[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"currency-rates":3,"$fyk2oeqxpb7bd":8,"compound-J-1960020-5":169,"verified-suppliers-J-1960020-5":343},{"rates":4,"source":7},{"USD":5,"CNY":6},1,6.679814,"live",{"rows":9,"total":167,"current":5,"size":168},[10,33,45,60,73,84,96,111,121,133,145,156],{"slug":11,"cid":12,"imgSvg":13,"name":14,"nameZh":15,"cas":16,"formula":17,"iupac":14,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":22,"offersCount":24,"supplierCount":25,"bestOffer":26},"843627791009189888","J-1971488-6","\u002Fimages\u002Fchem_structures_svg\u002F399\u002F65845-61-6.svg","N-Methylcyclohexanamine hydrochloride","N-甲基环己胺盐酸盐","65845-61-6","C7H16ClN","acids","有机酸","Organic Acids","",[23],"In Stock",4,2,{"unitPrice":27,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},2.64,"500g","CNY","China","CN","in-stock",{"slug":34,"cid":35,"imgSvg":36,"name":37,"nameZh":38,"cas":39,"formula":40,"iupac":37,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":41,"offersCount":24,"supplierCount":5,"bestOffer":42},"785882541994283008","J-1323843-2","\u002Fimages\u002Fchem_structures_svg\u002F104\u002F67627-18-3.svg","Potassium indigotrisulfonate","靛蓝三磺酸钾","67627-18-3","C16H7K3N2O11S3",[23],{"unitPrice":43,"pack":44,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},180,"5g",{"slug":46,"cid":47,"imgSvg":48,"name":49,"nameZh":50,"cas":51,"formula":52,"iupac":49,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":56,"offersCount":57,"supplierCount":25,"bestOffer":58},"785889752443260928","J-28559-6","\u002Fimages\u002Fchem_structures_svg\u002F292\u002F15060-55-6.svg","Ammonium tetrathiomolybdate","四硫钼酸铵","15060-55-6","H8MoN2S4","inorganic","无机化合物","Inorganic Chemicals",[23],10,{"unitPrice":59,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},24,{"slug":61,"cid":62,"imgSvg":63,"name":64,"nameZh":65,"cas":66,"formula":67,"iupac":64,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":68,"offersCount":69,"supplierCount":25,"bestOffer":70},"855452191530422272","J-1994428-6","\u002Fimages\u002Fchem_structures_svg\u002F500\u002F16350-96-2.svg","N-benzylcyclohexanamine.hydrochloride","N-苄基环己胺盐酸盐","16350-96-2","C13H20ClN",[23],5,{"unitPrice":71,"pack":28,"currency":29,"origin":72,"originFlag":31,"moq":21,"stock":32},6,"中国",{"slug":74,"cid":75,"imgSvg":76,"name":77,"nameZh":78,"cas":79,"formula":80,"iupac":77,"category":18,"categoryName":19,"categoryEnName":20,"industry":21,"tags":81,"offersCount":25,"supplierCount":25,"bestOffer":82},"785871840001134592","J-982001-3","\u002Fimages\u002Fchem_structures_svg\u002F001\u002F10517-44-9.svg","1,3-Diaminopropane dihydrochloride","1,3-二氨基丙烷二盐酸盐","10517-44-9","C3H12Cl2N2",[23],{"unitPrice":83,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},3.78,{"slug":85,"cid":86,"imgSvg":87,"name":88,"nameZh":89,"cas":90,"formula":91,"iupac":88,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":92,"offersCount":93,"supplierCount":94,"bestOffer":95},"785880365658017792","J-14975-7","\u002Fimages\u002Fchem_structures_svg\u002F262\u002F12003-67-7.svg","Lithium aluminate","氧化铝锂","12003-67-7","AlLiO2",[23],7,3,{"unitPrice":94,"pack":28,"currency":29,"origin":72,"originFlag":31,"moq":21,"stock":32},{"slug":97,"cid":98,"imgSvg":99,"name":100,"nameZh":101,"cas":102,"formula":103,"iupac":100,"category":104,"categoryName":105,"categoryEnName":106,"industry":21,"tags":107,"offersCount":94,"supplierCount":5,"bestOffer":109},"785871830249377792","J-6931-8","\u002Fimages\u002Fchem_structures_svg\u002F456\u002F58068-80-7.svg","1-Octanoylbenzotriazole","N-辛酰苯并三唑","58068-80-7","C14H19N3O","aromatics","芳香烃","Aromatic Hydrocarbons",[108],"Made to Order",{"unitPrice":110,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},0.56,{"slug":112,"cid":113,"imgSvg":114,"name":115,"nameZh":116,"cas":117,"formula":118,"iupac":115,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":119,"offersCount":69,"supplierCount":25,"bestOffer":120},"785871842446413824","J-1960944-0","\u002Fimages\u002Fchem_structures_svg\u002F495\u002F10534-86-8.svg","Hexaamminecobalt(III) nitrate","六氨合钴(III)硝酸盐","10534-86-8","CoH18N9O9",[23],{"unitPrice":71,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},{"slug":122,"cid":123,"imgSvg":124,"name":125,"nameZh":126,"cas":127,"formula":128,"iupac":125,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":129,"offersCount":24,"supplierCount":25,"bestOffer":130},"785871842576437248","J-814544-6","\u002Fimages\u002Fchem_structures_svg\u002F221\u002F12037-42-2.svg","vanadium oxide","氧化钒","12037-42-2","O13V6",[23],{"unitPrice":131,"pack":132,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},112.8,"100g",{"slug":134,"cid":135,"imgSvg":136,"name":137,"nameZh":138,"cas":139,"formula":140,"iupac":137,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":141,"offersCount":142,"supplierCount":5,"bestOffer":143},"785871842647740416","J-1333345-4","\u002Fimages\u002Fchem_structures_svg\u002F479\u002F26490-63-1.svg","COBALT TETRAFLUOROBORATE HEXAHYDRATE","四氟化硼钴水合物","26490-63-1","B2CoF8H12O6",[23],8,{"unitPrice":144,"pack":132,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},11,{"slug":146,"cid":147,"imgSvg":148,"name":149,"nameZh":150,"cas":151,"formula":152,"iupac":149,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":153,"offersCount":57,"supplierCount":94,"bestOffer":154},"785871842698072064","J-814953-9","\u002Fimages\u002Fchem_structures_svg\u002F432\u002F72259-10-0.svg","Copper(II) tetrafluoroborate hexahydrate","六水合四氟硼酸铜(II)","72259-10-0","B2CuF8H12O6",[23],{"unitPrice":155,"pack":28,"currency":29,"origin":21,"originFlag":21,"moq":21,"stock":32},2.6,{"slug":157,"cid":158,"imgSvg":159,"name":160,"nameZh":161,"cas":162,"formula":163,"iupac":160,"category":53,"categoryName":54,"categoryEnName":55,"industry":21,"tags":164,"offersCount":94,"supplierCount":5,"bestOffer":165},"785871863254355968","J-1990080-2","\u002Fimages\u002Fchem_structures_svg\u002F149\u002F123333-60-8.svg","Cerium(IV) sulfate hydrate","铈(IV)硫酸盐水合物","123333-60-8","CeH2O9S2",[108],{"unitPrice":166,"pack":28,"currency":29,"origin":30,"originFlag":31,"moq":21,"stock":32},5.6,3204,12,{"slug":170,"cid":171,"imgSvg":172,"name":173,"nameZh":174,"cas":175,"formula":176,"iupac":173,"mdl":21,"mw":177,"category":178,"categoryName":179,"categoryEnName":180,"industry":21,"tags":181,"synonyms":182,"properties":185,"ghs":209,"offers":210,"activity":211,"upstream":239,"downstream":252,"customs":253,"safetyRows":266,"updatedAt":268,"isProhibited":269,"related":270,"__ts":341,"__lang":342,"__slug":171},"785891777566478336","J-1960020-5","\u002Fimages\u002Fchem_structures_svg\u002F244\u002F726169-73-9.svg","Mocetinostat","莫西司他","726169-73-9","C23H20N6O","396.444","organic","有机化合物","Organic Compounds",[],[183,184],"莫西诺司他","MGCD0103",[186,191,195,198,201,205],{"label":187,"labelZh":188,"value":189,"prop":190},"Density","密度","1.3±0.1 g\u002Fcm3","density",{"label":192,"labelZh":193,"value":194},"Exact Mass","精确质量","396.169861",{"label":196,"labelZh":196,"value":197},"PSA","105.82000",{"label":199,"labelZh":199,"value":200},"LogP","1.88",{"label":202,"labelZh":203,"value":204},"Refractive Index","折射率","1.730",{"label":206,"labelZh":207,"value":208},"Storage Conditions","储存条件","-20°C",null,[],[212,215,218,221,224,227,230,233,236],{"key":213,"value":214},"描述","Mocetinostat (MGCD0103)是一种有效,可口服和同种型选择性的 HDAC (Class I\u002FIV) 抑制剂,抑制HDAC1,HDAC2,HDAC3 和 HDAC11 的IC50分别为0.15,0.29,1.66 和 0.59 μM。 Mocetinostat对HDAC4,HDAC5,HDAC6,HDAC7或HDAC8没有抑制作用。",{"key":216,"value":217},"相关类别","信号通路\n>>\n自噬\n>>\n自噬\n信号通路\n>>\n细胞周期\u002FDNA损伤\n>>\nHDAC\n信号通路\n>>\n表观遗传学\n>>\nHDAC\n研究领域\n>>\n癌症",{"key":219,"value":220},"靶点","HDAC1:0.15 μM (IC50)\nHDAC2:0.29 μM (IC50)\nHDAC11:0.59 μM (IC50)\nHDAC3:1.66 μM (IC50)",{"key":222,"value":223},"体外研究","Mocetinostat是一种有效的口服活性和同种型选择性HDAC(I\u002FIV类)抑制剂,HDAC1,HDAC2,HDAC3和HDAC11的IC50分别为0.15,0.29,1.66和0.59μM。 Mocetinostat对HDAC4,HDAC5,HDAC6,HDAC7或HDAC8没有抑制作用。 Mocetinostat(MGCD0103)在体外对广谱的人癌细胞系表现出有效的和选择性的抗增殖活性,并且这些作用需要HDAC抑制活性。在所有测试的细胞系中,Mocetinostat(MGCD0103)部分抑制细胞HDAC酶活性,尽管活性的最大抑制在细胞系中从总活性的75％至85％变化。 Mocetinostat在完整癌细胞中的IC50与组织来源无关。在A549细胞中,MGCD0103显示全细胞中HDAC活性的剂量依赖性抑制。在A549细胞中的高浓度下,Mocetinostat抑制最多80％的总活性。在HCT116细胞中,Mocetinostat诱导显着的S期耗竭以及G1和G2-M积累[1]。",{"key":225,"value":226},"体内研究","Mocetinostat(MGCD0103)以剂量依赖性方式显着抑制裸鼠中人肿瘤异种移植物的生长,并且抗肿瘤活性与肿瘤中组蛋白乙酰化的诱导相关。在每日施用13天后,Mocetinostat(MGCD0103)(2HBr盐)的po施用以剂量依赖性方式显着降低裸鼠中植入的晚期A549肿瘤的生长。 Mocetinostat(对于2HBr盐为170 mg\u002Fkg,相当于120 mg\u002Fkg游离碱)与单独载体治疗相比显着阻断了肿瘤的生长(在ANOVA Dunnett试验后P \u003C0.05),体重没有变化[1] 。",{"key":228,"value":229},"激酶实验","脱乙酰酶测定基于均相荧光释放测定。在室温下，将纯化的重组HDAC酶与在各种浓度下稀释的Mocetinostat（MGCD0103）在测定缓冲液[25mM HEPES（pH 8.0），137mM NaCl，1mM MgCl 2,2.7mM KCl]中孵育10分钟。将底物Boc-Lys（ε-Ac）-AMC（Bachem）加入到反应中，在37℃下进一步温育。对于HDAC酶的不同同种型，底物的浓度和孵育时间是不同的。在室温下孵育20分钟的胰蛋白酶允许从脱乙酰化的底物释放荧光团。通过荧光计在360nm的激发，470nm的发射和435nm的截止下检测荧光信号。通过分析剂量 - 反应抑制曲线[1]确定化合物的IC 50值。",{"key":231,"value":232},"细胞实验","将96孔板中的细胞与Mocetinostat以各种浓度在37℃，5％CO 2中孵育72小时。加入终浓度为0.5mg \u002F mL的MTT，并与细胞一起温育4小时，然后加入等体积的增溶缓冲液[50％N，N-二甲基甲酰胺，20％SDS（pH4.7）]。孵育过夜后，通过使用630nm处的参照在570nm处读数来定量溶解的染料。根据相关细胞系的标准生长曲线将吸光度值转换为细胞数。相对于DMSO处理的细胞，将细胞数减少至50％的浓度被确定为MTT IC50 [1]。",{"key":234,"value":235},"动物实验","小鼠[1]使用8至10周龄的雌性CD-1裸鼠。在全身麻醉下，通过小鼠侧腹上的小手术切口皮下植入已经在体内连续传代三次的肿瘤碎片（30mg）。将Mocetinostat溶于载体（用0.1N HCl或PEG400 \u002F 0.2N HCl盐水，40：60酸化的PBS）中，并每天以溶液形式给药。每周三次监测肿瘤体积和体重至少2周。每个实验组包含六至八只动物。对于药代动力学研究，在不同时间点从动物收集血液，并使用配有MDS Sciex API2000三重四极杆质谱仪的Agilent 1100 HPLC系统分析血浆样品。大鼠[2]将40只大鼠（220±20g）随机分成4个不同剂量的Mocetinostat组（低组，中组，高组和对照组，每组10只大鼠）。将莫西诺司他以三种不同浓度（20,40和80mg \u002F mL）的悬浮液溶解在玉米油中。三个不同的Mocetinostat组（低组，中组和高组）分别在每天早晨通过胃内给药给予Mocetinostat 20,40和80mg \u002F kg，持续7天。对照组采用相同的给药方法给予生理盐水。早上8天，六种探针药物，安非他酮，非那西丁，甲苯磺丁脲，美托洛尔，睾酮和奥美拉唑在玉米油中混合，给予三个莫西诺司他组和对照组大鼠，通过胃内给药，单次剂量为10毫克\u002F安非他酮，非那西丁，美托洛尔，睾酮和奥美拉唑的剂量为kg，托普他汀为1 mg \u002F kg。",{"key":237,"value":238},"参考文献","[1].\nFournel M, et al. MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo. Mol Cancer Ther. 2008 Apr;7(4):759-68.\n[2].\nCai J, et al. The Effect of MGCD0103 on CYP450 Isoforms Activity of Rats by Cocktail Method. Biomed Res Int. 2015;2015:517295.",[240,246],{"slug":241,"cid":242,"name":243,"nameZh":243,"cas":244,"imgSvg":245},"785894565868474400","J-38037-0","邻苯二胺(OPD)","95-54-5","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F056\u002F95-54-5.svg",{"slug":247,"cid":248,"name":249,"nameZh":249,"cas":250,"imgSvg":251},"785897955499446300","J-869696-6","1-(3-吡啶基)-3-(二甲...","55314-16-4","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F271\u002F55314-16-4.svg",[],[254,257,260,263],{"key":255,"value":256},"海关编码","2933990090",{"key":258,"value":259},"中文概述","2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%",{"key":261,"value":262},"申报要素","品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期",{"key":264,"value":265},"Summary","2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%",[267],{"key":255,"value":256},"2026-08-21T07:51:12.859463Z",false,[271,276,282,288,294,300,306,311,317,323,329,335],{"slug":272,"cid":273,"name":274,"nameZh":274,"cas":275},"785911446427930624","J-69315-2","9-Bromo-10-(naphthalen-1-yl-d7)anthracene-1,2,3,4,5,6,7,8-d8","2330770-73-3",{"slug":277,"cid":278,"name":279,"nameZh":280,"cas":281},"785882572553981952","J-1110759-8","Methyl Violet 2B","甲基紫2B","8004-87-3",{"slug":283,"cid":284,"name":285,"nameZh":286,"cas":287},"785893849972084736","J-1499066-0","Ferrocholinate","铁胆盐","1336-80-7",{"slug":289,"cid":290,"name":291,"nameZh":292,"cas":293},"785872510607429632","J-1334045-9","calcium saccharin","糖精钙","6485-34-3",{"slug":295,"cid":296,"name":297,"nameZh":298,"cas":299},"785898743068102656","J-1365189-3","Esomeprazole calcium","埃索美拉唑钙","161796-85-6",{"slug":301,"cid":302,"name":303,"nameZh":304,"cas":305},"785884051318771712","J-1114131-4","Alizarin Complexone","茜素络合指示剂","3952-78-1",{"slug":307,"cid":308,"name":309,"nameZh":309,"cas":310},"785914490636996608","J-1241469-6","2-Chloro-4-(1-dibenzofuranyl)-6-(1-naphthalenyl)-1,3,5-triazine","2417986-80-0",{"slug":312,"cid":313,"name":314,"nameZh":315,"cas":316},"785871874079854592","J-1110697-1","Crystal Violet","结晶紫","548-62-9",{"slug":318,"cid":319,"name":320,"nameZh":321,"cas":322},"785896769497075712","J-45303-2","Cholecalciferol","维生素D3","67-97-0",{"slug":324,"cid":325,"name":326,"nameZh":327,"cas":328},"785895040399446016","J-1110640-4","Solvent Red 27","溶剂红27","1320-06-5",{"slug":330,"cid":331,"name":332,"nameZh":333,"cas":334},"785888480654790656","J-1958131-8","Rabeprazole sodium","雷贝拉唑钠","117976-90-6",{"slug":336,"cid":337,"name":338,"nameZh":339,"cas":340},"785897800498941952","J-47960-7","Solvent Red 24","苏丹Ⅳ","85-83-6",1794253139068,"zh-CN",[]]