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mg\u002Fkg,ip)给药可将短期学习事件转化为WT的长期记忆体验,但不会消除组胺耗竭的小鼠[2]。同时给予ABT-239(1和3 mg\u002Fkg,ip)和尼古丁(0.035 mg\u002Fkg,ip)或ABT-239(0.1 mg\u002Fkg,ip)和尼古丁(0.0175 mg\u002Fkg,ip)进一步增加尼古丁诱导的记忆获得和巩固的改善[3]。",{"key":218,"value":219},"动物实验","KA，ABT-239和SVP的溶液在无热原的注射用生理盐水中制备，除了TDZD-8，其溶解在10％DMSO中并以不超过10mL \u002F kg的体积腹膜内给药。动物分为十组。第一组（CTRL）仅接受载体（0.9％氯化钠），而第二组（VEH）的动物接受载体，接着是KA，剂量为10 mg \u002F kg，ip（pH 7.2±1），这是在一项测距研究中，在所有动物中诱导低级癫痫发作（0-4期）而没有任何死亡的剂量。在各种研究中，KA剂量用于引起小鼠中的SE，其大多数从低至6-20mg \u002F kg至高至25-45mg \u002F kg不等。在KA攻击前30分钟，以增加剂量的1（AL）和3mg \u002F kg（AH）给予接下来两组动物ABT-239。这些剂量范围为0.1至3mg \u002F kg的ABT-239在阿尔茨海默病的小鼠模型中显示疾病改变属性以及改善的认知功能。第五组和第六组在注射KA之前30分钟接受150（SL）和300mg \u002F kg（SH）SVP的分级剂量。第7组和第8组分别接受150 mg \u002F kg的SVP的亚有效剂量（无保护的最大可能剂量）与ABT-239在1（SLAL）和3 mg \u002F kg（SLAH）的组合，随后30分钟由KA。在KA暴露之前，剩余的两组分别以1和5mg \u002F kg（ALTL）和3和10mg \u002F kg（AHTH）的ABT-239和TDZD-8的高剂量组合接受低剂量组合。选择的TDZD-8剂量基于先前的研究，其中剂量范围为1至10mg \u002F kg减少炎症和组织损伤以及改善精神病症。",{"key":221,"value":222},"参考文献","[1].\nBhowmik M, et al. Histamine H3 receptor antagonism by ABT-239 attenuates kainic acid induced excitotoxicity in mice. Brain Res. 2014 Sep 18;1581:129-40.\n[2].\nProvensi G, et al. Donepezil, an acetylcholine esterase inhibitor, and ABT-239, a histamine H3 receptor antagonist\u002Finverse agonist, require the integrity of brain histamine system to exert biochemical and procognitive effects in the mouse. Neuropharmacolo\n[3].\nKruk M, e tal. Effects of the histamine H2 receptor antagonist ABT-239 on cognition and nicotine-induced memory enhancement in mice. Pharmacol Rep. 2012;64(6):1316-25.\n[4].\nMunari L, et al. Selective brain region activation by histamine H2 receptor antagonist\u002Finverse agonist ABT-239 enhances acetylcholine and histamine release and increases c-Fos expression. 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