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mg\u002Fkg；皮下注射；感染后1、5、24和48小时注射4次)在感染耐阿莫西林肺炎链球菌的小鼠中显示出抗感染活性[3]。动物模型：30g成年雌性瑞士小鼠(由青霉素敏感菌株(AR33118)诱导的脓毒症)[3]剂量：25、50、100、200mg\u002Fkg给药：皮下注射。；在感染后1、5、24和48小时给予结果：在感染耐阿莫西林肺炎链球菌的小鼠中显示抗感染活性。",{"key":254,"value":255},"参考文献","[1].\nMarcu MG, et al. The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone. J Biol Chem. 2000 Nov 24;275(47):37181-6.\n[2].\nAli-Osman F, et al. Topoisomerase II inhibition and altered kinetics of formation and repair of nitrosourea and cisplatin-induced DNA interstrand cross-links and cytotoxicity in human glioblastoma cells. Cancer Res. 1993 Dec 1;53(23):5663-8.\n[3].\nRodríguez-Cerrato V, et al. Comparative efficacy of novobiocin and amoxicillin in experimental sepsis caused by beta-lactam-susceptible and highly resistant pneumococci. Int J Antimicrob Agents. 2010 Jun;35(6):544-9.\n[4].\nEder JP, et al. A phase I clinical trial of novobiocin, a modulator of alkylating agent cytotoxicity. Cancer Res. 1991 Jan 15;51(2):510-3.\n[5].\nBhatia S, et al. Targeting HSP90 dimerization via the C terminus is effective in imatinib-resistant CML and lacks the heat shock response.Blood. 2018 Jul 19;132(3):307-320.\n[6].\nSmee DF. Progress in the discovery of compounds inhibiting orthopoxviruses in animal models. Antivir Chem Chemother. 2008;19(3):115-24.\n[7].\nSmee DF. Progress in the discovery of compounds inhibiting orthopoxviruses in animal models. 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