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d)抑制肾素和降低血压,而不影响缺钠绒猴的心率[3]。盐酸阿利基林(10 mg\u002Fkg；p.o.；单剂量)延迟恶病质的发展,减少肿瘤,延长小鼠存活时间。此外,还能提高全身力量、灵活性和协调性,增强运动活性,抑制肌肉消耗[4]。盐酸阿利基林(10 mg\u002Fkg；p.o.；单剂量；C26注射后20天)可减少与癌症恶病质相关的氧化应激[4]。动物模型：缺钠绒猴[3]剂量：3 mg\u002Fkg,10 mg\u002Fkg给药：口服灌胃；每天一次；12天结果：血浆免疫反应性肾素水平升高,血压降低,但不影响心率。两种剂量的阿利吉仑治疗结束后,血压均无反弹增加。抑制RAS并控制促炎细胞因子的上调。动物模型：注射C26小鼠结肠癌细胞的BALB\u002Fc小鼠癌症恶病质模型[4]剂量：10 mg\u002Fkg给药：口服灌胃；C26注射后第5天(作为预防策略,AP组)或第12天(作为治疗策略,AT组)；结果：增强了握力、协调性和运动能力。抑制血清Ang I和II水平以及血清和肌肉肿瘤坏死因子‑α(TNF‑α)和白细胞介素-6(IL‑6)水平。",{"key":212,"value":213},"参考文献","[1].\nYuji Nakamura, et al. Discovery of DS-8108b, a Novel Orally Bioavailable Renin Inhibitor. ACS Med. Chem. Lett., 2012, 3 (9), pp 754–758\n[2].\nFerri N, et al. Aliskiren inhibits prorenin-induced human aortic smooth muscle cell migration. J Renin Angiotensin Aldosterone Syst. 2015 Jun;16(2):284-91.\n[3].\nWood JM, et al. Structure-based design of aliskiren, a novel orally effective renin inhibitor. Biochem Biophys Res Commun. 2003 Sep 5;308(4):698-705.\n[4].\nWang C, et al. Aliskiren targets multiple systems to alleviate cancer cachexia. 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