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202190)",[191,195,199,203,207,211,214,217,220,224,228],{"label":192,"labelZh":192,"value":193,"prop":194},"Melting Point","240-243℃","meltingPoint",{"label":196,"labelZh":196,"value":197,"prop":198},"Boiling Point","565.7±50.0 °C at 760 mmHg","boilingPoint",{"label":200,"labelZh":200,"value":201,"prop":202},"Density","1.3±0.1 g\u002Fcm3","density",{"label":204,"labelZh":204,"value":205,"prop":206},"Flash Point","295.9±30.1 °C","flashPoint",{"label":208,"labelZh":209,"value":210},"Exact Mass","精确质量","331.112091",{"label":212,"labelZh":212,"value":213},"PSA","61.80000",{"label":215,"labelZh":215,"value":216},"LogP","5.00",{"label":218,"labelZh":218,"value":219},"外观性状","淡黄色",{"label":221,"labelZh":222,"value":223},"Vapor Pressure","蒸汽压","0.0±1.6 mmHg at 25°C",{"label":225,"labelZh":226,"value":227},"Refractive Index","折射率","1.653",{"label":229,"labelZh":230,"value":231},"Storage Conditions","储存条件","2-8°C",null,[],[235,238,241,244,247,250,253,256,259],{"key":236,"value":237},"描述","SB 202190 是可渗透细胞的 p38 MAPK 抑制剂,抑制p38 和 p38β2的 IC50 分别为50 nM 和 100 nM。",{"key":239,"value":240},"相关类别","信号通路\n>>\n自噬\n>>\n自噬\n信号通路\n>>\nMAPK\u002FERK信号通路\n>>\np38 MAPK\n研究领域\n>>\n癌症",{"key":242,"value":243},"靶点","IC50: 50 nM (p38), 100 nM (p38β2)[1]",{"key":245,"value":246},"体外研究","如在用GST-hsp27作为底物的免疫复合物激酶测定中所测量的,用SB 202190(SB202190)处理细胞以剂量依赖性方式显着抑制基础和抗Fas抗体诱导的MAPKAPK 2活性。 Jurkat细胞用SB202190处理或不处理。 24小时后,收获细胞,通过裂解荧光肽DEVD-AMC测量细胞提取物中CPP32样半胱天冬酶的活性,所述荧光肽DEVD-AMC是CPP32样半胱天冬酶的特异性底物。在用SB202190处理的细胞中DEVD-AMC的切割显着增加,但在对照中没有[2]。",{"key":248,"value":249},"体内研究","在源自HCT-116的结肠直肠肿瘤中,施用SB 202190(SB202190),索拉非尼或两者的组合在外部肿瘤大小的测量方面给出类似的结果(与对照肿瘤相比,生长减少约58％)。 SB202190诱导肿瘤生长减少28％,而索拉非尼促进减少31％,而两种药物联合使肿瘤生长减少55％[3]。与模型组相比,SB202190组在Morris水迷宫隐藏平台试验中显示出明显更短的逃逸潜伏期(P \u003C0.01),并且在探针试验期间在原始平台象限中显示更长的时间(P \u003C0.01)。与VaD模型大鼠相比,SB202190组还显示海马神经细胞凋亡显着减少(P \u003C0.01)以及更高(抗凋亡)Bcl-2表达和更低(促凋亡)caspase-3表达(两者均P \u003C0.01)。总之,SB202190在永久性2-OV后阻断p38 MAPK信号通路减少了海马神经元的凋亡并挽救了空间学习和记忆缺陷[4]。",{"key":251,"value":252},"激酶实验","进行MAPKAPK 2测定。简言之，将Jurkat细胞血清饥饿24小时，然后与或不用特异性p38抑制剂SB 202190孵育30分钟，然后用抗Fas mAb（100 ng \u002F mL）处理2小时或单独留下，如图传说。在裂解缓冲液中收获细胞并通过离心澄清。用抗MAPKAPK 2多克隆抗体在4℃下免疫沉淀内源性MAPKAPK 2 3小时。在存在1μMATP\u002F10μCi[γ-32P] ATP（10 Ci \u002F mmol）和GST-hsp27作为底物的情况下，在30μL激酶缓冲液中在30℃下测定免疫复合物的活性30分钟。 。用Laemmli样品缓冲液终止反应。通过13％SDS-聚丙烯酰胺凝胶电泳然后进行放射自显影来分辨蛋白质。磷酸化蛋白质由PhosphorImager定量[2]。",{"key":254,"value":255},"细胞实验","在存在或不存在半胱天冬酶抑制剂苄氧基羰基-Val-Ala-Asp（zVAD） - 氟甲基酮的情况下，使用或不使用SB202190（50μM），PD098059（50μM）处理Jurkat \u002F neo或Jurkat \u002F bcl-2细胞（106个细胞）持续24小时。然后在裂解缓冲液（25mM Hepes，pH 7.4,0.25％Nonidet P-40,10μg\u002F mL亮肽素，10μg\u002F mL抑肽酶，5mM EDTA，2mM二硫苏糖醇和10mM洋地黄皂苷）中收获细胞。通过离心澄清裂解物，并将上清液用于半胱天冬酶测定。在含有20μg细胞提取物，20μM荧光素肽乙酰基-Asp-Glu-Val-Asp-氨基甲基香豆素（DEVD-AMC）的反应混合物中测量半胱天冬酶活性。使用Cytofluor II荧光板读数器在激发360nm，发射460nm下测量荧光AMC产物形成[2]。",{"key":257,"value":258},"动物实验","小鼠[3]使用雌性CD-1无胸腺裸鼠（6-8周龄）。将10×106个HT-29或10×106个HCT-116细胞皮下注射到雌性无胸腺裸CD-1小鼠的侧腹（每侧0.2mL）中。每2-3天测量肿瘤的体积。使用以下公式计算肿瘤体积：体积（mm 3）=（宽度）2×长度×0.5。当肿瘤体积达到60 mm3时，将小鼠随机分为4个治疗组（每组n≥6）：载体（对照），索拉非尼30 mg \u002F kg \u002F d，SB20219025μg\u002F kg \u002F d，索拉非尼30 mg \u002F kg \u002F d加SB20219025μg\u002F kg \u002F d。每天通过管饲给予索拉非尼药物治疗，腹膜内给予SB202190。处理小鼠12天，每2-3天记录肿瘤体积和体重。在治疗结束时，处死小鼠并移出肿瘤用于组织学和免疫组织化学分析。大鼠[4]使用无特定病原体（SPF）的雄性Wistar大鼠（3个月大，250±10g）。使用随机数表将60只Wistar大鼠随机分配到假手术组，VaD模型组和SB 202190组（每只20只动物）。通过双血管闭塞（2-VO）分离和结扎双侧颈动脉建立VaD大鼠模型（n = 40）。对于假手术组（n = 20）的动物，使用相同的方法分离双侧颈动脉但不结扎。恢复后，SB 202190组的动物接受脑室内（ICV）注射SB 202190，并且VaD模型和假手术组均接受ICV注射等体积0.1％DMSO。在每组中，在Morris水迷宫中检查8只大鼠以评估空间学习和记忆，处死6只大鼠并制备脑切片用于TUNEL染色和Bcl-2 \u002F caspase-3免疫组织化学，并且处死6只大鼠并且组织匀浆。准备用于磷酸化-p38MAPK表达的Western印迹分析。",{"key":260,"value":261},"参考文献","[1].\nDavies SP, et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105.\n[2].\nNemoto S, et al. Induction of apoptosis by SB202190 through inhibition of p38beta mitogen-activated protein kinase. J Biol Chem. 1998 Jun 26;273(26):16415-20.\n[3].\nGrossi V, et al. Sorafenib inhibits p38α activity in colorectal cancer cells and synergizes with the DFG-in inhibitor SB202190 to increase apoptotic response. Cancer Biol Ther. 2012 Dec;13(14):1471-81.\n[4].\nYang S, et al. Protective effects of p38 MAPK inhibitor SB202190 against hippocampal apoptosis and spatial learning and memory deficits in a rat model of vascular dementia. Biomed Res Int. 2013;2013:215798.\n[5].\nZhang Y, et al. PP2AC Level Determines Differential Programming of p38-TSC-mTOR Signaling and Therapeutic Response to p38-Targeted Therapy in Colorectal Cancer. EBioMedicine. 2015 Nov 19;2(12):1944-56.",[263,269,275,281,287,293],{"slug":264,"cid":265,"name":266,"nameZh":266,"cas":267,"imgSvg":268},"785884173477875700","J-1183388-2","N-甲基-N-甲氧基-4-氟苯甲酰胺","116332-54-8","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F463\u002F116332-54-8.svg",{"slug":270,"cid":271,"name":272,"nameZh":272,"cas":273,"imgSvg":274},"785883833907023900","J-1067767-4","4-(叔丁基二甲基甲硅烷基氧基甲基)吡啶","117423-41-3","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F126\u002F117423-41-3.svg",{"slug":276,"cid":277,"name":278,"nameZh":278,"cas":279,"imgSvg":280},"785882348351656000","J-1365916-1","4-甲基吡啶","108-89-4","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F144\u002F108-89-4.svg",{"slug":282,"cid":283,"name":284,"nameZh":284,"cas":285,"imgSvg":286},"785876553056653300","J-1051785-7","1-(4-氟苯基)-2-(4-...","6576-05-2","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F397\u002F6576-05-2.svg",{"slug":288,"cid":289,"name":290,"nameZh":290,"cas":291,"imgSvg":292},"785876825363451900","J-14789-9","对氟苯甲酰氯","403-43-0","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F164\u002F403-43-0.svg",{"slug":294,"cid":295,"name":296,"nameZh":296,"cas":297,"imgSvg":298},"785882348091609100","J-3224-1","4-羟基苯甲醛; 对羟基苯甲醛","123-08-0","https:\u002F\u002Fapi.chemical.xiaokangmed.com\u002Fimages\u002Fchem_structures_svg\u002F162\u002F123-08-0.svg",[],[],[302,305,308,311,314,317,320],{"key":303,"value":304},"个人防护装备","dust mask type N95 (US);Eyeshields;Gloves",{"key":306,"value":307},"危害码 (欧洲)","Xi: Irritant;",{"key":309,"value":310},"风险声明 (欧洲)","R36\u002F37\u002F38",{"key":312,"value":313},"安全声明 (欧洲)","S26-S36\u002F37",{"key":315,"value":316},"危险品运输编码","NONH for all modes of transport",{"key":318,"value":319},"WGK德国","3",{"key":321,"value":322},"海关编码","29333990","\u003Ctd>\n\n\u003Cb>1.1 产品标识符\u003C\u002Fb>\n\u003Cbr \u002F> : SB 202190\n\u003Cbr \u002F> 产品名称\n\u003Cbr \u002F>\n\u003Cb>1.2 鉴别的其他方法\u003C\u002Fb>\n\u003Cbr \u002F> 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole\n\u003Cbr \u002F>\n\u003Cb>1.3 有关的确定了的物质或混合物的用途和建议不适合的用途\u003C\u002Fb>\n\u003Cbr \u002F> 仅供科研用途，不作为药物、家庭备用药或其它用途。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块2. 危险性概述\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>2.1 GHS分类\u003C\u002Fb>\n\u003Cbr \u002F> 皮肤刺激 (类别2)\n\u003Cbr \u002F> 眼刺激 (类别2A)\n\u003Cbr \u002F> 特异性靶器官系统毒性（一次接触） (类别3)\n\u003Cbr \u002F>\n\u003Cb>2.2 GHS 标记要素，包括预防性的陈述\u003C\u002Fb>\n\u003Cbr \u002F> 象形图\n\u003Cbr \u002F> 警示词警告\n\u003Cbr \u002F> 危险申明\n\u003Cbr \u002F> H315造成皮肤刺激。\n\u003Cbr \u002F> H319造成严重眼刺激。\n\u003Cbr \u002F> H335可能引起呼吸道刺激。\n\u003Cbr \u002F> 警告申明\n\u003Cbr \u002F> 预防\n\u003Cbr \u002F> P261避免吸入粉尘\u002F烟\u002F气体\u002F烟雾\u002F蒸气\u002F喷雾.\n\u003Cbr \u002F> P264操作后彻底清洁皮肤。\n\u003Cbr \u002F> P271只能在室外或通风良好之处使用。\n\u003Cbr \u002F> P280穿戴防护手套\u002F 眼保护罩\u002F 面部保护罩。\n\u003Cbr \u002F> 措施\n\u003Cbr \u002F> P302 + P352如与皮肤接触，用大量肥皂和水冲洗受感染部位.\n\u003Cbr \u002F> P304 + P340如吸入，将患者移至新鲜空气处并保持呼吸顺畅的姿势休息.\n\u003Cbr \u002F> P305 + P351 + P338如与眼睛接触，用水缓慢温和地冲洗几分钟。如戴隐形眼镜并可方便地取\n\u003Cbr \u002F> 出，取出隐形眼镜，然后继续冲洗.\n\u003Cbr \u002F> P312如感觉不适，呼救中毒控制中心或医生.\n\u003Cbr \u002F> P321具体治疗(见本标签上提供的急救指导)。\n\u003Cbr \u002F> P332 + P313如发生皮肤刺激：求医\u002F 就诊。\n\u003Cbr \u002F> P337 + P313如仍觉眼睛刺激：求医\u002F就诊。 如仍觉眼睛刺激：求医\u002F就诊.\n\u003Cbr \u002F> P362脱掉沾染的衣服，清洗后方可重新使用。\n\u003Cbr \u002F> 储存\n\u003Cbr \u002F> P403 + P233存放于通风良的地方。 保持容器密闭。\n\u003Cbr \u002F> P405存放处须加锁。\n\u003Cbr \u002F> 处理\n\u003Cbr \u002F> P501将内容物\u002F 容器处理到得到批准的废物处理厂。\n\u003Cbr \u002F>\n\u003Cb>2.3 其它危害物 - 无\u003C\u002Fb>\n\u003Cbr \u002F>\n\n\u003Cstrong>模块3. 成分\u002F组成信息\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>3.1 物 质\u003C\u002Fb>\n\u003Cbr \u002F> : 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole\n\u003Cbr \u002F> 别名\n\u003Cbr \u002F> : C20H14FN3O\n\u003Cbr \u002F> 分子式\n\u003Cbr \u002F> : 331.34 g\u002Fmol\n\u003Cbr \u002F> 分子量\n\u003Cbr \u002F> 组分浓度或浓度范围\n\u003Cbr \u002F> SB 202190\n\u003Cbr \u002F> -\n\u003Cbr \u002F> CAS 号152121-30-7\n\u003Cbr \u002F>\n\n\u003Cstrong>模块4. 急救措施\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>4.1 必要的急救措施描述\u003C\u002Fb>\n\u003Cbr \u002F> 一般的建议\n\u003Cbr \u002F> 请教医生。 出示此安全技术说明书给到现场的医生看。\n\u003Cbr \u002F> 吸入\n\u003Cbr \u002F> 如果吸入,请将患者移到新鲜空气处。 如果停止了呼吸,给于人工呼吸。 请教医生。\n\u003Cbr \u002F> 皮肤接触\n\u003Cbr \u002F> 用肥皂和大量的水冲洗。 请教医生。\n\u003Cbr \u002F> 眼睛接触\n\u003Cbr \u002F> 用大量水彻底冲洗至少15分钟并请教医生。\n\u003Cbr \u002F> 食入\n\u003Cbr \u002F> 切勿给失去知觉者从嘴里喂食任何东西。 用水漱口。 请教医生。\n\u003Cbr \u002F>\n\u003Cb>4.2 主要症状和影响，急性和迟发效应\u003C\u002Fb>\n\u003Cbr \u002F> 据我们所知，此化学，物理和毒性性质尚未经完整的研究。\n\u003Cbr \u002F>\n\u003Cb>4.3 及时的医疗处理和所需的特殊处理的说明和指示\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\n\u003Cstrong>模块5. 消防措施\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>5.1 灭火介质\u003C\u002Fb>\n\u003Cbr \u002F> 灭火方法及灭火剂\n\u003Cbr \u002F> 用水雾,耐醇泡沫,干粉或二氧化碳灭火。\n\u003Cbr \u002F>\n\u003Cb>5.2 源于此物质或混合物的特别的危害\u003C\u002Fb>\n\u003Cbr \u002F> 碳氧化物, 氮氧化物, 氟化氢\n\u003Cbr \u002F>\n\u003Cb>5.3 给消防员的建议\u003C\u002Fb>\n\u003Cbr \u002F> 如必要的话,戴自给式呼吸器去救火。\n\u003Cbr \u002F>\n\u003Cb>5.4 进一步信息\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\n\u003Cstrong>模块6. 泄露应急处理\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>6.1 人员的预防,防护设备和紧急处理程序\u003C\u002Fb>\n\u003Cbr \u002F> 使用个人防护设备。 防止粉尘的生成。 防止吸入蒸汽、气雾或气体。 保证充分的通风。\n\u003Cbr \u002F> 将人员撤离到安全区域。 避免吸入粉尘。\n\u003Cbr \u002F>\n\u003Cb>6.2 环境保护措施\u003C\u002Fb>\n\u003Cbr \u002F> 不要让产物进入下水道。\n\u003Cbr \u002F>\n\u003Cb>6.3 抑制和清除溢出物的方法和材料\u003C\u002Fb>\n\u003Cbr \u002F> 收集、处理泄漏物，不要产生灰尘。 扫掉和铲掉。 存放进适当的闭口容器中待处理。\n\u003Cbr \u002F>\n\u003Cb>6.4 参考其他部分\u003C\u002Fb>\n\u003Cbr \u002F> 丢弃处理请参阅第13节。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块7. 操作处置与储存\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>7.1 安全操作的注意事项\u003C\u002Fb>\n\u003Cbr \u002F> 避免接触皮肤和眼睛。 防止粉尘和气溶胶生成。\n\u003Cbr \u002F> 在有粉尘生成的地方,提供合适的排风设备。一般性的防火保护措施。\n\u003Cbr \u002F>\n\u003Cb>7.2 安全储存的条件,包括任何不兼容性\u003C\u002Fb>\n\u003Cbr \u002F> 贮存在阴凉处。 容器保持紧闭，储存在干燥通风处。\n\u003Cbr \u002F> 建议的贮存温度： 2 - 8 °C\n\u003Cbr \u002F>\n\u003Cb>7.3 特定用途\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\n\u003Cstrong>模块8. 接触控制和个体防护\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>8.1 容许浓度\u003C\u002Fb>\n\u003Cbr \u002F> 最高容许浓度\n\u003Cbr \u002F> 没有已知的国家规定的暴露极限。\n\u003Cbr \u002F>\n\u003Cb>8.2 暴露控制\u003C\u002Fb>\n\u003Cbr \u002F> 适当的技术控制\n\u003Cbr \u002F> 按照良好工业和安全规范操作。 休息前和工作结束时洗手。\n\u003Cbr \u002F> 个体防护设备\n\u003Cbr \u002F> 眼\u002F面保护\n\u003Cbr \u002F> 带有防护边罩的安全眼镜符合 EN166要求请使用经官方标准如NIOSH (美国) 或 EN 166(欧盟)\n\u003Cbr \u002F> 检测与批准的设备防护眼部。\n\u003Cbr \u002F> 皮肤保护\n\u003Cbr \u002F> 戴手套取 手套在使用前必须受检查。\n\u003Cbr \u002F> 请使用合适的方法脱除手套(不要接触手套外部表面),避免任何皮肤部位接触此产品.\n\u003Cbr \u002F> 使用后请将被污染过的手套根据相关法律法规和有效的实验室规章程序谨慎处理. 请清洗并吹干双手\n\u003Cbr \u002F> 所选择的保护手套必须符合EU的89\u002F686\u002FEEC规定和从它衍生出来的EN 376标准。\n\u003Cbr \u002F> 身体保护\n\u003Cbr \u002F> 防渗透的衣服, 防护设备的类型必须根据特定工作场所中的危险物的浓度和含量来选择。\n\u003Cbr \u002F> 呼吸系统防护\n\u003Cbr \u002F> 如须暴露于有害环境中,请使用P95型(美国)或P1型(欧盟 英国\n\u003Cbr \u002F> 143)防微粒呼吸器。如需更高级别防护,请使用OV\u002FAG\u002FP99型(美国)或ABEK-P2型 (欧盟 英国 143)\n\u003Cbr \u002F> 防毒罐。\n\u003Cbr \u002F> 呼吸器使用经过测试并通过政府标准如NIOSH（US）或CEN（EU）的呼吸器和零件。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块9. 理化特性\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>9.1 基本的理化特性的信息\u003C\u002Fb>\n\u003Cbr \u002F> a) 外观与性状\n\u003Cbr \u002F> 形状: 固体\n\u003Cbr \u002F> b) 气味\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> c) 气味阈值\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> d) pH值\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> e) 熔点\u002F凝固点\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> f) 起始沸点和沸程\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> g) 闪点\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> h) 蒸发速率\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> i) 易燃性(固体,气体)\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> j) 高的\u002F低的燃烧性或爆炸性限度 无数据资料\n\u003Cbr \u002F> k) 蒸汽压\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> l) 蒸汽密度\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> m) 相对密度\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> n) 水溶性\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> o) n-辛醇\u002F水分配系数\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> p) 自燃温度\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> q) 分解温度\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> r) 粘度\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\n\u003Cstrong>模块10. 稳定性和反应活性\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>10.1 反应性\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>10.2 稳定性\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>10.3 危险反应的可能性\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>10.4 应避免的条件\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>10.5 不兼容的材料\u003C\u002Fb>\n\u003Cbr \u002F> 强氧化剂\n\u003Cbr \u002F>\n\u003Cb>10.6 危险的分解产物\u003C\u002Fb>\n\u003Cbr \u002F> 其它分解产物 - 无数据资料\n\u003Cbr \u002F>\n\n\u003Cstrong>模块11. 毒理学资料\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>11.1 毒理学影响的信息\u003C\u002Fb>\n\u003Cbr \u002F> 急性毒性\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> 皮肤刺激或腐蚀\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> 眼睛刺激或腐蚀\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> 呼吸道或皮肤过敏\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> 生殖细胞突变性\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> 致癌性\n\u003Cbr \u002F> IARC:\n\u003Cbr \u002F> 此产品中没有大于或等于 0。1%含量的组分被 IARC鉴别为可能的或肯定的人类致癌物。\n\u003Cbr \u002F> 生殖毒性\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> 特异性靶器官系统毒性（一次接触）\n\u003Cbr \u002F> 吸入 - 可能引起呼吸道刺激。\n\u003Cbr \u002F> 特异性靶器官系统毒性（反复接触）\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> 吸入危险\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F> 潜在的健康影响\n\u003Cbr \u002F> 吸入吸入可能有害。 引起呼吸道刺激。\n\u003Cbr \u002F> 摄入如服入是有害的。\n\u003Cbr \u002F> 皮肤如果通过皮肤吸收可能是有害的。 造成皮肤刺激。\n\u003Cbr \u002F> 眼睛造成严重眼刺激。\n\u003Cbr \u002F> 接触后的征兆和症状\n\u003Cbr \u002F> 据我们所知，此化学，物理和毒性性质尚未经完整的研究。\n\u003Cbr \u002F> 附加说明\n\u003Cbr \u002F> 化学物质毒性作用登记: 无数据资料\n\u003Cbr \u002F>\n\n\u003Cstrong>模块12. 生态学资料\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>12.1 生态毒性\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>12.2 持久存留性和降解性\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>12.3 潜在的生物蓄积性\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>12.4 土壤中的迁移性\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>12.5 PBT 和 vPvB的结果评价\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cb>12.6 其它不利的影响\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\n\u003Cstrong>模块13. 废弃处置\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>13.1 废物处理方法\u003C\u002Fb>\n\u003Cbr \u002F> 产品\n\u003Cbr \u002F> 将剩余的和未回收的溶液交给处理公司。 联系专业的拥有废弃物处理执照的机构来处理此物质。\n\u003Cbr \u002F> 与易燃溶剂相溶或者相混合，在备有燃烧后处理和洗刷作用的化学焚化炉中燃烧\n\u003Cbr \u002F> 受污染的容器和包装\n\u003Cbr \u002F> 作为未用过的产品弃置。\n\u003Cbr \u002F>\n\n\u003Cstrong>模块14. 运输信息\u003C\u002Fstrong>\n\u003Cbr \u002F>\n\u003Cb>14.1 联合国危险货物编号\u003C\u002Fb>\n\u003Cbr \u002F> 欧洲陆运危规: -国际海运危规: -国际空运危规: -\n\u003Cbr \u002F>\n\u003Cb>14.2 联合国（UN）规定的名称\u003C\u002Fb>\n\u003Cbr \u002F> 欧洲陆运危规: 非危险货物\n\u003Cbr \u002F> 国际海运危规: 非危险货物\n\u003Cbr \u002F> 国际空运危规: 非危险货物\n\u003Cbr \u002F>\n\u003Cb>14.3 运输危险类别\u003C\u002Fb>\n\u003Cbr \u002F> 欧洲陆运危规: -国际海运危规: -国际空运危规: -\n\u003Cbr \u002F>\n\u003Cb>14.4 包裹组\u003C\u002Fb>\n\u003Cbr \u002F> 欧洲陆运危规: -国际海运危规: -国际空运危规: -\n\u003Cbr \u002F>\n\u003Cb>14.5 环境危险\u003C\u002Fb>\n\u003Cbr \u002F> 欧洲陆运危规: 否国际海运危规 海运污染物: 否国际空运危规: 否\n\u003Cbr \u002F>\n\u003Cb>14.6 对使用者的特别提醒\u003C\u002Fb>\n\u003Cbr \u002F> 无数据资料\n\u003Cbr \u002F>\n\u003Cbr \u002F>\n\n\u003Cstrong> 模块 15 - 法规信息 \u003C\u002Fstrong>\n\u003Cbr \u002F>N\u002FA\n\u003Cbr \u002F>\n\u003Cbr \u002F>\n\n\u003Cstrong> 模块16 - 其他信息 \u003C\u002Fstrong>\n\u003Cbr \u002F>N\u002FA\n\u003Cbr \u002F>\u003Cbr \u002F>\u003Cbr \u002F>\n\u003Cbr \u002F>\u003Cbr \u002F>\n\u003C\u002Ftd>","2026-08-21T07:51:12.859463Z",false,[327,333,339,345,351,357],{"slug":328,"cid":329,"name":330,"nameZh":331,"cas":332},"785896711993167872","J-45096-4","Sulfadimethoxine sodium","磺胺间二甲氧嘧啶钠","1037-50-9",{"slug":334,"cid":335,"name":336,"nameZh":337,"cas":338},"785881303210790912","J-18675-7","2,2'-Dithiobis(benzothiazole)","二硫化二苯并噻唑","120-78-5",{"slug":340,"cid":341,"name":342,"nameZh":343,"cas":344},"785884139273326592","J-22916-0","(2,2′-Bipyridine)dichloropalladium(II)","(2,2′-联吡啶)二氯化钯(II)","14871-92-2",{"slug":346,"cid":347,"name":348,"nameZh":349,"cas":350},"785911505320153088","J-1067964-3","3-Chloro-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)dibenzofuran","3-氯-1-(4,4,5,5-四甲基-1,3,2-二氧硼杂环戊烷-2-基)二苯并呋喃","2404594-48-3",{"slug":352,"cid":353,"name":354,"nameZh":355,"cas":356},"852210178647396352","J-1130840-7","5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine hydrochloride","5-[(3,4,5-三甲氧基苯基)甲基]嘧啶-2,4-二胺盐酸盐","60834-30-2",{"slug":358,"cid":359,"name":360,"nameZh":361,"cas":362},"785898440834945024","J-50423-4","Poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate)","聚(3,4-亚乙二氧基噻吩)-聚(苯乙烯磺酸)","155090-83-8",1792634457183,"zh-CN",[]]