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mRNA水平的抑制可在孵育约3小时时检测到,在12小时时基本上具有最大抑制。用0.5μM全反式维甲酸孵育24小时后,ODC mRNA水平降低,同时ODC酶活性降低[1]。",{"key":239,"value":240},"体内研究","该初步报告的目的是测量10天内每天一次口服10mg\u002Fkg Temarotene的无毛大鼠中Ro 15-0778及其酚类代谢物Ro 14-6113的血浆和皮肤浓度。在最后一次剂量后0.5和240小时之间的不同时间点采集血液(2-3mL)和皮肤(200-300mg)样品。高灵敏度HPLC方法用于同时测定两种化合物,血浆中定量限为2 ng\u002FmL,总皮肤(表皮和真皮)中定量限为10 ng\u002Fg。 10小时后,Ro 14-6113的血浆浓度比Ro 15-0778高5-13倍。在最初的48小时内,皮肤中的Ro 14-6113浓度比Ro 15-0778高4-10倍。皮肤中两种化合物的浓度都高于血浆中的浓度[1]。",{"key":242,"value":243},"参考文献","[1].\nOlsen DR, et al. Suppression of ornithine decarboxylase gene expression by retinoids in cultured human keratinocytes. J Invest Dermatol. 1990 Jan;94(1):33-6.\n[2].\nFenina N, et al. Concentration of Temarotene (Ro 15-0778) and its metabolite Ro 14-6113 in plasma and skin of hairless rat. 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