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mL范围内的稳态血浆浓度[3]。小鼠[6]将骨髓移植（BMT）小鼠分成五组，每组由6至10只小鼠组成。一组小鼠在常压室中暴露于缺氧（10％吸入氧气分数），而动物的第二组（对照BMT）置于具有正常氧气环境（21％吸入O2分数）的常氧室中28天。假手术组小鼠接受盐水治疗，而另外两组小鼠接受不同剂量水平（14 ng \u002F kg和70 ng \u002F kg \u002F min）的曲前列环素输注，并暴露于缺氧4周。相比之下，PAH治疗中的人类输注率为10至60 ng \u002F kg \u002F min [6]。",{"key":248,"value":249},"参考文献","[1].\nWhittle BJ, et al. Binding and activity of the prostacyclin receptor (IP) agonists, treprostinil and iloprost, at human prostanoid receptors: treprostinil is a potent DP1 and EP2 agonist. Biochem Pharmacol. 2012 Jul 1;84(1):68-75.\n[2].\nFerrantino M, et al. Inhaled treprostinil sodium for the treatment of pulmonary arterial hypertension. Expert Opin Pharmacother. 2011 Nov;12(16):2583-93.\n[3].\nGhonem N, et al. Treprostinil, a prostacyclin analog, ameliorates ischemia-reperfusion injury in rat orthotopic liver transplantation. Am J Transplant. 2011 Nov;11(11):2508-16.\n[4].\nSmadja DM, et al. Treprostinil indirectly regulates endothelial colony forming cell angiogenic properties by increasing VEGF-A produced by mesenchymal stem cells. Thromb Haemost. 2015 Oct;114(4):735-47.\n[5].\nKazemi Z, et al. Repurposing Treprostinil for Enhancing Hematopoietic Progenitor Cell Transplantation. Mol Pharmacol. 2016 Jun;89(6):630-44.\n[6].\nNikam VS, et al. Treprostinil inhibits the recruitment of bone marrow-derived circulating fibrocytes in chronic hypoxic pulmonary hypertension. 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