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50）。通过流式细胞术进行细胞周期分析。通过膜联蛋白V-FITC细胞凋亡检测试剂盒测量细胞凋亡。",{"key":254,"value":255},"动物实验","通过皮下注射100至200μL肿瘤细胞（在与基质胶50：50混合的1×10 6和1×10 7个细胞之间）来建立人肿瘤异种移植物。当肿瘤达到确定的可触知大小（分别为小鼠和大鼠0.2-0.3cm 3和0.5-1cm 3）时，将动物随机分成治疗组（每组n = 8-11）。 AZD1152在Tris缓冲液（pH 9）中制备，并按照推注注射（静脉注射或腹腔注射）或连续48小时输注，通过sc植入的渗透微型泵（按顺序植入两个24小时泵）按照制造商的说明。用卡尺每周测量肿瘤最多三次，计算肿瘤体积，并使用每组的几何平均值对时间绘制数据。计算肿瘤体积和肿瘤生长抑制。使用Student's单尾t检验进行肿瘤体积变化的统计分析（P值\u003C0.05被认为是统计学上显着的）。",{"key":257,"value":258},"参考文献","[1].\nWilkinson RW, et al. AZD1152, a selective inhibitor of Aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis. Clin Cancer Res. 2007 Jun 15;13(12):3682-8.\n[2].\nYang, Jing., et al. AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo. Blood. 2007 Sep 15;110(6):2034-40.\n[3].\nZekri A, et al. AZD1152-HQPA induces growth arrest and apoptosis in androgen-dependent prostate cancer cell line (LNCaP) via producing aneugenic micronuclei and polyploidy. 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