[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"currency-rates":3,"$fyk2oeqxpb7bd":8,"compound-J-1963197-6":171,"verified-suppliers-J-1963197-6":337},{"rates":4,"source":7},{"USD":5,"CNY":6},1,6.689327,"live",{"rows":9,"total":170,"current":5,"size":145},[10,33,45,60,74,85,96,113,123,135,146,158],{"slug":11,"cid":12,"imgSvg":13,"name":14,"nameZh":15,"cas":16,"formula":17,"iupac":14,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":22,"offersCount":24,"supplierCount":25,"bestOffer":26},"843627791009189888","J-1971488-8","\u002Fimages\u002Fchem_structures_svg\u002F399\u002F65845-61-6.svg","N-Methylcyclohexanamine hydrochloride","N-甲基环己胺盐酸盐","65845-61-6","C7H16ClN","acids","有机酸","Organic Acids","",[23],"In Stock",4,2,{"unitPrice":27,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},2.64,"500g","CNY","China","CN","in-stock",{"slug":34,"cid":35,"imgSvg":36,"name":37,"nameZh":38,"cas":39,"formula":40,"iupac":37,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":41,"offersCount":24,"supplierCount":5,"bestOffer":42},"785882541994283008","J-1323843-4","\u002Fimages\u002Fchem_structures_svg\u002F104\u002F67627-18-3.svg","Potassium indigotrisulfonate","靛蓝三磺酸钾","67627-18-3","C16H7K3N2O11S3",[23],{"unitPrice":43,"pack":44,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},180,"5g",{"slug":46,"cid":47,"imgSvg":48,"name":49,"nameZh":50,"cas":51,"formula":52,"iupac":49,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":56,"offersCount":57,"supplierCount":25,"bestOffer":58},"785889752443260928","J-28559-9","\u002Fimages\u002Fchem_structures_svg\u002F292\u002F15060-55-6.svg","Ammonium tetrathiomolybdate","四硫钼酸铵","15060-55-6","H8MoN2S4","inorganic","无机化合物","Inorganic Chemicals",[23],7,{"unitPrice":59,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},24,{"slug":61,"cid":62,"imgSvg":63,"name":64,"nameZh":65,"cas":66,"formula":67,"iupac":64,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":68,"offersCount":69,"supplierCount":25,"bestOffer":70},"855452191530422272","J-1994428-7","\u002Fimages\u002Fchem_structures_svg\u002F500\u002F16350-96-2.svg","N-benzylcyclohexanamine.hydrochloride","N-苄基环己胺盐酸盐","16350-96-2","C13H20ClN",[23],5,{"unitPrice":71,"pack":72,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},6,"1000g","中国",{"slug":75,"cid":76,"imgSvg":77,"name":78,"nameZh":79,"cas":80,"formula":81,"iupac":78,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":82,"offersCount":25,"supplierCount":25,"bestOffer":83},"785871840001134592","J-982001-0","\u002Fimages\u002Fchem_structures_svg\u002F001\u002F10517-44-9.svg","1,3-Diaminopropane dihydrochloride","1,3-二氨基丙烷二盐酸盐","10517-44-9","C3H12Cl2N2",[23],{"unitPrice":84,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},3.78,{"slug":86,"cid":87,"imgSvg":88,"name":89,"nameZh":90,"cas":91,"formula":92,"iupac":89,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":93,"offersCount":57,"supplierCount":94,"bestOffer":95},"785880365658017792","J-14975-6","\u002Fimages\u002Fchem_structures_svg\u002F262\u002F12003-67-7.svg","Lithium aluminate","氧化铝锂","12003-67-7","AlHLiO2",[23],3,{"unitPrice":94,"pack":28,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},{"slug":97,"cid":98,"imgSvg":99,"name":100,"nameZh":101,"cas":102,"formula":103,"iupac":100,"category":104,"categoryName":105,"categoryEnName":106,"industry":21,"tags":107,"offersCount":108,"supplierCount":108,"bestOffer":109},"785871830249377792","J-6931-9","\u002Fimages\u002Fchem_structures_svg\u002F456\u002F58068-80-7.svg","1-Octanoylbenzotriazole","N-辛酰苯并三唑","58068-80-7","C14H19N3O","aromatics","芳香烃","Aromatic Hydrocarbons",[],0,{"unitPrice":110,"pack":21,"currency":111,"origin":21,"originFlag":21,"moq":21,"stock":112},9007199254740991,"USD","made-to-order",{"slug":114,"cid":115,"imgSvg":116,"name":117,"nameZh":118,"cas":119,"formula":120,"iupac":117,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":121,"offersCount":69,"supplierCount":25,"bestOffer":122},"785871842446413824","J-1960944-3","\u002Fimages\u002Fchem_structures_svg\u002F495\u002F10534-86-8.svg","Hexaamminecobalt(III) nitrate","六氨合钴(III)硝酸盐","10534-86-8","CoH18N9O9",[23],{"unitPrice":71,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},{"slug":124,"cid":125,"imgSvg":126,"name":127,"nameZh":128,"cas":129,"formula":130,"iupac":127,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":131,"offersCount":24,"supplierCount":25,"bestOffer":132},"785871842576437248","J-814544-6","\u002Fimages\u002Fchem_structures_svg\u002F221\u002F12037-42-2.svg","vanadium oxide","氧化钒","12037-42-2","O13V6",[23],{"unitPrice":133,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},112.8,"100g",{"slug":136,"cid":137,"imgSvg":138,"name":139,"nameZh":140,"cas":141,"formula":142,"iupac":139,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":143,"offersCount":57,"supplierCount":5,"bestOffer":144},"785871842647740416","J-1333345-2","\u002Fimages\u002Fchem_structures_svg\u002F479\u002F26490-63-1.svg","COBALT TETRAFLUOROBORATE HEXAHYDRATE","四氟化硼钴水合物","26490-63-1","B2CoF8H12O6",[23],{"unitPrice":145,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},12,{"slug":147,"cid":148,"imgSvg":149,"name":150,"nameZh":151,"cas":152,"formula":153,"iupac":150,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":154,"offersCount":155,"supplierCount":94,"bestOffer":156},"785871842698072064","J-814953-0","\u002Fimages\u002Fchem_structures_svg\u002F432\u002F72259-10-0.svg","Copper(II) tetrafluoroborate hexahydrate","六水合四氟硼酸铜(II)","72259-10-0","B2CuF8H12O6",[23],10,{"unitPrice":157,"pack":28,"currency":29,"origin":21,"originFlag":21,"moq":21,"stock":32},2.6,{"slug":159,"cid":160,"imgSvg":161,"name":162,"nameZh":163,"cas":164,"formula":165,"iupac":162,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":166,"offersCount":25,"supplierCount":5,"bestOffer":168},"785871863254355968","J-1990080-7","\u002Fimages\u002Fchem_structures_svg\u002F149\u002F123333-60-8.svg","Cerium(IV) sulfate hydrate","铈(IV)硫酸盐水合物","123333-60-8","CeH2O9S2",[167],"Made to Order",{"unitPrice":169,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},5.6,3204,{"slug":172,"cid":173,"imgSvg":174,"name":175,"nameZh":175,"cas":176,"formula":177,"iupac":175,"mdl":21,"mw":178,"category":179,"categoryName":180,"categoryEnName":181,"industry":21,"tags":182,"synonyms":183,"properties":191,"ghs":235,"offers":236,"activity":237,"upstream":262,"downstream":293,"customs":294,"safetyRows":295,"updatedAt":296,"isProhibited":297,"related":298,"__ts":335,"__lang":336,"__slug":173},"785893575337447424","J-1963197-6","\u002Fimages\u002Fchem_structures_svg\u002F460\u002F243984-11-4.svg","瑞沙托维","243984-11-4","C15H17ClFNO4S","361.816","organic","有机化合物","Organic Compounds",[],[184,185,186,187,188,189,190],"TAK-242","化合物TAK-242","TAK-242,TLR4信号传导抑制剂","(R)-6-(N-(2-氯-4-氟苯基)氨磺酰基)环己-1-烯羧酸乙酯","(R)-6-[N-(2-氯-4-氟苯基)氨基磺酰基]-1-环己烷甲酸乙酯","瑞沙托维 Resatorvid","CS-1150",[192,197,202,207,212,216,220,223,227,231],{"label":193,"labelZh":194,"value":195,"prop":196},"Melting Point","熔点","68-69ºC","meltingPoint",{"label":198,"labelZh":199,"value":200,"prop":201},"Boiling Point","沸点","462.0±55.0 °C at 760 mmHg","boilingPoint",{"label":203,"labelZh":204,"value":205,"prop":206},"Density","密度","1.4±0.1 g\u002Fcm3","density",{"label":208,"labelZh":209,"value":210,"prop":211},"Flash Point","闪点","233.2±31.5 °C","flashPoint",{"label":213,"labelZh":214,"value":215},"Exact Mass","精确质量","361.055084",{"label":217,"labelZh":218,"value":219},"PSA","其他信息","80.85000",{"label":221,"labelZh":221,"value":222},"LogP","3.58",{"label":224,"labelZh":225,"value":226},"Vapor Pressure","蒸汽压","0.0±1.1 mmHg at 25°C",{"label":228,"labelZh":229,"value":230},"Refractive Index","折射率","1.574",{"label":232,"labelZh":233,"value":234},"Storage Conditions","储存条件","2-8℃",null,[],[238,241,244,247,250,253,256,259],{"key":239,"value":240},"描述","Resatorvid (TAK-242) 是一种有效的 TLR4 信号传导抑制剂,可选择性地抑制TLR-介导的细胞因子和一氧化氮的产生。",{"key":242,"value":243},"相关类别","信号通路\n>>\n自噬\n>>\n自噬\n信号通路\n>>\n免疫及炎症\n>>\nToll样受体(TLR)\n研究领域\n>>\n炎症\u002F免疫",{"key":245,"value":246},"靶点","TLR4[1]",{"key":248,"value":249},"体外研究","在RAW264.7细胞和小鼠腹腔巨噬细胞中,Resatorvid(TAK-242)抑制脂多糖(LPS)诱导的NO,肿瘤坏死因子-α(TNF-α)和白细胞介素(IL)-6的产生,IC50为1.1到11 nM。 Resatorvid(TAK-242)还抑制LPS刺激的人外周血单核细胞(PBMCs)中这些细胞因子的产生,IC50值为11至33 nM [1]。",{"key":251,"value":252},"体内研究","Resatorvid(TAK-242)显然降低了两种基因型小鼠的血清抗dsDNA水平。或者,Resatorvid(TAK-242)显着抑制IFN-γ,TNF-α和IL-1β的产生,但它们的浓度仍然远高于NS处理的对应物[2]。 Resatorvid(TAK-242)预应力给药可防止大鼠大脑额叶皮质中潜在有害的炎症和氧化\u002F亚硝化介质的积累。在应激期开始时,Resatorvid(TAK-242)iv给药完全阻断应激暴露后TLR-4 mRNA和蛋白质上调[3]。",{"key":254,"value":255},"细胞实验","将RAW264.7细胞以3×10 6个细胞\u002F孔的密度接种在六孔培养板中并孵育过夜。用补充有1％FCS和10μg\u002F mL卡那霉素的RPMI 1640培养基洗涤后，在存在或不存在Resatorvid（TAK-242）的情况下用5ng \u002F mL LPS和1U \u002F mL IFN-γ刺激细胞（1） -100 nM）指示的时间。除去培养上清液，使用总RNA分离试剂ISOGEN分离总RNA。通过使用TaqMan逆转录试剂将总RNA逆转录成cDNA。使用预先开发的TaqMan测定试剂和Universal PCR master mix在ABI Prism 7700上进行TNF-α和IL-6的定量实时PCR分析。使用比较阈值循环方法进行mRNA的定量。通过刺激获得的最高对照水平（没有Resatorvid（TAK-242））被认为是100％，并且对照组在其他时间点和TAK-242添加组的水平被表示为最高对照水平的百分比。 [1]。",{"key":257,"value":258},"动物实验","C57BL \u002F 6背景（雌性，10周龄）的小鼠[2] 30只ApoE  -  \u002F  - 和30只野生型小鼠在标准光照条件下喂食含有0.25％胆固醇和15％可可脂的高脂肪饮食（12 h亮 - 暗循环）和温度（21±1℃）。矿泉水随意饮用。将两种基因型的小鼠随机分配至LPS或LPS + Resatorvid（TAK-242）或盐水给药。 LPS（2.5mg \u002F kg），LPS（2.5mg \u002F kg）加Resatorvid（TAK-242）（0.3mg \u002F kg）和生理盐水分别通过腹膜内注射给药，每周两次，持续4周。在实验结束时，所有小鼠都接受了安乐死，注射过量戊巴比妥（50mg \u002F kg）。大鼠[3]使用最初重200至225g的雄性远交Wistar Hannover大鼠。在将动物引入塑料限制器后立即（约10秒）立即以0.5mg \u002F kg的剂量在尾静脉中静脉内注射Resatorvid（TAK-242）。该剂量是基于之前的体内研究选择的，该研究报告了其在暴露于缺氧的小胶质细胞中的抗炎\u002F抗氧化和神经保护特性。浓度为0.9％的二甲基亚砜用作载体。",{"key":260,"value":261},"参考文献","[1].\nIi M, et al. A novel cyclohexene derivative, ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling.\n[2].\nNi JQ, et al. Role of toll-like receptor 4 on lupus lung injury and atherosclerosis in LPS-challenge ApoE?\u002F? mice. Clin Dev Immunol. 2013;2013:476856.\n[3].\nGárate I, et al. Toll-like 4 receptor inhibitor TAK-242 decreases neuroinflammation in rat brain frontal cortex after stress. J Neuroinflammation. 2014 Jan 11;11:8.\n[4].\nWang L, et al. Doxorubicin-Induced Systemic Inflammation Is Driven by Upregulation of Toll-Like Receptor TLR4 and Endotoxin Leakage. Cancer Res. 2016 Nov 15;76(22):6631-6642.\n[5].\nShibata A, et al. Toll-like receptor 4 antagonist TAK-242 inhibits autoinflammatory symptoms in DITRA. J Autoimmun. 2017 Jun;80:28-38.\n[6].\nJanda J, et al. Resatorvid-based Pharmacological Antagonism of Cutaneous TLR4 Blocks UV-induced NF-κB and AP-1 Signaling in Keratinocytes and Mouse Skin. Photochem Photobiol. 2016 Nov;92(6):816-825.\n[7].\nKrock E, et al. Low back pain and disc degeneration are decreased following chronic toll-like receptor 4 inhibition in a mouse model. Osteoarthritis Cartilage. 2018 Sep;26(9):1236-1246.",[263,269,275,281,287],{"slug":264,"cid":265,"name":266,"nameZh":266,"cas":267,"imgSvg":268},"785897383459295200","J-1620412-6","6-(N-(2-氯-4-氟苯基...","243983-70-2","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F092\u002F243983-70-2.svg",{"slug":270,"cid":271,"name":272,"nameZh":272,"cas":273,"imgSvg":274},"785872761993039900","J-977330-9","2-疏基环己烯-1-羧酸乙酯","54928-91-5","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F369\u002F54928-91-5.svg",{"slug":276,"cid":277,"name":278,"nameZh":278,"cas":279,"imgSvg":280},"785881341739667500","J-18892-8","2-环己酮甲酸乙酯","1655-07-8","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F370\u002F1655-07-8.svg",{"slug":282,"cid":283,"name":284,"nameZh":284,"cas":285,"imgSvg":286},"785897383534792700","J-1520672-3","2-(氯磺酰基)环己烯-1-羧酸乙酯","243984-26-1","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F053\u002F243984-26-1.svg",{"slug":288,"cid":289,"name":290,"nameZh":290,"cas":291,"imgSvg":292},"785893833480081400","J-1327518-7","乙醇","64-17-5","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F081\u002F64-17-5.svg",[],[],[],"2026-08-21T07:51:12.859463Z",false,[299,305,311,317,323,329],{"slug":300,"cid":301,"name":302,"nameZh":303,"cas":304},"785888251297665024","J-1341832-2","Bathocuproine","浴铜灵","4733-39-5",{"slug":306,"cid":307,"name":308,"nameZh":309,"cas":310},"785880742256185344","J-1111861-9","Malachite green","孔雀石绿","569-64-2",{"slug":312,"cid":313,"name":314,"nameZh":315,"cas":316},"785872950262763520","J-1319798-8","EDTA ferric sodium salt","EDTA铁-钠盐","18154-32-0",{"slug":318,"cid":319,"name":320,"nameZh":321,"cas":322},"785881392557854720","J-19181-0","Curcumin","姜黄素","458-37-7",{"slug":324,"cid":325,"name":326,"nameZh":327,"cas":328},"785894536923582464","J-37904-3","Cinnarizine","桂利嗪","298-57-7",{"slug":330,"cid":331,"name":332,"nameZh":333,"cas":334},"785881207576465408","J-18377-6","Reinecke salt","利英钠克盐","13573-16-5",1792681139518,"zh-CN",[]]