[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"currency-rates":3,"$fyk2oeqxpb7bd":8,"compound-J-1962553-1":171,"verified-suppliers-J-1962553-1":322},{"rates":4,"source":7},{"USD":5,"CNY":6},1,6.691314,"live",{"rows":9,"total":170,"current":5,"size":145},[10,33,45,60,74,85,96,113,123,135,146,158],{"slug":11,"cid":12,"imgSvg":13,"name":14,"nameZh":15,"cas":16,"formula":17,"iupac":14,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":22,"offersCount":24,"supplierCount":25,"bestOffer":26},"843627791009189888","J-1971488-8","\u002Fimages\u002Fchem_structures_svg\u002F399\u002F65845-61-6.svg","N-Methylcyclohexanamine hydrochloride","N-甲基环己胺盐酸盐","65845-61-6","C7H16ClN","acids","有机酸","Organic Acids","",[23],"In Stock",4,2,{"unitPrice":27,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},2.64,"500g","CNY","China","CN","in-stock",{"slug":34,"cid":35,"imgSvg":36,"name":37,"nameZh":38,"cas":39,"formula":40,"iupac":37,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":41,"offersCount":24,"supplierCount":5,"bestOffer":42},"785882541994283008","J-1323843-4","\u002Fimages\u002Fchem_structures_svg\u002F104\u002F67627-18-3.svg","Potassium indigotrisulfonate","靛蓝三磺酸钾","67627-18-3","C16H7K3N2O11S3",[23],{"unitPrice":43,"pack":44,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},180,"5g",{"slug":46,"cid":47,"imgSvg":48,"name":49,"nameZh":50,"cas":51,"formula":52,"iupac":49,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":56,"offersCount":57,"supplierCount":25,"bestOffer":58},"785889752443260928","J-28559-9","\u002Fimages\u002Fchem_structures_svg\u002F292\u002F15060-55-6.svg","Ammonium tetrathiomolybdate","四硫钼酸铵","15060-55-6","H8MoN2S4","inorganic","无机化合物","Inorganic Chemicals",[23],7,{"unitPrice":59,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},24,{"slug":61,"cid":62,"imgSvg":63,"name":64,"nameZh":65,"cas":66,"formula":67,"iupac":64,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":68,"offersCount":69,"supplierCount":25,"bestOffer":70},"855452191530422272","J-1994428-7","\u002Fimages\u002Fchem_structures_svg\u002F500\u002F16350-96-2.svg","N-benzylcyclohexanamine.hydrochloride","N-苄基环己胺盐酸盐","16350-96-2","C13H20ClN",[23],5,{"unitPrice":71,"pack":72,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},6,"1000g","中国",{"slug":75,"cid":76,"imgSvg":77,"name":78,"nameZh":79,"cas":80,"formula":81,"iupac":78,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":82,"offersCount":25,"supplierCount":25,"bestOffer":83},"785871840001134592","J-982001-0","\u002Fimages\u002Fchem_structures_svg\u002F001\u002F10517-44-9.svg","1,3-Diaminopropane dihydrochloride","1,3-二氨基丙烷二盐酸盐","10517-44-9","C3H12Cl2N2",[23],{"unitPrice":84,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},3.78,{"slug":86,"cid":87,"imgSvg":88,"name":89,"nameZh":90,"cas":91,"formula":92,"iupac":89,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":93,"offersCount":57,"supplierCount":94,"bestOffer":95},"785880365658017792","J-14975-6","\u002Fimages\u002Fchem_structures_svg\u002F262\u002F12003-67-7.svg","Lithium aluminate","氧化铝锂","12003-67-7","AlHLiO2",[23],3,{"unitPrice":94,"pack":28,"currency":29,"origin":73,"originFlag":31,"moq":21,"stock":32},{"slug":97,"cid":98,"imgSvg":99,"name":100,"nameZh":101,"cas":102,"formula":103,"iupac":100,"category":104,"categoryName":105,"categoryEnName":106,"industry":21,"tags":107,"offersCount":108,"supplierCount":108,"bestOffer":109},"785871830249377792","J-6931-9","\u002Fimages\u002Fchem_structures_svg\u002F456\u002F58068-80-7.svg","1-Octanoylbenzotriazole","N-辛酰苯并三唑","58068-80-7","C14H19N3O","aromatics","芳香烃","Aromatic Hydrocarbons",[],0,{"unitPrice":110,"pack":21,"currency":111,"origin":21,"originFlag":21,"moq":21,"stock":112},9007199254740991,"USD","made-to-order",{"slug":114,"cid":115,"imgSvg":116,"name":117,"nameZh":118,"cas":119,"formula":120,"iupac":117,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":121,"offersCount":69,"supplierCount":25,"bestOffer":122},"785871842446413824","J-1960944-3","\u002Fimages\u002Fchem_structures_svg\u002F495\u002F10534-86-8.svg","Hexaamminecobalt(III) nitrate","六氨合钴(III)硝酸盐","10534-86-8","CoH18N9O9",[23],{"unitPrice":71,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},{"slug":124,"cid":125,"imgSvg":126,"name":127,"nameZh":128,"cas":129,"formula":130,"iupac":127,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":131,"offersCount":24,"supplierCount":25,"bestOffer":132},"785871842576437248","J-814544-6","\u002Fimages\u002Fchem_structures_svg\u002F221\u002F12037-42-2.svg","vanadium oxide","氧化钒","12037-42-2","O13V6",[23],{"unitPrice":133,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},112.8,"100g",{"slug":136,"cid":137,"imgSvg":138,"name":139,"nameZh":140,"cas":141,"formula":142,"iupac":139,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":143,"offersCount":57,"supplierCount":5,"bestOffer":144},"785871842647740416","J-1333345-2","\u002Fimages\u002Fchem_structures_svg\u002F479\u002F26490-63-1.svg","COBALT TETRAFLUOROBORATE HEXAHYDRATE","四氟化硼钴水合物","26490-63-1","B2CoF8H12O6",[23],{"unitPrice":145,"pack":134,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},12,{"slug":147,"cid":148,"imgSvg":149,"name":150,"nameZh":151,"cas":152,"formula":153,"iupac":150,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":154,"offersCount":155,"supplierCount":94,"bestOffer":156},"785871842698072064","J-814953-0","\u002Fimages\u002Fchem_structures_svg\u002F432\u002F72259-10-0.svg","Copper(II) tetrafluoroborate hexahydrate","六水合四氟硼酸铜(II)","72259-10-0","B2CuF8H12O6",[23],10,{"unitPrice":157,"pack":28,"currency":29,"origin":21,"originFlag":21,"moq":21,"stock":32},2.6,{"slug":159,"cid":160,"imgSvg":161,"name":162,"nameZh":163,"cas":164,"formula":165,"iupac":162,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":166,"offersCount":25,"supplierCount":5,"bestOffer":168},"785871863254355968","J-1990080-7","\u002Fimages\u002Fchem_structures_svg\u002F149\u002F123333-60-8.svg","Cerium(IV) sulfate hydrate","铈(IV)硫酸盐水合物","123333-60-8","CeH2O9S2",[167],"Made to Order",{"unitPrice":169,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},5.6,3204,{"slug":172,"cid":173,"imgSvg":174,"name":175,"nameZh":175,"cas":176,"formula":177,"iupac":175,"mdl":21,"mw":178,"category":179,"categoryName":180,"categoryEnName":181,"industry":21,"tags":182,"synonyms":183,"properties":187,"ghs":212,"offers":213,"activity":214,"upstream":242,"downstream":279,"customs":280,"safetyRows":281,"updatedAt":282,"isProhibited":283,"related":284,"__ts":320,"__lang":321,"__slug":173},"785893339034554368","J-1962553-1","\u002Fimages\u002Fchem_structures_svg\u002F336\u002F405169-16-6.svg","多韦替尼","405169-16-6","C21H21FN6O","392.429","organic","有机化合物","Organic Compounds",[],[184,185,186],"多维替尼","4-氨基-5-氟-3-[5-(4-甲基哌嗪-1-基)-1H-苯并咪唑-2-基]喹啉-2(1H)-酮","多韦替尼碱",[188,193,197,201,204,208],{"label":189,"labelZh":190,"value":191,"prop":192},"Density","密度","1.4±0.1 g\u002Fcm3","density",{"label":194,"labelZh":195,"value":196},"Exact Mass","精确质量","392.176086",{"label":198,"labelZh":199,"value":200},"PSA","其他信息","94.04000",{"label":202,"labelZh":202,"value":203},"LogP","1.59",{"label":205,"labelZh":206,"value":207},"Refractive Index","折射率","1.691",{"label":209,"labelZh":210,"value":211},"Storage Conditions","储存条件","-20°C",null,[],[215,218,221,224,227,230,233,236,239],{"key":216,"value":217},"描述","Dovitinib是多靶点的酪氨酸激酶抑制剂,抑制FLT3,c-Kit,FGFR1\u002F3,VEGFR1\u002F2\u002F3 和 PDGFRα\u002Fβ 的 IC50 值分别为1,2,8\u002F9,10\u002F13\u002F8,27\u002F210 nM。",{"key":219,"value":220},"相关类别","信号通路\n>>\n蛋白酪氨酸激酶\n>>\nc-Kit\n信号通路\n>>\n蛋白酪氨酸激酶\n>>\nFGFR\n信号通路\n>>\n蛋白酪氨酸激酶\n>>\nFLT3\n信号通路\n>>\n蛋白酪氨酸激酶\n>>\nPDGFR\n研究领域\n>>\n癌症",{"key":222,"value":223},"靶点","FGFR1:8 nM (IC50)\nFGFR3:9 nM (IC50)\nVEGFR1:1 nM (IC50)\nVEGFR2:13 nM (IC50)\nVEGFR3:8 nM (IC50)\nPDGFRα:27 nM (IC50)\nPDGFRβ:210 nM (IC50)\nFLT3:1 nM (IC50)\nc-Kit:2 nM (IC50)",{"key":225,"value":226},"体外研究","Dovitinib有效抑制表达WT和F384L-FGFR3的B9细胞的FGF刺激的生长,IC50值为25nM。 B9-MINV细胞在浓度高达1μM时对Dovitinib的抑制活性具有抗性。 Dovitinib抑制KMS11(FGFR3-Y373C),OPM2(FGFR3-K650E)和KMS18(FGFR3-G384D)细胞的细胞增殖,IC50值分别为90 nM(KMS11和OPM2)和550 nM [1]。 Dovitinib显着降低SK-HEP1和21-0208细胞中FGFR-1,FGFR底物2α(FRS2-α)和ERK1\u002F2的基础磷酸化水平,但不显着降低Akt [2]。 Dovitinib增强BMP-2诱导的碱性磷酸酶(ALP)诱导,这是成骨细胞分化的代表性标志物。 Dovitinib还可以刺激磷酸化Smad1\u002F5\u002F8向细胞核的转位和丝裂原活化蛋白激酶的磷酸化,包括ERK1\u002F2和p38 [3]。 Dovitinib强烈抑制TNIK与ATP(Ki,13 nM)的相互作用和Wnt信号传导因子如β-catenin和TCF4的激活。 Dovitinib还在IM-9细胞中诱导胱天蛋白酶依赖性细胞凋亡,而在PBMC中没有显着的细胞毒性[4]。",{"key":228,"value":229},"体内研究","Dovitinib(10 mg\u002Fkg,30 mg\u002Fkg,60 mg\u002Fkg,口服)在携带KMS11的小鼠模型中显示出显着的抗肿瘤作用,10 mg\u002Fml的生长抑制率为48％,78.5％和94％与安慰剂治疗的小鼠相比,分别为kg,30 mg\u002Fkg和60 mg\u002Fkg治疗组[1]。 Dovitinib(50和75 mg\u002Fkg)分别导致97％和98％的肿瘤生长抑制,最大疗效为50 mg\u002Fkg [2]。",{"key":231,"value":232},"激酶实验","用时间分辨荧光（TRF）或放射性形式测定Dovitinib对RTK抑制的50％（IC 50）抑制浓度，测量Dovitinib通过相应酶将磷酸盐转移到底物上的抑制。在50mM HEPES（N-2-羟乙基哌嗪-N'-2-乙磺酸），pH 7.0,2mM MgCl 2,10mM MnCl 2 1mM中测定FGFR3，FGFR1，PDGFR-β和VEGFR1-3的激酶结构域。 NaF，1mM二硫苏糖醇（DTT），1mg \u002F mL牛血清白蛋白（BSA），0.25μM生物素化肽底物（GGGGQDGKDYIVLPI）和1至30μM三磷酸腺苷（ATP），取决于各酶的Km。 ATP浓度等于或略低于Km。对于c-KIT和FLT3反应，在0.25至1μM生物素化的肽底物（GGLFDDPSYVNVQNL）存在下，用0.2至8μMATP将pH升至7.5。将反应物在室温下温育1至4小时，并在含有终止反应缓冲液（25mM EDTA [乙二胺四乙酸]，50mM HEPES，pH7.5）的链霉抗生物素蛋白包被的微量滴定板上捕获磷酸化肽。使用铕标记的抗磷酸酪氨酸抗体PT66，用DELFIA TRF系统测量磷酸化肽。使用XL-Fit数据分析软件4.1版，使用非线性回归计算Dovitinib对IC50的浓度。使用IC50 Profiler Express服务确定集落刺激因子-1受体（CSF-1R），PDGFR-α，胰岛素受体（InsR）和胰岛素样生长因子受体1（IGFR1）激酶活性的抑制。",{"key":234,"value":235},"细胞实验","根据制造商的说明书，通过3-（4,5-二甲基噻唑）-2,5-二苯基四唑（MTT）染料吸光度评估细胞活力。将细胞以每孔5000个（B9细胞）或20000个（MM细胞系）细胞的密度接种在96孔板中。将细胞与30ng \u002F mL aFGF和100μg\u002F mL肝素或1％IL-6一起孵育，其中指示并增加浓度的Dovitinib。对于每种浓度的Dovitinib，加入在培养基中稀释的10-μL等分试样的药物或DMSO。对于药物组合研究，将细胞与0.5μM地塞米松，100nM Dovitinib或两者同时孵育，如果指出的话。为了评估Dovitinib对粘附于BMSC的MM细胞生长的影响，在存在或不存在Dovitinib的情况下，在BMSC包被的96孔板上培养10000个KMS11细胞。将板孵育48至96小时。为了评估巨噬细胞集落刺激因子（M-CSF）介导的生长，将5000 M-NFS-60细胞\u002F孔与连续稀释的CHIR-25 ZS8与10ng \u002F mL M-CSF一起孵育，并且没有粒细胞 - 巨噬细胞集落。 - 刺激因子（GM-CSF）。 72小时后，使用Cell Titer-Glo Assay测定细胞活力。每个实验条件一式三份进行。",{"key":237,"value":238},"动物实验","如前所述制备异种移植小鼠模型。简而言之，将6至8周龄雌性BNX小鼠皮下接种于右侧腹部，其中含有3×107 KMS11细胞的150μLIMDM，以及150μL基质胶基底膜基质。当肿瘤达到200mm 3的体积时开始治疗，此时小鼠随机接受10,30或60mg \u002F kg Dovitinib或5mM柠檬酸盐缓冲液。通过强饲法每天给药21天。每个治疗组包括8至10只小鼠。使用以下公式每周两次进行卡尺测量以估计肿瘤体积：4π\u002F 3×（宽度\u002F 2）2×（长度\u002F 2）。单因素方差分析用于比较载体和多吉替尼治疗组之间的差异。",{"key":240,"value":241},"参考文献","[1].\nTrudel S, et al. CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma. Blood. 2005, 105(7), 2941-2948.\n[2].\nHuynh H, et al. Dovitinib demonstrates antitumor and antimetastatic activities in xenograft models of hepatocellular carcinoma. J Hepatol. 2012, 56(3), 595-601.\n[3].\nLee Y, et al. A Receptor Tyrosine Kinase Inhibitor, Dovitinib (TKI-258), Enhances BMP-2-Induced Osteoblast Differentiation In Vitro. Mol Cells. 2016 May 31;39(5):389-94\n[4].\nChon HJ, et al. Traf2- and Nck-interacting kinase (TNIK) is involved in the anti-cancer mechanism of dovitinib in human multiple myeloma IM-9 cells. Amino Acids. 2016 Jul;48(7):1591-9.",[243,249,255,261,267,273],{"slug":244,"cid":245,"name":246,"nameZh":246,"cas":247,"imgSvg":248},"785893333166723100","J-1481059-8","2-[5-(4-甲基哌嗪)苯并...","402948-37-2","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F247\u002F402948-37-2.svg",{"slug":250,"cid":251,"name":252,"nameZh":252,"cas":253,"imgSvg":254},"785873092898459600","J-1993907-8","2-氨基-6-氟苯腈","77326-36-4","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F400\u002F77326-36-4.svg",{"slug":256,"cid":257,"name":258,"nameZh":258,"cas":259,"imgSvg":260},"785892462550847500","J-32558-3","N-甲基哌嗪","109-01-3","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F278\u002F109-01-3.svg",{"slug":262,"cid":263,"name":264,"nameZh":264,"cas":265,"imgSvg":266},"785891643751403500","J-30560-4","5-氯-2-硝基苯胺","1635-61-6","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F282\u002F1635-61-6.svg",{"slug":268,"cid":269,"name":270,"nameZh":270,"cas":271,"imgSvg":272},"785873295256850400","J-1327129-5","5-(4-甲基哌嗪)-2-硝基苯胺","23491-48-7","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F452\u002F23491-48-7.svg",{"slug":274,"cid":275,"name":276,"nameZh":276,"cas":277,"imgSvg":278},"785889609346191400","J-1471715-6","4-(4-甲基哌嗪基)-1,2-苯二胺","54998-08-2","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F445\u002F54998-08-2.svg",[],[],[],"2026-08-21T07:51:12.859463Z",false,[285,291,297,302,308,314],{"slug":286,"cid":287,"name":288,"nameZh":289,"cas":290},"785882572553981952","J-1110759-4","Methyl Violet 2B","甲基紫2B","8004-87-3",{"slug":292,"cid":293,"name":294,"nameZh":295,"cas":296},"785884696738271232","J-1324442-0","Ethylenediaminetetraacetate-copper-ammonia complex","EDTA-铜铵络合物","67989-88-2",{"slug":298,"cid":299,"name":300,"nameZh":300,"cas":301},"785911446427930624","J-69315-4","9-Bromo-10-(naphthalen-1-yl-d7)anthracene-1,2,3,4,5,6,7,8-d8","2330770-73-3",{"slug":303,"cid":304,"name":305,"nameZh":306,"cas":307},"785898743068102656","J-1365189-3","Esomeprazole calcium","埃索美拉唑钙","161796-85-6",{"slug":309,"cid":310,"name":311,"nameZh":312,"cas":313},"785884051318771712","J-1114131-2","Alizarin Complexone","茜素络合指示剂","3952-78-1",{"slug":315,"cid":316,"name":317,"nameZh":318,"cas":319},"785896769497075712","J-45303-5","Cholecalciferol","维生素D3","67-97-0",1792645197747,"zh-CN",[]]