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kg体重），每天腹腔注射15天;和（d）B-DIM和厄洛替尼，按照时间表进行个别治疗。在最后一剂治疗后第3天处死所有小鼠，并测定它们的体重。将组织的一部分在液氮中快速冷冻并储存在-70℃以备将来使用，另一部分在福尔马林中固定并加工成石蜡块。固定组织切片的H＆E染色用于确认每个胰腺中肿瘤的存在。大鼠[3]使用体重为180至210g的6周龄雄性Sprague-Dawley（SD）大鼠。顺铂（CP）在盐水中以1mg \u002F mL的浓度新鲜制备，然后在第0天以7mg \u002F kg的剂量腹膜内注射SD大鼠（n = 28）。为了研究厄洛替尼的作用，28 CP -N-大鼠分为两组。从第-1天开始，每天通过口服管饲给每只动物的单独组（n = 14）施用厄洛替尼（20mg \u002F kg）（CP + E，n = 14）或载体（CP + V，n = 14）（在CP注射前24小时至第3天。媒介物处理组接受等量的盐水。将6周龄的5只雄性SD大鼠用作正常对照组（NC，n = 5）。从第-1天到第3天，通过口服管饲法每天给NC大鼠施用等量的盐水。在第4天（CP注射后96小时），将每只大鼠麻醉并在心脏穿刺后通过放血处死;通过心脏穿刺收集血液并收集肾脏。肾组织分裂;将分开的部分在液氮中快速冷冻或在2％多聚甲醛\u002F磷酸盐缓冲盐水（PBS）中固定以备后用。所有手术均在乙醚气体麻醉下进行，并且尽一切努力使痛苦最小化。",{"key":267,"value":268},"参考文献","[1].\nMoyer JD, et al. Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer Res. 1997, 57(21), 4838-4848.\n[2].\nAli S, et al. Apoptosis-inducing effect of erlotinib is potentiated by 3,3'-diindolylmethane in vitro and in vivo using an orthotopic model of pancreatic cancer. Mol Cancer Ther, 2008, 7(6), 1708-1719.\n[3].\nWada Y, et al. Epidermal growth factor receptor inhibition with erlotinib partially prevents cisplatin-induced nephrotoxicity in rats. 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