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kg）。对照组和柚皮苷组腹膜内注射相同体积的0.1M柠檬酸盐缓冲液。注射STZ 3天和5天后，通过尾静脉穿刺血液采样测量血糖水平[1]。小鼠：将60只4周龄雄性小鼠随机分成4组，用对照饮食或高脂饮食饲料喂养20周。每天给小鼠服用100mg \u002F kg的柚皮苷。每周测量小鼠体重和食物摄入量。在行为评估之后，用异氟烷深度麻醉动物并在禁食至少5小时后通过断头处死。收集他们的血浆用于进一步分析[4]。",{"key":257,"value":258},"参考文献","[1].\nChen F, et al. Naringin Alleviates Diabetic Kidney Disease through Inhibiting Oxidative Stress and Inflammatory Reaction. PLoS One. 2015 Nov 30;10(11):e0143868.\n[2].\nRaha S, et al. Naringin induces autophagy-mediated growth inhibition by downregulating the PI3K\u002FAkt\u002FmTOR cascade via activation of MAPK pathways in AGS cancer cells. Int J Oncol. 2015 Sep;47(3):1061-9.\n[3].\nKulasekaran G, et al. Neuroprotective efficacy of naringin on 3-nitropropionic acid-induced mitochondrial dysfunction through the modulation of Nrf2 signaling pathway in PC12 cells. Mol Cell Biochem. 2015 Nov;409(1-2):199-211.\n[4].\nWang D, et al. Naringin Improves Neuronal Insulin Signaling, Brain Mitochondrial Function, and Cognitive Function in High-Fat Diet-Induced Obese Mice. 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