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3的平均大小或当判断肿瘤对动物的健康有不利影响时，终止研究。大鼠[4]使用40只雌性Sprague-Dawley大鼠（200-230g）。每组由5-10只随意喂养的动物组成。在气体麻醉（2％异氟烷）下，将1×104Walker 256细胞注入左腹部乳腺脂肪垫中。每天称重大鼠并通过管饲法给予苹果酸舒尼替尼（30mg \u002F kg）和\u002F或芬戈莫德（5mg \u002F kg）橄榄油。用卡尺测量肿瘤。在肿瘤溃疡之前，通过心内注射氯胺酮（50mg \u002F mL）麻醉并杀死动物。解剖大鼠以检测肺，肝，肾或肠转移。",{"key":256,"value":257},"参考文献","[1].\nSun L, et al. Discovery of 5-[5-fluoro-2-oxo-1,2- dihydroindol-(3Z)-ylidenemethyl]-2,4- dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor r\n[2].\nMendel DB, et al. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic\u002Fpharmacodynamic relationship. Clin Can\n[3].\nO'Farrell AM, et al. SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood. 2003 May 1;101(9):3597-605.\n[4].\nMousseau Y, et al. Fingolimod potentiates the effects of sunitinib malate in a rat breast cancer model. Breast Cancer Res Treat. 2012 Jul;134(1):31-40.\n[5].\nSmall J, et al. The addition of abemaciclib to sunitinib induces regression of renal cell carcinoma xenograft tumors. 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