[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"currency-rates":3,"$fyk2oeqxpb7bd":8,"compound-J-1963076-2":171,"verified-suppliers-J-1963076-2":353},{"rates":4,"source":7},{"USD":5,"CNY":6},1,6.691314,"live",{"rows":9,"total":170,"current":5,"size":145},[10,33,45,60,74,85,96,113,123,135,146,158],{"slug":11,"cid":12,"imgSvg":13,"name":14,"nameZh":15,"cas":16,"formula":17,"iupac":14,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":22,"offersCount":24,"supplierCount":25,"bestOffer":26},"843627791009189888","J-1971488-8","\u002Fimages\u002Fchem_structures_svg\u002F399\u002F65845-61-6.svg","N-Methylcyclohexanamine hydrochloride","N-甲基环己胺盐酸盐","65845-61-6","C7H16ClN","acids","有机酸","Organic Acids","",[23],"In Stock",4,2,{"unitPrice":27,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},2.64,"500g","CNY","China","CN","in-stock",{"slug":34,"cid":35,"imgSvg":36,"name":37,"nameZh":38,"cas":39,"formula":40,"iupac":37,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":41,"offersCount":24,"supplierCount":5,"bestOffer":42},"785882541994283008","J-1323843-4","\u002Fimages\u002Fchem_structures_svg\u002F104\u002F67627-18-3.svg","Potassium indigotrisulfonate","靛蓝三磺酸钾","67627-18-3","C16H7K3N2O11S3",[23],{"unitPrice":43,"pack":44,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},180,"5g",{"slug":46,"cid":47,"imgSvg":48,"name":49,"nameZh":50,"cas":51,"formula":52,"iupac":49,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":56,"offersCount":57,"supplierCount":25,"bestOffer":58},"785889752443260928","J-28559-9","\u002Fimages\u002Fchem_structures_svg\u002F292\u002F15060-55-6.svg","Ammonium tetrathiomolybdate","四硫钼酸铵","15060-55-6","H8MoN2S4","inorganic","无机化合物","Inorganic Chemicals",[23],7,{"unitPrice":59,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},24,{"slug":61,"cid":62,"imgSvg":63,"name":64,"nameZh":65,"cas":66,"formula":67,"iupac":64,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":68,"offersCount":69,"supplierCount":25,"bestOffer":70},"855452191530422272","J-1994428-7","\u002Fimages\u002Fchem_structures_svg\u002F500\u002F16350-96-2.svg","N-benzylcyclohexanamine.hydrochloride","N-苄基环己胺盐酸盐","16350-96-2","C13H20ClN",[23],5,{"unitPrice":71,"pack":72,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},6,"1000g","中国",{"slug":75,"cid":76,"imgSvg":77,"name":78,"nameZh":79,"cas":80,"formula":81,"iupac":78,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":82,"offersCount":25,"supplierCount":25,"bestOffer":83},"785871840001134592","J-982001-0","\u002Fimages\u002Fchem_structures_svg\u002F001\u002F10517-44-9.svg","1,3-Diaminopropane dihydrochloride","1,3-二氨基丙烷二盐酸盐","10517-44-9","C3H12Cl2N2",[23],{"unitPrice":84,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},3.78,{"slug":86,"cid":87,"imgSvg":88,"name":89,"nameZh":90,"cas":91,"formula":92,"iupac":89,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":93,"offersCount":57,"supplierCount":94,"bestOffer":95},"785880365658017792","J-14975-6","\u002Fimages\u002Fchem_structures_svg\u002F262\u002F12003-67-7.svg","Lithium aluminate","氧化铝锂","12003-67-7","AlHLiO2",[23],3,{"unitPrice":94,"pack":28,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},{"slug":97,"cid":98,"imgSvg":99,"name":100,"nameZh":101,"cas":102,"formula":103,"iupac":100,"category":104,"categoryName":105,"categoryEnName":106,"industry":21,"tags":107,"offersCount":108,"supplierCount":108,"bestOffer":109},"785871830249377792","J-6931-9","\u002Fimages\u002Fchem_structures_svg\u002F456\u002F58068-80-7.svg","1-Octanoylbenzotriazole","N-辛酰苯并三唑","58068-80-7","C14H19N3O","aromatics","芳香烃","Aromatic Hydrocarbons",[],0,{"unitPrice":110,"pack":21,"currency":111,"origin":21,"originFlag":21,"moq":21,"stock":112},9007199254740991,"USD","made-to-order",{"slug":114,"cid":115,"imgSvg":116,"name":117,"nameZh":118,"cas":119,"formula":120,"iupac":117,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":121,"offersCount":69,"supplierCount":25,"bestOffer":122},"785871842446413824","J-1960944-3","\u002Fimages\u002Fchem_structures_svg\u002F495\u002F10534-86-8.svg","Hexaamminecobalt(III) nitrate","六氨合钴(III)硝酸盐","10534-86-8","CoH18N9O9",[23],{"unitPrice":71,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},{"slug":124,"cid":125,"imgSvg":126,"name":127,"nameZh":128,"cas":129,"formula":130,"iupac":127,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":131,"offersCount":24,"supplierCount":25,"bestOffer":132},"785871842576437248","J-814544-6","\u002Fimages\u002Fchem_structures_svg\u002F221\u002F12037-42-2.svg","vanadium oxide","氧化钒","12037-42-2","O13V6",[23],{"unitPrice":133,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},112.8,"100g",{"slug":136,"cid":137,"imgSvg":138,"name":139,"nameZh":140,"cas":141,"formula":142,"iupac":139,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":143,"offersCount":57,"supplierCount":5,"bestOffer":144},"785871842647740416","J-1333345-2","\u002Fimages\u002Fchem_structures_svg\u002F479\u002F26490-63-1.svg","COBALT TETRAFLUOROBORATE HEXAHYDRATE","四氟化硼钴水合物","26490-63-1","B2CoF8H12O6",[23],{"unitPrice":145,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},12,{"slug":147,"cid":148,"imgSvg":149,"name":150,"nameZh":151,"cas":152,"formula":153,"iupac":150,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":154,"offersCount":155,"supplierCount":94,"bestOffer":156},"785871842698072064","J-814953-0","\u002Fimages\u002Fchem_structures_svg\u002F432\u002F72259-10-0.svg","Copper(II) tetrafluoroborate hexahydrate","六水合四氟硼酸铜(II)","72259-10-0","B2CuF8H12O6",[23],10,{"unitPrice":157,"pack":28,"currency":29,"origin":21,"originFlag":21,"moq":21,"stock":32},2.6,{"slug":159,"cid":160,"imgSvg":161,"name":162,"nameZh":163,"cas":164,"formula":165,"iupac":162,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":166,"offersCount":25,"supplierCount":5,"bestOffer":168},"785871863254355968","J-1990080-7","\u002Fimages\u002Fchem_structures_svg\u002F149\u002F123333-60-8.svg","Cerium(IV) sulfate hydrate","铈(IV)硫酸盐水合物","123333-60-8","CeH2O9S2",[167],"Made to Order",{"unitPrice":169,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},5.6,3204,{"slug":172,"cid":173,"imgSvg":174,"name":175,"nameZh":175,"cas":176,"formula":177,"iupac":175,"mdl":21,"mw":178,"category":179,"categoryName":180,"categoryEnName":181,"industry":21,"tags":182,"synonyms":183,"properties":187,"ghs":226,"offers":227,"activity":228,"upstream":250,"downstream":293,"customs":294,"safetyRows":307,"updatedAt":312,"isProhibited":313,"related":314,"__ts":351,"__lang":352,"__slug":173},"785893565455667200","J-1963076-2","\u002Fimages\u002Fchem_structures_svg\u002F230\u002F201530-41-8.svg","地拉罗司","201530-41-8","C21H15N3O4","373.362","organic","有机化合物","Organic Compounds",[],[184,185,186],"4-[3,5-二(2-羟基苯基)-1,2,4-三唑-1-基]苯甲酸","去铁斯若","地拉罗司(去铁斯若)",[188,192,196,200,204,208,211,214,218,222],{"label":189,"labelZh":189,"value":190,"prop":191},"Melting Point","260-262ºC","meltingPoint",{"label":193,"labelZh":193,"value":194,"prop":195},"Boiling Point","672.1±65.0 °C at 760 mmHg","boilingPoint",{"label":197,"labelZh":197,"value":198,"prop":199},"Density","1.4±0.1 g\u002Fcm3","density",{"label":201,"labelZh":201,"value":202,"prop":203},"Flash Point","360.3±34.3 °C","flashPoint",{"label":205,"labelZh":206,"value":207},"Exact Mass","精确质量","373.106262",{"label":209,"labelZh":209,"value":210},"PSA","107.95000",{"label":212,"labelZh":212,"value":213},"LogP","6.43",{"label":215,"labelZh":216,"value":217},"Vapor Pressure","蒸汽压","0.0±2.2 mmHg at 25°C",{"label":219,"labelZh":220,"value":221},"Refractive Index","折射率","1.699",{"label":223,"labelZh":224,"value":225},"Storage Conditions","储存条件","-20°C Freezer",null,[],[229,232,235,238,241,244,247],{"key":230,"value":231},"描述","Deferasirox (ICL 670) 是具有口活性的,用于治疗铁离子过量的螯合剂。",{"key":233,"value":234},"相关类别","信号通路\n>>\n其他\n>>\n其他\n研究领域\n>>\n其他",{"key":236,"value":237},"体外研究","在用50μM地拉罗司处理12小时的LX-2细胞中,α1(I)原胶原表达降低25％,在处理24-120小时后观察到最大降低(10倍)。同样,α-平滑肌肌动蛋白(αSMA)表达显着降低[1]。 Deferasirox对HL-60或KG-1骨髓白血病细胞系具有抗增殖作用,浓度低至5μM。细胞毒性与剂量和时间有关[2]。用地拉罗司孵育的EL4细胞和L1210细胞的活力均以浓度依赖性方式降低[3]。",{"key":239,"value":240},"体内研究","与对照组相比,用地拉罗司治疗的SIO小鼠的肿瘤明显较小。用DFX治疗的小鼠显示出比其他组更长的存活期。在铁螯合和抗白血病治疗方面,Deferasirox对SIO白血病小鼠模型具有生存益处[3]。",{"key":242,"value":243},"细胞实验","将Deferasirox溶解在DMSO中。用0,5,10,50μM地拉罗司处理HL-60或KG-1细胞24或48小时，并通过MTT测定确定增殖[2]。",{"key":245,"value":246},"动物实验","小鼠：将鼠白血病细胞皮下注射到小鼠的右侧腹部。将地拉罗司溶解于蒸馏水中并以20mg \u002F kg口服给药直至累积剂量达到300mg \u002F kg。每天观察小鼠并称重[3]。",{"key":248,"value":249},"参考文献","[1].\nSobbe A, et al. Inconsistent hepatic antifibrotic effects with the iron chelator deferasirox. J Gastroenterol Hepatol. 2015 Mar;30(3):638-45.\n[2].\nKim JL, et al. The oral iron chelator deferasirox induces apoptosis in myeloid leukemia cells by targetingcaspase. Acta Haematol. 2011;126(4):241-5.\n[3].\nLee DH, et al. Deferasirox shows in vitro and in vivo antileukemic effects on murine leukemic cell lines regardless of iron status. Exp Hematol. 2013 Jun;41(6):539-46.",[251,257,263,269,275,281,287],{"slug":252,"cid":253,"name":254,"nameZh":254,"cas":255,"imgSvg":256},"785896883527618600","J-1517675-2","4-肼基苯甲酸乙酯","14685-90-6","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F057\u002F14685-90-6.svg",{"slug":258,"cid":259,"name":260,"nameZh":260,"cas":261,"imgSvg":262},"785884392839974900","J-23323-3","4-肼基苯甲酸","619-67-0","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F051\u002F619-67-0.svg",{"slug":264,"cid":265,"name":266,"nameZh":266,"cas":267,"imgSvg":268},"785889094105305100","J-1359082-8","2-(2-羟基苯基)-4H-苯...","1218-69-5","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F312\u002F1218-69-5.svg",{"slug":270,"cid":271,"name":272,"nameZh":272,"cas":273,"imgSvg":274},"785898349470421000","J-1144532-0","2-羟基-N-(2-羟基苯基)苯甲酰胺","1972-71-0","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F251\u002F1972-71-0.svg",{"slug":276,"cid":277,"name":278,"nameZh":278,"cas":279,"imgSvg":280},"785882704859107300","J-5417-7","水杨酸","69-72-7","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F279\u002F69-72-7.svg",{"slug":282,"cid":283,"name":284,"nameZh":284,"cas":285,"imgSvg":286},"785881390972407800","J-19169-6","水杨酰胺","65-45-2","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F180\u002F65-45-2.svg",{"slug":288,"cid":289,"name":290,"nameZh":290,"cas":291,"imgSvg":292},"785892441952620500","J-1492378-4","地拉罗司甲酯","1266741-05-2","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F292\u002F1266741-05-2.svg",[],[295,298,301,304],{"key":296,"value":297},"海关编码","2933990090",{"key":299,"value":300},"中文概述","2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%",{"key":302,"value":303},"申报要素","品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期",{"key":305,"value":306},"Summary","2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%",[308,311],{"key":309,"value":310},"危害码 (欧洲)","Xi",{"key":296,"value":297},"2026-08-21T07:51:12.859463Z",false,[315,321,327,333,339,345],{"slug":316,"cid":317,"name":318,"nameZh":319,"cas":320},"785896553968570368","J-1516137-4","Solvent Brown 53","溶剂棕53","64696-98-6",{"slug":322,"cid":323,"name":324,"nameZh":325,"cas":326},"785892567169372160","J-1114822-9","Methylene Blue trihydrate","亚甲基蓝三水合物","7220-79-3",{"slug":328,"cid":329,"name":330,"nameZh":331,"cas":332},"785894613603848192","J-38281-2","Fluorescein sodium","荧光素钠","518-47-8",{"slug":334,"cid":335,"name":336,"nameZh":337,"cas":338},"785894656863899648","J-1114938-7","Riboflavin","核黄素","83-88-5",{"slug":340,"cid":341,"name":342,"nameZh":343,"cas":344},"785894536923582464","J-37904-3","Cinnarizine","桂利嗪","298-57-7",{"slug":346,"cid":347,"name":348,"nameZh":349,"cas":350},"785895822460981248","J-42947-6","D-(+)-Trehalose dihydrate","D-(+)-海藻糖二水合物","6138-23-4",1792626505466,"zh-CN",[]]