiomolybdate","四硫钼酸铵","15060-55-6","H8MoN2S4","inorganic","无机化合物","Inorganic Chemicals",[18],7,{"unitPrice":55,"pack":23,"currency":24,"origin":25,"originFlag":26,"moq":16,"stock":27},24,{"slug":57,"cid":58,"imgSvg":59,"name":60,"nameZh":61,"cas":62,"formula":63,"iupac":60,"category":13,"categoryName":14,"categoryEnName":15,"industry":16,"tags":64,"offersCount":65,"supplierCount":20,"bestOffer":66},"855452191530422272","J-1994428-7","\u002Fimages\u002Fchem_structures_svg\u002F500\u002F16350-96-2.svg","N-benzylcyclohexanamine.hydrochloride","N-苄基环己胺盐酸盐","16350-96-2","C13H20ClN",[18],5,{"unitPrice":67,"pack":68,"currency":24,"origin":69,"originFlag":26,"moq":16,"stock":27},6,"1000g","中国",{"slug":71,"cid":72,"imgSvg":73,"name":74,"nameZh":75,"cas":76,"formula":77,"iupac":74,"category":13,"categoryName":14,"categoryEnName":15,"industry":16,"tags":78,"offersCount":20,"supplierCount":20,"bestOffer":79},"785871840001134592","J-982001-0","\u002Fimages\u002Fchem_structures_svg\u002F001\u002F10517-44-9.svg","1,3-Diaminopropane dihydrochloride","1,3-二氨基丙烷二盐酸盐","10517-44-9","C3H12Cl2N2",[18],{"unitPrice":80,"pack":23,"currency":24,"origin":25,"originFlag":26,"moq":16,"stock":27},3.78,{"slug":82,"cid":83,"imgSvg":84,"name":85,"nameZh":86,"cas":87,"formula":88,"iupac":85,"category":49,"categoryName":50,"categoryEnName":51,"industry":16,"tags":89,"offersCount":53,"supplierCount":90,"bestOffer":91},"785880365658017792","J-14975-6","\u002Fimages\u002Fchem_structures_svg\u002F262\u002F12003-67-7.svg","Lithium aluminate","氧化铝锂","12003-67-7","AlHLiO2",[18],3,{"unitPrice":90,"pack":23,"currency":24,"origin":69,"originFlag":26,"moq":16,"stock":27},{"slug":93,"cid":94,"imgSvg":95,"name":96,"nameZh":97,"cas":98,"formula":99,"iupac":96,"category":100,"categoryName":101,"categoryEnName":102,"industry":16,"tags":103,"offersCount":104,"supplierCount":104,"bestOffer":105},"785871830249377792","J-6931-9","\u002Fimages\u002Fchem_structures_svg\u002F456\u002F58068-80-7.svg","1-Octanoylbenzotriazole","N-辛酰苯并三唑","58068-80-7","C14H19N3O","aromatics","芳香烃","Aromatic Hydrocarbons",[],0,{"unitPrice":106,"pack":16,"currency":107,"origin":16,"originFlag":16,"moq":16,"stock":108},9007199254740991,"USD","made-to-order",{"slug":110,"cid":111,"imgSvg":112,"name":113,"nameZh":114,"cas":115,"formula":116,"iupac":113,"category":49,"categoryName":50,"categoryEnName":51,"industry":16,"tags":117,"offersCount":65,"supplierCount":20,"bestOffer":118},"785871842446413824","J-1960944-3","\u002Fimages\u002Fchem_structures_svg\u002F495\u002F10534-86-8.svg","Hexaamminecobalt(III) nitrate","六氨合钴(III)硝酸盐","10534-86-8","CoH18N9O9",[18],{"unitPrice":67,"pack":23,"currency":24,"origin":25,"originFlag":26,"moq":16,"stock":27},{"slug":120,"cid":121,"imgSvg":122,"name":123,"nameZh":124,"cas":125,"formula":126,"iupac":123,"category":49,"categoryName":50,"categoryEnName":51,"industry":16,"tags":127,"offersCount":19,"supplierCount":20,"bestOffer":128},"785871842576437248","J-814544-6","\u002Fimages\u002Fchem_structures_svg\u002F221\u002F12037-42-2.svg","vanadium oxide","氧化钒","12037-42-2","O13V6",[18],{"unitPrice":129,"pack":130,"currency":24,"origin":25,"originFlag":26,"moq":16,"stock":27},112.8,"100g",{"slug":132,"cid":133,"imgSvg":134,"name":135,"nameZh":136,"cas":137,"formula":138,"iupac":135,"category":49,"categoryName":50,"categoryEnName":51,"industry":16,"tags":139,"offersCount":53,"supplierCount":37,"bestOffer":140},"785871842647740416","J-1333345-2","\u002Fimages\u002Fchem_structures_svg\u002F479\u002F26490-63-1.svg","COBALT TETRAFLUOROBORATE HEXAHYDRATE","四氟化硼钴水合物","26490-63-1","B2CoF8H12O6",[18],{"unitPrice":141,"pack":130,"currency":24,"origin":25,"originFlag":26,"moq":16,"stock":27},12,{"slug":143,"cid":144,"imgSvg":145,"name":146,"nameZh":147,"cas":148,"formula":149,"iupac":146,"category":49,"categoryName":50,"categoryEnName":51,"industry":16,"tags":150,"offersCount":151,"supplierCount":90,"bestOffer":152},"785871842698072064","J-814953-0","\u002Fimages\u002Fchem_structures_svg\u002F432\u002F72259-10-0.svg","Copper(II) tetrafluoroborate hexahydrate","六水合四氟硼酸铜(II)","72259-10-0","B2CuF8H12O6",[18],10,{"unitPrice":153,"pack":23,"currency":24,"origin":16,"originFlag":16,"moq":16,"stock":27},2.6,{"slug":155,"cid":156,"imgSvg":157,"name":158,"nameZh":159,"cas":160,"formula":161,"iupac":158,"category":49,"categoryName":50,"categoryEnName":51,"industry":16,"tags":162,"offersCount":20,"supplierCount":37,"bestOffer":164},"785871863254355968","J-1990080-7","\u002Fimages\u002Fchem_structures_svg\u002F149\u002F123333-60-8.svg","Cerium(IV) sulfate hydrate","铈(IV)硫酸盐水合物","123333-60-8","CeH2O9S2",[163],"Made to Order",{"unitPrice":165,"pack":23,"currency":24,"origin":25,"originFlag":26,"moq":16,"stock":27},5.6,3204,{"rates":168,"source":170},{"USD":37,"CNY":169},6.691314,"live",{"slug":172,"cid":173,"imgSvg":174,"name":175,"nameZh":175,"cas":176,"formula":177,"iupac":175,"mdl":16,"mw":178,"category":179,"categoryName":180,"categoryEnName":181,"industry":16,"tags":182,"synonyms":183,"properties":189,"ghs":220,"offers":221,"activity":222,"upstream":238,"downstream":269,"customs":270,"safetyRows":283,"updatedAt":285,"isProhibited":286,"related":287,"__ts":324,"__lang":325,"__slug":173},"785880704478089216","J-1975052-9","\u002Fimages\u002Fchem_structures_svg\u002F375\u002F92206-54-7.svg","罗替戈汀","92206-54-7","C19H25NOS","315.47","organic","有机化合物","Organic Compounds",[],[184,185,186,187,188],"5,6,7,8-四氢-6-[丙基[2-(2-噻吩基)乙基]氨基]-1-羟基萘","6-(丙基(2-(噻吩-2-基)乙基)氨基)-5,6,7,8-四氢萘-1-醇","罗替伐汀","罗替戊汀","罗替戈汀 (外消旋体)",[190,194,198,202,206,209,212,216],{"label":191,"labelZh":191,"value":192,"prop":193},"Boiling Point","470.1±45.0 °C at 760 mmHg","boilingPoint",{"label":195,"labelZh":195,"value":196,"prop":197},"Density","1.2±0.1 g\u002Fcm3","density",{"label":199,"labelZh":199,"value":200,"prop":201},"Flash Point","238.1±28.7 °C","flashPoint",{"label":203,"labelZh":204,"value":205},"Exact Mass","精确质量","315.165680",{"label":207,"labelZh":207,"value":208},"PSA","51.71000",{"label":210,"labelZh":210,"value":211},"LogP","4.96",{"label":213,"labelZh":214,"value":215},"Vapor Pressure","蒸汽压","0.0±1.2 mmHg at 25°C",{"label":217,"labelZh":218,"value":219},"Refractive Index","折射率","1.611",null,[],[223,226,229,232,235],{"key":224,"value":225},"描述","(Rac)-Rotigotine (N-0437) 是 Rotigotine 的外消旋体。Rotigotine 是?dopamine receptor 激动剂,是 5-HT1A receptor 的部分激动剂,以及 α2B-adrenergic receptor?的拮抗剂,Ki?值分别为 0.71?nM (dopamine D3 receptor),4-15?nM (D2,D5,D4 receptors),83?nM (dopamine D1 receptor)。",{"key":227,"value":228},"相关类别","研究领域\n>>\n内分泌\n信号通路\n>>\nG 蛋白偶联受体\u002FG 蛋白\n>>\n肾上腺素能受体\n信号通路\n>>\nG 蛋白偶联受体\u002FG 蛋白\n>>\n多巴胺受体\n信号通路\n>>\n神经信号通路\n>>\n多巴胺受体\n研究领域\n>>\n神经疾病\n信号通路\n>>\nG 蛋白偶联受体\u002FG 蛋白\n>>\n5-HT受体\n信号通路\n>>\n神经信号通路\n>>\n5-HT受体",{"key":230,"value":231},"靶点","Ki: Dopamine receptor; 5-HT receptor[1][2]",{"key":233,"value":234},"体外研究","与D2、D4和D5(pKi=8.5-8.0)相比,罗替戈汀对D3受体(pKi=9.2)具有10倍的选择性,与D1受体(pKi=7.2)相比具有100倍的选择性。在功能研究中,罗替戈汀在所有多巴胺受体上表现为完全激动剂,但值得注意的是,刺激D1受体的效力与刺激D2和D3受体的效力相似(pEC50？分别为：9.0、9.4-8.6、9.7)[1]。在原代中脑细胞培养中,罗替戈廷(10μM)可将THir神经元的数量减少40%。罗替戈汀(0.01μM)轻微保护多巴胺能神经元对抗MPP+？毒性,显著保护多巴胺能神经元免受鱼藤酮诱导的细胞死亡,并显著抑制鱼藤酮产生ROS[4]。",{"key":236,"value":237},"参考文献","[1].\nWood M, et al. Rotigotine is a potent agonist at dopamine D1 receptors as well as at dopamine D2 and D3 receptors. Br J Pharmacol. 2015 Feb;172(4):1124-35.\n[2].\nScheller D, et al. The in vitro receptor profile of rotigotine: a new agent for the treatment of Parkinson's disease. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):73-86.\n[3].\nFenu S, et al. In vivo dopamine agonist properties of rotigotine: Role of D1 and D2 receptors. Eur J Pharmacol. 2016 Oct 5;788:183-91.\n[4].\nRadad K, et al. Neuroprotective effect of rotigotine against complex I inhibitors, MPP+ and rotenone, in primary mesencephalic cell culture. Folia Neuropathol. 2014;52(2):179-86.",[239,245,251,257,263],{"slug":240,"cid":241,"name":242,"nameZh":242,"cas":243,"imgSvg":244},"785881293261901800","J-1108788-3","2-(噻吩-2-基)乙基 4-...","40412-06-4","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F445\u002F40412-06-4.svg",{"slug":246,"cid":247,"name":248,"nameZh":248,"cas":249,"imgSvg":250},"785896377661001700","J-44000-8","2-噻吩乙酸","1918-77-0","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F133\u002F1918-77-0.svg",{"slug":252,"cid":253,"name":254,"nameZh":254,"cas":255,"imgSvg":256},"785884573840969700","J-23628-1","5-甲氧基-2-萘满酮","32940-15-1","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F175\u002F32940-15-1.svg",{"slug":258,"cid":259,"name":260,"nameZh":260,"cas":261,"imgSvg":262},"785888861178826800","J-1357091-6","2-丙氨基-5-甲氧基四嗪","78598-91-1","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F022\u002F78598-91-1.svg",{"slug":264,"cid":265,"name":266,"nameZh":266,"cas":267,"imgSvg":268},"785892021662388200","J-1458042-4","(S)-5-甲氧基-n-丙基-...","101945-65-7","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F198\u002F101945-65-7.svg",[],[271,274,277,280],{"key":272,"value":273},"海关编码","2934999090",{"key":275,"value":276},"中文概述","2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%",{"key":278,"value":279},"申报要素","品名, 成分含量, 用途",{"key":281,"value":282},"Summary","2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%",[284],{"key":272,"value":273},"2026-08-21T07:51:12.859463Z",false,[288,294,300,306,312,318],{"slug":289,"cid":290,"name":291,"nameZh":292,"cas":293},"785882530409615360","J-1955871-6","Febuxostat","非布索坦","144060-53-7",{"slug":295,"cid":296,"name":297,"nameZh":298,"cas":299},"785892364030840832","J-1381949-5","Alcloxa","铝克洛沙","1317-25-5",{"slug":301,"cid":302,"name":303,"nameZh":304,"cas":305},"785893129814282240","J-1962350-6","Phytosphingosine","糖脂","554-62-1",{"slug":307,"cid":308,"name":309,"nameZh":310,"cas":311},"785875984183201792","J-11597-3","Aflatoxin B1","黄曲霉毒素B1","1162-65-8",{"slug":313,"cid":314,"name":315,"nameZh":316,"cas":317},"785898371956084736","J-50383-9","alpha-Amylase","α-淀粉酶","9000-90-2",{"slug":319,"cid":320,"name":321,"nameZh":322,"cas":323},"785882574428835840","J-1094601-1","Methylene Blue","亚甲基蓝","61-73-4",1792623097736,"zh-CN",[]]