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CYP1A2,CYP2A6,CYP2C9,CYP2D6,CYP2E1和CYP2C19对STS代谢的影响很小或没有影响[3]。丹参酮IIA磺酸钠在HLM和CYP3A4同种型中以剂量依赖性方式抑制CYP3A4的活性。丹参酮IIA磺酸钠在体外主要抑制CYP3A4的活性,丹参酮IIA磺酸钠有可能与其他CYP3A4底物发生药物-药物相互作用[4]。",{"key":219,"value":220},"体内研究","丹参酮IIA磺酸钠(10mg\u002Fkg,20mg\u002Fkg)和多奈哌齐缩短逃避潜伏期,增加平台原始位置的交叉时间,并增加在目标象限中花费的时间。丹参酮IIA磺酸钠降低乙酰胆碱酯酶(AChE)的活性,并增加SCOP处理的小鼠的海马和皮质中胆碱乙酰转移酶(ChAT)的活性。丹参酮IIA磺酸钠增加超氧化物歧化酶(SOD)的活性,降低海马和皮质中丙二醛(MDA)和活性氧(ROS)的水平[1]。预防丹参酮IIA磺酸钠(30 mg\u002Fkg \u002F天)可缓解慢性缺氧PH大鼠模型中缺氧诱导的特征性改变[2]。丹参酮IIA磺酸钠(20,10和5mg\u002Fkg,ip)有效地防止腹膜粘连而不影响大鼠的吻合口愈合。与粘连模型组相比,丹参酮IIA磺酸钠处理组在缺血组织中表现出腹膜灌洗液tPA活性和tPA\u002FPAI-1比值增加,缺血组织中TGF-β1和Ⅰ型胶原表达缺失[5]。",{"key":222,"value":223},"动物实验","小鼠[1]将雄性昆明小鼠（KM，重35-40g）维持在标准实验室条件下，自由饮水和食物。将小鼠随机分为5组：媒介物对照组（CON，0.9％生理盐水，n = 10），东莨菪碱组（SCOP，n = 10），低剂量丹参酮IIA磺酸钠组（丹参酮IIA磺酸钠，SCOP 3 mg） \u002F kg +丹参酮IIA磺酸钠10 mg \u002F kg，n = 10），高剂量丹参酮IIA磺酸钠组（丹参酮IIA磺酸钠H，SCOP 3 mg \u002F kg +丹参酮IIA磺酸钠20 mg \u002F kg，n = 10）和Donepezil组（DON，SCOP 3 mg \u002F kg + ARI 3 mg \u002F kg，n = 10）。分别通过管饲法用盐水，丹参酮IIA磺酸钠和多奈哌齐治疗小鼠，每天一次，持续两周。 SCOP从第8天开始注射一周（腹膜内注射，IP）。在Morris水迷宫测试前0.5小时注射SCOP。大鼠[2]将雄性Sprague-Dawley大鼠（200-250g）随机分为4组：1）常氧对照组，2）常氧+丹参酮ⅡA磺酸钠组，3）缺氧对照组， 4）缺氧+丹参酮IIA磺酸钠基团。第1组和第2组置于常氧条件下，第3组和第4组置于正常压力的低氧舱中，如前所述，其中氧浓度维持在10±1％，持续缺氧状态持续21天。从缺氧第一天开始，第2组和第4组分别腹膜内注射30mg \u002F kg丹参酮IIA磺酸盐;同时，第1组和第3组接受相同剂量的盐水。",{"key":225,"value":226},"参考文献","[1].\nXu QQ, et al. Sodium Tanshinone IIA Sulfonate Attenuates Scopolamine-Induced Cognitive Dysfunctions via Improving Cholinergic System. Biomed Res Int. 2016;2016:9852536.\n[2].\nJiang Q, et al. Sodium tanshinone IIA sulfonate inhibits hypoxia-induced enhancement of SOCE in pulmonary arterial smooth muscle cells via the PKG-PPAR-γ signaling axis. Am J Physiol Cell Physiol. 2016 Jul 1;311(1):C136-49.\n[3].\nOuyang DS, et al. Kinetics of cytochrome P450 enzymes for metabolism of sodium tanshinone IIA sulfonate in vitro. Chin Med. 2016 Mar 22;11:11.\n[4].\nChen D, et al. Sodium tanshinone IIA sulfonate and its interactions with human CYP450s. Xenobiotica. 2016 Dec;46(12):1085-1092. Epub 2016 Mar 2.\n[5].\nLin S, et al. [Sodium tanshinone IIA sulfonate prevents postoperative peritoneal adhesions in rats by enhancing the activity of the peritoneal fibrinolytic system]. 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