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+和CD8 +细胞中,Pomalidomide(CC-4047)是最有效的IL-2升降机,其次是CC-6032和CC-5013。 Pomalidomide在提高IL-2,IL-5和IL-10方面明显比CC-5013更有效,在提高IFN-γ方面比CC-5013更有效[3]。",{"key":258,"value":259},"体内研究","在mAb治疗前连续两天施用Pomalidomide(CC-4047)增强了利妥昔单抗的抗肿瘤活性,并使携带淋巴瘤的小鼠的中位存活倍增。统计学上,在用利妥昔单抗治疗的动物与Pomalidomide +利妥昔单抗治疗的动物之间观察到显着差异。使用Pomalidomide和利妥昔单抗治疗的动物的中位生存时间比使用利妥昔单抗单药治疗的动物更长(中位生存期,74天; 95％CI,70-78)(中位生存期,38天; 95％CI,26-50; log-试验,P = 0.002)。连续两天施用CC-5013或Pomalidomide导致循环NK细胞数量的显着增加,如流式细胞术分析所示,在携带淋巴瘤的SCID小鼠中[2]。向大鼠施用50mg\u002Fkg PO施用Pomalidomide(POM)后,血液中未结合的浓度在4.6±2.4小时达到1100±82ng\u002FmL的Cmax值,伴随的AUC(0-10)值为6800± 2000 ng•hr\u002FmL。然而,大脑中未结合的POM在4.1±1.5小时时的Cmax值为430±63 ng\u002FmL,AUC(0-10)值为2700±740 ng•hr\u002FmL,从而得出未结合的AUC脑与AUC血液比率0.39±0.03。这些值与优秀的血脑屏障穿透一致。在该研究中获得的结果与在对小鼠口服给药后观察全脑POM含量的同时研究中观察到的结果一致[4]。",{"key":261,"value":262},"细胞实验","将淋巴瘤细胞系置于96孔板（每孔1×10 5个细胞）中并暴露于升高浓度的CC-5013，Pomalidomide（2.5,5,10,20和40μg\u002F mL）或载体对照单一试剂或与利妥昔单抗或曲妥珠单抗（同种型）组合，最终抗体浓度为10μg\u002F mL。用10％RPMI将终浓度调节至200μL。将细胞系在37℃和5％CO 2下孵育24和48小时。 24或48小时后，加入1μCi\u002F孔的[3H]  - 胸苷，将细胞再孵育18小时。然后使用Harvest系统将细胞收获到96孔玻璃滤器中，并使用自动闪烁计数器测量[3H]  - 胸苷摄取。每个实验在三个不同的时间一式三份进行;结果表示为24和48小时时的每分钟计数（cpm）±SD [2]。",{"key":264,"value":265},"动物实验","小鼠[2]将6至8周龄的SCID小鼠用于此目的。在第0天，所有动物通过尾静脉注射接受1×106个Raji细胞。在肿瘤移植72小时后，将动物分成七组。第一组（A组）作为对照并且不接受治疗。 B组和C组由用CC-5013（0.5 mg \u002F kg）或Pomalidomide（0.5 mg \u002F kg）治疗的动物组成，每天+3，+ 4，+ 8，+ 9，+ 13，+ 14，+ 18，+ 19。组D和E用利妥昔单抗或曲妥珠单抗（同种型对照）单一疗法治疗，通过尾静脉注射以10mg \u002F kg在+ 5，+ 10，+ 15和+20天给予。最后，F组和G组由用利妥昔单抗联合CC-5013（E组）或Pomalidomide（G组）治疗的动物组成。在每剂利妥昔单抗之前连续两天给予IMID。治疗结束后，观察动物90天。该研究的终点是生存，定义为发生肢体麻痹的时间。通过颈椎脱位处死达到终点或在观察3个月后存活的动物。对所有器官（肝，肺和脑）进行病理检查以检测任何残留的疾病。在三个不同的场合重复实验。大鼠[4]使用总共3只雄性CD-IGS大鼠。 Pomalidomide通过胃插管以0.5mg \u002F kg（5mL \u002F kg）在0.5％羧甲基纤维素\u002F0.25%吐温80悬浮液制剂中作为单次PO给药施用。将微透析液收集在冷却馏分收集器中，在给药后以25分钟的间隔设定在4℃下10小时。为了计算AUC，将每个样品的校正浓度乘以收集样品的间隔;在这种情况下25分钟，除以每小时60分钟。这些值的总和表示在指定时间范围内的总AUC值。为了生成图，每个时间点的浓度绘制在每个收集间隔的中点。在指定的时间点收集微透析液，并在12小时内使用LC-MS \u002F MS测定法分析Pomalidomide浓度。",{"key":267,"value":268},"参考文献","[1].\nZhu YX, et al. Molecular mechanism of action of the immune-modulatory drugs, thalidomide, lenalidomide and pomalidomide in multiple myeloma. Leuk Lymphoma. 2013 Apr;54(4):683-7.\n[2].\nHernandez-Ilizaliturri FJ1, et al. Immunomodulatory drug CC-5013 or CC-4047 and rituximab enhance antitumor activity in a severe combined immunodeficient mouse lymphoma model. Clin Cancer Res. 2005 Aug 15;11(16):5984-92.\n[3].\nSchafer PH, et al. Enhancement of cytokine production and AP-1 transcriptional activity in T cells by thalidomide-related immunomodulatory drugs. J Pharmacol Exp Ther. 2003 Jun;305(3):1222-32.\n[4].\nLi Z, et al. Pomalidomide shows significant therapeutic activity against CNS lymphoma with a major impact on the tumor microenvironment in murine models. PLoS One. 2013 Aug 5;8(8):e71754.\n[5].\nLiu D, et al. Tumour necrosis factor-α inhibits hepatic lipid deposition through GSK-3β\u002Fβ-catenin signaling in juvenile turbot (Scophthalmus maximus L.). 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1;228:1-8.",[270,276,282,288,294,300],{"slug":271,"cid":272,"name":273,"nameZh":273,"cas":274,"imgSvg":275},"785882047888494600","J-1123348-0","4-硝基沙利度胺","19171-18-7","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F123\u002F19171-18-7.svg",{"slug":277,"cid":278,"name":279,"nameZh":279,"cas":280,"imgSvg":281},"785876800336040000","J-1100166-4","3-氨基-2,6-哌啶二酮盐酸盐","24666-56-6","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F239\u002F24666-56-6.svg",{"slug":283,"cid":284,"name":285,"nameZh":285,"cas":286,"imgSvg":287},"785882201987223600","J-897728-4","3-氨基邻苯二甲酸盐酸盐","6946-22-1","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F096\u002F6946-22-1.svg",{"slug":289,"cid":290,"name":291,"nameZh":291,"cas":292,"imgSvg":293},"785873085923332100","J-1993882-0","3-硝基邻苯二甲酸酐","641-70-3","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F157\u002F641-70-3.svg",{"slug":295,"cid":296,"name":297,"nameZh":297,"cas":298,"imgSvg":299},"785876761027022800","J-14401-4","N-苄氧羰基-L-谷氨酰胺","2650-64-8","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F311\u002F2650-64-8.svg",{"slug":301,"cid":302,"name":303,"nameZh":303,"cas":304,"imgSvg":305},"785881692412842000","J-1481533-9","(2,6-二氧代哌啶-3-基)...","24666-55-5","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F277\u002F24666-55-5.svg",[],[308,311,314,317],{"key":309,"value":310},"海关编码","2925190090",{"key":312,"value":313},"中文概述","2925190090 其他酰亚胺及其衍生物盐. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%",{"key":315,"value":316},"申报要素","品名, 成分含量, 用途",{"key":318,"value":319},"Summary","2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%",[321,324,327,330],{"key":322,"value":323},"危害码 (欧洲)","Xi",{"key":325,"value":326},"危险品运输编码","NONH for all modes of transport",{"key":328,"value":329},"RTECS号","NR3397905",{"key":309,"value":310},"\u003Ctd>\n\n\u003Cb>1.1 产品标识符\u003C\u002Fb>\n\u003Cbr \u002F> : Pomalidomide\n\u003Cbr \u002F> 产品名称\n\u003Cbr \u002F>\n\u003Cb>1.2 鉴别的其他方法\u003C\u002Fb>\n\u003Cbr \u002F> 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline\n\u003Cbr \u002F> 3-amino-N-(2,6-dioxo-3-piperidyl)phthalamide\n\u003Cbr \u002F> Actimid\n\u003Cbr \u002F> 4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione\n\u003Cbr \u002F> CC-4047\n\u003Cbr \u002F> IMiD 3\n\u003Cbr \u002F>\n\u003Cb>1.3 有关的确定了的物质或混合物的用途和建议不适合的用途\u003C\u002Fb>\n\u003Cbr \u002F> 仅供科研用途，不作为药物、家庭备用药或其它用途。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块2. 危险性概述\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>2.1 GHS分类\u003C\u002Fb>\n\u003Cbr \u002F> 根据化学品全球统一分类与标签制度(GHS)的规定，不是危险物质或混合物。\n\u003Cbr \u002F>\n\u003Cb>2.3 其它危害物\u003C\u002Fb>\n\u003Cbr \u002F> 可能敏\n\u003Cbr \u002F>\n\n\u003Cstrong>模块3. 成分\u002F组成信息\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>3.1 物 质\u003C\u002Fb>\n\u003Cbr \u002F> : 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline\n\u003Cbr \u002F> 别名\n\u003Cbr \u002F> 3-amino-N-(2,6-dioxo-3-piperidyl)phthalamide\n\u003Cbr \u002F> Actimid\n\u003Cbr \u002F> 4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione\n\u003Cbr \u002F> CC-4047\n\u003Cbr \u002F> IMiD 3\n\u003Cbr \u002F> : C13H11N3O4\n\u003Cbr \u002F> 分子式\n\u003Cbr \u002F> : 273.24 g\u002Fmol\n\u003Cbr \u002F> 分子量\n\u003Cbr \u002F> 无\n\u003Cbr \u002F>\n\n\u003Cstrong>模块4. 急救措施\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>4.1 必要的急救措施描述\u003C\u002Fb>\n\u003Cbr \u002F> 吸入\n\u003Cbr \u002F> 如果吸入,请将患者移到新鲜空气处。 如果停止了呼吸,给于人工呼吸。\n\u003Cbr \u002F> 皮肤接触\n\u003Cbr \u002F> 用肥皂和大量的水冲洗。\n\u003Cbr \u002F> 眼睛接触\n\u003Cbr \u002F> 用水冲洗眼睛作为预防措施。\n\u003Cbr \u002F> 食入\n\u003Cbr \u002F> 切勿给失去知觉者从嘴里喂食任何东西。 用水漱口。\n\u003Cbr \u002F>\n\u003Cb>4.2 主要症状和影响，急性和迟发效应\u003C\u002Fb>\n\u003Cbr \u002F> 据我们所知，此化学，物理和毒性性质尚未经完整的研究。\n\u003Cbr \u002F>\n\u003Cb>4.3 及时的医疗处理和所需的特殊处理的说明和指示\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\n\u003Cstrong>模块5. 消防措施\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>5.1 灭火介质\u003C\u002Fb>\n\u003Cbr \u002F> 灭火方法及灭火剂\n\u003Cbr \u002F> 用水雾,耐醇泡沫,干粉或二氧化碳灭火。\n\u003Cbr \u002F>\n\u003Cb>5.2 源于此物质或混合物的特别的危害\u003C\u002Fb>\n\u003Cbr \u002F> 碳氧化物, 氮氧化物\n\u003Cbr \u002F>\n\u003Cb>5.3 给消防员的建议\u003C\u002Fb>\n\u003Cbr \u002F> 如必要的话,戴自给式呼吸器去救火。\n\u003Cbr \u002F>\n\u003Cb>5.4 进一步信息\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\n\u003Cstrong>模块6. 泄露应急处理\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>6.1 人员的预防,防护设备和紧急处理程序\u003C\u002Fb>\n\u003Cbr \u002F> 防止粉尘的生成。 防止吸入蒸汽、气雾或气体。\n\u003Cbr \u002F>\n\u003Cb>6.2 环境保护措施\u003C\u002Fb>\n\u003Cbr \u002F> 不要让产物进入下水道。\n\u003Cbr \u002F>\n\u003Cb>6.3 抑制和清除溢出物的方法和材料\u003C\u002Fb>\n\u003Cbr \u002F> 扫掉和铲掉。 存放进适当的闭口容器中待处理。\n\u003Cbr \u002F>\n\u003Cb>6.4 参考其他部分\u003C\u002Fb>\n\u003Cbr \u002F> 丢弃处理请参阅第13节。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块7. 操作处置与储存\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>7.1 安全操作的注意事项\u003C\u002Fb>\n\u003Cbr \u002F> 在有粉尘生成的地方,提供合适的排风设备。\n\u003Cbr \u002F>\n\u003Cb>7.2 安全储存的条件,包括任何不兼容性\u003C\u002Fb>\n\u003Cbr \u002F> 贮存在阴凉处。 容器保持紧闭，储存在干燥通风处。\n\u003Cbr \u002F> 建议的贮存温度： 2 - 8 °C\n\u003Cbr \u002F>\n\u003Cb>7.3 特定用途\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\n\u003Cstrong>模块8. 接触控制和个体防护\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>8.1 容许浓度\u003C\u002Fb>\n\u003Cbr \u002F> 最高容许浓度\n\u003Cbr \u002F> 没有已知的国家规定的暴露极限。\n\u003Cbr \u002F>\n\u003Cb>8.2 暴露控制\u003C\u002Fb>\n\u003Cbr \u002F> 适当的技术控制\n\u003Cbr \u002F> 常规的工业卫生操作。\n\u003Cbr \u002F> 个体防护设备\n\u003Cbr \u002F> 眼\u002F面保护\n\u003Cbr \u002F> 请使用经官方标准如NIOSH (美国) 或 EN 166(欧盟) 检测与批准的设备防护眼部。\n\u003Cbr \u002F> 皮肤保护\n\u003Cbr \u002F> 戴手套取 手套在使用前必须受检查。\n\u003Cbr \u002F> 请使用合适的方法脱除手套(不要接触手套外部表面),避免任何皮肤部位接触此产品.\n\u003Cbr \u002F> 使用后请将被污染过的手套根据相关法律法规和有效的实验室规章程序谨慎处理. 请清洗并吹干双手\n\u003Cbr \u002F> 所选择的保护手套必须符合EU的89\u002F686\u002FEEC规定和从它衍生出来的EN 376标准。\n\u003Cbr \u002F> 身体保护\n\u003Cbr \u002F> 根据危险物质的类型，浓度和量，以及特定的工作场所来选择人体保护措施。,\n\u003Cbr \u002F> 防护设备的类型必须根据特定工作场所中的危险物的浓度和含量来选择。\n\u003Cbr \u002F> 呼吸系统防护\n\u003Cbr \u002F> 不需要保护呼吸。如需防护粉尘损害，请使用N95型（US）或P1型（EN 143)防尘面具。\n\u003Cbr \u002F> 呼吸器使用经过测试并通过政府标准如NIOSH（US）或CEN（EU）的呼吸器和零件。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块9. 理化特性\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>9.1 基本的理化特性的信息\u003C\u002Fb>\n\u003Cbr \u002F> a) 外观与性状\n\u003Cbr \u002F> 形状: 固体\n\u003Cbr \u002F> b) 气味\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> c) 气味阈值\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> d) pH值\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> e) 熔点\u002F凝固点\n\u003Cbr \u002F> 315.5 - 317.5 °C\n\u003Cbr \u002F> f) 起始沸点和沸程\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> g) 闪点\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> h) 蒸发速率\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> i) 易燃性(固体,气体)\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> j) 高的\u002F低的燃烧性或爆炸性限度 无数据资料\n\u003Cbr \u002F> k) 蒸汽压\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> l) 蒸汽密度\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> m) 相对密度\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> n) 水溶性\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> o) n-辛醇\u002F水分配系数\n\u003Cbr \u002F> 辛醇--水的分配系数的对数值: 0.226\n\u003Cbr \u002F> p) 自燃温度\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> q) 分解温度\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> r) 粘度\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\n\u003Cstrong>模块10. 稳定性和反应活性\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>10.1 反应性\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>10.2 稳定性\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>10.3 危险反应的可能性\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>10.4 应避免的条件\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>10.5 不兼容的材料\u003C\u002Fb>\n\u003Cbr \u002F> 强氧化剂\n\u003Cbr \u002F>\n\u003Cb>10.6 危险的分解产物\u003C\u002Fb>\n\u003Cbr \u002F> 其它分解产物 - 无数据资料\n\u003Cbr \u002F>\n\n\u003Cstrong>模块11. 毒理学资料\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>11.1 毒理学影响的信息\u003C\u002Fb>\n\u003Cbr \u002F> 急性毒性\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> 皮肤刺激或腐蚀\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> 眼睛刺激或腐蚀\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> 呼吸道或皮肤过敏\n\u003Cbr \u002F> 长期或反复接触导致个别人过敏反应 前面的数据或数据判读是根据定量结构活性关系(QSAR)确定的。\n\u003Cbr \u002F> 生殖细胞突变性\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> 致癌性\n\u003Cbr \u002F> IARC:\n\u003Cbr \u002F> 此产品中没有大于或等于 0。1%含量的组分被 IARC鉴别为可能的或肯定的人类致癌物。\n\u003Cbr \u002F> 生殖毒性\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> 特异性靶器官系统毒性（一次接触）\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> 特异性靶器官系统毒性（反复接触）\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> 吸入危险\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> 潜在的健康影响\n\u003Cbr \u002F> 吸入吸入可能有害。 可能引起呼吸道刺激。\n\u003Cbr \u002F> 摄入如服入是有害的。\n\u003Cbr \u002F> 皮肤如果通过皮肤吸收可能是有害的。 可能引起皮肤刺激。\n\u003Cbr \u002F> 眼睛可能引起眼睛刺激。\n\u003Cbr \u002F> 接触后的征兆和症状\n\u003Cbr \u002F> 据我们所知，此化学，物理和毒性性质尚未经完整的研究。\n\u003Cbr \u002F> 附加说明\n\u003Cbr \u002F> 化学物质毒性作用登记: 无数据资料\n\u003Cbr \u002F>\n\n\u003Cstrong>模块12. 生态学资料\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>12.1 生态毒性\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>12.2 持久存留性和降解性\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>12.3 潜在的生物蓄积性\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>12.4 土壤中的迁移性\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>12.5 PBT 和 vPvB的结果评价\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>12.6 其它不利的影响\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\n\u003Cstrong>模块13. 废弃处置\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>13.1 废物处理方法\u003C\u002Fb>\n\u003Cbr \u002F> 产品\n\u003Cbr \u002F> 将剩余的和未回收的溶液交给处理公司。\n\u003Cbr \u002F> 受污染的容器和包装\n\u003Cbr \u002F> 作为未用过的产品弃置。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块14. 运输信息\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>14.1 联合国危险货物编号\u003C\u002Fb>\n\u003Cbr \u002F> 欧洲陆运危规: -国际海运危规: -国际空运危规: -\n\u003Cbr \u002F>\n\u003Cb>14.2 联合国（UN）规定的名称\u003C\u002Fb>\n\u003Cbr \u002F> 欧洲陆运危规: 非危险货物\n\u003Cbr \u002F> 国际海运危规: 非危险货物\n\u003Cbr \u002F> 国际空运危规: 非危险货物\n\u003Cbr \u002F>\n\u003Cb>14.3 运输危险类别\u003C\u002Fb>\n\u003Cbr \u002F> 欧洲陆运危规: -国际海运危规: -国际空运危规: -\n\u003Cbr \u002F>\n\u003Cb>14.4 包裹组\u003C\u002Fb>\n\u003Cbr \u002F> 欧洲陆运危规: -国际海运危规: -国际空运危规: -\n\u003Cbr \u002F>\n\u003Cb>14.5 环境危险\u003C\u002Fb>\n\u003Cbr \u002F> 欧洲陆运危规: 否国际海运危规 海运污染物: 否国际空运危规: 否\n\u003Cbr \u002F>\n\u003Cb>14.6 对使用者的特别提醒\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> 上述信息视为正确，但不包含所有的信息，仅作为指引使用。本文件中的信息是基于我们目前所知，就正\n\u003Cbr \u002F> 确的安全提示来说适用于本品。该信息不代表对此产品性质的保证。\n\u003Cbr \u002F> 参见发票或包装条的反面。\n\u003Cbr \u002F>\n\u003Cbr \u002F>\n\n\u003Cstrong> 模块 15 - 法规信息 \u003C\u002Fstrong>\n\u003Cbr \u002F>N\u002FA\n\u003Cbr \u002F>\n\u003Cbr \u002F>\n\n\u003Cstrong> 模块16 - 其他信息 \u003C\u002Fstrong>\n\u003Cbr \u002F>N\u002FA\n\u003Cbr \u002F>\u003Cbr \u002F>\u003Cbr \u002F>\n\u003Cbr \u002F>\u003Cbr \u002F>\n\u003C\u002Ftd>","2026-08-21T07:51:12.859463Z",false,[335,341,347,353,359,365,371,377,383,389,395,401],{"slug":336,"cid":337,"name":338,"nameZh":339,"cas":340},"785883749286940672","J-865877-3","Acetylcholine iodide","乙酰胆碱碘化物","2260-50-6",{"slug":342,"cid":343,"name":344,"nameZh":345,"cas":346},"785894691114586112","J-38657-2","4,4'-Dimethyltriphenylamine","4,4'-二甲基三苯胺","20440-95-3",{"slug":348,"cid":349,"name":350,"nameZh":351,"cas":352},"785889168273182720","J-979574-8","N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide","N-[4-氰基-3-(三氟甲基)苯基]-2-甲基环氧乙烷-2-甲酰胺","90357-51-0",{"slug":354,"cid":355,"name":356,"nameZh":357,"cas":358},"785881563773538304","J-1346516-2","Dinonylamine","二壬基胺","2044-21-5",{"slug":360,"cid":361,"name":362,"nameZh":363,"cas":364},"785884693554794496","J-23900-9","2,2'-Dinaphthylamine","2,2'-二萘胺","532-18-3",{"slug":366,"cid":367,"name":368,"nameZh":369,"cas":370},"785876207542472704","J-1070257-5","3-iodonaphthalen-2-amine","3-碘萘-2-胺","116632-14-5",{"slug":372,"cid":373,"name":374,"nameZh":375,"cas":376},"785882614962589696","J-5065-7","Bis(1,3-propanediamine) Copper(II) Dichloride","双(1,3-丙二胺)氯化铜(II)","32270-93-2",{"slug":378,"cid":379,"name":380,"nameZh":381,"cas":382},"785895727434829824","J-42657-3","Lithium bis(trifluoromethanesulfonyl)imide","双三氟甲基磺酰亚胺锂","90076-65-6",{"slug":384,"cid":385,"name":386,"nameZh":387,"cas":388},"785882424125952000","J-1025966-2","Phosphocholine chloride calcium salt tetrahydrate","氯化磷酰胆碱钙盐","4826-71-5",{"slug":390,"cid":391,"name":392,"nameZh":393,"cas":394},"785880568788160512","J-1079694-8","N-Benzyl-2-bromobenzamide","N-苄基-2-溴苯甲酰胺","82082-50-6",{"slug":396,"cid":397,"name":398,"nameZh":399,"cas":400},"785883358587523072","J-1158550-5","N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methacrylamide","N-(4-氰基-3-三氟甲基苯基)甲基丙烯酰胺","90357-53-2",{"slug":402,"cid":403,"name":404,"nameZh":405,"cas":406},"785882075285688320","J-1125063-8","2-Bromo-N-cyclohexylbenzenamine","2-溴-N-环己基苯胺","858516-27-5",1794259523779,"zh-CN",[]]